Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 28, 2024
Language: Английский
Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(9), P. 875 - 889
Published: July 10, 2024
Endometriosis is a common disorder associated with pain, gastrointestinal and urinary symptoms, infertility, fatigue. It defined by the presence of endometrial-like lesions found predominantly in pelvis. Mechanisms that contribute to disease aetiology include changes hormonal, inflammatory, pain pathways. In this article, we focus on recent developments imaging technologies, our improved understanding mechanisms contributing drug therapies are clinical trials, insights from studies gut offer potential support self-management strategies. We postulate improvements quality life patients will be accelerated reframing endometriosis as multi-system learning treatments targeting symptoms shared between endometriosis, neuroinflammatory, disorders.
Language: Английский
Citations
11
Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1476 - 1476
Published: July 4, 2024
Endometriosis is a chronic proinflammatory pathology characterized by the growth of tissue similar to endometrium outside uterus, affecting approximately 5 15% women worldwide. Suffering from endometriosis entails complex pathophysiological process, significantly impacting quality life and reproductive function affected women; therefore, it must be addressed in personalized comprehensive manner, as its management requires multidisciplinary approach. This article aims conduct literature review endometriosis, not only condition but also significant factor social, nutritional, mental well-being those who experience it. Emphasis placed on importance understanding assessing impact provide better more approach, integrating various alternatives strategic treatments for factors involved development. The aim complete overview pathophysiology patients, well current treatment options, both pharmacological alternative, order broaden perspective improve care patients with this disease.
Language: Английский
Citations
10
BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 18, 2024
Abstract Background Endometriosis, defined as the presence of endometrial-like tissue outside uterus, is one most prevalent gynecological disorders. Although different theories have been proposed, its pathogenesis not clear. Novel studies indicate that gut microbiome may be involved in etiology endometriosis; nevertheless, connection between microbes, their dysbiosis, and development endometriosis understudied. This case–control study analyzed women with without to identify microbial targets disease. Methods A subsample 1000 from Estonian Microbiome cohort, including 136 864 control women, was analyzed. Microbial composition determined by shotgun metagenomics functional pathways were annotated using Kyoto Encyclopedia Genes Genomes (KEGG) database. Partitioning Around Medoids (PAM) algorithm performed cluster profile population. The alpha- beta-diversity differential abundance analyses assess (species KEGG orthologies (KO)) both groups. Metagenomic reads mapped estrobolome-related enzymes’ sequences potential microbiome-estrogen metabolism axis alterations endometriosis. Results Diversity did detect significant differences (alpha-diversity: all p -values > 0.05; beta-diversity: PERMANOVA, R 2 < 0.0007, 0.05). No species or detected after multiple testing adjustment (all FDR Sensitivity analysis excluding at menopause (> 50 years) confirmed our results. Estrobolome-associated sequence significantly groups Conclusions Our findings do provide enough evidence support existence a microbiome-dependent mechanism directly implicated To best knowledge, this largest metagenome on conducted date.
Language: Английский
Citations
5
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 348 - 348
Published: Feb. 3, 2025
Background/Objectives: Endometriosis has a marked impact on fertility, although the mechanisms behind this relationship remain poorly understood, particularly in cases without significant anatomical distortions or context of ovarian endometriomas. This study aimed to investigate effect peritoneal endometriosis function by assessing reserve and apoptosis. Methods: Peritoneal was surgically induced Sprague Dawley rats through autotransplantation uterine fragments onto bowel mesothelium. One month post-surgery, structures were counted, follicle corpora lutea apoptosis evaluated TUNEL, apoptotic-related protein expression ovaries assessed Western blot. Additionally, co-culture system using 12Z endometriotic KGN granulosa cell lines utilized evaluate gene RT-qPCR. Results: Rats with exhibited reduction characterized low number total follicles, primordial, primary, preantral, late-antral follicles. Consistently, AMH decreased presence endometriosis. In addition, disease led increase follicles that TUNEL-positive apoptotic cells lutea, indicating higher ovaries. Concomitantly, altered apoptosis-related proteins observed, increased procaspase 3 BCL-2 expression. co-cultured displayed reduced KITLG mRNA AMHR2 Conclusions: significantly impairs health disrupting folliculogenesis, reducing reserve, increasing apoptosis, potentially accelerating aging contributing infertility. These results underscore need for further research identify molecular pathways involved develop targeted therapeutic strategies.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 17, 2025
Human longevity is a sex-biased process in which sex chromosomes and sex-specific immunity may play crucial role the health lifespan disparities between men women. Generally, women have higher life expectancy than men, exhibiting lower infection rates for broad range of pathogens, results prevalence female centenarians compared to males. Investigation immunological changes that occur during healthy aging, while taking into account differences sexes, can significantly enhance our understanding mechanisms underlie longevity. In this review, we aim summarize current knowledge on sexual dimorphism human immune system gut microbiome with particular focus centenarians, based exclusively data.
