Systemic immune-inflammation index and all-cause and cause-specific mortality in sarcopenia: a study from National Health and Nutrition Examination Survey 1999-2018

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 4, 2024

Background Sarcopenia, common in the elderly, often linked to chronic diseases, correlates with inflammation.The association between SII and mortality sarcopenia patients is underexplored, this study investigates relationship a U.S. adult cohort. Methods We analyzed 1999–2018 NHANES data, focusing on 2,974 adults sarcopenia. Mortality outcomes were determined by linking National Death Index (NDI) records up December 31, 2019. Using weighted sampling design, participants grouped into three groups Systemic Immune-Inflammation (SII). used Cox regression models, adjusting for demographic clinical variables, explore SII’s all-cause cause-specific sarcopenia, performing sensitivity analyses robustness. Results Over median follow-up of 9.2 years, 829 deaths occurred. Kaplan-Meier analysis showed significant survival differences across groups. The highest group higher hazard ratios (HRs) both crude adjusted models. had HR all-cause(1.57, 1.25–1.98), cardiovascular(1.61, 1.00–2.58), cancer(2.13, 1.32–3.44), respiratory disease mortality(3.21, 1.66–6.19) fully Subgroup revealed various demographics, including age, gender, presence diabetes or cardiovascular disease. Sensitivity analyses, excluding those who died within two years follow-up, under 45 largely reflected these results, consistently demonstrating HRs all types unadjusted Conclusion Our first demonstrate increased risks population.

Language: Английский

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Osteoarthritis and hypertension: observational and Mendelian randomization analyses

Arthritis Research & Therapy, Journal Year: 2024, Volume and Issue: 26(1)

Published: April 17, 2024

Abstract Background The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, the underlying causal relationship them remains elusive. Methods This study retrospectively included 24,871 participants National Health Nutrition Examination Survey (NHANES) from 2013 to 2020. Weighted logistic regression was performed investigate connection OA hypertension. Additionally, Mendelian randomization (MR) analysis conducted explore potential Results In NHANES data, after adjusting for multiple confounding factors, there no significant (OR 1.30, 95% CI, 0.97–1.73, P = 0.089). However, among males, appeared be associated with higher risk 2.25, 1.17–4.32, 0.019). Furthermore, MR results indicate phenotypes hypertension: knee (IVW, OR 1.024, CI: 0.931–1.126, 0.626), hip 0.990, 0.941–1.042, 0.704), or 1.005, 0.915–1.105, 0.911), UK Biobank 0.796, 0.233–2.714, 0.715). Importantly, these findings remained consistent across different genders reverse MR. Conclusions Our found that patients had only males study. did not uncover any

Language: Английский

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C-reactive protein-induced injury in Mycoplasma pneumoniae -infected lung epithelial cells is mediated by the P38 MAPK/mitochondrial apoptosis pathway

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Patients with Mycoplasma pneumoniae (MP) infections have markedly higher C-reactive protein (CRP). We investigated how CRP contributes to lung epithelial cell death following MP infection. levels were assessed in children diagnosed pneumonia (MPP) and A549 cells infected MP. genetically modified overexpress CRP. Effects on viability, apoptosis, reactive oxygen species (ROS) mitochondrial membrane potential (ΔΨm) evaluated. The expression of proteins implicated the p38 MAPK/mitochondrial apoptotic pathway was analyzed. protective effects MAPK inhibitor SB203580 protector cyclosporin A (CsA) assessed. elevated both MPP patients MP-infected compared controls. Increased apoptosis reduced viability observed cells. overexpression led upregulation pathway, increased cytoplasmic Cyt C, decreased Tom 20 ΔΨm, ROS. Pretreatment or posttreatment CsA damage enhanced survival. during infection promote by activating pathway. Targeting this could offer therapeutic reduce patients.IMPORTANCEThis study provides critical information understanding pathophysiological mechanisms for concerning mediating injury. This outlines significant increase shows its direct involvement through By explaining possibility targeting connected signaling devise interventions amelioration is brought light. implications such data are not merely added knowledge disease pathobiology but also it brings new promise novel intervention strategies result improved clinical outcomes. elucidation specific molecular targets inside heralds a area regarding direction future research application humanity general broader relevance impact respiratory diseases.

Language: Английский

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Association between Inflammatory Burden Index and cardiovascular disease in adult Americans: evidence from NHANES 2005-2010

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e38273 - e38273

Published: Sept. 1, 2024

Language: Английский

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Biomarkers That Seem to Have the Greatest Impact on Promoting the Formation of Atherosclerotic Plaque in Current Scientific Research

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 9503 - 9522

Published: Aug. 29, 2024

Atherosclerosis is a chronic inflammatory disease that causes degenerative and productive changes in the arteries. The resulting atherosclerotic plaques restrict vessel lumen, causing blood flow disturbances. Plaques are formed mainly large- medium-sized arteries, usually at bends forks where there turbulence flow. Depending on their location, they can lead to various states such as myocardial infarction, stroke, renal failure, peripheral vascular diseases, or sudden cardiac death. In this work, we reviewed literature early detection of atherosclerosis markers application photodynamic therapy atherosclerosis-related diseases. Herein, described roles C-reactive protein, insulin, osteopontin, osteoprotegerin, copeptin, TGF-β cytokine family, amino acid homocysteine. Also, discuss role microelements iron, copper, zinc, Vitamin D promoting formation plaque. Dysregulation administered compounds associated with an increased risk atherosclerosis. Additionally, taking into account pathophysiology plaque formation, believe maintaining homeostasis range biomarkers mentioned article crucial for slowing down process development stability already formed.

