Effect of Solid-State Fermentation Products of Lactobacillus plantarum, Candida utilis, and Bacillus coagulans on Growth Performance of Broilers and Prevention of Avian Colibacillosis DOI Creative Commons
Fangfang Li,

Bing Lv,

Jiakun Zuo

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(10), P. 468 - 468

Published: Oct. 1, 2024

This study investigates the impact of solid-state fermentation products Lactobacillus plantarum, Candida utilis, and Bacillus coagulans (LCBs) on growth characteristics, immune function, intestinal morphology, cecum microbial community, prevention avian colibacillosis in broilers. One hundred twenty Hyland Brown broilers (aged one day) were divided randomly into three groups (four replicates ten per group). (1) The CON group was fed a basal diet. (2) MOD On day 40, APEC strain SX02 (1.1 × 105 CFU/g) administered to breasts chickens this group. (3) LCBs diet supplemented with (98.5% + 0.5% plantarum utilis 1.0% products). received same treatment as experiment lasted 43 days. found that average daily gain (ADG) significantly higher than (p < 0.05), indicating can increase ADG improve feed conversion ratio. Furthermore, compared group, heart bacterial load reduced lesions less severe heart, liver, jejunum observed 0.05). Additionally, detection flora showed significant abundance beneficial bacteria while number Escherichia coli Shigella decreased significantly. In conclusion, solid performance also protecting against pathogenic infection. demonstrates potential usefulness these production.

Language: Английский

Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis DOI

Haihua Ji,

Xiao-Chen Yan, Li Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 297 - 316

Published: Feb. 7, 2025

Language: Английский

Citations

3
Potential Molecular Mechanisms of Alcohol Use Disorder with Non-Coding RNAs and Gut Microbiota for the Development of Superior Therapeutic Application DOI Open Access

Moeka Nakashima,

Naoko Suga,

Sayuri Yoshikawa

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(4), P. 431 - 431

Published: March 29, 2024

Many investigations have evaluated the expression of noncoding RNAs (ncRNAs) as well their related molecular functions and biological machineries in individuals with alcohol dependence. Alcohol dependence may be one most prevailing psychological disorders globally, its pathogenesis is intricate inadequately comprehended. There substantial evidence indicating significant links between multiple genetic factors development In particular, critical roles ncRNAs been emphasized pathology mental illnesses, probably including comprehension action modification, furthermore, they emerged therapeutic targets for a variety psychiatric It worth mentioning that dysregulated has regularly detected An in-depth knowledge m6A modification valuable novel treatment against general, more profound understanding practical might make important contributions to precise diagnosis and/or actual management Here, this review, we mostly focused on up-to-date regarding alterations modifications Then, present prospects future research applications concept engram system.

Language: Английский

Citations

2
The Therapeutic Effects of Lactic Acid Bacteria Isolated from Spotted Hyena on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice DOI Open Access
Mengen Xu, Miao Hu, Jingbo Han

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3682 - 3682

Published: Oct. 29, 2024

Background: Inflammatory bowel disease (IBD) is a chronic condition characterized by recurrent episodes and an unclear etiology. Given the limitations of current therapeutic options, which include suboptimal efficacy significant side effects, there pressing need to explore novel treatments. Probiotics derived from diverse species have been identified as promising approach for managing IBD, owing their anti-inflammatory properties ability regulate gut flora, among other beneficial effects. Methods: In this study, three strains lactic acid bacteria (LAB) were isolated feces scavenger spotted hyena (Crocuta crocuta), scavenging mammal. Based on capability survive within adhere gastrointestinal tract, along with profile antibiotic resistance, high-quality strain Lactobacillus acidophilus (LA) was selected demonstrated be safe mice. Subsequently, LA evaluated using dextran sulfate sodium (DSS)-induced model ulcerative colitis in Results: The results indicated that restored activity index improved histopathological lesions group. It also reduced inflammation oxidative stress significantly expression mucins intestinal tight junction (TJ) proteins (ZO-1, Occludin). Furthermore, corrected DSS-induced disruption leading decrease prevalence potentially harmful bacterial genera, such Bacteroides, increase including Lactobacillus. conclusion, LA1, feces, has potential functional supplement alleviating symptoms IBD regulating flora.

