Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 135 - 151
Published: Oct. 1, 2024
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 2, 2024
Abstract Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays critical role in development cancer affecting genomic stability signaling pathways cellular microenvironment. Elevated levels ROS disrupt homeostasis contribute to loss normal functions, which are associated initiation progression various types cancer. In this review, we have focused on elucidating downstream that influenced oxidative stress carcinogenesis. These include p53, Keap1-NRF2, RB1, p21, APC, tumor suppressor genes, cell type transitions. Dysregulation these can lead uncontrolled growth, impaired DNA repair mechanisms, evasion death, all hallmark features development. Therapeutic strategies aimed at targeting emerged as area investigation for molecular biologists. The objective is limit response time cancer, including liver, breast, prostate, ovarian, lung cancers. By modulating redox balance restoring homeostasis, it may be possible mitigate damaging effects enhance efficacy treatments. targeted therapies interventions specifically address impact holds great promise improving patient outcomes. approaches antioxidant-based treatments, redox-modulating agents, restore function affected stress. summary, understanding carcinogenesis process through therapeutic utmost importance combating Further research needed unravel complex mechanisms underlying stress-related develop effective translated into clinical applications management treatment
Language: Английский
Citations
132
European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 265, P. 116129 - 116129
Published: Jan. 5, 2024
Language: Английский
Citations
35
Genes, Journal Year: 2025, Volume and Issue: 16(1), P. 93 - 93
Published: Jan. 17, 2025
Male reproductive health is governed by an intricate interplay of genetic, epigenetic, and environmental factors. Epigenetic mechanisms—encompassing DNA methylation, histone modifications, non-coding RNA activity—are crucial both for spermatogenesis sperm maturation. However, oxidative stress, driven excessive reactive oxygen species, disrupts these processes, leading to impaired function male infertility. This disruption extends epigenetic resulting in abnormal gene expression chromatin remodeling that compromise genomic integrity fertilization potential. Importantly, oxidative-stress-induced alterations can be inherited, affecting the fertility offspring future generations. review investigates how stress influences regulation reproduction modifying RNAs, ultimately compromising spermatogenesis. Additionally, it discusses transgenerational implications disruptions their potential role hereditary infertility disease predisposition. Understanding mechanisms vital developing therapeutic strategies mitigate damage restore homeostasis germline. By integrating insights from molecular, clinical, research, this work emphasizes need targeted interventions enhance prevent adverse outcomes progeny. Furthermore, elucidating dose–response relationships between changes remains a critical research priority, informing personalized diagnostics interventions. In context, studies should adopt standardized markers damage, robust clinical trials, multi-omic approaches capture complexity Such rigorous investigations will reduce risk disorders optimize outcomes.
Language: Английский
Citations
3
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 606 - 606
Published: May 15, 2024
Epigenetics defines changes in cell function without involving alterations DNA sequence. Neuroepigenetics bridges neuroscience and epigenetics by regulating gene expression the nervous system its impact on brain function. With increase research recent years, it was observed that did not always originate from genetic sequence, which has led to understanding role of neurodegenerative diseases (NDDs) including Alzheimer's disease (AD) Parkinson's (PD). Epigenetic contribute aberrant genes involved neuroinflammation, protein aggregation, neuronal death. Natural phytochemicals have shown promise as potential therapeutic agents against NDDs because their antioxidant, anti-inflammatory, neuroprotective effects cellular animal models. For instance, resveratrol (grapes), curcumin (turmeric), epigallocatechin gallate (EGCG; green tea) exhibit through influence methylation patterns, histone acetylation, non-coding RNA profiles. Phytochemicals also aid slowing progression, preserving function, enhancing cognitive motor abilities. The present review focuses various epigenetic modifications pathology NDDs, AD PD, regulation related alterations, specific polyphenols influencing PD.
