Recent advances and future directions in sonodynamic therapy for cancer treatment DOI Creative Commons
Priyankan Datta, Sreejesh Moolayadukkam,

Dhrubajyoti Chowdhury

et al.

BME Frontiers, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Deep-tissue solid cancer treatment has a poor prognosis, resulting in very low 5-year patient survival rate. The primary challenges facing tumor therapies are accessibility, incomplete surgical removal of tissue, the resistance hypoxic and heterogeneous microenvironment to chemotherapy radiation, suffering caused by off-target toxicities. Here, sonodynamic therapy (SDT) is an evolving therapeutic approach that uses low-intensity ultrasound target deep-tissue tumors. ability deliver energy safely precisely into small (>10 cm) volumes makes SDT more effective than conventional photodynamic therapy. While currently phase 1/2 clinical trials for glioblastoma multiforme, its use other treatments, such as breast, pancreatic, liver, prostate cancer, still preclinical stage, with further investigation required improve efficacy. This review, therefore, focuses on recent advances treatments. We describe interaction between sonosensitizer molecules associated transfer mechanism malignant cells, which plays central role SDT-mediated cell death. Different sensitizers used various treatments listed, critical parameters reviewed. also discuss approaches efficacies these sonosensitizers, 3-dimensional spheroid vitro investigations, ultrasound-controlled CAR-T SDT-based multimodal therapy, machine learning optimization, could facilitate translation SDT.

Language: Английский

Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy DOI

Chaonan He,

Peipei Feng, Mingming Hao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 27, 2024

Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability sensitizers, improve strengthen photodynamic/sonodynamic properties (modification absorption efficiency light/ultrasonic response stress by modulation nanoparticle shape, size, structure). Also, they modifiability (controlling release rate time sensitizer needed optimize therapeutic effect), programmability multifunctionality (flexible application nanotechnology designing with multiple functions, such drug delivery, targeted therapy, monitoring), expand possibilities combination therapies (the can be loaded other agents, enabling therapies). expected further promote development achieve improved effects. This review summarizes progress nanomaterials recent years based on current strategies provide a theoretical reference aPDT/aSDT.

Language: Английский

Citations

54
Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis DOI
Sijia Wu, Qian Wang, Junhui Du

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.

Language: Английский

Citations

9
Hybrid amorphous titanium dioxide/amphiphilic graft copolymer nano-sonosensitizers DOI Creative Commons
L. Weiss, Ivan Zlotver,

Diana Solovyov

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: 45, P. 112260 - 112260

Published: March 18, 2025

Language: Английский

Citations

1
Inorganic sonosensitizer nanomaterials for sonodynamic therapy of diseases beyond cancer DOI
Alejandro Sosnik, Ivan Zlotver,

Harischandra Potthuri

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: unknown, P. 101384 - 101384

Published: Oct. 1, 2024

Language: Английский

Citations

8
Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review DOI
Xing Yang, Feroza Yasinjan,

Shuhao Sun

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386

Published: July 13, 2024

Language: Английский

Citations

7
Deciphering the hydrodynamics of lipid-coated microbubble sonoluminescence for sonodynamic therapy DOI Creative Commons
Priyankan Datta, Sreejesh Moolayadukkam, Rakesh P. Sahu

et al.

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 111, P. 107090 - 107090

Published: Oct. 2, 2024

Sonodynamic therapy (SDT) is a minimally invasive targeted cancer that uses focused low-intensity ultrasound (<10 MPa, <10 W/cm

Language: Английский

Citations

6
An Ultrasound-Activated Nanozyme Sonosensitizer for Photoacoustic Imaging-Guided Breast Cancer Sonodynamic and Starvation Combination Therapy DOI