Language: Английский

Citations

2
Gut Microbiota and Non-coding RNAs Might Be Involved in the Pathogenesis of Alcohol Dependence DOI Open Access

Moeka Nakashima,

Naoko Suga,

Sayuri Yoshikawa

et al.

Published: Feb. 27, 2024

A great deal of studies have assessed the expression noncoding RNAs (ncRNAs) as well their relevant molecular functions and biological mechanisms in individuals alcohol dependence. Alcohol dependence is one most prevalent neuropsychological disorders worldwide, its pathogenesis intricate inadequately understood. There considerable evidence demonstrating substantial links between multiple genetic factors development Critical roles ncRNAs been emphasized pathophysiology mental diseases including In comprehension action modification, they emerged therapeutic targets for a variety psychiatric illness Worth mentioning, dysregulated has regularly detected An in-depth knowledge m6A modification may be valuable novel treatment against general, deeper functional make significant contributions to precise diagnosis and/or actual Here this review, we mostly focused on up-to-date regarding alterations modifications dependence, then, presented prospects future research application with concept engram-system.

Language: Английский

Citations

1
GutEggerthella lentapromotes the efficacy of resveratrol through reductive metabolism DOI Open Access

Zhixiang Dong,

Peijun Yu,

Hui Zhou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 11, 2024

Abstract Resveratrol (RSV) is a plant-derived natural product with diverse biological activities. It has attracted considerable attention for its notable efficacy in nutritional health and disease treatment. The physiological impact of RSV the human body closely connected to gut microbiota; however, primary microorganisms responsible metabolism underlying mechanisms remain unclear. Here, based on ex vivo culturing microbiota from feces, we isolated bacterium capable efficiently metabolizing RSV, namely Eggerthella lenta J01. Through induced enrichment transcriptomics bioinformatic analyses, further identified resveratrol reductase (RER) E. J01, which specifically catalyzes hydrogenation C9–C10 double bond initiates RSV’s metabolism. RER homologs represent novel class ene-reductases. abundance healthy individuals was significantly higher than that patients inflammatory bowel disease, suggesting crucial function. Cell culture experiments animal studies showed dihydroresveratrol (DHR), metabolite catalyzed by RER, exhibited stronger activity inhibiting growth colon cancer cells alleviating symptoms enteritis mouse models. Our results expand understanding microbial medicinal functions, providing possible guidance optimizing bioavailability body.

Language: Английский

Citations

1
Effect of Solid-State Fermentation Products of Lactobacillus plantarum, Candida utilis, and Bacillus coagulans on Growth Performance of Broilers and Prevention of Avian Colibacillosis DOI Creative Commons
Fangfang Li,

Bing Lv,

Jiakun Zuo

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(10), P. 468 - 468

Published: Oct. 1, 2024

This study investigates the impact of solid-state fermentation products Lactobacillus plantarum, Candida utilis, and Bacillus coagulans (LCBs) on growth characteristics, immune function, intestinal morphology, cecum microbial community, prevention avian colibacillosis in broilers. One hundred twenty Hyland Brown broilers (aged one day) were divided randomly into three groups (four replicates ten per group). (1) The CON group was fed a basal diet. (2) MOD On day 40, APEC strain SX02 (1.1 × 105 CFU/g) administered to breasts chickens this group. (3) LCBs diet supplemented with (98.5% + 0.5% plantarum utilis 1.0% products). received same treatment as experiment lasted 43 days. found that average daily gain (ADG) significantly higher than (p < 0.05), indicating can increase ADG improve feed conversion ratio. Furthermore, compared group, heart bacterial load reduced lesions less severe heart, liver, jejunum observed 0.05). Additionally, detection flora showed significant abundance beneficial bacteria while number Escherichia coli Shigella decreased significantly. In conclusion, solid performance also protecting against pathogenic infection. demonstrates potential usefulness these production.

Language: Английский

Citations

1