A Narrative Review Regarding Implication of Ovarian Endometriomas in Infertility

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 161 - 161

Published: Jan. 23, 2025

Endometriosis is a multifaceted gynecological disorder defined by endometrium-like tissue outside the uterine cavity. It mainly localized in pelvis and creates local inflammatory environment responsible for its manifestations complications. In 30–50% of cases, endometriosis associated with infertility. 17–44% ovaries are affected form ovarian endometriomas (OEs). The symptoms OEs not very pronounced. development slow. Diagnosis difficult because resemble cystic pathology, which so diverse. actual diagnosis possible through direct visualization or laparoscopy. Surgical treatment cystectomy common OEs. Recently, other therapeutic modalities have emerged that less impact on reserves pregnancy rates. this context, review attempts to shed light best diagnostic methods an insidious pathology major fertility.

Language: Английский

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Assessing the Relationships of Expenditure and Health Outcomes in Healthcare Systems: A System Design Approach

Healthcare, Journal Year: 2025, Volume and Issue: 13(4), P. 352 - 352

Published: Feb. 7, 2025

Background/Objectives: The COVID-19 pandemic has significantly altered healthcare systems worldwide, highlighting expenditure’s critical role in fostering population resilience and wellness. This extraordinary situation brought to light the delicate balance that governments must maintain between need protect public health budgetary restraints. relationship expenditure outcomes, such as healthy life years, expectancy, standardized death rate, become a central point understanding dynamics of their capacity adapt emerging challenges. Methods: Using extensive datasets predictive approaches artificial neural networks, exponential smoothing models, ARIMA techniques, this study explores these connections context European Union. Results: better explains how financing schemes influence important outcomes by examining past trends forecasting future developments. results show household expenditures correlate negatively with rates substantially benefit years expectancy. These findings underline significance contributions influencing across various systems. Long-term strategic investments services are essential, demonstrated proactive well-designed reduce risks enhance overall resilience. suggest focused can raise expectancy lower rates, supporting development robust, adaptable post-pandemic era. Conclusions: main contribution research is demonstrating significant expenditure, particularly contributions, improving key system EU context.

Language: Английский

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The Role of Mast Cells in the Development and Advancement of Endometriosis

American Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 93(3)

Published: March 1, 2025

ABSTRACT Endometriosis is a medical condition identified by the presence of endometrium‐like tissue outside uterus. This known to result in symptoms such as frequent pelvic pain, infertility, and irregularities menstrual cycle. The development endometriosis complex and, involving abnormal body responses, hormonal imbalances, genetic predispositions. Although common affects quality life, its mechanisms progression are not fully understood. Mast cells (MCs), type immune cell, renowned for their involvement allergic inflammatory responses. These essential modulation system process through secretion different mediators like histamine, cytokines, proteases. In recent years, MCs have been shown play role pathogenesis many diseases, including endometriosis. article explores relationship between endometriosis, disease development, pain perception, angiogenesis, other important processes. It elucidates how MCs, via mediators, actively participate associated environment. Moreover, research emphasizes potential targeting therapeutic approach treating Insight into interplay holds promise developing innovative strategies manage this effectively.

Language: Английский

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The Role of the Workplace Environment in Shaping Employees’ Well-Being

Sustainability, Journal Year: 2025, Volume and Issue: 17(6), P. 2613 - 2613

Published: March 16, 2025

In recent years, researchers and organizations have increasingly focused on understanding how various aspects of the work environment affect employees’ well-being, acknowledging its critical influence organizational performance employee satisfaction. This study aims to evaluate effects paying attention physical social dimensions, job characteristics, intrinsic factors, perspectives their roles. The research used a survey collect data from Romanian employees across diverse sectors. Structural equation modeling enabled analysis relationships between these variables direct or indirect well-being. results demonstrate that environment’s aspects, future significantly contribute Key such as autonomy managerial support, enhance experience. findings indicate enhancing workplace conditions can positively with broader implications for productivity retention. emphasizes need comprehensive approach design, integrating elements promote higher levels engagement.