Language: Английский
Citations
0
BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 17, 2025
Micronutrient deficiency is commonly observed in patients with inflammatory bowel disease (IBD), yet the role of certain dietary trace elements risk IBD development remains unclear. This study aimed to investigate relationship between vitamin C, D, and K intake risk. included 3,591 participants from 2009–2010 National Health Nutrition Examination Survey (NHANES). Multivariable logistic regression were conducted assess associations while controlling for multiple confounders. Subgroup analyses employed test robustness across various characteristics. Additionally, restricted cubic spline (RCS) analysis was potential nonlinear relationships. In fully adjusted model, each 1 mcg increase D linked an approximately 51% decrease (adjusted OR = 0.49, 95% CI: 0.25–0.98, p 0.045). The benefit appeared stronger women, individuals without hypertension, non-smokers. No statistically significant found C or However, among diabetes, associated approximate 67% reduction 0.33, 0.12–0.94, 0.039). RCS suggested a linear micronutrient (vitamin D: nonlinearity 0.127, overall 0.015; C: 0.984, 0.937; K: 0.736, 0.434). Increased may reduce IBD, more pronounced benefits subgroups, highlighting supplementation as novel therapeutic approach prevention management. Future well-designed studies should further effects other better inform treatment approaches.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: April 4, 2025
Background Infertility has become a global health concern, especially as the aging population continues to grow. Previous studies suggest that gut microbiota plays crucial role in female reproductive health. This study aimed investigate association between Dietary Index for Gut Microbiota (DI-GM) and infertility. Methods We analyzed data from 8,910 participants aged 20–45 years NHANES 2013–2018 cycles. DI-GM scores were calculated based on dietary recall interviews, including 14 foods nutrients associated with Female infertility was identified through questionnaires. Weighted logistic regression models used assess relationship infertility, adjustments demographic, lifestyle, health-related covariates. Restricted cubic spline (RCS) analyses explored non-linear associations, subgroup ensured robustness of results. Results A significant negative observed (adjusted OR = 0.89, 95% CI: 0.83–0.95, p < 0.001). Participants ≥6 had 40% lower risk compared those 0–3 (OR 0.60, 0.44–0.82, RCS revealed an L-shaped relationship, threshold at 5. Subgroup indicated stronger associations women education levels coronary heart disease ( P interaction <0.05). Conclusion Our findings demonstrate higher score is reduced suggesting interventions targeting may offer cost-effective strategy improving Further longitudinal interventional are warranted confirm causality elucidate underlying mechanisms.
Language: Английский
Citations
0
American Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 232(4), P. S105 - S123
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: April 17, 2025
As a heterogeneous disease, endometriosis is associated with diagnostic delay. Delayed diagnosis, physical discomfort, hormone therapy, and inconvenience in daily life work all contribute to decreased quality of for patients. Early clinical diagnosis highly important the intervention treatment endometriosis. Currently, reliable non-invasive methods are lacking, laparoscopic examination combined pathological considered "gold standard" definitively diagnosing An increasing number studies have confirmed correlation between microbial ecological changes. Microbial dysbiosis an factor development progression Certain key species their metabolites can induce functional alterations endometrial cells through various mechanisms, often preceding emergence symptoms. Endometriosis chronic inflammatory diseases, immunoinflammatory response as foundation. The microbiome may participate mechanisms multiple pathways, including mediating responses, regulating immune participating estrogen regulation, interfering metabolic activities, modulating gut-brain axis. Therefore, holds potential early therapeutic target This study summarizes analyses correlations microorganisms onset endometriosis, aiming provide novel insights into etiology,
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1696 - 1696
Published: Dec. 7, 2023
Endometriosis is a common inflammatory disease affecting women of reproductive age, characterized by the growth endometrial tissue beyond uterus. In addition to gynecological manifestations, many endometriosis patients experience gastrointestinal symptoms, indicating potential association between gut health and disease. Recent studies have revealed alterations in microbiota individuals with endometriosis, including reduced diversity, microbial composition imbalances, pathogenic bacteria. These changes can disrupt immune function, increase inflammation, contribute chronic state observed endometriosis. Moreover, dysregulation intestinal permeability may further exacerbate symptoms affected individuals. Understanding role provide valuable insights into pathogenesis, aid non-invasive diagnostic approaches, open new avenues for therapeutic interventions. Probiotics, particular, shown promise improving endometriosis-associated pain reducing endometriotic lesions animal models. This review suggests that additional research well-designed clinical trials are necessary validate benefits manipulating managing its thereby quality life those affected.
Language: Английский
Citations
8