Vascular Mesenchymal Stromal Cells and Cellular Senescence: A Two-Case Study Investigating the Correlation Between an Inflammatory Microenvironment and Abdominal Aortic Aneurysm Development DOI Open Access
Gabriella Teti,

Riccardo Camiletti,

Valentina Gatta

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12495 - 12495

Published: Nov. 21, 2024

An abdominal aortic aneurysm (AAA) is described as a gradual and localized permanent expansion of the aorta resulting from weakening vascular wall. The key aspects AAA's progression are high proteolysis structural elements wall, depletion smooth muscle cells (VSMCs), chronic immunoinflammatory response. pathological mechanisms underpinning development an AAA complex still unknown. At present, there no successful drug treatments available that can slow or prevent rupture aneurysmal Recently, it has been suggested endothelial cellular senescence may be involved in aging diseases, but clear correlation between AAAs. Therefore, aim this study was to identify presence senescent on wall aneurysmatic aortas correlate their distribution with morphological markers Pathological healthy segments were collected during repair surgery immediately processed for histological immunohistochemical analyses. Hematoxylin/eosin, Verhoeff-van Gieson, Goldner's Masson trichrome staining procedures carried out investigate features related pathology. Immunohistochemical investigations p21

Language: Английский

The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update DOI Creative Commons
Roberto Campagna, Laura Mazzanti, Veronica Pompei

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1469 - 1469

Published: Sept. 1, 2024

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known be longevity regulators, and exerts a key role in prevention of vascular aging. By aging, expression levels Sirt1 decline with severe impact on function, such as rise endothelial dysfunction, which turn promotes development cardiovascular diseases. In this context, activity preventing senescence is particularly important. Given counteracting senescence, great efforts have been made deepen knowledge about intricate cross-talks interactions other molecules, order set up possible strategies boost prevent or treat The aim review provide proper background regulation function endothelium discuss recent advances regarding therapeutic targeting counteract

Language: Английский

Citations

11
Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging DOI

Anna De Bartolo,

Tommaso Angelone, Carmine Rocca

et al.

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107462 - 107462

Published: Jan. 1, 2025

Language: Английский

Citations

1
Hallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan DOI Creative Commons

Teow J. Phua

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 7, 2025

Aging is a complex process marked by various changes at both cellular and systemic levels, impacting the functioning lifespan of organisms. Over time, researchers have pinpointed several significant hallmarks aging that lead to gradual deterioration tissue function, regulation, homeostasis associated with in humans. Despite this, intricate interactions cumulative effects these are still mostly uncharted territory. Understanding this web major challenge Geroscience, yet it crucial for developing effective strategies promote healthy aging, reduce medical costs, ensure sustainability health systems. Gaining insights area essential creating interventions can slow process, enhance healthspan, decrease likelihood age-related diseases. The integration knowledge from fields concerning middle-aging nitric oxide (NO)-mediated hypovascularity hypoxia hemodynamic hypothesis points systems-based approach biological aging. Key evidence suggests connection between endocrine system (specifically sex hormones), endogenous NO deficiency, vascular system, which serves as network microvascular structures perfusion functions level. These processes also involve oxidative stress inflammation triggered hypoxia.

Language: Английский

Citations

0
Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone? DOI Creative Commons
Lara Russo, Serena Babboni, Maria Grazia Andreassi

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 99 - 99

Published: Jan. 16, 2025

Cellular senescence is a state of permanent cell cycle arrest accompanied by metabolic activity and characteristic phenotypic changes. This process crucial for developing age-related diseases, where excessive calorie intake accelerates dysfunction aging. Overnutrition disturbs key pathways, including insulin/insulin-like growth factor signaling (IIS), the mammalian target rapamycin (mTOR), AMP-activated protein kinase. The dysregulation these pathways contributes to insulin resistance, impaired autophagy, exacerbated oxidative stress, mitochondrial dysfunction, further enhancing cellular systemic derangements. On other hand, dysfunctional endothelial cells adipocytes contribute inflammation, reduced nitric oxide production, altered lipid metabolism. Numerous factors, extracellular vesicles, mediate pathological communication between vascular system adipose tissue, amplifying imbalances. Meanwhile, caloric restriction (CR) emerges as potent intervention counteract overnutrition effects, improve function, reduce restore balance. CR modulates such IIS, mTOR, sirtuins, glucose metabolism, reducing promoting autophagy. can extend health span mitigate diseases delaying improving healthy endothelial-adipocyte interactions. review highlights crosstalk adipocytes, emphasizing potential in counteracting overnutrition-induced restoring homeostasis.

