A Review of Cyclic Phosphatidic Acid and Other Potential Therapeutic Targets for Treating Osteoarthritis DOI Creative Commons
Tamotsu Tsukahara,

Shigeyuki Imamura,

Toshiro Morohoshi

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2790 - 2790

Published: Oct. 14, 2023

Osteoarthritis (OA), a chronic degenerative joint disease, is the most common form of arthritis. OA occurs when protective cartilage that cushions ends bones gradually breaks down. This leads to rubbing against each other, resulting in pain and stiffness. Cyclic phosphatidic acid (cPA) shows promise as treatment for OA. In this article, we review recent findings regarding biological functions cPA signaling mammalian systems, specifically relation naturally occurring phospholipid mediator with unique cyclic phosphate rings at sn-2 sn-3 positions glycerol backbone. promotes various responses, including cell proliferation, migration, survival. possesses physiological activities are distinct from those elicited by lysophosphatidic acid; however, its biochemical origin has rarely been studied. Although there currently no cure OA, advances medical research may lead new therapies or strategies future, potential therapeutic applications.

Language: Английский

Knee osteoarthritis: Current status and research progress in treatment (Review) DOI Open Access
Ruizhi Geng, Jiayi Li,

Chen Yu

et al.

Experimental and Therapeutic Medicine, Journal Year: 2023, Volume and Issue: 26(4)

Published: Aug. 25, 2023

Knee osteoarthritis (KOA) is a common chronic articular disease worldwide. It also the most form of OA and characterized by high morbidity disability rates. With gradual increase in life expectancy ageing population, KOA not only affects quality patients, but poses burden on global public health. unknown etiology complex pathogenesis. commonly joints subjected to greater loads higher levels activity. The knee joint, which joint human body bears greatest load among all joints, therefore susceptible development OA. lesions may involve cartilage, synovium, capsule periarticular muscles, causing irreversible damage. Factors such as mechanical overload, inflammation, metabolism, hormonal changes serve key roles acceleration progression. clinical diagnosis primarily based combined analysis symptoms, signs, imaging laboratory examination results. At present, there no cure for currently available therapies focus symptomatic treatment delay replacement surgery typically performed patients with advanced disease. current study presents review epidemiological characteristics, risk factors, histopathological manifestations, pathogenesis, diagnosis, modalities progress research.

Language: Английский

Citations

90
Immunomodulation Effects of Porcine Cartilage Acellularized Matrix (pCAM) for Osteoarthritis Treatment DOI

J. Kim,

Hyeon Jae Kwon, Ing‐Shiou Hwang

et al.

Tissue Engineering and Regenerative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

Citations

1
Current Practices and Perceived Effectiveness of Clinicians Regarding Polynucleotide Injection for Knee Osteoarthritis: A Survey-Based Evaluation DOI Open Access
Dagyeong Lee,

Wan-ho Kim,

Han‐Ha Chai

et al.

Healthcare, Journal Year: 2025, Volume and Issue: 13(2), P. 113 - 113

Published: Jan. 9, 2025

Aims: Intra-articular (IA) injection therapy, particularly IA hyaluronic acid (HA), is a common treatment for knee osteoarthritis, but it does have limitations. The of polynucleotide (PN) has emerged as an alternative, potentially offering superior clinical outcomes. This study investigates current practice patterns and the perceived effectiveness PN among clinicians treating osteoarthritis in Republic Korea. Methods: Based on survey conducted who use practice, we explored practices assessed osteoarthritis. Results: A total 265 used participated survey. Most (73.3%) therapy chronic pain, with varying administration frequencies. In addition, 25.8% acute flare-ups. cases effusion, 55.5% removed effusion prior to administering PN. Clinicians rated more effective than HA both pain flare-ups, higher scores cushioning, anti-inflammatory effects, delaying joint degeneration. stated that patients expressed satisfaction compared HA, noting improvement smoothness, noise reduction, relief, reduction heat sensation swelling. Conclusions: results present highlight extensive benefits Further research warranted explore flare-ups validate these findings broader populations.

Language: Английский

Citations

1
From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules DOI Creative Commons

Cíntia Marques,

Alexandre Porcello,

Marco Cerrano

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 148 - 148

Published: Jan. 19, 2025

Polydeoxyribonucleotides (PDRNs) and polynucleotides (PNs) are similar DNA-derived biopolymers that have garnered significant scientific attention since the 1990s for their potential applications in wound healing skin rejuvenation. These exhibit a broad molecular weight (MW) range, typically spanning from 50 to 1500 kDa. However, recent studies expanded this range encompass fragments as small 1 kDa large 10,000 Clinically, PDRN/PN formulations, commercially available various galenic forms (gels, creams, serums, masks, injectables), demonstrated promising effects significantly promoting regeneration, reducing inflammation, improving texture, preventing scar formation, mitigating wrinkles. Importantly, despite widespread use cosmetology aesthetic dermatology, interchangeable of terms “PDRN” “PN” literature (to describe polymers varying lengths) has led considerable confusion within medical communities. To specifically address ambiguity, narrative review proposes standardized structure-based nomenclature these polymers, “Marques Polynucleotide Cutoff”, set at Thus, we propose term should be exclusively reserved small- medium-chain (MW < kDa), while used denote longer-chain ≥ kDa). In broader perspective, classification is based on distinct physicochemical properties therapeutic DNA MWs, which comprehensively discussed present review.

