Deciphering the role of neuropeptides as biomarkers for early diagnosis of Parkinson's disease
Life Sciences,
Journal Year:
2025,
Volume and Issue:
363, P. 123376 - 123376
Published: Jan. 8, 2025
Language: Английский
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders
Frontiers in Cellular Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Oct. 25, 2024
Neurovascular
unit
(NVU)
inflammation
via
activation
of
glial
cells
and
neuronal
damage
plays
a
critical
role
in
neurodegenerative
diseases.
Though
the
exact
mechanism
disease
pathogenesis
is
not
understood,
certain
biomarkers
provide
valuable
insight
into
pathogenesis,
severity,
progression
therapeutic
efficacy.
These
markers
can
be
used
to
assess
pathophysiological
status
brain
including
neurons,
astrocytes,
microglia,
oligodendrocytes,
specialized
microvascular
endothelial
cells,
pericytes,
NVU,
blood-brain
barrier
(BBB)
disruption.
Damage
or
derangements
tight
junction
(TJ),
adherens
(AdJ),
gap
(GJ)
components
BBB
lead
increased
permeability
neuroinflammation
various
disorders
disorders.
Thus,
neuroinflammatory
evaluated
blood,
cerebrospinal
fluid
(CSF),
tissues
determine
neurological
progression,
responsiveness.
Chronic
common
age-related
Alzheimer's
(AD),
Parkinson's
(PD),
dementia.
Neurotrauma/traumatic
injury
(TBI)
also
leads
acute
chronic
responses.
The
expression
some
may
altered
many
years
even
decades
before
onset
In
this
review,
we
discuss
neuroinflammation,
neurodegeneration
associated
with
disorders,
especially
those
neurovascular
pathologies.
CSF,
tissues.
Neurofilament
light
(NfL),
ubiquitin
C-terminal
hydrolase-L1
(UCHL1),
fibrillary
acidic
protein
(GFAP),
Ionized
calcium-binding
adaptor
molecule
1
(Iba-1),
transmembrane
119
(TMEM119),
aquaporin,
endothelin-1,
platelet-derived
growth
factor
receptor
beta
(PDGFRβ)
are
important
markers.
Recent
BBB-on-a-chip
modeling
offers
promising
potential
for
providing
an
in-depth
understanding
neurotherapeutics.
Integration
these
clinical
practice
could
potentially
enhance
early
diagnosis,
monitor
improve
outcomes.
Language: Английский
CoPPIs algorithm: a tool to unravel protein cooperative strategies in pathophysiological conditions
Briefings in Bioinformatics,
Journal Year:
2025,
Volume and Issue:
26(2)
Published: March 1, 2025
Abstract
We
present
here
the
co-expressed
protein–protein
interactions
algorithm.
In
addition
to
minimizing
correlation-causality
imbalance
and
contextualizing
protein-protein
investigated
systems,
it
combines
protein
co-expression
networks
identify
differentially
correlated
functional
modules.
To
test
algorithm,
we
processed
a
set
of
proteomic
profiles
from
different
brain
regions
controls
subjects
affected
by
idiopathic
Parkinson’s
disease
or
carrying
GBA1
mutation.
Its
robustness
was
supported
extraction
modules,
related
translation
mitochondria,
whose
involvement
in
pathogenesis
is
well
documented.
Furthermore,
selection
hubs
bottlenecks
weightedprotein-protein
provided
molecular
clues
consistent
with
Parkinson
pathophysiology.
Of
note,
like
quantification,
algorithm
revealed
less
variations
when
comparing
groups
than
diseased
controls.
However,
correlation
quantification
results
showed
low
overlap,
suggesting
complementarity
these
measures.
An
observation
that
opens
way
new
investigation
strategy
takes
into
account
not
only
expression,
but
also
level
coordination
among
proteins
cooperate
perform
given
function.
Language: Английский
Gene-modified animal models of Parkinson's disease
Experimental Neurology,
Journal Year:
2025,
Volume and Issue:
390, P. 115287 - 115287
Published: May 4, 2025
Language: Английский
UCHL1 regulates adiponectin receptors in Sertoli cells to maintain testicular homeostatic balance
Journal of Biological Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 110221 - 110221
Published: May 1, 2025
Disruptions
in
testicular
homeostasis
can
lead
to
impaired
spermatogenesis
and
male
infertility.