Language: Английский
Citations
14
Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: April 2, 2024
In the dynamic landscape of targeted therapeutics, drug discovery has pivoted towards understanding underlying disease mechanisms, placing a strong emphasis on molecular perturbations and target identification. This paradigm shift, crucial for discovery, is underpinned by big data, transformative force in current era. Omics characterized its heterogeneity enormity, ushered biological biomedical research into data domain. Acknowledging significance integrating diverse omics strata, known as multi-omics studies, researchers delve intricate interrelationships among various layers. review navigates expansive landscape, showcasing tailored assays each layer through genomes to metabolomes. The sheer volume generated necessitates sophisticated informatics techniques, with machine-learning (ML) algorithms emerging robust tools. These datasets not only refine classification but also enhance diagnostics foster development therapeutic strategies. Through integration high-throughput focuses targeting modeling multiple disease-regulated networks, validating interactions targets, enhancing potential using network pharmacology approaches. Ultimately, this exploration aims illuminate impact era, shaping future research.
Language: Английский
Citations
11
Biology, Journal Year: 2024, Volume and Issue: 13(8), P. 638 - 638
Published: Aug. 20, 2024
Depression, a significant mental health disorder, is under intense research scrutiny to uncover its molecular foundations. Epigenetics, which focuses on controlling gene expression without altering DNA sequences, offers promising avenues for innovative treatment. This review explores the pivotal role of epigenetics in depression, emphasizing two key aspects: (I) identifying epigenetic targets new antidepressants and (II) using personalized medicine based distinct profiles, highlighting potential focal points such as methylation, histone structure alterations, non-coding RNA molecules miRNAs. Variations methylation individuals with depression provide opportunities target genes that are associated neuroplasticity synaptic activity. Aberrant acetylation may indicate antidepressant strategies involve enzyme modifications. Modulating miRNA levels can reshape depression-linked expression. The second section discusses profiles. Analyzing these patterns could identify biomarkers treatment response susceptibility facilitating tailored treatments proactive care. Addressing ethical concerns regarding information, privacy stigmatization, crucial understanding biological basis depression. Therefore, researchers must consider issues when examining disorders. importance critical aspect modern medical research. These findings hold great novel medications treatments, would significantly improve patient outcomes, transform psychiatry. As progresses, it expected more complex aspects processes enhance our comprehension, increase effectiveness therapies.
Language: Английский
Citations
8
ONCOLOGIE, Journal Year: 2024, Volume and Issue: 26(4), P. 493 - 507
Published: July 1, 2024
Language: Английский
Citations
6
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: April 12, 2024
Epigenetic changes are heritable in gene expression without the nucleotide sequence of genes. play an important role development cancer and process malignancy metastasis. Previous studies have shown that abnormal epigenetic can be used as biomarkers for disease status prediction. The reversibility controllability modification also provide new strategies early prevention treatment. In addition, corresponding drug has reached clinical stage. this paper, we will discuss recent progress application tumor from three perspectives: DNA methylation, non-coding RNA, histone modification, order to opportunities additional research applications.
Language: Английский
Citations
5
MedComm, Journal Year: 2024, Volume and Issue: 5(11)
Published: Oct. 15, 2024
Abstract Aging is a complex biological process characterized by the gradual decline of cellular functions, increased susceptibility to diseases, and impaired stress responses. Hypoxia, defined as reduced oxygen availability, critical factor that influences aging through molecular pathways involving hypoxia‐inducible factors (HIFs), oxidative stress, inflammation, epigenetic modifications. This review explores interconnected roles hypoxia in aging, highlighting how hypoxic conditions exacerbate damage, promote senescence, contribute age‐related pathologies, including cardiovascular neurodegenerative disorders, cancer, metabolic dysfunctions, pulmonary conditions. By examining mechanisms linking we identify key serve potential therapeutic targets. Emerging interventions such HIF modulators, antioxidants, senolytics, lifestyle modifications hold promise mitigating adverse effects on tissues. However, challenges heterogeneity lack reliable biomarkers, safety concerns regarding hypoxia‐targeted therapies remain. emphasizes need for personalized approaches advanced technologies develop effective antiaging interventions. integrating current knowledge, this provides comprehensive framework underscores importance targeting hypoxia‐induced enhance healthy reduce burden diseases.
Language: Английский
Citations
4
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189270 - 189270
Published: Jan. 1, 2025
Language: Английский
Citations
0