Language: Английский

Citations

1
Clinical effectiveness of polynucleotides TMJ Injections compared to physiotherapy. A 3 months randomized clinical trial DOI Creative Commons
Niccolò Cenzato,

Roberta Crispino,

A. Russillo

et al.

British Journal of Oral and Maxillofacial Surgery, Journal Year: 2024, Volume and Issue: 62(9), P. 807 - 812

Published: July 20, 2024

IntroductionJoint visco-supplementation is an effective therapeutic approach against signs and symptoms of osteoarthrosic/arthritic degeneration mandibular condyle. Supplements choice are usually delivered inside TMJs through intra-articular infiltrations. The present study aims to assess the clinical effectiveness peri-capsular injections polinucleotides (PN) hyaluronic acid (HA).Materials methods60 patients suffering from TMJ osteoarthrosis were recruited divided in 2 groups (test group: n=30, injections; control self-delivered physiotherapeutic exercises). For each patient, maximum opening, right left lateral excursion VAS recorded at 4 different timepoints by a blinded investigator. Paired Student's t-test was used compare consecutive measurements parameters evaluated within groups. Unpaired student's for between-group comparisons.ResultsAll investigated displayed progressive improvement both groups, which more accentuated test group. decrease score differed significantly between (p<0.0001); opening showed continuous increase baseline (37.70±8.33 mm) T3 (39.68±7.64 mm), reflecting improvement, but it not statistically significant (P=0.089 respect T0).ConclusionPN HA represent minimally invasive treatment option reducing pain improving kinematic.

Language: Английский

Citations

6
Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review DOI Open Access
Kun‐Chi Wu,

Yu-Hsun Chang,

Dah‐Ching Ding

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12911 - 12911

Published: Nov. 30, 2024

Cartilage degeneration is a key feature of aging and osteoarthritis, characterized by the progressive deterioration joint function, pain, limited mobility. Current treatments focus on symptom relief, not cartilage regeneration. Mesenchymal stromal cells (MSCs) offer promising therapeutic option due to their capability differentiate into chondrocytes, modulate inflammation, promote tissue This review explores potential MSCs for regeneration, examining biological properties, action mechanisms, applications in preclinical clinical settings. derived from bone marrow, adipose tissue, other sources can self-renew multiple cell types. In cartilage, they aid regeneration secreting growth factors cytokines that enhance repair immune responses. Recent studies show restore integrity, reduce improve although translation remains challenging limitations such as viability, scalability, regulatory concerns. Advancements MSC delivery, including scaffold-based approaches engineered exosomes, may effectiveness. Potential risks, tumorigenicity rejection, are also discussed, emphasizing need optimized treatment protocols large-scale trials develop effective, minimally invasive therapies

Language: Английский

Citations

4
In reply to the Letter to Editor regarding “Clinical effectiveness of polynucleotides TMJ injections 1 compared to physiotherapy. A 3 months randomized clinical trial” DOI
Niccolò Cenzato,

Roberta Crispino,

Margherita Tumedei

et al.

British Journal of Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Comment on “Clinical effectiveness of polynucleotide TMJ injection compared with physiotherapy: a 3-month randomised clinical trial” DOI

Srinivedha Cv,

Rosmy George,

Raghu Kumaravelu

et al.

British Journal of Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Polynucleotides as a novel therapeutic approach in androgenetic alopecia: an analysis of effectiveness and safety DOI
Wilai Thanasarnaksorn,

Nathamon Limsuchaiwat,

Punyaphat Sirithanabadeekul

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 14, 2025

Language: Английский

Citations

0
A literature review on polynucleotide efficacy on skin rejuvenation, and review of the regulatory status and guidelines around polynucleotides DOI

Lauren Titcomb

Journal of Aesthetic Nursing, Journal Year: 2025, Volume and Issue: 14(2), P. 98 - 126

Published: April 2, 2025

The study on polynucleotide efficacy in skin rejuvenation, alongside the review of regulatory status and guidelines within UK, delineates a progressive outlook this emerging therapeutic modality aesthetic medicine. Polynucleotides have demonstrated notable enhancing hydration, elasticity, overall dermal health, primarily through mechanisms that promote cellular repair collagen synthesis. This systematic synthesises findings from various clinical studies to elucidate significant potentials polynucleotides, revealing their capacity improve texture integrity, which are critical rejuvenation aging skin. Further, highlights gap framework governing use polynucleotides United Kingdom.

Language: Английский

Citations

0