The Potential Role of PSMA-Targeted PET in Salivary Gland Malignancies: An Updated Systematic Review DOI Creative Commons
Alessio Rizzo, Domenico Albano, Federica Elisei

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(14), P. 1516 - 1516

Published: July 14, 2024

Background: Recent studies have suggested using positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals for the detection of salivary gland malignancies (SGM), particularly adenoid-cystic carcinoma (ACC). Methods: The authors conducted an extensive review scientific literature to examine potential diagnostic role PET/CT PSMA-targeting in (SGMs) and adenoid cystic This study included newly diagnosed SGM patients those disease recurrence their imaging evaluation. Results: updated systematic a total six that examined performance PSMA-targeted ACC. articles provided evidence high rate ACC across all clinical contexts examined. SGMs other than exhibited poorer performance. Conclusions: seems promising detecting lesions; moreover, PSMA appears be suitable target radioligand therapy. Prospective multicentric are warranted strengthen ACC, as both theragnostic agents.

Language: Английский

Evaluation of FAPI PET imaging in gastric cancer: a systematic review and meta-analysis DOI Creative Commons
Dan Ruan, Liang Zhao, Jiayu Cai

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(13), P. 4694 - 4710

Published: Jan. 1, 2023

Purpose: Recent studies suggest that 68 Ga-FAPI PET/CT demonstrated superiority over 18 F-FDG in the evaluation of various cancer types, especially gastric (GC).By comprehensively reviewing and analysing differences between GC, some evidence is provided to foster broader clinical application FAPI PET imaging.Methods: In this review, published up July 3, 2023, employed radionuclide labelled as a diagnostic radiotracer for GC were analysed.These sourced from both PubMed Web Science databases.Our statistical analysis involved bivariate meta-analysis data quantitative metrics.These performed using R language.Results: The included 14 studies, with 527 patients, which 358 diagnosed GC.Overall, showed higher pooled sensitivity (0.84 [95% CI 0.67-0.94]vs. 0.46 0.32-0.60]),specificity (0.91 0.76-0.98]vs. 0.88 0.74-0.96])and area under curve (AUC) (0.92 0.77-0.98]vs. 0.52 0.38-0.86])than F-FDG.The superior sensitivities primary tumours, local recurrence, lymph node metastases, distant peritoneal metastases.Furthermore, maximum standardized uptake value (SUVmax) tumour-to-background ratios (TBR).For bone while slightly lower patient-based (0.93 vs. 1.00), it significantly outperformed lesion-based (0.95 0.65).However, SUVmax (mean difference ) TBR .80]) metastases no significant PET/CT.Conclusion: Compared F-FDG, imaging improved accuracy GC.It can be effectively applied early diagnosis, initial staging, detection recurrence/metastases GC. may have potential replacing future applications.

Language: Английский

Citations

20
The Contribution of 68Ga-FAPI-04 PET/CT to Staging and Prognosis in Gastric Cancer DOI
Ediz Beyhan, Tevfik Fikret Çermik, Özge Erol Fenercioğlu

et al.

Clinical Nuclear Medicine, Journal Year: 2024, Volume and Issue: 49(10), P. e485 - e491

Published: July 31, 2024

This study aimed to compare the diagnostic capabilities of 18 F-FDG PET/CT and 68 Ga-FAPI-04 imaging in staging gastric carcinoma, exploring impact on treatment planning its prognostic significance.

Language: Английский

Citations

7
Folic acid-mediated hollow $$\text {Mn}_{3}\text {O}_{4}$$ nanocomposites for in vivo MRI/FLI monitoring the metastasis of gastric cancer DOI Creative Commons
Zhihua Yang, Chenying Wang,

Shangting Du

et al.

BioMedical Engineering OnLine, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 10, 2024

Language: Английский

Citations

5
Predictive Value of 18F‐FDG PET/CT in LA‐HNSCC Patients Undergoing Neoadjuvant Chemoimmunotherapy: A Prospective Study DOI Open Access
Rong Huang, Xiaoxu Lü,

Xueming Sun

et al.

Oral Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

ABSTRACT Objective The study evaluates the efficacy of 18 F‐2‐fluoro‐2‐deoxy‐d‐glucose FDG PET/CT in predicting outcomes patients with advanced head and neck squamous cell carcinoma receiving neoadjuvant chemoimmunotherapy. Methods In this prospective study, we compared parameters 63 LA‐HNSCC who underwent F‐FDG before chemoimmunotherapy, divided into responders (47) non‐responders (16), after three cycles ratio maximum standardized uptake value (SUVmax) primary tumor to SUVmean normal tissue (muscle blood) was recorded as target background (TBR muscle TBR blood). Results TBRblood were significantly lower responding group than non‐responding group. Receiver operating characteristic (ROC) curve analysis identified (area under (AUC) = 0.931, p 0.001) (AUC 0.894, significant predictors chemoimmunotherapy efficacy. found that SUVmean, TBRblood, age, Eastern Cooperative Oncology Group (ECOG) scores correlated short‐term efficacy, while an independent predictor. Conclusion scans, higher baseline associated a poor response chemoradiotherapy LA‐HNSCC.