Linjie Huang,

Yina Su,

Xueqi Hu

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 4441 - 4452

Published: Feb. 7, 2024

Sonodynamic therapy (SDT) is a promising ultrasound (US)-triggered therapeutic modality for anticancer treatments due to its high penetration, safety, and noninvasiveness. Its efficiency closely related the performance of sonosensitizers oxygen concentration tumor microenvironment (TME). Herein, inspired by adhesion cocklebur, rough-surface sonosensitizer gold platinum encapsulated with magnesium silicate loaded glucose oxidase (AuPt@MgSiO3@GOx, APMS-GOx) an enzymatic cascade activity was designed improve delivery capability, produce reactive species, reduce in tissue. The rough surface APMS-GOx can ability nanomaterials deliver areas. reaction induce starvation level oxygen. Adequate not only alleviate hypoxia TME but also further convert singlet (1O2) under US activation. Moreover, GOx increases involvement US, resulting positive effect on therapy. Furthermore, exhibits near-infrared absorption properties, providing photoacoustic imaging-guided combination breast strategy.

Language: Английский

Citations

5
The Immunomodulatory Effects of Fluorescein-Mediated Sonodynamic Treatment Lead to Systemic and Intratumoral Depletion of Myeloid-Derived Suppressor Cells in a Preclinical Malignant Glioma Model DOI Open Access
Serena Pellegatta, Nicoletta Corradino,

Manuela Zingarelli

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 792 - 792

Published: Feb. 15, 2024

Fluorescein-mediated sonodynamic therapy (FL-SDT) is an extremely promising approach for glioma treatment, resulting from the combination of low-intensity focused ultrasound (FUS) with a sonosensitizer. In present study, we evaluated efficacy and immunomodulation SDT fluorescein as sonosensitizer in immunocompetent GL261 mice first time. vitro studies demonstrated that exposure cells to FL-SDT induced immunogenic cell death relevant upregulation MHC class I, CD80 CD86 expression. vivo were then performed treat glioma-bearing FL-SDT, alone, or FUS alone. Perturbation glioma-associated macrophage subset within immune microenvironment was by all treatments. Notably, depletion myeloid-derived suppressor (MDSCs) concomitant robust infiltration CD8+ T observed SDT-FL-treated mice, significant radiological delay progression consequent improvement survival. Tumor control improved survival also treated FL alone (median 41.5 days, p > 0.0001 compared untreated mice), reflecting considerable modulation microenvironment. Interestingly, high circulating lymphocyte-to-monocyte ratio very low proportion MDSCs predictive better FL- FL-SDT-treated than FUS-treated which elevated monocyte MDSC frequencies correlated worse The immunostimulatory potential treatment profound most immunosuppressive components encouraged exploration immunotherapeutic strategies.

Language: Английский

Citations

5
Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy DOI Creative Commons

Sohaib Mahri,

Raffaella Villa,

Ya‐Ping Shiau

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Cancer is a daunting global health problem with steadily rising incidence. Despite the wide arsenal of current anticancer therapies, challenges such as drug resistance, tumor heterogeneity, poor targeting, and severe side effects often lead to suboptimal efficacy patient outcomes, highlighting need for innovative therapies. Autophagy modulation has emerged an attractive approach complement existing The dual role autophagy in cancer promotion suppression inspired development new drugs therapeutic strategies focusing on both inhibition induction. promising results modulators preclinical studies, lack selectivity potency, toxicity, pharmacokinetics, inadequate targeting continue limit their successful clinical translation. Many these could be overcome using nanomedicine. This review explores recent advancements nanomedicine modulation. Successful combination leveraging nanoparticles synergy chemotherapy, immunotherapy, phototherapy, gene therapy, other modalities are presented. Additionally, nanomaterials intrinsic autophagy‐modulating capabilities, self‐assembling inhibitors, discussed. Finally, limitations currently trials discussed, future perspectives designing implementation explored.

Language: Английский

Citations

0
Comparative study of the effect of photo and photoacoustic stimulation on singlet oxygen production of neutral and water-soluble cationic zinc phthalocyanines DOI Creative Commons
Öznur Dülger Kutlu

Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

Citations

0