Chemico-Biological Interactions,
Journal Year:
2024,
Volume and Issue:
394, P. 111002 - 111002
Published: April 9, 2024
Lung
inflammatory
disorders
are
a
major
global
health
burden,
impacting
millions
of
people
and
raising
rates
morbidity
death
across
many
demographic
groups.
An
industrial
chemical
common
environmental
contaminant,
formaldehyde
(FA)
presents
serious
concerns
to
the
respiratory
system,
including
onset
aggravation
lung
disorders.
Epidemiological
studies
have
shown
significant
associations
between
FA
exposure
levels
incidence
severity
several
diseases.
causes
inflammation
in
tract
via
immunological
activation,
oxidative
stress,
airway
remodelling,
aggravating
pre-existing
pulmonary
compromising
function.
Additionally,
functions
as
sensitizer,
causing
allergic
responses
hypersensitivity
pneumonitis
sensitive
people.
Understanding
complicated
processes
behind
formaldehyde-induced
is
critical
for
directing
targeted
strategies
aimed
at
minimizing
exposures
alleviating
burden
formaldehyde-related
illnesses
on
health.
This
abstract
explores
intricate
relationship
diseases,
asthma,
bronchitis,
inflammation,
injury
fibrosis.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(6), P. 1035 - 1035
Published: May 21, 2024
Hepatitis
C
virus
(HCV)
remains
a
significant
global
health
challenge.
Approximately
50
million
people
were
living
with
chronic
hepatitis
based
on
the
World
Health
Organization
as
of
2024,
contributing
extensively
to
morbidity
and
mortality.
The
advent
approval
several
direct-acting
antiviral
(DAA)
regimens
significantly
improved
HCV
treatment,
offering
potentially
high
rates
cure
for
C.
However,
promising
aim
eventual
eradication
challenging.
Key
challenges
include
variability
in
DAA
access
across
different
regions,
slightly
variable
response
DAAs
diverse
patient
populations
genotypes/subtypes,
emergence
resistance-associated
substitutions
(RASs),
conferring
resistance
DAAs.
Therefore,
periodic
reassessment
current
knowledge
is
needed.
An
up-to-date
review
also
necessitated
observed
shifts
epidemiological
trends,
continuous
development
therapeutic
strategies,
changes
public
policies.
Thus,
comprehensive
aimed
integrate
latest
epidemiology,
pathophysiology,
diagnostic
approaches,
treatment
options
preventive
strategies
HCV,
particular
focus
associated
RASs
ongoing
efforts
vaccine
development.
This
sought
provide
healthcare
professionals,
researchers,
policymakers
necessary
insights
address
burden
more
effectively.
We
highlight
progress
made
managing
preventing
infection
persistent
barriers
challenging
prevention
infection.
overarching
goal
was
align
objectives
towards
reducing
hepatitis,
aiming
its
elimination
threat
by
2030.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 24, 2025
The
liver
is
a
vital
organ
responsible
for
numerous
metabolic
processes
in
the
human
body,
including
metabolism
of
drugs
and
nutrients.
After
damage,
can
rapidly
return
to
its
original
size
if
causative
factor
promptly
eliminated.
However,
when
harmful
stimulus
persists,
liver’s
regenerative
capacity
becomes
compromised.
Substantial
theoretical
feasibility
has
been
demonstrated
at
levels
gene
expression,
molecular
interactions,
intercellular
dynamics,
complemented
by
successful
animal
studies.
robust
model
carrier
that
closely
resemble
physiology
are
still
lacking
translating
these
theories
into
practice.
potential
regeneration
central
focus
ongoing
research.
Over
past
decade,
advent
organoid
technology
provided
improved
models
materials
advancing
research
efforts.
Liver
represents
novel
vitro
culture
system.
several
years
refinement,
organoids
now
accurately
replicate
morphological
structure,
nutrient
drug
metabolism,
secretory
functions,
providing
disease
Regenerative
medicine
aims
or
tissue
functions
repair
replace
damaged
tissues,
restore
their
structure
function,
stimulate
tissues
organs
within
body.
possess
same
function
as
tissue,
offering
serve
viable
replacement
liver,
aligning
with
goals
medicine.
This
review
examines
role
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(7)
Published: Feb. 1, 2025
Abstract
Liver
fibrosis,
a
progressive
condition
resulting
from
chronic
liver
injury,
can
lead
to
cirrhosis
and
hepatocellular
carcinoma.
Nanoparticles
have
emerged
as
promising
tools
for
their
diagnosis
treatment
due
unique
properties.
This
review
highlights
advances
in
lipid‐based
(e.g.,
liposomes,
solid
lipid
nanoparticles),
polymer‐based
nanocapsules,
dendrimers),
inorganic
iron
oxide,
gold
biological
nanoparticles
extracellular
vesicles,
exosomes).
These
enhance
imaging
contrast
MRI
CT,
enabling
non‐invasive
fibrosis
detection,
deliver
drugs
or
gene‐editing
hepatic
stellate
cells
(HSCs)
targeted
therapy.
Extracellular
vesicles
(EVs)
exosomes
also
show
potential
biomarkers
therapeutic
carriers.
However,
challenges
such
limited
targeting
efficiency,
toxicity,
difficulties
clinical
translation
remain.
Future
research
should
focus
on
optimizing
nanoparticle
design,
improving
biocompatibility,
addressing
regulatory
issues
facilitate
application.