Language: Английский

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Potential Association Between Atherogenic Coefficient, Prognostic Nutritional Index, and Various Obesity Indices in Diabetic Nephropathy

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1339 - 1339

Published: April 14, 2025

Background/Objectives: Type 2 diabetes mellitus (T2DM), is a rapidly growing global health concern, often accompanied by chronic kidney disease (CKD) and metabolic disturbances. Obesity-related indices, such as the visceral adiposity index (VAI) body (BAI), have been linked to cardiovascular renal complications in diabetic patients. However, studies integrating both atherogenic coefficient (AC) prognostic nutritional (PNI) for evaluating nephropathy (DN) remain limited. This study aimed assess associations of obesity-related indices with immunological factors patients T2DM prediabetes (PreDM). Methods: A retrospective, cross-sectional was conducted over six months at university clinical hospital Dolj County, Romania. The enrolled 268 newly diagnosed 150 PreDM Anthropometric parameters, laboratory tests, demographic data were collected. AC PNI calculated using standard formulas, statistical analyses performed determine their inflammatory markers. Results: Our found that had significantly lower values, indicating mild malnutrition, while maintained normal status. higher patients, correlating lipid profile alterations systemic inflammation. Obesity particularly VAI, elevated values. Statistically significant differences total cholesterol, low-density lipoprotein cholesterol (LDL-c), triglycerides observed between subgroups, reinforcing its role risk assessment. Conclusions: findings highlight potential biomarkers assessing nutritional, inflammatory, lipemic status profiles, inflammation markers suggest early assessment these parameters may potentially aid predicting complications. Further are needed explore utility managing CKD progression. Future research should investigate how lipidic spectrum alters progression DN across various patient groups

Language: Английский

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Circular RNAs in endometriosis analyzed through RNA sequencing and bioinformatics for expression profile

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19298 - e19298

Published: April 16, 2025

Background Endometriosis severely affects women’s physical and mental health; it is particularly important to find targets for the treatment diagnosis of endometriosis. Method This research aimed investigate circRNA expression pattern in endometriosis, a type non-coding RNA that can modulate parental gene by acting as miRNA sponges. Through high-throughput sequencing, we analyzed profile endometriosis patients comparison individuals without condition. Results We detected 371 circular RNAs (circRNAs) showing increased 308 circRNAs displaying decreased levels. To validate these findings, employed quantitative real-time PCR (qRT-PCR) confirm top three differential expressed listed circBase. inferred potential roles differentially development Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis. Moreover, examining circRNA-microRNA-target network, uncovered plausible mechanism. Specifically, interactions involving markedly upregulated hsa_circ_000005 significantly downregulated hsa_circ_000011 with miR-5787 may influence downstream targets, potentially contributing pathogenesis Our study offers foundational crucial within framework

Language: Английский

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New Evidence About Malignant Transformation of Endometriosis—A Systematic Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 2975 - 2975

Published: April 25, 2025

Background: Endometriosis is a benign gynecologic condition that has the risk of malignant transformation in approximately 0.5–1% cases, most which develop into endometriosis-associated ovarian cancers (EAOCs), such as clear cell and endometrioid adenocarcinomas. The current systematic review aims to condense recent information on genetic molecular mechanisms, clinical factors, possible therapeutic targets endometriosis. Methods: A literature search PubMed, Europe PMC, Google Scholar was carried out according PRISMA guidelines for articles published until December 2024. Following screening 44,629 titles, 43 full were included after meeting inclusion criteria. No case reports or reviews included, had mention endometriosis not just diagnosis cancer. quality bias studies evaluated using ROBINS-I. Results: Malignant associated with alterations, including ARID1A mutations, microsatellite instability, abnormal PI3K/Akt mTOR pathway activation. Increased oxidative stress, inflammation-driven mismatch repair deficiency, epigenetic alterations like RUNX3 RASSF2 hypermethylation are implicated carcinogenesis. Clinical factors advanced age (40–60 years), large endometriomas (>9 cm), postmenopausal status, prolonged estrogen exposure. Imaging techniques MR relaxometry models based machine learning highly predictive early detection. Conclusions: carcinogenesis multifactorial process driven by changes, inflammatory mechanisms. Identification high-risk individuals through imaging biomarkers may result detection personalized therapy. Further research should aim at development more precise exploration precision medicine approaches inhibit emergence EAOC.

