Therapeutic Apheresis and Dialysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 3, 2024
Abstract
Introduction
Biological
invasions
may
promote
the
onset
of
systemic
inflammatory
response
syndrome
in
patients
eligible
for
continuous
renal
replacement
therapy
(CRRT),
leading
to
poor
prognosis.
Hence,
we
aimed
examine
reactions
circulation
using
vitamin
E‐coated
polysulfone
hollow
fiber
membrane
(ViLIFE).
Methods
Lipopolysaccharides
were
intravenously
administered
pigs
(2
μg/kg/30
min)
establish
an
acute
inflammation
model.
Extracorporeal
was
performed
6
h
venovenous
hemodiafiltration
mode
a
hemofilter
CRRT
filled
with
or
ViLIFE,
and
differences
evaluated.
Results
The
ViLIFE
group
exhibited
low
platelet
cytokine
levels
(
p
<
0.05
vs.
sham‐CRRT
group).
Additionally,
had
lower
lactate
high
mobility
box
1
than
other
groups.
Conclusion
represents
promising
modality
that
can
inhibit
further
biological
invasions.
Foods,
Journal Year:
2025,
Volume and Issue:
14(8), P. 1389 - 1389
Published: April 17, 2025
Artemisia
alba
Turra
is
a
plant
used
in
folk
medicine.
Due
to
its
significant
polymorphism,
there
are
different
chemotypes.
This
study
aimed
characterize
the
specific
chemotypes
and
evaluate
anti-inflammatory,
antioxidant,
antiproliferative
potential
of
an
ethanol
extract
A.
aerial
parts
prepared
from
plants
harvested
“Alexandru
Borza”
Botanical
Garden,
Cluj-Napoca,
Romania.
The
phytochemical
analysis
performed
by
measuring
total
polyphenol
content
(3.4
±
0.21
mgGAE/g
d.w.),
polyphenolic
flavonoids
(147.12
10.09
mg
QE/100
g
HPLC-ESI
MS
profiles
indicated
that
Tura
hydroxycinnamic
acids
chlorogenic
acid,
caffeoyl
tartaric
3,4-dicaffeoylquinic
3,5-dicaffeoylquinic
4,5-dicaffeoylquinic
acid
had
flavonols,
isorhamnetin-rutinoside
rutin
highest
concentration.
exhibited
good
vitro
vivo
antioxidant
activity
reducing
oxidants
without
effects
on
antioxidants.
anti-inflammatory
effect
tested
rat
turpentine
oil-induced
inflammation
was
reduction
NLRP3
inflammasome
markers,
NfkB-p65,
IL-1β,
IL-18,
caspase-1,
gasdermin
D.
against
ovarian
tumor
cell
lines
at
concentrations
12.5
50
μg/mL,
this
mechanism
linked
MDR
NF-κB
modulation.
no
liver
toxicity
reduced
kidney
injury
associated
with
inflammation.
These
findings
Romanian
chemotype
has
properties
applications
as
microenvironment-targeted
therapy.
Toxicology Reports,
Journal Year:
2024,
Volume and Issue:
13, P. 101808 - 101808
Published: Nov. 12, 2024
Cytokine-releasing
syndrome
(CRS)
is
a
special
form
of
systemic
inflammatory
response
provoked
by
factors
like
viral
infections
and
certain
immunomodulatory
drugs.
To
elucidate
the
potential
role
rifaximin
(RIF)
its
combination
with
methylprednisolone
(MP)
against
development
progression
CRS
in
mice.
This
experiment
consists
two
parts:
protective
therapeutic
interventions.
The
experiment:
induction
group,
mice
received
an
intraperitoneal
injection
(IP)
5
mg/kg
lipopolysaccharide
(LPS)
without
intervention.
other
group
various
drugs
before
three
days,
then
observed
for
additional
days
(50
MP,
50
RIF,
25
RIF
MP.
second
part
study
involves
potential;
all
groups
similar
doses
to
that
prevention
groups,
except
LPS
was
given
first,
after
one
hour,
daily
five
days.
At
end
experiment,
blood
tissue
samples
were
obtained.
Mice
treated
MP
showed
improved
serum
TNF-α,
IL-6,
IL-8,
IL-1β,
INF-γ,
MDA,
GSH
both
groups.
Histopathologically,
ameliorates
damage
lung
liver
tissues
following
induction.
In
conclusion,
effects
LPS-induced
cytokine
storms
through
anti-inflammatory
antioxidant
mechanisms,
additive/
synergistic
action.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
69(4), P. 224 - 235
Published: Oct. 17, 2024
Neutrophil
gelatinase-associated
lipocalin
(NGAL)
is
a
protein
secreted
by
activated
neutrophils
and
certain
tissues.
The
aim
of
this
study
was
to
investigate
the
prognostic
role
urinary
neutrophil
(uNGAL)
in
hospitalized
COVID-19
patients
with
regard
mortality.
prospective
observational
cohort
involved
86
adult
patients.
Patients’
urine
samples
were
collected
upon
admission
48–72
h
after
admission.
General
anamnesis
clinical
status
information
obtained
from
medical
records.
Within
24
sample
collection,
aliquots
centrifuged,
supernatant
separated,
frozen
at
−80
°C
until
uNGAL
concentration
measurement,
which
performed
within
two
years
collection.
categorized
into
groups
based
on
disease
outcome
(survived/deceased).
Data
analysis
identify
predictive
factors
diagnostic
indicators
for
unfavorable
group
using
logistic
regression
ROC
curve
methods.
Logistic
associated
age,
cardiomyopathy,
invasive
mechanical
ventilation,
(follow-up
sampling)
identified
as
an
indicator
mortality,
cut-off
value
>23.8
ng/mL.