Language: Английский

Citations

0
Cellular Senescence and Cardiovascular Aging DOI

Dharmesh Kapoor,

Imteyaz Qamar

Published: Jan. 1, 2025

Citations

0
Impact of insulin resistance and microvascular ischemia on myocardial energy metabolism and cardiovascular function: pathophysiology and therapeutic approaches DOI Creative Commons

Ariana Ramirez,

Elizabeth R. Doman, Katherine Sanchez

et al.

Cardiovascular Endocrinology & Metabolism, Journal Year: 2025, Volume and Issue: 14(2)

Published: April 16, 2025

Insulin resistance (IR) and microvascular ischemia together result in cardiovascular dysfunction by impairing the heart’s energy balance. IR cardiomyocytes disrupts glucose metabolism, leading to deficits that can drive cardiac hypertrophy heart failure. Microvascular exacerbates these effects limiting oxygen nutrient delivery, intensifying oxidative stress, mitochondrial dysfunction, cell death. also reduces effectiveness of vasodilators like nitroglycerin sodium nitroprusside, exacerbating endothelial thus delivery during ischemia. This combination heightens risk left ventricular Understanding interactions is critical for developing targeted therapies improve outcomes patients with ischemic disease. study examines relationship between IR, ischemia, myocardial a focus on clinical management therapeutic strategies.

Language: Английский

Citations

0
From Microcirculation to Aging-Related Diseases: A Focus on Endothelial SIRT1 DOI Creative Commons
Martin Law,

Peichun Wang,

Zhong-Yan Zhou

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1495 - 1495

Published: Nov. 7, 2024

Silent information regulator sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase with potent anti-arterial aging activities. Its protective function in aging-related diseases has been extensively studied. In the microcirculation, SIRT1 plays a crucial role preventing microcirculatory endothelial senescence by suppressing inflammation and oxidative stress while promoting mitochondrial optimizing autophagy. It suppresses hypoxia-inducible factor-1α (HIF-1α)-mediated pathological angiogenesis healthy, physiological capillarization. As result, protects against microvascular dysfunction, such as diabetic microangiopathy, enhancing exercise-induced skeletal muscle capillarization energy metabolism. brain, upregulates tight junction proteins strengthens their interactions, thus maintaining integrity of blood-brain barrier. The present review summarizes recent findings on regulation SIRT1, underlying mechanisms, various approaches to modulate activity microcirculation. importance molecular target diseases, retinopathy stroke, underscored, along need for more clinical evidence support modulation

Language: Английский

Citations

3
The Impact of Disease Duration on Microcirculatory Dysfunction in Young Patients with Uncomplicated Type 1 Diabetes DOI Creative Commons
Jolanta Neubauer‐Geryk, Melanie Wielicka,

Magdalena Hoffmann

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1020 - 1020

Published: May 6, 2024

This study aimed to evaluate the earliest changes in structure and function of peripheral microcirculation using capillaroscopy transcutaneous oxygen pressure measurement children adolescents with type 1 diabetes mellitus at baseline during post-occlusive reactive hyperemia (PORH) duration. Sixty-seven patients (T1D), aged 8 18 years, twenty-eight age- sex-matched healthy subjects were included analysis. Diabetic divided into subgroups based on median disease The differed chronological age, lipid levels, thyroid hormones. Capillaroscopy was performed twice: then again after PORH test. Transcutaneous also recorded under conditions Comparison parameters rest showed no statistically significant difference between subgroups. remained true adjusting for variables that differentiated two However, group long-standing diabetes, negative correlations observed Coverage value test capillary reactivity TcPO2_zero (biological zero). Significant positive found distance TcPO2_zero. results our indicate a shorter duration use multiple tests provides better characterization because onset dysfunction does not occur same time all tests.

Language: Английский

Citations

2
The Role of Endothelial Cell Mitophagy in Age-Related Cardiovascular Diseases DOI Creative Commons

Quancheng Han,

Yiding Yu,

Xiujuan Liu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Aging is a major risk factor for cardiovascular diseases (CVD), and mitochondrial autophagy impairment considered significant physiological change associated with aging. Endothelial cells play crucial role in maintaining vascular homeostasis function, participating various processes such as regulating tone, coagulation, angiogenesis, inflammatory responses. As aging progresses, endothelial worsens, leading to the development of numerous diseases. Therefore, vital preventing treating age-related However, there currently lack systematic reviews this area. To address gap, we have written review provide new research therapeutic strategies managing

Language: Английский

Citations

2
2,7-Phloroglucinol-6,6′-bieckol from Ecklonia cava ameliorates nanoplastics-induced premature endothelial senescence and dysfunction DOI

Hwan-Hee Sim,

Saugat Shiwakoti,

Ji‐Hyeok Lee

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175007 - 175007

Published: July 23, 2024

Language: Английский

Citations

2