Advances in Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 33(8), P. 831 - 841
Published: Nov. 14, 2023
Cardiac hypertrophy can be a pathological process that impairs heart function. Anthocyanins are well-characterized type of natural antioxidant, and recent studies have shown this compound has potential cardioprotective effects against different disorders, such as cardiac hypertrophy.
Language: Английский
Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 234 - 234
Published: Jan. 16, 2025
Red currant (Ribes rubrum L.) berries are rich in bioactive compounds and exhibit nutritive protective features. This research examined the content of secondary metabolites red variety Redpoll lyophilized juice waste extract their antioxidative spasmolytic effects. The flavonol anthocyanin contents samples were determined using high-performance liquid chromatography. antispasmodic effects assessed vitro conditions, potential impact possible action mechanisms revealed. results showed prevalence cyanidin-3-O-glucoside as dominant with higher sample. Quercetin content, prevalent flavonol, was berry a greater ability for scavenging free radicals, whereas better inhibited lipid peroxidation. superior agent spontaneous, KCl-, CaCl2-, BaCl2-, histamine-, acetylcholine-induced ileal contractions. first evaluation indicated beneficial an antioxidant agent. Therefore, this sample could be designated prevention or treatment gastrointestinal disorders.
Language: Английский
Citations
0
Life, Journal Year: 2025, Volume and Issue: 15(3), P. 406 - 406
Published: March 5, 2025
Berries from the Vaccinium genus, known for their rich array of bioactive metabolites, are recognized antioxidant, anti-inflammatory, and anticancer properties. These compounds, including anthocyanins, flavonoids, phenolic acids, have attracted significant attention potential health benefits, particularly in cancer prevention treatment. Gastric (GC), a leading cause cancer-related deaths worldwide, remains challenging to treat, especially its advanced stages. This study investigates therapeutic species GC treatment using computational methods. RNA sequencing revealed upregulated genes associated with GC, while network pharmacology molecular docking approaches identified strong interactions between cyanidin 3-O-glucoside (C3G), key metabolite. Furthermore, dynamics simulations HSP90AA1-C3G complex demonstrated stable binding structural integrity, suggesting that C3G may inhibit HSP90AA1, protein involved progression. findings highlight offering novel approach by targeting pathways. research provides valuable insights into role berries as natural therapeutics, supporting integration future gastric strategies.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: March 28, 2025
Crohn's disease (CD) and ulcerative colitis (UC), referred to as inflammatory bowel (IBD), pose considerable challenges in treatment because they are chronic conditions that easily relapse. The occurrence of IBD continues rise developing countries. Nonetheless, the existing therapies for have limitations fail address needs patients thoroughly. There is an increasing need new, safe, highly effective alternative medications patients. Traditional Chinese Medicine (TCM) employed drug development management due its wide-range biological activities, minimal toxicity, limited side effects. Extensive research has shown certain TCM exhibits significant therapeutic benefits treatments. Honeysuckle (Lonicera japonica) was used clinical settings IBD. Bioactive metabolites L. japonica, such luteolin, quercetin, cyanidin, chlorogenic acid (CGA), caffeic (CA), saponin, exhibit managing honeysuckle flower a potential candidate anti-inflammatory, immune system-regulating, antioxidant qualities. This paper reviews It discusses fundamental mechanism japonica bioactive prevention
Language: Английский
Citations
0
Nutritional Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20
Published: April 28, 2025
This review examines the neuroprotective potential of paddy rice bioactive compounds, with a focus on antioxidant, anti-inflammatory, and neuroregenerative properties that may aid in preventing neurodegenerative diseases. Key compounds analyzed include tocotrienols, gamma-oryzanol, phenolic acids. We conducted comprehensive existing studies detailing mechanisms by which bioactives support brain health. These were examined for their effects oxidative stress reduction, neuroinflammation modulation, neurotransmitter regulation, neurogenesis promotion. Bioactives such as gamma-oryzanol ferulic acid found to decrease neuroinflammatory markers function. Research shows enhance neural resilience cognitive function, suggesting role managing disorders like Parkinson's Alzheimer's disease. While preclinical evidence underscores therapeutic promise bioactives, further clinical are needed confirm efficacy, establish optimal dosages, improve bioavailability. advocates advanced nutraceutical development using bridge findings applications.
