Materials Today Communications, Journal Year: 2024, Volume and Issue: unknown, P. 111242 - 111242
Published: Dec. 1, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: May 31, 2024
Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.
Language: Английский
Citations
23
Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35541 - e35541
Published: Aug. 1, 2024
Physical vapor deposition (PVD) coating is a versatile and well-liked method for depositing thin films of materials onto surfaces in range industries. Due to their numerous functional aesthetic benefits, PVD coatings are beneficial several applications, from electronics optics automotive medical equipment. technology dramatically improves the effectiveness quality implants. PVD-coated implants improve osseointegration, lower wear friction, increase corrosion resistance, have antibacterial properties, which lead better patient outcomes, fewer complications, overall higher life people who need implantable devices. The essential concepts techniques used covered at study's outset. specific uses then highlighted, including those orthopedic dental cardiovascular neurosurgical review also emphasizes critical contribution reducing improving augmenting biocompatibility, enhancing appeal. challenges prospects technologies were further addressed this article. This invaluable academics, doctors, businesspeople interested combination implantology.
Language: Английский
Citations
13
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Despite the unique properties of clay nanocomposites for cardiovascular applications, there are few data on hemocompatibility these nanomaterials. This study represents first comprehensive investigation hemo/biocompatibility in vitro. Nanocomposite coatings polylactic acid (PLA)-polyethylene glycol (3 wt %)-Cloisite20A nanoclay %) were produced using electrospraying technique as potential drug-eluting stent (DES) coatings. Pristine PLA coating served a control. The ' different structural and biological assessed, including surface morphology, topography, hydrophobicity, mechanics, interaction with blood components, endothelial cells (EC), bacteria. Findings indicated that all highly hydrophobic microbead/nanofiber morphology had antifouling properties. absorption profiles plasma proteins similar groups, did not trigger coagulation cascade complement activation. increase hemolysis or platelet leukocyte adhesion Interestingly, exhibited lowest levels interleukin-6 production. Cellular experiments showed reduce ECs survival compared to control group, continuous layer covered nanocomposite surfaces after 4 days. These results demonstrate exceptional as-prepared promising biomaterials implants such DESs.
Language: Английский
Citations
1
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(5), P. 3098 - 3111
Published: April 12, 2024
Biodegradable stents are the most promising alternatives for treatment of cardiovascular disease nowadays, and strategy preparing functional coatings on surface is highly anticipated addressing adverse effects such as in-stent restenosis stent thrombosis. Yet, inadequate mechanical stability biomultifunctionality limit their clinical application. In this study, we developed a multicross-linking hydrogel polylactic acid substrates by dip coating that boasts impressive antithrombotic ability, antibacterial capability, stability, self-healing ability. Gelatin methacryloyl, carboxymethyl chitosan, oxidized sodium alginate construct double-cross-linking through dynamic Schiff base chemical in situ blue initiation reaction. Inspired adhesion mechanism employed mussels, triple-cross-linked formed with addition tannic to increase antibiofouling properties. The strength hydrophilicity regulated changing composition ratio cross-linking degree. It has been demonstrated tests vitro significantly reduces proteins, MC3T3-E1 cells, platelets, bacteria 85% minimizes formation blood clots. also exhibits excellent antimicrobial antiinflammatory properties vivo, indicating its potential value vascular intervention other biomedical fields.
Language: Английский
Citations
6
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Contrary to intuitive thinking, air cannot stop platelet adhesion on superhydrophobic materials; instead, it rearranges or even increases it.
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 152 - 152
Published: Jan. 9, 2025
Novel ferrite/polyurethane nanocomposites were synthesized using the in situ polymerization method after addition of different spinel nanoferrite particles (copper, zinc, and copper–zinc) examined as potential coatings for medical devices implants vascular tissue engineering. The influence type on structure functional characteristics polyurethane composites was investigated by FTIR, SWAXS, AFM, TGA, DSC, nanoindentation, swelling behavior, water contact angle, absorption measurements. Biocompatibility evaluated examining cytotoxicity adhesion human endothelial cells fibroblasts onto prepared performing a protein adsorption test. antioxidant activity detected UV–VIS spectroscopy 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay. Embedding types nanoparticles matrix increased phase mixing, ability, DPPH scavenging, decreased surface roughness, differently affected stiffness materials. composite with zinc ferrite showed improved mechanical properties, hydrophilicity, cell adhesion, similar thermal stability, but lower roughness crosslinking density compared to pristine matrix. vitro biocompatibility evaluation demonstrates that all are non-toxic, exhibit good hemocompatibility, promote recommends their use biocompatible materials development implants.
Language: Английский
Citations
0
Biomaterials Advances, Journal Year: 2025, Volume and Issue: 172, P. 214244 - 214244
Published: Feb. 27, 2025
Language: Английский
Citations
0
Micromachines, Journal Year: 2025, Volume and Issue: 16(4), P. 419 - 419
Published: March 31, 2025
The rapid evolution of micro- and nano-architectures is revolutionizing biomedical engineering, particularly in the fields therapeutic diagnostic micromechanics. This review explores recent innovations nanostructured materials their transformative impact on healthcare applications, ranging from drug delivery tissue engineering to biosensing diagnostics. Key advances fabrication techniques, such as lithography, 3D printing, self-assembly, have enabled unprecedented control over material properties functionalities at microscopic scales. These engineered architectures offer enhanced precision targeting controlled release delivery, foster cellular interactions improve sensitivity specificity devices. We examine critical design parameters, including biocompatibility, mechanical resilience, scalability, which influence clinical efficacy long-term stability. also highlights translational potential current limitations bringing these laboratory research practical applications. By providing a comprehensive overview trends, challenges, future perspectives, this article aims inform inspire further development that hold promise for advancing personalized medicine.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101259 - 101259
Published: Sept. 19, 2024
Language: Английский
Citations
2
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 29, 2024
Physical activity has been shown to alleviate negative emotions. We examined whether physical is associated with lower non-suicidal self-injurious behavior in adolescents and the mediating chain-mediating roles of psychological capital relative deprivation this association.
Language: Английский
Citations
2