Nanoparticle‐based
strategies
hold
great
promise
revolutionizing
management.
BMC Gastroenterology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 6, 2025
Chronic
liver
disease
is
an
on-going
loss
of
structure
and
functions
that
lasts
for
at
least
six
months.
About
1.5
billion
population
suffered
with
this
devastating
worldwide.
The
aim
study
to
assess
the
treatment
outcome
associated
factors
in
patients
chronic
Bahir
Dar,
North
West
Ethiopia.
A
retrospective
cross
sectional
was
conducted
both
governmental
private
hospitals
Dar
city
from
January
August
2024.
All
months
treated
their
specific
causes
and/or
complications
were
included.
Descriptive
statistics
employed
explain
socio-demographic
relevant
clinical
characteristics.
Binary
logistic
regression
determine
poor
outcome.
Texts,
tables
charts
used
present
statistically
clinically
significant
results.
p-value
<
0.05
considered
significant.
total
213
medical
records
reviewed.
Most
participants
(72.8%)
male
resided
rural
area
(63.8%).
Viral
hepatitis
most
frequent
(60.0%)
etiology
followed
by
parasitic
(23.0%)
alcohol
misuse
(11.5%).
percentage
who
experienced
outcomes
39.0%
54.2%
not
taking
medications
specifically
tailored
condition.
Stages
(AOR
=
2.68;
95%CI:
1.50-4.76,
p
0.001),
carcinoma
status
1.07-6.68,
0.035)
duration
0.38;
0.15-0.98,
0.045)
independent
predictors
overall
our
inadequate.
Decompensated
stages
cirrhosis,
cellular
shorter
failure.
Timely
initiation
appropriate
therapy
warranted
improve
patients.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 13, 2025
Liver
is
an
important
target
organ
of
ambient
fine
particulate
matter
(PM2.5).
Numerous
studies
have
shown
that
PM2.5
exposure
can
cause
liver
lipid
metabolism
disorders
and
other
damage
in
mammals.
However,
the
impact
on
health
during
pregnancy,
a
sensitive
life
stage,
remains
understudied,
underlying
mechanisms
are
also
unknown.
Given
critical
role
adenosine
5'-monophosphate
activated
protein
kinase
(AMPK)
regulating
inflammation,
we
hypothesize
AMPK
activation
may
mitigate
maternal
hepatic
disorders,
reduce
attenuate
fibrosis
induced
by
pregnancy.
To
test
this
hypothesis,
pregnant
C57BL/6
mice
were
randomly
assigned
to
4
groups:
filtered
air
(FA)
+
NS
(normal
saline),
PM2.5+NS,
FA
AICAR
(acadesine,
activator),
PM2.5+AICAR.
PM2.5+NS
PM2.5+AICAR
groups
continuously
exposed
with
whole-body
chamber,
while
two
chamber.
Simultaneously,
received
intraperitoneal
injections
agonist
(200
mg/kg∙bw
per
day)
from
gestational
day
13
(GD13)
GD17,
administered
normal
saline
injection.
We
found
dyslipidemia
mice,
which
was
alleviated
treatment.
Histopathological
analysis
showed
pregnancy
deposition
biochemical
assays
revealed
triglyceride
cholesterol
levels
significantly
increased
after
PM2.5,
whereas
treatment
ameliorated
Furthermore,
disrupted
expression
key
genes
proteins
associated
synthesis,
fibrosis,
mitigated
these
effects.
These
findings
demonstrated
ameliorates
reduces
attenuates
caused
be
action
for
injury
Future Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: April 22, 2025
Abstract
Background
Polycystic
ovary
syndrome
(PCOS)
is
a
prevalent
endocrine
disorder
affecting
women
of
reproductive
age,
characterized
by
range
metabolic
and
complications,
including
insulin
resistance,
hyperandrogenism,
menstrual
irregularities.
The
complexity
PCOS
necessitates
innovative
therapeutic
strategies
that
extend
beyond
conventional
pharmacological
treatments.
Main
body
Ursolic
acid
(UA),
natural
pentacyclic
triterpenoid
found
in
various
plants,
has
gained
significant
attention
for
its
diverse
properties
anti-inflammatory,
antioxidant,
anticancer,
antidiabetic,
antimicrobial,
antihyperlipidemic,
anti-obesity,
neuroprotective,
hepatoprotective,
cardioprotective
activities.
Additionally,
the
integration
predictive
tools,
such
as
artificial
intelligence
bioinformatics
databases
like
STRING
(Search
Tool
Retrieval
Interacting
Genes/Proteins)
KEGG
(Kyoto
Encyclopedia
Genes
Genomes),
allows
identification
key
protein
targets
pathways
influenced
UA,
TP53
(Tumor
Protein
P53),
AR
(Androgen
Receptor),
ESR1
(Estrogen
Receptor
1),
BCL2
(B-cell
Lymphoma
2),
STAT3
(Signal
Transducer
Activator
Transcription
3),
IL6
(Interleukin
6).
These
are
crucial
inflammatory
regulation
have
been
linked
to
symptoms
PCOS.
Further
silico
studies
were
conducted
validate
these
findings,
highlighting
need
additional
preclinical
clinical
research.
Conclusion
Comprehensive
guidelines
effective
use
UA
managing
warranted
ensure
optimal
treatment
strategies.