Language: Английский

Citations

0
The cutting edge: Promising oncology radiotracers in clinical development DOI
Jorge D. Oldan, Martin G. Pomper, Rudolf A. Werner

et al.

Diagnostic and Interventional Imaging, Journal Year: 2024, Volume and Issue: 105(10), P. 400 - 406

Published: May 14, 2024

Language: Английский

Citations

3
The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review DOI Creative Commons
Domenico Albano, Alessio Rizzo, Riemer H. J. A. Slart

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 716 - 716

Published: May 31, 2024

The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment non-oncological diseases, such as inflammatory and infectious even if evidence in literature still its initial phases. We conducted a systematic search Scopus, PubMed/MEDLINE, Embase, Cochrane library databases studies published before 31 December 2023 reporting disease imaging with FAPI PET/CT. included twenty-one total 1046 patients. most frequent studied was lung interstitial disease, investigated six 200 patients, followed by bone joint diseases two 185 IgG4-related 53 Crohn’s 30 Despite heterogeneity terms study design technical features, PET/CT showed high detection rate diagnostic role. Moreover, when compared 2-[18F]FDG (n = 7 studies), seems to have better performances. presence chronic inflammation tissue remodeling, typical immune-mediated conditions, may be underlying mechanism uptake.

Language: Английский

Citations

3
Surface electric field enhanced biosensor based on symmetrical U-tapered HCF structure for gastric carcinoma biomarker trace detection DOI

Ben Li,

Qi Wang

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 264, P. 116666 - 116666

Published: Aug. 12, 2024

Language: Английский

Citations

3
Diagnostic Accuracy of [68Ga]Ga Labeled Fibroblast-Activation Protein Inhibitors in Detecting Head and Neck Cancer Lesions Using Positron Emission Tomography: A Systematic Review and a Meta-Analysis DOI Creative Commons
Alessio Rizzo, Alberto Miceli, Manuela Racca

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1664 - 1664

Published: Nov. 30, 2023

Several studies have examined the use of positron emission tomography (PET) using [68Ga]Ga-radiolabeled fibroblast-activation protein inhibitors (FAPi) across multiple subtypes head and neck cancer (HNC). The purpose present study was to evaluate diagnostic accuracy a newly developed molecular imaging approach in context HNC through comprehensive review meta-analysis. A thorough literature conducted identify scholarly articles about effectiveness FAP-targeted PET imaging. incorporates original publications assessing efficacy this innovative test both diagnosed previously treated patients. This systematic eleven investigations, which nine were deemed suitable for inclusion subsequent quantitative synthesis yielded pooled detection rate 99% primary lesions. Additionally, on per patient-based analysis, sensitivity specificity regional lymph node metastases found be 90% 84%, respectively. analysis revealed statistical heterogeneity among findings presented indicate favorable performance detecting tumors. In contrast, discordant results concerning found. However, further multicentric trials are required validate specific group

Language: Английский

Citations

7
PET in inflammatory bowel diseases: a new FAPI era? DOI
Federica Galiandro, Franco Scaldaferri,

Luigi Sofo

et al.

Clinical and Translational Imaging, Journal Year: 2024, Volume and Issue: 12(6), P. 563 - 565

Published: June 25, 2024

Language: Английский

Citations

0
The Potential Role of PSMA-Targeted PET in Salivary Gland Malignancies: An Updated Systematic Review DOI Creative Commons
Alessio Rizzo, Domenico Albano, Federica Elisei

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(14), P. 1516 - 1516

Published: July 14, 2024

Background: Recent studies have suggested using positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals for the detection of salivary gland malignancies (SGM), particularly adenoid-cystic carcinoma (ACC). Methods: The authors conducted an extensive review scientific literature to examine potential diagnostic role PET/CT PSMA-targeting in (SGMs) and adenoid cystic This study included newly diagnosed SGM patients those disease recurrence their imaging evaluation. Results: updated systematic a total six that examined performance PSMA-targeted ACC. articles provided evidence high rate ACC across all clinical contexts examined. SGMs other than exhibited poorer performance. Conclusions: seems promising detecting lesions; moreover, PSMA appears be suitable target radioligand therapy. Prospective multicentric are warranted strengthen ACC, as both theragnostic agents.

Language: Английский

Citations

0