International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12784 - 12784
Published: Nov. 28, 2024
Resolvins
are
specialized
pro-resolving
mediators
(SPMs)
derived
from
omega-3
fatty
acids
that
play
a
critical
role
in
resolving
inflammation
and
restoring
tissues
to
state
of
health
after
an
immune
response.
Their
chronic
inflammatory
conditions
highlights
their
importance
maintaining
balance
between
effective
response
the
resolution
prevent
tissue
damage.
Periodontal
disease
is
condition
affecting
surrounding
teeth,
leading
gum
damage
bone
loss.
Chronic
periodontal
can
exacerbate
systemic
influence
other
conditions,
such
as
diabetes.
There
bidirectional
relationship
diabetes
disease,
both
characterized
by
oral
complications.
This
narrative
review
aims
synthesize
current
knowledge
on
how
resolvins
pathways
repair
mechanism
patients
with
type
2
Furthermore,
this
serves
foundation
for
developing
targeted
therapeutic
strategies,
addressing
pressing
need
treatments
consider
outcomes.
Healthcare,
Journal Year:
2024,
Volume and Issue:
12(13), P. 1288 - 1288
Published: June 27, 2024
Patient
compliance
following
periodontal
therapy
is
extremely
important
in
predicting
the
prognosis
of
disease
and
maintaining
treatment
outcomes.
Therefore,
this
study
aimed
to
investigate
perception
periodontitis
patients
about
A
cross-sectional
was
conducted
among
a
single
dental
center
through
pre-validated
questionnaire
that
distributed
each
participant
waiting
area
clinics
by
utilizing
convenience
sampling
technique.
Median
interquartile
ranges
were
used
addition
frequency
percentages.
Bivariate
analyses
performed
using
Mann-Whitney
U
Kruskal-Wallis
test.
Among
300
male
female
participants,
median
score
(interquartile
range)
current
level
pain
revealed
males
experienced
more
than
females,
with
5
(0-7)
for
4
(0-6)
women.
However,
desired
expected
levels
both
genders
0
(0-1),
(0-4).
There
significant
differences
ratings
between
females
expected,
distress,
success,
importance
(p-value
<
0.05).
Patients
provided
valuable
insights
into
experiences
individuals
undergoing
disease,
indicating
overall
patient
satisfaction
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2645 - 2645
Published: Nov. 19, 2024
Autophagy
is
an
intrinsic
breakdown
system
that
recycles
organelles
and
macromolecules,
which
influences
metabolic
pathways,
differentiation,
thereby
cell
survival.
Oral
health
essential
component
of
integrated
well-being,
it
critical
for
developing
therapeutic
interventions
to
understand
the
molecular
mechanisms
underlying
maintenance
oral
homeostasis.
However,
because
complex
dynamic
relationship
between
autophagy
health,
associated
treatment
modalities
have
not
yet
been
well
elucidated.
Determining
how
affects
at
level
may
enhance
understanding
prevention
targeted
diseases.
At
level,
hard
soft
tissues
develop
interactions
epithelial
mesenchymal
cells.
Aging
contributes
progression
various
disorders
including
periodontitis,
cancer,
periapical
lesions
during
aging.
levels
decrease
with
age,
thus
indicating
a
possible
association
In
this
review,
we
critically
review
aspects
their
significance
in
context
diseases
lesions,
periodontal
conditions,
candidiasis.
A
better
its
can
guide
us
new
preventative
strategies
management
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 22, 2024
Mitochondrial
membrane
potential
(MMP)
and
mitochondrial
mass
(MM)
affect
function
lymphocyte
activation,
but
few
studies
on
HBV
infection
exist.
This
study
aimed
to
investigate
the
regulatory
mechanism
of
dysfunction
during
its
clinical
significance
by
analyzing
alterations
MM
MMP
Advanced Therapeutics,
Journal Year:
2024,
Volume and Issue:
7(7)
Published: May 29, 2024
Abstract
Accumulating
evidence
has
suggested
a
strong
correlation
between
age‐related
bone
diseases
and
abnormal
metabolism
of
microenvironment‐related
cells,
including
mesenchymal
stem
cells
(MSCs),
osteoblasts,
osteoclasts,
osteocytes,
chondrocytes.
Mitochondrial
dysfunction
significantly
impacts
cell
initiates
the
development
progress
numerous
diseases.
autophagy
or
mitophagy,
process
that
selectively
removes
damaged
dysfunctional
mitochondria,
is
closely
associated
with
maintaining
mitochondrial
quality
control
homeostasis.
Recent
studies
indicate
decisive
regulatory
role
mitophagy
in
diseases,
thereby
pointing
toward
potential
for
manipulating
levels
as
new
treatment
paradigm.
Based
on
importance
novelty
present
review
offers
an
overview
pathways
involved
meticulously
examines
its
function
Various
methods
targeting
are
also
discussed,
mainly
biomaterials
mitophagy‐modulatory
capabilities,
“old
drugs
bottle”
(e.g.,
Metformin,
Rapamycin),
natural
compounds,
endogenous
factors,
cell‐based
therapies.
In
conclusion,
these
innovative
approaches
uncover
mitophagy‐related
signals,
pathways,
mechanisms,
may
shed
light
mitophagy‐targeting
treatments
future.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7955 - 7955
Published: July 21, 2024
A
growing
number
of
studies
indicate
that
mitochondrial
dysfunction
serves
as
a
pathological
mechanism
for
periodontitis.
Therefore,
this
two-sample
Mendelian
randomization
(MR)
study
was
carried
out
to
explore
the
causal
associations
between
biological
function
and
periodontitis,
because
specific
nature
relationship
remains
inconclusive
in
existing
MR
studies.
Inverse
variance
weighting,
randomization-Egger,
weighted
mode,
simple
median
analyses
were
performed
assess
relationships
exposure
factors
The
results
present
revealed
association
periodontitis
medium-chain
acyl-CoA
dehydrogenase
(MCAD),
malonyl-CoA
decarboxylase
(MLYCD),
glutaredoxin
2
(Grx2),
oligoribonuclease
(ORN),
pyruvate
carboxylase
(PC).
Notably,
MCAD
MLYCD
are
causally
linked
serve
protective
factors.
However,
Grx2,
ORN,
PC
risk
Our
established
such
insights
may
provide
promising
approach
treating
via
regulation.
