Recent advances in the prevention and treatment of dental erosion: a narrative review. DOI Open Access
Lucia Memè, Paola Nardelli,

Silvia Chieppa

et al.

Oral & Implantology, Journal Year: 2024, Volume and Issue: 16(3.1suppl), P. 261 - 272

Published: Dec. 23, 2024

Dental erosion is a progressive and irreversible loss of dental tissues caused by chemical processes from intrinsic or extrinsic acids without bacterial involvement. This condition, categorized as part tooth wear, has gained increasing attention due to its rising prevalence, particularly among children adolescents. Teeth often linked modern dietary habits, including consuming acidic foods, beverages, certain medications. The impact varies, localized damage the entire dentition, with factors such acid exposure, pH, type contributing severity. Prevention strategies focus on oral health education, modifications, remineralization fluoride-based products, while emerging biomimetic technologies, nanomaterials bioactive polymers, show promise. Restorative treatments, composite restorations veneers, are used for advanced cases but lack standardized guidelines optimal application. Thirty-four studies were included in this article, focusing innovative varnishes, minimally invasive restorative techniques like CAD-CAM injection molding. review highlights need further research long-term effectiveness these interventions development clinical improve treatment outcomes.

Language: Английский

Periodontal disease: A systemic condition DOI Creative Commons
German Eduardo Miguel Villoria, Ricardo Guimarães Fischer, Eduardo Muniz Barretto Tinoco

et al.

Periodontology 2000, Journal Year: 2024, Volume and Issue: 96(1), P. 7 - 19

Published: Oct. 1, 2024

Abstract For decades, periodontitis has been considered to be a local inflammatory disease of the periodontal tissues in oral cavity. Initially, associations with multitude noncommunicable diseases were each studied separately, and relationships shown. The morbidities, such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, respiratory have demonstrated. As most studies cross‐sectional nature, questions about causality cannot univocally answered. And an independent risk factor for one systemic disease, becomes even more difficult assess since recently also associated multimorbidity. Periodontitis many share environmental, lifestyle genetic factors, immunopathology. Moreover, suffering from common may increase susceptibility another chronic disease; effects condition various factors disease. overarching effect any is it causing pro‐inflammatory state individual; this shown periodontitis. prothrombotic elevated immunological activity such, when we consider can affect progression other importantly, vice versa. this, not surprising that variety diseases. medical definition includes different organs systems. Thus, aim opinion paper propose should its own right affects individual's wellbeing. dental profession researchers alike, adapt paradigm shift, advancing out isolated anatomical location into total being some conditions comorbid and, versa, comorbidities initiation

Language: Английский

Citations

24
Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets DOI

Qibing Wu,

Weijia Zhang,

Yaqiong Lu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 128, P. 111558 - 111558

Published: Jan. 23, 2024

Language: Английский

Citations

17
The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series DOI Creative Commons
Giuseppina Malcangi, Angelo Michele Inchingolo, Alessio Danilo Inchingolo

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 84 - 84

Published: Jan. 7, 2025

Background and objectives: Due to the regeneration potential of growth factors (GFs) platelet concentrates (PCs), facial rejuvenation has been a major area attention in esthetic medicine. The effectiveness safety PCs GFs promoting face are examined this systematic review, which is complemented by case series. essential for collagen production dermal matrix remodeling, while PCs, like Platelet-Rich Plasma (PRP), abundant bioactive chemicals that promote tissue healing cellular regeneration. Materials Methods: A comprehensive literature search was performed on PubMed, Web Science, Scopus, focusing human clinical trials published between February 2019 2024 related PRP esthetics. Results: Thirteen studies met inclusion criteria were analyzed. Conclusions: review summarizes most recent data patient outcomes, treatment regimens, possible hazards. series goes with it shows real-world examples how improve skin elasticity, texture, general appearance little negative side effects. These results highlight use as minimally invasive procedures.

