Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155946 - 155946
Published: March 1, 2025
Language: Английский
ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(2), P. 309 - 334
Published: Jan. 24, 2024
The emergence of peptide–drug conjugates (PDCs) that utilize target-oriented peptide moieties as carriers cytotoxic payloads, interconnected with various cleavable/noncleavable linkers, resulted in the key-foundation new era targeted therapeutics. They are capable retaining integrity blood circulatory system well releasing drugs at tumor microenvironment. Other valuable advantages specificity and selectivity toward targeted-receptors, higher penetration ability, drug-loading capacity, making them a suitable candidate to play their vital role promising carrier agents. In this review, we summarized types cell-targeting (CTPs) cell-penetrating peptides (CPPs) have broad applications advancement drug-delivery systems (DDS). Moreover, techniques overcome limitations peptide-chemistry for extensive implementation construct PDCs. Besides this, diversified breakthrough linker chemistry, ample knowledge payloads used PDCs recent years, mechanism action was critically discussed. principal aim is provide scattered one place help researchers understand pinching knots science PDC development, also progression bright future novel theranostics clinical practice.
Language: Английский
Citations
19
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489
Published: Feb. 3, 2025
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16359 - 16394
Published: June 11, 2024
Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in spectrum brain tumors, primarily due to blood–brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, presence treatment-resistant stem cells contribute recurrence. Nanoparticles (NPs) have been used overcome these obstacles by attaching targeting ligands enhance therapeutic efficacy. Among ligands, peptides stand out their ease synthesis high selectivity. This article aims review single multiligand strategies critically. In addition, it highlights other integrate effects external stimuli, biomimetic approaches, chemical approaches as nanocatalytic medicine, revealing significant potential treating GBM with peptide-functionalized NPs. Alternative routes parenteral administration, specifically nose-to-brain delivery local within resected cavity, are also discussed. Finally, an overview them discussed provide a perspective on this promising field therapy.
Language: Английский
Citations
15
Food Research International, Journal Year: 2024, Volume and Issue: 180, P. 114060 - 114060
Published: Jan. 26, 2024
Language: Английский
Citations
12
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 240 - 240
Published: Feb. 6, 2024
Effective drug delivery is essential for cancer treatment. Drug systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of Peptides play a significant role various biological physiological functions offer high design flexibility, excellent biocompatibility, adjustable morphology, biodegradability, making them promising candidates delivery. This paper reviews peptide-mediated focusing on self-assembled peptides peptide–drug conjugates. It discusses mechanisms structural control peptides, varieties roles conjugates, strategies augment peptide stability. The review concludes by addressing challenges future directions.
Language: Английский
Citations
11
Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(6), P. 2420 - 2471
Published: May 5, 2024
The development of peptide drugs has made tremendous progress in the past few decades because advancements modification chemistry and analytical technologies. novel-designed have been modified through various biochemical methods with improved diagnostic, therapeutic, drug-delivery strategies. Researchers found it a helping hand to overcome inherent limitations peptides bring continued their applications. Furthermore, emergence peptide-drug conjugates (PDCs)-utilizes target-oriented moieties as vehicle for cytotoxic payloads via conjugation cleavable chemical agents, resulting key foundation new era targeted drugs. This review summarizes classifications drugs, suitable strategies improve ADME (adsorption, distribution, metabolism, excretion) features recent (2015-early 2024) progress/achievements peptide-based drug delivery systems well fruitful implication preclinical clinical studies. we also summarized brief description other types PDCs, including peptide-MOF peptide-UCNP conjugates. principal aim is provide scattered diversified knowledge one place help researchers understand pinching knots science PDC toward bright future novel
Language: Английский
Citations
11
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: June 12, 2024
Abstract Photoresponsive drug delivery systems (PDDSs) have emerged as a promising toolbox for delivery, offering precise control over the site, duration, and dosage of light‐triggered medication. It allows controlled release, photo‐triggered targeting, diagnosis, treatment, improving precision efficacy therapies various diseases. Despite progress in designing different PDDSs, clinical translation has been limited due to obstacles. Herein, this review article focuses on three critical challenges PDDSs: 1) accumulation at diseased lesions, 2) light irradiation, 3) penetration tissues. Also, summarizes discusses current advancements strategies address these challenges. Overall, it emphasizes need clarify from bench bedside develop enhance therapeutic outcomes, increase compatibility patient compliance, unlock possibilities therapies.
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7264 - 7264
Published: July 1, 2024
Cancer is one of the leading causes morbidity and death worldwide, making it a serious global health concern. Chemotherapy, radiotherapy, surgical treatment are most used conventional therapeutic approaches, although they show several side effects that limit their effectiveness. For these reasons, discovery new effective alternative therapies still represents an enormous challenge for tumour diseases. Recently, anticancer peptides (ACPs) have gained attention cancer diagnosis treatment. ACPs small bioactive molecules which selectively induce cell through variety mechanisms such as apoptosis, membrane disruption, DNA damage, immunomodulation, well inhibition angiogenesis, survival, proliferation pathways. can also be employed targeted delivery drugs into cells. With over 1000 clinical trials using ACPs, potential application in therapy seems promising. Peptides utilized conjunction with imaging agents molecular methods, MRI, PET, CT, NIR, improving detection classification cancer, monitoring response. In this review we will provide overview biological activity some natural synthetic common malignant tumours affecting people around world.
Language: Английский
Citations
10
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105838 - 105838
Published: June 3, 2024
Language: Английский
Citations
9
Journal of Peptide Science, Journal Year: 2025, Volume and Issue: 31(2)
Published: Jan. 7, 2025
ABSTRACT Peptides are molecules that consist of at least two amino acids linked by peptide bonds. The difference between peptides and proteins is primarily based on size structure. Typically, oligopeptides fewer than about 10–20 acids, polypeptides more 20 whereas usually made up 50 often contain multiple subunits as stated in the International Union Pure Applied Chemistry rules. Beyond nutritional properties, also structural components hormones, enzymes, toxins, antibiotics play several fundamental physiological roles body. Since introduction first commercial drug, insulin, peptide‐based drugs have gained increased interest. So far, 80 reached market for a wide range conditions, such diabetes, cardiovascular diseases, urological disorders. Meanwhile, significant attention cosmetic industry because their potential boosting skin health. In this review, were comprehensively summarized aspects sources, function, use cosmetics care, indications delivery peptides.
Language: Английский
Citations
1