This
concludes
that
there
association
between
However,
understanding
dynamics
during
remains
limited,
crucial
its
effective
application.
Reports — Medical Cases Images and Videos,
Journal Year:
2024,
Volume and Issue:
7(4), P. 89 - 89
Published: Nov. 2, 2024
Background:
The
systemic
stress
response
to
surgery
is
a
complex
physiological
process
characterized
by
neuroendocrine,
sympathetic,
and
inflammatory
activation.
While
necessary
for
survival,
this
can
lead
adverse
outcomes
such
as
hyperglycemia,
immune
suppression,
cardiovascular
complications,
delayed
recovery.
Regional
anesthesia
(RA)
has
been
shown
modulate
more
effectively
than
general
(GA)
blocking
nociceptive
signaling
attenuating
the
release
of
mediators.
Objectives:
This
review
aims
elucidate
how
RA
influences
response,
highlighting
its
clinical
benefits
in
reducing
postoperative
pain,
improving
hemodynamic
stability,
minimizing
responses,
preserving
function.
Additionally,
examines
evidence
from
trials
supporting
using
improve
surgical
outcomes,
particularly
high-risk
populations.
Methods:
A
comprehensive
narrative
literature
was
conducted
explore
impact
on
associated
outcomes.
Studies
comparing
GA
across
various
procedures
were
evaluated,
focusing
neuroendocrine
modulation,
sympathetic
inhibition,
attenuation,
implications
pain
management,
pulmonary
function,
preservation.
Results:
significantly
attenuates
cortisol
catecholamines,
thereby
stability
myocardial
oxygen
consumption.
also
inhibits
nervous
system,
leading
improved
Furthermore,
mitigates
pro-inflammatory
cytokine
levels,
risk
syndrome
(SIRS),
sepsis,
complications.
Clinical
studies
meta-analyses
consistently
demonstrate
that
reduces
opioid
consumption,
incidence
elderly
patients.
Conclusions:
offers
significant
advantage
modulating
surgery,
enhancing
Its
are
pronounced
populations
or
those
with
pre-existing
comorbidities.
Given
growing
efficacy,
should
be
considered
critical
component
multimodal
perioperative
care
strategies
aimed
at
Future
research
optimize
techniques
identify
patient-specific
factors
enhance
therapeutic
benefits.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 20, 2024
Background
Previous
studies
have
reported
an
association
between
obesity
and
risk
of
sepsis.
However,
the
results
been
inconsistent,
no
causal
inference
can
be
drawn
from
them.
Therefore,
we
conducted
a
Mendelian-randomization
(MR)
study
to
investigate
relationships
available
obesity-related
anthropometric
indicators
sepsis
risk.
Methods
We
performed
MR
analyses
using
genome-wide
(GWAS)
summary
statistics
on
14
[namely
body
mass
index
(BMI),
waist
hip
circumferences
(WC,
HC),
basal
metabolic
rate
(BMR),
whole-body
fat
(WBFM),
trunk
(TFM),
leg
(LFM),
arm
(AFM),
percentage
(BFP),
fat-free
(WBFFM),
(TFFM),
(LFFM),
(AFFM),
water
(WBWM)],
sepsis,
critical
care
28-day
death
due
UK
Biobank
FinnGen
cohort.
The
primary
method
analysis
was
inverse
variance-weighted
average
method.
Sensitivity
analyses,
including
heterogeneity
horizontal-pleiotropy
tests,
were
assess
stability
results.
Additionally,
applied
multiple-variable
(MVMR)
evaluate
effect
BMI
relationship
each
indicator
Results
Our
demonstrated
different
severities.
After
adjusted
for
BMI,
MVMR
indicated
that
WC,
BMR,
LFM,
WBFFM,
TFFM,
AFFM,
WBWM
remained
significantly
associated
with
presence
(all
p
<
0.05).
A
sensitivity
confirmed
reliability
our
results,
significant
horizontal
pleiotropy
detected.
Conclusion
This
revealed
increases
in
had
associations
higher
which
might
provide
important
insights
identification
individuals
at
community
hospital
settings.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
unknown, P. 83 - 126
Published: Nov. 17, 2024
Damage
to
tissues
and
abnormal
function
of
organs
are
hallmarks
inflammatory
disorders,
which
characterized
by
an
overactive
inadequately
controlled
immune
response.
Inflammation
chronic
diseases
can
result
from
microbial
infections,
tissue
damage,
autoimmune
dysregulation.
These
stimuli
trigger
macrophages
neutrophils,
releasing
ROS
RNS.
ROS/RNS
overwhelm
the
body's
antioxidant
defenses,
causing
oxidative
assault
signaling
cascades.
NF-кβ
AP-1
activate
amid
assault.
transcription
factors
regulate
expression
pro-inflammatory
genes
that
create
cytokines
(TNF,
ILs),
chemokines,
adhesion
molecules,
enhance
inflammation
recruit
cells
damaged
areas.
Antioxidants
oversight
several
They're
able
block
production
pro-
reducing
activation.
Crucial
MAPK
pathways
like
ERK,
JNK,
p38
be
modulated
antioxidants.
decrease
mediator
synthesis
because
they
interfere
with
these
pathways.
Directly
scavenging
neutralizing
is
how
antioxidants
do
their
job.
Scavenging
protects
lipids,
proteins,
DNA
against
damage.
SOD,
catalase,
glutathione
peroxidase,
body-produced
enzymes.
Thus,
increasing
enzyme
activity
strengthens
cells'
defenses.
induce
anti-inflammatory
phenotype
in
T
cells.
They
capable
shifting
M1
M2.
M2
aid
repair
immunomodulation.
also
promote
formation
regulatory
cells,
system
inhibiting
other
In
conclusion,
this
abstract
emphasizes
crucial
role
potential
as
therapeutic
agents.