Language: Английский
Citations
0
Plants, Journal Year: 2023, Volume and Issue: 12(22), P. 3889 - 3889
Published: Nov. 17, 2023
Obesity has become a major health issue worldwide and obese individuals possess higher levels of adipose tissue when compared with healthy individuals. is highly associated the development different chronic diseases, such as diabetes, cardiovascular hypertension, cancers, etc. Previous studies established that anthocyanin compounds play an important role in attenuating obesity-related consequences. Among various compounds, cyanidin-3-O-β-glucoside (C3G) most component widely distributed colored edible plant materials, especially berries, cherries, black rice, purple corn, In recent decades, several have reported therapeutical properties C3G. C3G biological benefits, antioxidant, antimicrobial, anti-inflammatory, antidiabetic, anti-obesity, neuroprotective, anticancer, this review, we summarized vitro vivo relation to complications. Several mechanistic demonstrated maintains metabolism glucose, fatty acids, lipids by regulating genes signaling pathways. It could be concluded consumption protects from issues maintaining body weight their energy balance. This review provides some pathways/targets facilitate prevention treatment obesity, leading food supplements.
Language: Английский
Citations
6
Çukurova medical journal (Online)/Çukurova medical journal, Journal Year: 2024, Volume and Issue: 49(2), P. 471 - 478
Published: June 30, 2024
Purpose: Due to the diverse biological activities attributed its antioxidant, antidiabetic, anti-inflammatory, and cytoprotective properties, cyanidin-3-glucoside (Cy3G) has been widely studied. The present study was conducted investigate effects of Cy3G supplementation on redox balance disruption during acute exercise. Materials Methods: To this end, 28 male Balb-C mice were divided into four groups: control, exercise, Cy3G, exercise+Cy3G. During experimental period, in exercise+Cy3G groups administered 5 mg per kg body weight, while control exercise fed standard chow. trained treadmill for 10 min every day at speed m/min 2 weeks. On 15th day, an exhaustion applied. Then, all sacrificed, serum samples taken analyze native thiol, total disulfide, thiol-disulfide indices. Results: findings showed that combination significantly increased thiol levels decreased disulfide compared other groups. However, it did not cause any change levels. Native measured as 114.6±64.1, 106.4 ±57.9, 200.1±84.2, 262.1±105.9; Disulfide determined 253.2±71.6, 257.4±31.5, 213.8±44.8 188.4±32.2; Total 621.1±116.1, 621.2±100.1, 627.7±125.8 639.0±105.3 (respectively; exercise+Cy3G). Conclusion: can potentially maintain by supporting antioxidant defense systems reducing oxidative stress. use may have a positive effect preventing exercise-induced stress fatigue.
Language: Английский
Citations
1
Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18
Published: Aug. 3, 2024
Cyanidin-3-O-glucoside (C3G), is an anthocyanin mainly found in berries, and can also be produced by microorganisms. It has been traditionally used as a natural coloring agent for decades. Recently, it investigated its high antioxidant activity anti-cancer attributes. C3G low bioavailability sensitive to oxidation gastric pH; therefore, encapsulated nanoliposomes enhance bio-availability, targeted delivery- efficacy against chronic disease.
Language: Английский
Citations
1
Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 14, P. 100565 - 100565
Published: Dec. 14, 2024
Language: Английский
Citations
1
Antibiotics, Journal Year: 2024, Volume and Issue: 13(5), P. 450 - 450
Published: May 15, 2024
The increasing rates of morbidity and mortality owing to bacterial infections, particularly
Language: Английский
Citations
0
Food Research International, Journal Year: 2024, Volume and Issue: 192, P. 114802 - 114802
Published: July 20, 2024
Language: Английский
Citations
0