Young Age and Concomitant Cannabis (THC) and Ethanol (EtOH) Exposure Enhances Rat Brain Damage Through Decreased Cerebral Mitochondrial Respiration
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 918 - 918
Published: Feb. 17, 2025
The
reason
why
young
people
taking
concomitantly
cannabis
(THC)
and
ethanol
(EtOH)
are
more
prone
to
stroke
is
underresearched.
To
investigate
whether
an
underlying
mechanism
of
increased
brain
damage
could
be
impaired
mitochondrial
function,
this
experiment
determined
the
acute
effects
EtOH,
both
alone
associated
with
THC,
on
respiration
oxidative
stress
(hydrogen
peroxide
H2O2)
(11
weeks)
middle-aged
(45
in
rats,
using
a
high-resolution
oxygraph
(Oxygraph-2K,
Oroboros
instruments).
In
brains,
EtOH
decreased
by
-51.76
±
2.60%
(from
32.76
3.82
17.41
1.42
pmol/s/mL,
p
<
0.0001).
45-week-old
decrease
was
lesser,
but
still
significant
-36.0
2.80%
30.73
7.72
20.59
5.48
Concomitant
THC
aggravated
decreases
at
11
weeks
(-86.86
1.74%,
0.0001)
45
(-73.95
3.69%,
Such
additional
injury
enhanced
brains
(p
0.01).
H2O2
production
similar
age
groups
(1.0
0.2
versus
1.1
0.08
pmol
O2/s/mL)
not
modified
addition.
conclusion,
significantly
impairs
concomitant
further
aggravates
such
damage,
particularly
brains.
These
data
support
hypothesis
that
dysfunction
might
participate
occurrence
urge
for
better
prevention
against
addictions
adolescents.
Language: Английский
Special Issue “Mitochondrial Metabolism Alterations in Health and Disease”
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4826 - 4826
Published: May 18, 2025
Mitochondria
are
central
hubs
of
cellular
metabolism
and
signaling
that
play
key
roles
in
stress
response,
inflammation,
calcium
homeostasis,
mitochondrial
quality
control,
cell
death,
with
impairment
potentially
being
the
underlying
cause
several
conditions,
including
metabolic,
neurodegenerative,
cardiovascular
diseases
[...]
Language: Английский
Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review
Matthew V. DiLeo,
No information about this author
R Hall,
No information about this author
Heather L. Vellers
No information about this author
et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12280 - 12280
Published: Nov. 15, 2024
Bioenergetic
pathways
uniquely
support
sarcomere
function
which,
in
turn,
helps
to
maintain
functional
skeletal
muscle
(SKM)
mass.
Emerging
evidence
supports
alcohol
(EtOH)-induced
bioenergetic
impairments
SKM
and
precursor
cells.
We
performed
a
scoping
review
synthesize
existing
regarding
the
effects
of
EtOH
on
bioenergetics.
Eligible
articles
from
six
databases
were
identified,
titles,
abstracts,
full
texts
for
potentially
relevant
screened
against
inclusion
criteria.
Through
search,
we
identified
555
unique
articles,
21
met
Three
studies
investigated
adenosine
triphosphate
(ATP)-phosphocreatine
(PCr)
system,
twelve
glycolytic
metabolism,
seventeen
mitochondrial
metabolism.
Despite
increased
ATP-PCr
system
reliance,
led
an
overall
decrease
through
decreased
expression
activity
pathway
components.
However,
varied
depending
dose
duration,
model
sample
type.
The
results
detail
EtOH-induced
shifts
energy
which
may
adversely
affect
contribute
myopathy.
These
findings
should
be
used
develop
targeted
interventions
that
improve
function,
thus
people
with
Alcohol
Use
Disorder
(AUD).
Key
areas
need
further
investigation
are
also
identified.
Language: Английский
Cannabis (THC) Aggravates the Deleterious Effects of Alcohol (EtOH) on Skeletal Muscles’ Mitochondrial Respiration: Modulation by Age and Metabolic Phenotypes
Biology,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1080 - 1080
Published: Dec. 21, 2024
The
anti-inflammatory
and
analgesic
properties
of
cannabis
might
be
useful
to
treat
muscle
diseases,
including
those
linked
or
not
alcohol.
Nevertheless,
delta
9
tetrahydrocannabinol
(THC)
ethanol
(EtOH),
often
used
concomitantly,
can
have
deleterious
effects
on
cardiac
mitochondria.
We
therefore
determined
whether
EtOH,
alone
associated
with
THC,
impairs
skeletal
mitochondrial
respiration.
Further,
we
investigated
potential
modulation
by
metabolic
phenotype
age
analyzing
predominantly
glycolytic
gastrocnemius
oxidative
soleus
muscles
in
young
middle-aged
rats
(12
49
weeks).
Considering
the
gastrocnemius,
EtOH
impaired
respiration
a
similar
manner
young-
(-34.97
±
2.97%
vs.
-37.50
6.03%
at
2.1
×
10-5
M;
p
<
0.05).
Interestingly,
concomitant
THC
aggravated
EtOH-related
impairment
(-49.92
1.69%,
-34.97
2.97
Concerning
soleus,
mainly
decreased
(-42.39
2.42%
-17.09
7.61%
M,
0.001,
12
was
less
weeks
association
than
±1.69
-27.22
8.96%
respectively,
In
conclusion,
significantly
aggravates
EtOH-induced
muscle.
Age
phenotypes
modulate
these
effects,
being
more
prone
impairments
muscles.
Language: Английский