Pathogens,
Journal Year:
2024,
Volume and Issue:
14(1), P. 14 - 14
Published: Dec. 30, 2024
Chronic
rhinosinusitis
(CRS)
is
a
common
inflammatory
disease
of
the
paranasal
sinuses
with
yet
unknown
etiology.
As
studies
continue
to
elucidate
disease's
heterogeneity
profile
and
presentation,
there
growing
interest
in
influence
nasal
microbiome
on
pathogenesis
chronicity.
The
sinus
microbiota
appear
dominated
by
Staphylococcus
Corynebacterium
genera;
known
upper
airway
pathogens,
such
as
Haemophilus
influenza,
are
present
airways
healthy
individuals,
though
at
relatively
lower
abundances
than
CRS
patients.
Viral
culprits
may
induce
an
unhindered
local
immune
response
that
contributes
recurrence
chronicity
inverted
papillomas-benign
mucosal
lesions
propensity
for
destruction
malignant
transformation
can
be
found
patients
history
infection.
persistence
papillomas
warrants
investigation
into
their
how
they
contribute
landscape
promoting
CRS.
Further
needed
uncover
interplay
between
resident
viral,
fungal,
immunological
influence.
Discerning
'healthy'
'diseased'
sinonasal
microbiomes
'keystone'
species
could
shed
light
etiology
provide
opportunity
treatment
tailored
individual's
microbiome.
This
review
aims
explore
interrelation
microbial
residents
diseased
environment.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: May 13, 2024
Staphylococcus
aureus
and
epidermidis
stand
as
notorious
threats
to
human
beings
owing
the
myriad
of
infections
they
cause.
The
bacteria
readily
form
biofilms
that
help
in
withstanding
effects
antibiotics
immune
system.
Intending
combat
biofilm
formation
reduce
virulence
pathogens,
we
investigated
carotenoids,
crocetin,
crocin,
on
four
Staphylococcal
strains.
Crocetin
was
found
be
most
effective
it
diminished
S.
ATCC
6538
significantly
at
50
µg/mL
without
exhibiting
bactericidal
effect
(MIC
>800
µg/mL)
also
inhibited
by
MSSA
25923
a
concentration
low
2
µg/mL,
methicillin-resistant
MW2
100
µg/mL.
It
displayed
minimal
no
antibiofilm
efficacy
Gram-negative
strains
Escherichia
coli
O157:H7
Pseudomonas
aeruginosa
well
fungal
strain
Candida
albicans
.
could
curb
fibrils,
which
partly
contributes
Additionally,
ADME
analysis
crocetin
proclaims
how
relatively
non-toxic
chemical
is.
Also,
synergistic
characteristics
combination
with
tobramycin.
presence
polyene
chain
carboxylic
acid
groups
its
ends
is
hypothesized
contribute
strong
crocetin.
These
findings
suggest
using
apocarotenoids,
particularly
might
epidermidis.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 623 - 623
Published: Jan. 13, 2025
Vibrios
are
naturally
present
in
marine
ecosystems
and
commonly
allied
with
live
seafood.
Vibrio
species
frequently
cause
foodborne
infections,
parahaemolyticus
recently
becoming
a
significant
contributor
to
illness
outbreaks.
In
response,
aniline
68
of
its
derivatives
were
studied
due
their
antibacterial
effects
targeting
V.
harveyi.
Among
these,
4-amino-3-chloro-5-nitrobenzotrifluoride
(ACNBF)
2-iodo-4-trifluoromethylaniline
(ITFMA)
demonstrated
both
antibiofilm
properties.
The
minimum
inhibitory
concentrations
(MIC)
for
ACNBF
ITFMA
100
µg/mL
50
µg/mL,
respectively,
against
planktonic
cells.
active
compounds
effectively
suppressed
biofilm
formation
manner
dependent
on
the
dosage.
Additionally,
these
trifluoro-anilines
significantly
reduced
virulence
factors
such
as
motility,
protease
activity,
hemolysis,
indole
production.
Both
caused
noticeable
destruction
membrane
bacterial
cells
and,
at
exhibited
bactericidal
activity
within
30
min.
Toxicity
assays
using
Caenorhabditis
elegans
seed
germination
models
showed
that
displayed
mild
toxicity.
As
result,
inhibited
growth
formation.
Furthermore,
prevented
surfaces
shrimp
squid
models,
highlighting
potential
use
controlling
seafood
contamination.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(15)
Published: April 1, 2025
Abstract
Candida
albicans
,
a
type
of
fungi,
is
quite
adaptable
and
can
survive
in
various
parts
the
body
including
bloodstream,
skin,
mucosal
surfaces,
different
organs.
This
pathogen
cause
debilitating
mucocutaneous
disease
life‐threatening
systemic
infections
humans.
In
this
study,
we
investigated
how
effective
newly
synthesized
pyrimidine
derivatives
are
as
antifungal
agents.
Pyrimidines
special
compounds
made
six‐membered
rings
containing
two
nitrogen
atoms.
We
have
molecules
by
substituting
hydrogen
mono‐
di‐fluorophenyl.
Further
all
were
tested
against
C.
.
shown
that
(80,
40,
20
µg/mL)
exhibit
inhibitory
effect
at
growth
stages:
adhesion,
development,
maturation
biofilm
formation.
Overall,
study
presents
design,
synthesis,
anticandidal
evaluation
novel
class
derivatives.
Specifically,
observe
fluorine‐substituted
inhibition
These
findings
contribute
to
development
more
potent
pyrimidine‐based
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(4), P. 386 - 386
Published: April 15, 2025
Staphylococcus
aureus
is
a
formidable
pathogen
notorious
for
its
antibiotic
resistance
and
diverse
virulence
mechanisms,
including
toxin
production,
biofilm
formation,
immune
evasion.
This
article
explores
innovative
anti-virulence
strategies
to
disarm
S.
by
targeting
critical
factors
without
exerting
bactericidal
pressure.
Key
approaches
include
inhibiting
adhesion
neutralizing
toxins,
disrupting
quorum
sensing
(e.g.,
Agr
system
inhibitors),
blocking
iron
acquisition
pathways.
Additionally,
interventions
two-component
regulatory
systems
are
highlighted.
While
promising,
challenges
such
as
strain
variability,
resilience,
pharmacokinetic
limitations,
evolution
underscore
the
need
combination
therapies
advanced
formulations.
Integrating
with
traditional
antibiotics
host-directed
offers
sustainable
solution
combat
multidrug-resistant
aureus,
particularly
methicillin-resistant
strains
(MRSA),
mitigate
global
public
health
crisis.
World Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 2338 - 2352
Published: Nov. 14, 2024
Shikonin
is
a
natural
remedy
that
effective
at
treating
diabetic
wounds.
NFAT5
potential
therapeutic
target
for
diabetes,
and
mitochondrial
function
essential
wound
healing.
However,
the
relationship
among
Shikonin,
NFAT5,
has
not
been
thoroughly
studied.
Here,
we
offer
new
perspectives
on
advantages
of
shikonin
managing
diabetes.