Language: Английский

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Associations of iron metabolism and inflammation with all-cause and cardiovascular mortality in a large NHANES community sample: Moderating and mediating effects

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(8), P. 1854 - 1863

Published: March 27, 2024

Language: Английский

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Bias from heritable confounding in Mendelian randomization studies

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Mendelian randomization (MR) is an approach to causal inference that utilises genetic variants obtain estimates of the effect exposure on outcome in presence unobserved confounding. MR relies a set assumptions unbiased estimates, one these there no pathway from does not act through exposure. Increasing genome-wide association study (GWAS) sample sizes for enables discovery instrumental variables with smaller sizes. We illustrate simulations how could arise traits have greater liability confound exposure-outcome relationship. When such are selected as instruments this can bias estimate obtained instrument same direction confounded observational but larger magnitude. Through simulation we total increases across range standard estimation methods proportion associated confounder increases. However, if heritable confounders known and be instrumented, free applying pre-estimation filtering methods, removing explain more variation than exposure, or by estimating effects multivariable MR. highlight potential SNPs identified GWAS examination recent C-Reactive Protein. Finally, our age at menarche type 2 diabetes, hypothesising may biased confounding due inclusion early life adiposity instruments.

Language: Английский

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New Modifiable Risk Factors Influencing Coronary Artery Disease Severity

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7766 - 7766

Published: July 16, 2024

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide with coronary artery disease (CAD) being first culprit in this group. In terms CAD, not only its presence but also severity plays a role patient’s treatment and prognosis. CAD complexity can be assessed indicator named SYNTAX score (SS). A higher SS is associated major adverse cardiovascular event (MACE) occurrence short- long-term observations. Hence, risk factors affecting based on results may help lower among patients already developed to reduce their impact atherosclerosis progression. The well-established are consistent those plaque burden. However, recently, it was shown that new indicators exist, which we present paper, significantly contribute such as inflammatory parameters, C-reactive protein (CRP), ratios blood smear results, uric acid. Moreover, microbiota alteration, vitamin D deficiency, obstructive sleep apnea (OSA) predicted severity. sometimes, certain were revealed significant chronic syndromes (CCSs) or specific acute (ACSs). Importantly, there need apply interdisciplinary translational approach novel assessment maximize secondary prevention at

Language: Английский

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Mendelian Randomization Study on hs-CRP and Dyslipidemia in Koreans: Identification of Novel SNP rs76400217

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 506 - 506

Published: Jan. 9, 2025

High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammation and associated with developing dyslipidemia. However, the causality between hs-CRP dyslipidemia remains unresolved. This study aimed to investigate relationship concentrations explore potential causal link using Mendelian randomization (MR) analysis. A nested case–control was conducted 1174 participants, genotype data were analyzed Korean Chip. genome-wide association (GWAS) identified rs76400217 as suitable instrumental variable (IV) due its significant (p < 10−8). Logistic regression models, adjusted for confounders, used evaluate An MR analysis performed two-stage least squares (2SLS) method, IV assess causality. showed (OR 2.08, 95% CI: 1.81–2.39, p 0.001). remained after adjusting factors such age, sex, alcohol consumption, BMI. The confirmed strong associations 0.001) in all but not statistically significant. Thus, no evidence risk found population. observed may be other contributing rather than direct cause.

Language: Английский

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Multivariable Mendelian Randomization adjusting for heritable confounding analyzes the causal effects of C-reactive protein on multiple diseases

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Abstract Background C-reactive protein (CRP) is a marker of inflammation associated with autoimmune, cardiovascular, and neuropsychiatric disorders. However, it remains unclear whether CRP causally affects these traits or if observed associations result from reverse causation confounding. Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate causal effects avoid the biases present in observational studies. Prior MR studies have suggested on several traits, including schizophrenia, bipolar disorder, colorectal cancer. may produce biased results factors that confound exposure outcome are heritable, resulting horizontal pleiotropy. This major concern for CRP, because levels increase response caused by wide range heritable conditions. Methods Multivariable (MVMR) can be used eliminate bias confounding when GWAS summary data available confounders. In this study, we use MVMR 12 outcomes prior evidence associational link CRP. We novel computational pipeline identify broad set potential confounders between each trait MRC-IEU OpenGWAS database. compare computationally selected univariable using narrower, literature derived Results find suggests risk-increasing effect coronary artery disease, knee osteoarthritis, rheumatoid arthritis, protective schizophrenia. after adjusting confounders, only arthritis (OR 1.18, 95% CI [1.07,1.31], p=0.0010 GRAPPLE) schizophrenia 0.87, [0.79,0.96], p=0.0038 remain significant. Additionally, disorder at nominal significance level, which not analysis. Conclusion These suggest analyses high confounding, though indeed play role development some diseases, potentially mediated its innate immunity. also high-light automatic confounder selection improve robustness analyses. Key Messages multivariable various diseases proposed phenome-wide Our study did multiple except rheuma-toid highlights an indicator rather than factor disease risk, suggesting previous been

Language: Английский

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