Language: Английский

Citations

2
Management of Rheumatoid Arthritis in Primary Care: A Scoping Review DOI Open Access
Francesco Inchingolo, Angelo Michele Inchingolo, Maria Celeste Fatone

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(6), P. 662 - 662

Published: May 22, 2024

Rheumatoid arthritis (RA) can lead to severe joint impairment and chronic disability. Primary care (PC), provided by general practitioners (GPs), is the first level of contact for population with healthcare system. The aim this scoping review was analyze approach RA in PC setting. PubMed, Scopus, Web Science were searched using MESH terms “rheumatoid arthritis” “primary care” from 2013 2023. search strategy followed PRISMA-ScR guidelines. 61 articles selected analyzed qualitatively a table discussed two sections, namely criticisms strategies management PC. main critical issues are following: difficulty delay diagnosis, accessing rheumatological care, DMARDs GPs; ineffective communication between GPs specialists; poor patient education; lack cardiovascular prevention; increase costs. To overcome these criticisms, several have been identified, early diagnosis RA, quick access rheumatology effective specialists, active involvement, screening risk factors comorbidities, clinical audit, interdisciplinary management, digital health, cost analysis. appears be ideal setting reduce morbidity mortality disease, including if widespread change GPs’ disease patients mandatory.

Language: Английский

Citations

7
Tooth‐ and implant‐related prognostic factors in treatment planning DOI Creative Commons

Anastasiya Orishko,

Jean‐Claude Imber, Andrea Roccuzzo

et al.

Periodontology 2000, Journal Year: 2024, Volume and Issue: 95(1), P. 102 - 128

Published: June 1, 2024

Abstract Following a comprehensive patient examination, including the assessment of periodontal and peri‐implant diseases as well considering patient's needs, pretherapeutic prognosis for each tooth implant is given. Teeth implants with secure require simple procedures may be regarded abutments function doubtful usually need therapy. Such teeth must brought into category by means additional therapy such endodontic, restorative, surgical procedures. hopeless should extracted/explanted during initial phase cause‐related (i.e., infection control). For example, vertical root fracture or unrestorable caries mobility malposition fall units. The primary goal to arrest disease progression. latest consensus statement highlights that periodontitis can successfully controlled treated retained life. Nevertheless, patients uncontrolled contributing factors, endpoints might not always achievable, low activity an acceptable therapeutic goal. Similarly, management peri‐implantitis frequently requires intervention following nonsurgical due incomplete treatment outcomes. Different modalities effective lead significant improvement; however, achieving complete resolution challenging, predictable, depend on multiple baseline factors. Therefore, this review aims at summarising available evidence rationale incorporating systemic, lifestyle‐related, clinical, radiographic prognostic factors planning diagnosed diseases.

Language: Английский

Citations

7
Clinical Efficacy of Extracellular Vesicle Therapy in Periodontitis: Reduced Inflammation and Enhanced Regeneration DOI Open Access
Miljan Puletić, Gordana Velikić, D Marić

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5753 - 5753

Published: May 25, 2024

Periodontitis, a prevalent inflammatory condition, affects the supporting structures of teeth, leading to significant oral health challenges. Traditional treatments have primarily focused on mechanical debridement, antimicrobial therapy, and surgery, which often fail restore lost periodontal structures. Emerging as novel approach in regenerative medicine, extracellular vesicle (EV) including exosomes, leverages nano-sized vesicles known for facilitating intercellular communication modulating physiological pathological processes. This study is proof-of-concept type that evaluates clinical efficacy EV therapy non-surgical treatment stage I–III periodontitis, focusing its anti-inflammatory potential. The research involved seven patients undergoing healthy individuals. Clinical parameters, plaque index, bleeding probing, probing depth, attachment level, were assessed alongside cytokine levels gingival crevicular fluid. found improvements marked reduction pro-inflammatory cytokines post-treatment, matching subjects, underscoring therapy’s ability not only attenuate inflammation enhance tissue regeneration, but also highlighting potential restoring health. investigation illuminates promising role treatment, advocating shift towards therapies halt disease progression promote structural functional restoration tissues.