Such
disturbances
may
result
from
various
factors,
including
viral
or
bacterial
infections,
toxic
injuries,
genetic
mutations
deletions.
The
maintenance
of
is
governed
by
a
complex
interplay
cells,
hormones,
paracrine
genes,
enzymes.
UCHL1,
member
the
deubiquitinating
enzyme
family,
recognized
for
its
role
neuronal
function.
However,
contribution
remains
unclear.
This
study
uncovers
critical
Uchl1
maintaining
homeostasis,
acting
as
regulatory
switch
spermatogenesis.
We
demonstrate
that
knockout
(Uchl1_KO)
mice
exhibit
reduced
body
weight,
decreased
specific
gravity,
Single-nucleus
RNA
sequencing
(snRNA-seq)
analysis
Uchl1_KO
testes
reveals
significant
decrease
oxidative
phosphorylation
(OXPHOS)
levels
an
increase
Sertoli
cell
abnormalities.
Notably,
Uchl1_KO/knockdown
down-regulates
metabolism-related
adiponectin
signaling
(ADIPOR1/AMPK)
up-regulates
inflammation-related
SEMA7A/PLXNC1
pathway.
lines
(oeAdipor1/shUchl1)
confirm
UCHL1's
dual
these
pathways
vitro
experiments.
Our
findings
identify
UCHL1
key
regulator
spermatogenesis,
it
dynamically
controls
balance
between
metabolic
inflammatory
testis.
provides
valuable
theoretical
foundation
exploring
molecular
mechanisms
underlying
advancing
human
reproductive
health.
Language: Английский
The delayed effect of rotenone on the relative content of brain isatin-binding proteins of rats with experimental parkinsonism
Biomeditsinskaya Khimiya,
Journal Year:
2024,
Volume and Issue:
70(1), P. 25 - 32
Published: Jan. 1, 2024
Isatin
(indoldione-2,3)
is
an
endogenous
biological
regulator
found
in
the
brain,
peripheral
tissues,
and
fluids
of
humans
animals.
Its
activity
realized
via
isatin-binding
proteins,
many
which
were
identified
during
proteomic
profiling
brain
mice
rats.
A
number
these
proteins
are
related
to
development
neurodegenerative
diseases.
Previously,
using
a
model
experimental
Parkinsonism
induced
by
seven-day
course
rotenone
injections,
we
have
observed
behavioral
disturbances,
as
well
changes
profile
relative
content
proteins.
In
this
study,
investigated
responses
rats
with
rotenone-induced
5
days
after
last
administration
neurotoxin.
Despite
elimination
rotenone,
animals
exhibited
motor
coordination
impairments.
Proteomic
revealed
120
(the
83
increased
that
37
decreased).
Comparison
characterized
right
injection
(n=16)
later
(n=11)
only
two
common
(glyceraldehyde-3-phosphate
dehydrogenase
subunit
B
V-type
proton
ATPase).
However,
most
associated
neurodegeneration,
including
Parkinson's
Alzheimer's
Language: Английский
Insights into Dysregulated Neurological Biomarkers in Cancer
Cancers,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2680 - 2680
Published: July 27, 2024
The
link
between
neurodegenerative
diseases
(NDs)
and
cancer
has
generated
greater
interest
in
biomedical
research,
with
decades
of
global
studies
investigating
biomarkers
to
better
understand
possible
connections.
Tau,
amyloid-β,
α-synuclein,
SOD1,
TDP-43,
other
proteins
associated
nervous
system
have
also
been
identified
various
types
solid
malignant
tumors,
suggesting
a
potential
overlap
pathological
processes.
In
this
review,
we
aim
provide
an
overview
current
evidence
on
the
role
these
cancer,
specifically
examining
their
effects
cell
proliferation,
apoptosis,
chemoresistance,
tumor
progression.
Additionally,
discuss
diagnostic
therapeutic
implications
interconnection,
emphasizing
importance
further
research
completely
comprehend
clinical
tumors.
Finally,
explore
challenges
opportunities
targeting
for
development
new
targeted
anticancer
therapies,
providing
insight
into
how
integrate
knowledge
NDs
oncology
research.
Language: Английский