SLEEP,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
Abstract
Study
Objectives
Visual
stimulation
(VS)
at
40
Hz
is
being
tested
as
a
non-invasive
approach
against
dementias
such
Alzheimer’s
disease.
Applying
it
during
sleep
could
increase
the
convenience,
duration,
and
efficacy
of
stimulation.
Here,
we
feasibility
VS
in
proof-of-concept
study.
Methods
Thirty
healthy
participants
underwent
one
control
experimental
night
polysomnography
laboratory.
was
delivered
wakefulness
(W),
NREM
stages
2
3,
REM
sleep.
Results
As
expected,
EEG
spectral
power
increased
all
four
condition,
compared
to
control.
It
highest
W
similar
across
2,
REM,
with
large
medium
effect
sizes,
respectively.
Steady-state
visually
evoked
potential
(SSVEP)
analyses
time
domain
confirmed
specificity
effect.
Secondary
revealed
that
intervention
did
not
impair
objective
subjective
quality
beyond
first-night
Conclusions
effectively
neuronal
gamma
activity
frequency
without
degrading
quality,
supporting
this
approach.
These
findings
lay
groundwork
for
optimizing
gamma-band
sensory
tool
causally
study
cognitive
functions
scalable,
dementias.
Frontiers of Optoelectronics,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: Sept. 18, 2023
With
the
increase
in
aging
population,
global
number
of
people
with
Alzheimer's
disease
(AD)
progressively
increased
worldwide.
The
situation
is
aggravated
by
fact
that
there
no
effective
pharmacological
therapy
AD.
Photobiomodulation
(PBM)
non-pharmacological
approach
has
shown
very
promising
results
AD
pilot
clinical
and
animal
studies.
However,
mechanisms
therapeutic
effects
PBM
for
are
poorly
understood.
In
this
study
on
mice,
we
demonstrate
photodynamic
5-aminolevulenic
acid
laser
635
nm
cause
reduction
network
meningeal
lymphatic
vessels
(MLVs)
leading
to
suppression
removal
beta-amyloid
(Aβ)
from
right
lateral
ventricle
hippocampus.
Using
original
protocol
under
electroencephalographic
monitoring
wakefulness
sleep
stages
non-anesthetized
discover
7-day
course
during
deep
vs.
provides
better
restoration
clearance
Aβ
ventricular
system
brain
Our
shed
light
mechanism
show
stimulating
drainage
promotes
transport
via
pathway.
lymphatics
sleeping
open
a
new
niche
restorative
functions
as
well
it
an
important
informative
platform
development
innovative
smart
technologies
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
94, P. 102183 - 102183
Published: Jan. 11, 2024
Brain
diseases
present
a
significant
obstacle
to
both
global
health
and
economic
progress,
owing
their
elusive
pathogenesis
the
limited
effectiveness
of
pharmaceutical
interventions.
Phototherapy
has
emerged
as
promising
non-invasive
therapeutic
modality
for
addressing
age-related
brain
disorders,
including
stroke,
Alzheimer's
disease
(AD),
Parkinson's
(PD),
among
others.
This
review
examines
recent
progressions
in
phototherapeutic
Firstly,
article
elucidates
various
wavelengths
visible
light
that
possess
capability
penetrate
skin
skull,
well
pathways
stimulation,
encompassing
eyes,
skin,
veins,
skull.
Secondly,
it
deliberates
on
molecular
mechanisms
photosensitive
proteins,
within
context
disorders
other
modulation.
Lastly,
practical
application
phototherapy
diverse
clinical
neurological
is
indicated.
Additionally,
this
presents
novel
approaches
combine
pharmacological
Moreover,
outlines
limitations
phototherapeutics
proposes
innovative
strategies
improve
treatment
cerebral
disorders.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
A
non-invasive
device
to
measure
the
dynamics
of
cerebrospinal
fluid
(CSF)
is
highly
desirable
because
CSF
facilitates
cleaning
neurotoxic
wastes
in
brain.
better
understanding
helps
promote
healthy
aging
older
adults
and
treat
patients
with
neurological
diseases.
This
study
employed
a
multi-color
optical
method
quantify
prefrontal
two
groups:
(1)
(n
=
16)
without
27)
Alzheimer's
disease
(2)
young
26)
before
after
light
stimulation.
The
results
revealed
that
coupling
strengths
between
cerebral
blood
volume
(CBV)
were
age-dependent
significantly
higher
AD
than
controls.
Prefrontal
stimulation
enhanced
CBV-CSF
coupling,
suggesting
improved
drainage.
underscores
strategy
as
unique
tool
for
monitoring
interaction
CBV
CSF,
well
metabolic
functions
human
brain,
while
demonstrating
therapeutic
potential
brain
treating
neurodegenerative
diseases
involving
drainage
dysfunction.
Biomedical Optics Express,
Journal Year:
2023,
Volume and Issue:
15(1), P. 44 - 44
Published: Nov. 24, 2023
In
this
study
on
healthy
male
mice
using
confocal
imaging
of
dye
spreading
in
the
brain
and
its
further
accumulation
peripheral
lymphatics,
we
demonstrate
stronger
effects
photobiomodulation
(PBM)
brain's
drainage
system
sleeping
vs.
awake
animals.
Using
Pavlovian
instrumental
transfer
probe
2-objects-location
test,
found
that
10-day
course
PBM
during
sleep
wakefulness
promotes
improved
learning
spatial
memory
mice.
For
first
time,
present
technology
for
under
electroencephalographic
(EEG)
control
incorporates
modern
state
art
facilities
optoelectronics
biopotential
detection
can
be
built
relatively
cheap
commercially
available
components.
These
findings
open
a
new
niche
development
smart
technologies
phototherapy
diseases
sleep.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(6), P. 788 - 788
Published: June 16, 2024
The
COVID-19
pandemic,
caused
by
infection
with
the
SARS-CoV-2
virus,
is
associated
cognitive
impairment
and
Alzheimer’s
disease
(AD)
progression.
Once
it
enters
brain,
virus
stimulates
accumulation
of
amyloids
in
brain
that
are
highly
toxic
to
neural
cells.
These
may
trigger
neurological
symptoms
COVID-19.
meningeal
lymphatic
vessels
(MLVs)
play
an
important
role
removal
toxins
mediate
viral
drainage
from
brain.
MLVs
considered
a
promising
target
prevent
COVID-19-exacerbated
dementia.
However,
there
limited
methods
for
augmentation
MLV
function.
This
review
highlights
new
discoveries
field
COVID-19-mediated
amyloid
development
strategies
stimulate
clearance
through
other
pathways.
based
on
innovative
treating
dysfunction
induced
infection,
including
use
photobiomodulation,
plasmalogens,
medicinal
herbs,
which
offer
hope
addressing
challenges
posed
virus.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(18), P. 13696 - 13696
Published: Sept. 5, 2023
Over
sixty
years,
laser
technologies
have
undergone
a
technological
revolution
and
become
one
of
the
main
tools
in
biomedicine,
particularly
neuroscience,
neurodegenerative
diseases
brain
tumors.
Glioblastoma
is
most
lethal
form
cancer,
with
very
limited
treatment
options
poor
prognosis.
In
this
study
on
rats,
we
demonstrate
that
glioblastoma
(GBM)
growth
can
be
suppressed
by
photosensitizer-free
(PS-free-LT)
using
quantum-dot-based
1267
nm
diode.
This
wavelength,
highly
absorbed
oxygen,
capable
turning
triplet
oxygen
to
singlet
form.
Applying
irradiation
for
4
week
course
total
dose
12.7
kJ/cm