Language: Английский

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Correlation Between Prognostic Nutritional Index, Glasgow Prognostic Score, and Different Obesity-Related Indices in People with Diabetes or Prediabetes

Diagnostics, Journal Year: 2024, Volume and Issue: 14(23), P. 2661 - 2661

Published: Nov. 26, 2024

Background/Objectives: The prognostic nutritional index (PNI) and Glasgow Prognostic Score (GPS) are associated with patients’ immune statuses. One important factor in the pathophysiology of type 2 diabetes mellitus (T2DM) is inflammation. Being present insulin-target tissues, chronic tissue inflammation has become recognized as a crucial aspect obesity diabetes. This study aimed to compare PNI GPS levels subjects T2DM those prediabetes (preDM) individuals. Furthermore, goal was investigate how these inflammatory markers relate different types whether combination PNI, GPS, obesity-related indices any particular variables. Methods: In this study, we enrolled one-hundred patients newly diagnosed preDM. Results: Four findings emerged from observational study. As first observation, 28% preDM 15% had normal weight, while up 43% 60% were obese. second observation that significantly lower than (p < 0.0001). showed moderate-to-severe malnutrition status (median value 38.00). Patients mild-to-moderate 61.00) at diagnosis. Third, observed current 61.00 38.00 higher median values waist-to-height ratio (WHtR) = 0.041, p 0.034, respectively) body mass (BMI) 0.016, respectively). Fourth, also revealed, group, moderate statistically significant negative correlation between weight (rho −0.322, 0.035), waist circumference (WC) −0.308, 0.042), hip (HC) −0.338, 0.039), WHtR −0.341, 0.022), adiposity (BAI) −0.312, 0.032), fasting plasma glucose (FPG) −0.318, 0.029). Additionally, expressed weak BMI −0.279, 0.015), glycated hemoglobin A1c (HbA1c) −0.245, 0.025). exhibited single positive correlation, but significant, estimated glomerular filtration rate (eGFR-CKD-EPI) 0.263, 0.018). Conclusions: regarding correlations people or suggest indices, which assess status, can be used independent predictor factors four pillars DM management (glucose, blood pressure, lipids, control) recommended by American Diabetes Association (ADA).

Language: Английский

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A Practical Multidisciplinary Approach to Identifying Interstitial Lung Disease in Systemic Autoimmune Rheumatic Diseases: A Clinician’s Narrative Review

Diagnostics, Journal Year: 2024, Volume and Issue: 14(23), P. 2674 - 2674

Published: Nov. 27, 2024

Interstitial lung disease (ILD) is one of the common and potentially lethal manifestations systemic autoimmune rheumatic diseases (SARDs). ILD’s prevalence, clinical patterns, imaging, natural history are variable. Each representative diseases—systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIMs), rheumatoid arthritis (RA), Sjӧgren’s syndrome (SjS), mixed connective tissue (MCTD), lupus erythematosus (SLE)—have distinct clinical, paraclinical evolutionary features. Risk factors with predictive value for ILD have been identified. This review summarizes, from clinician’s perspective, recent data literature regarding specificity each diseases, an emphasis on role multidisciplinary team in early diagnosis, case management, as well particularities approach to progressive phenotype SARDs.

Language: Английский

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Adenomyosis: An Update Concerning Diagnosis, Treatment, and Fertility

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(17), P. 5224 - 5224

Published: Sept. 3, 2024

This review article aims to summarize current tools used in the diagnosis of adenomyosis with relative pharmacological and surgical treatment clarify association between infertility, considering importance an accurate this heterogeneous disease. Among different reported concepts, direction invagination gland cells from basalis endometrium deep into myometrium is most widely accepted opinion on development adenomyosis. Adenomyosis has been increasingly identified young women pain, AUB, or no symptoms by using imaging techniques such as transvaginal ultrasound magnetic resonance. Furthermore, often coexists other gynecological conditions, endometriosis uterine fibroids, increasing heterogeneity available data. However, there agreement definition classification adenomyotic lesions both histopathology points view, remains difficult unclear. A standard, universally system needs be implemented improve our understanding inform precise type could key designing RCT studies evaluating impact quality life terms menstrual symptoms, fertility, pregnancy outcome, given high risk miscarriage obstetric complications.

Language: Английский

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