Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1333 - 1333
Published: Oct. 5, 2024
Glaucoma is a progressive optic neuropathy characterized by the neurodegeneration and death of retinal ganglion cells (RGCs), leading to blindness. Current glaucoma interventions reduce intraocular pressure but do not address neurodegeneration. In this effort, identify new pharmacological targets for management, we employed network pharmacology approach.
Language: Английский
Circulation Journal, Journal Year: 2024, Volume and Issue: 88(10), P. 1689 - 1696
Published: July 23, 2024
Background: Systemic hypertension (HT) is associated with the development of increased intraocular pressure (IOP), a risk factor for glaucoma. However, it remains unclear whether high IOP HT.
Language: Английский
Citations
6
Klinische Monatsblätter für Augenheilkunde, Journal Year: 2024, Volume and Issue: 241(02), P. 162 - 169
Published: Feb. 1, 2024
Abstract Aging is a major risk factor for retinal neurodegenerative diseases. Aged mammalian ganglion cells (RGCs) lack the ability to regenerate axons after injury. Rodent models suggest that older age increases vulnerability of RGCs injury and impairs RGC function as well their functional recovery. Molecular changes – including decreased circulating levels brain-derived neurotrophic (BDNF) might contribute impaired dendritic extension during aging. Moreover, age-related mitochondrial dysfunction plays role in aging processes, it leads reduced adenosine triphosphate increased generation reactive oxygen species. Autophagy activity necessary maintenance cellular homeostasis decreases with central nervous system. During aging, vascular insufficiency may lead nutrient supply RGCs. Microglial undergo morphological impairment which compromise promote an inflammatory environment. Addressing these by means low-energy diet, exercise, factors prevent This review focuses on current understanding key players modulating those underlying mechanisms.
Language: Английский
Citations
5
Pharmacological Research, Journal Year: 2024, Volume and Issue: 205, P. 107253 - 107253
Published: June 9, 2024
Melatonin, a versatile hormone produced by the pineal gland, has garnered considerable scientific interest due to its diverse functions. In eye, melatonin regulates variety of key processes like inhibiting angiogenesis reducing vascular endothelial growth factor levels and protecting blood-retinal barrier (BRB) integrity enhancing tight junction proteins pericyte coverage. Melatonin also maintains cell health modulating autophagy via Sirt1/mTOR pathways, reduces inflammation, promotes antioxidant enzyme activity, intraocular pressure fluctuations. Additionally, protects retinal ganglion cells aging inflammatory pathways. Understanding melatonin's multifaceted functions in ocular could expand knowledge pathogenesis, shed new light on therapeutic approaches diseases. this review, we summarize current evidence potential describe roles angiogenesis, BRB maintenance, modulation various eye diseases, which leads conclusion that holds promising treatment for wide range conditions.
Language: Английский
Citations
4
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
ABSTRACT Sex chromosome trisomies (SCT) are the most common whole aneuploidy in humans. Yet, our understanding of prevalence and associated health outcomes is largely driven by observational studies clinically diagnosed cases, resulting a disproportionate focus on 47,XXY hypogonadism. We analyzed microarray intensity data sex chromosomes for 1.5 million individuals enrolled three large cohorts—Million Veteran Program, FinnGen, UK Biobank—to identify with 47,XXY, 47,XYY, 47,XXX. examined disease conditions SCTs performing phenome-wide association (PheWAS) using electronic records (EHR) each cohort, followed meta-analysis across cohorts. Association results presented SCT also stratified presence or absence documented clinical diagnosis 47,XXY. identified 2,769 (47,XXY: 1,319; 47,XYY: 1,108; 47,XXX: 342), whom had no 73.8%; 98.6%; 93.6%). The phenotypic associations spanned all PheWAS categories except neoplasms. Many shared among subtypes, particularly vascular diseases (e.g., chronic venous insufficiency (OR [95% CI] 4.7 [3.9,5.8]; 47,XYY 5.6 [4.5,7.0]; 4 7,XXX 4.6 [2.7,7.6], thromboembolism (47,XXY [3.7-5.6]; 4.1 [3.3-5.0]; 47,XXX 8.1 [4.2-15.4]), glaucoma 2.5 [2.1-2.9]; 2.4 [2.0-2.8]; 2.3 [1.4-3.5]). A third confers an increased risk systemic comorbidities, even if not documented. phenotypes overlap, suggesting one more X/Y homolog genes may underlie pathophysiology comorbidities SCTs.