Language: Английский

Citations

6
The Gut Microbiota’s Role in Neurological, Psychiatric, and Neurodevelopmental Disorders DOI Open Access
Ioannis Alexandros Charitos, Angelo Michele Inchingolo, Laura Ferrante

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4404 - 4404

Published: Dec. 22, 2024

Aim: This article aims to explore the role of human gut microbiota (GM) in pathogenesis neurological, psychiatric, and neurodevelopmental disorders, highlighting its influence on health disease, investigating potential therapeutic strategies targeting GM modulation. Materials Methods: A comprehensive analysis microbiota’s composition interaction with body, particularly, neurological psychiatric conditions, is provided. The review discusses factors influencing composition, including birth mode, breastfeeding, diet, medications, geography. Additionally, it examines GM’s functions, such as nutrient absorption, immune regulation, pathogen defense, alongside interactions nervous system through gut–brain axis, neurotransmitters, short-chain fatty acids (SCFAs). Results: Alterations are linked various Parkinson’s multiple sclerosis, depression, schizophrenia, ADHD, autism. influences cognitive stress responses, mood regulation. Antibiotic use disrupts diversity, increasing risk metabolic obesity, allergic diseases. Emerging therapies probiotics, prebiotics, transplantation show promise modulating alleviating symptoms conditions. Conclusions. modulation represents a promising approach for personalized treatment strategies. Further research needed better understand underlying mechanisms develop targeted aimed at restoring balance improved clinical outcomes.

Language: Английский

Citations

5
Management of Patients Receiving Anticoagulation Therapy in Dental Practice: A Systematic Review DOI Open Access
Francesco Inchingolo, Angelo Michele Inchingolo, Fabio Piras

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(15), P. 1537 - 1537

Published: Aug. 2, 2024

Background: Anticoagulant drugs are a valuable tool for minimizing thrombotic risks in at-risk patients. The purpose of this study is to conduct literature review highlighting the management these during daily clinical dental practice. Materials and Methods: We limited our search English-language papers published between 1 January 1989, 7 March 2024, PubMed, Scopus Web Science that were relevant topic. In approach, Boolean keywords “anticoagulant AND dentistry” used. Results: Twenty-five trials included final from 623 articles obtained databases (83), PubMed (382), (158), eliminating duplicates 79 off-topic items, resulting 419 after removing 315 entries confirming eligibility. Overall, studies support use local hemostatic measures manage risk bleeding patients on anticoagulant therapy undergoing procedures highlight importance greater education collaboration among healthcare professionals. Conclusions: Research investigation have improved understanding or antiplatelet therapy. Hemostatic agents, protocols, factors, continuous essential navigating complexities therapy, ensuring optimal outcomes enhancing patient well-being.

Language: Английский

Citations

4
Porphyromonas gingivalis und die Brücke zwischen Parodontologie und Rheumatologie DOI Creative Commons

John J. Schwab,

Rudolf Puchner

rheuma plus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Zusammenfassung Die beiden chronisch-entzündlichen Erkrankungen rheumatoide Arthritis (RA) und Parodontitis (PA) stehen schon seit geraumer Zeit unter dem Verdacht, in unmittelbarem bilateralem Zusammenhang zu stehen. Aktuelle wissenschaftliche Literatur zeigt mögliche Parallelen der Pathogenese Therapie beider Krankheiten auf diskutiert konkret kausale Zusammenhänge. Dabei steht neben genetischen Faktoren, Immun- Umweltveränderungen Parodontalkeim Porphyromonas gingivalis ( P. ) im Zentrum. Das Bakterium führt über verschiedene molekularbiologische Mechanismen zur Antikörperproduktion. Zu diesen zählen: Bildung zitrullinierter Proteine, Gingipaine, die Carbamylierung von Proteinen Malondialdehyd-Acetaldehyd-Addukt-Formation. Gebildete Autoantikörper können schließlich Destruktion Gewebe Gelenk sowie Parodont (dem Zahnhalteapparat) führen. Neben scheinen sich auch Therapien gegenseitig positiv beeinflussen, weshalb eine interdisziplinäre Kommunikation zwischen Rheumatologie Parodontologie sinnvoll wünschenswert wäre, um den Verlauf mitzuverfolgen abzuschätzen, ob Therapieversuche anschlagen. Somit würde Zusammenarbeit Zahnmedizin einen wichtigen Schritt weiter Richtung personalisierter Medizin – Zukunft darstellen.

Citations

0
The Oral Microbiome and Us DOI
Nailê Damé‐Teixeira, Thuy Do, Dongmei Deng

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 3 - 9

Published: Jan. 1, 2025

Language: Английский

Citations

0