Language: Английский
Citations
0
Applied Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 1627 - 1627
Published: Feb. 6, 2025
The diagnosis of primary open-angle glaucoma (POAG) progression based on structural imaging such as color fundus photos (CFPs) is challenging due to the limited number early biomarkers, commonly determined by clinicians, and inherent variability in optic nerve heads (ONHs) between individuals. Moreover, while visual function main concern for patients, ability infer future outcome from will benefit patients intervention, there currently no available tool this. To detect ocular hypertension both structurally functionally, identify potential objective biomarkers associated with progression, we developed evaluated deep convolutional long short-term memory (CNN-LSTM) neural network models using longitudinal CFPs Ocular Hypertension Treatment Study (OHTS). Patients were categorized into four diagnostic groups model input: healthy, POAG disc changes, field (VF) VF changes. Gradient-weighted class activation mapping (Grad-CAM) was employed post hoc visualization image features, which may be (rather than clinicians). CNN-LSTM detection achieved promising performance results functional models, an area under curve (AUC) 0.894 disc-only group, 0.911 VF-only 0.939 group. demonstrated high precision (0.984) F1-score (0.963) both-changes group (disc + VF). Our preliminary investigation Grad-CAM feature signified that retinal vasculature could serve biomarker complementing traditionally used features improving clinical workflows.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0314644 - e0314644
Published: Feb. 14, 2025
This study aims to analyse the efficacy of GBE administration in patients with glaucoma and healthy volunteers. systematic review was performed according PRISMA 2020 guidelines. All clinical studies investigating on intraocular pressure (IOP), corrected pattern standard deviation (CPSD) mean visual field testing, heart rate were considered. The weighted difference (MD) effect measure, 95% confidence interval (CI), t-test used for continuous variables. Data from 8 studies, including 428 patients, retrieved. age all 51.1 ± 15.5 years. median follow-up 3.7 (IQR 9.4) months. not associated an improvement IOP (MD -1.5; 95%CI -7.1 9.6; P = 0.5), 0.7; -9.4 8.2; 0.8), CPSD -1.6; -3.8 6.9; or -2.5; -11.5 16.5; 0.4) baseline last follow-up. There no between versus control group 1.1; -5.7 3.5; 0.4), -0.4; -9.1 9.9; 0.9), 0.3; -6.8 6.2; -1.3; -15.1 17.7; 0.8) at Currently, evidence is sufficient conclude that affects IOP, deviation, CPSD, These conclusions must be interpreted caution given limitations reviewed particularly time included studies.
Language: Английский
Citations
0
The Ocular Surface, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Biomedical Microdevices, Journal Year: 2025, Volume and Issue: 27(2)
Published: April 21, 2025
Abstract Glaucoma is a leading cause of irreversible blindness worldwide, affecting millions individuals due to its progressive damage the optic nerve, often caused by elevated intraocular pressure (IOP). Conventional methods IOP monitoring, such as tonometry, provide sporadic and inaccurate readings fluctuations throughout day, leaving significant gaps in diagnosis treatment. This review explores transformative potential smart contact lenses equipped with continuous monitoring therapeutic capabilities. These integrate advanced materials graphene, nanogels, magnetic oxide nanosheets alongside sophisticated biosensing wireless communication systems. By offering continuous, real-time data, these can detect subtle immediate feedback patients clinicians. Moreover, drug-eluting capabilities embedded present groundbreaking approach glaucoma therapy improving medication adherence providing controlled drug release directly eye. Beyond management, innovations also pave way for biochemical markers other ocular diseases. Challenges biocompatibility, long-term wearability, affordability remain, but integration cutting-edge technologies signifies paradigm shift care. developments hold immense promise advancing personalized medicine, patient outcomes, mitigating global burden blindness.
Language: Английский
Citations
0
Kerala Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: 37(1), P. 4 - 8
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: July 3, 2024
Lycium ruthenicum Murray (LR) , known as “black goji berry” or wolfberry”, is widely utilized in chinese herbal medicine. LR fruit showed its antioxidant and/or anti-inflammation activity treating cardiac injury, experimental colitis, nonalcoholic fatty liver disease, fatigue, and aging. Glaucoma the leading cause of irreversible blindness. Besides elevated intraocular pressure (IOP), oxidative stress neuroinflammation were recognized to contribute pathogenesis glaucoma. This study investigated treatment effects water extract (LRE) on retinal ganglion cells (RGCs) threatened by sustained IOP elevation a laser-induced chronic ocular hypertension (COH) mouse model DBA/2J strain. The antioxidation LRE further tested H 2 O -challenged immortalized microglial (IMG) cell line vitro . oral feeding (2 g/kg) preserved function RGCs promoted their survival both models mimicking decreased 8-hydroxyguanosine (oxidative marker) expression retina. reduced number Iba-1+ microglia retina COH mice, but not mice. At mRNA level, reversed induced HO-1 SOD-2 overexpressions Further demonstrated that pretreatment IMG could significantly reduce H2O2 through upregulation GPX-4, Prdx-5, HO-1, SOD-2. Our work daily intake can be used preventative/treatment agent protect under high probably reducing inhibiting activation
Language: Английский
Citations
3