Young Age and Concomitant Cannabis (THC) and Ethanol (EtOH) Exposure Enhances Rat Brain Damage Through Decreased Cerebral Mitochondrial Respiration

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 918 - 918

Published: Feb. 17, 2025

The reason why young people taking concomitantly cannabis (THC) and ethanol (EtOH) are more prone to stroke is underresearched. To investigate whether an underlying mechanism of increased brain damage could be impaired mitochondrial function, this experiment determined the acute effects EtOH, both alone associated with THC, on respiration oxidative stress (hydrogen peroxide H2O2) (11 weeks) middle-aged (45 in rats, using a high-resolution oxygraph (Oxygraph-2K, Oroboros instruments). In brains, EtOH decreased by -51.76 ± 2.60% (from 32.76 3.82 17.41 1.42 pmol/s/mL, p < 0.0001). 45-week-old decrease was lesser, but still significant -36.0 2.80% 30.73 7.72 20.59 5.48 Concomitant THC aggravated decreases at 11 weeks (-86.86 1.74%, 0.0001) 45 (-73.95 3.69%, Such additional injury enhanced brains (p 0.01). H2O2 production similar age groups (1.0 0.2 versus 1.1 0.08 pmol O2/s/mL) not modified addition. conclusion, significantly impairs concomitant further aggravates such damage, particularly brains. These data support hypothesis that dysfunction might participate occurrence urge for better prevention against addictions adolescents.

Language: Английский

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Special Issue “Mitochondrial Metabolism Alterations in Health and Disease”

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4826 - 4826

Published: May 18, 2025

Mitochondria are central hubs of cellular metabolism and signaling that play key roles in stress response, inflammation, calcium homeostasis, mitochondrial quality control, cell death, with impairment potentially being the underlying cause several conditions, including metabolic, neurodegenerative, cardiovascular diseases [...]

Language: Английский

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Alcohol Alters Skeletal Muscle Bioenergetic Function: A Scoping Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12280 - 12280

Published: Nov. 15, 2024

Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments SKM and precursor cells. We performed a scoping review synthesize existing regarding the effects of EtOH on bioenergetics. Eligible articles from six databases were identified, titles, abstracts, full texts for potentially relevant screened against inclusion criteria. Through search, we identified 555 unique articles, 21 met Three studies investigated adenosine triphosphate (ATP)-phosphocreatine (PCr) system, twelve glycolytic metabolism, seventeen mitochondrial metabolism. Despite increased ATP-PCr system reliance, led an overall decrease through decreased expression activity pathway components. However, varied depending dose duration, model sample type. The results detail EtOH-induced shifts energy which may adversely affect contribute myopathy. These findings should be used develop targeted interventions that improve function, thus people with Alcohol Use Disorder (AUD). Key areas need further investigation are also identified.

Language: Английский

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Cannabis (THC) Aggravates the Deleterious Effects of Alcohol (EtOH) on Skeletal Muscles’ Mitochondrial Respiration: Modulation by Age and Metabolic Phenotypes

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1080 - 1080

Published: Dec. 21, 2024

The anti-inflammatory and analgesic properties of cannabis might be useful to treat muscle diseases, including those linked or not alcohol. Nevertheless, delta 9 tetrahydrocannabinol (THC) ethanol (EtOH), often used concomitantly, can have deleterious effects on cardiac mitochondria. We therefore determined whether EtOH, alone associated with THC, impairs skeletal mitochondrial respiration. Further, we investigated potential modulation by metabolic phenotype age analyzing predominantly glycolytic gastrocnemius oxidative soleus muscles in young middle-aged rats (12 49 weeks). Considering the gastrocnemius, EtOH impaired respiration a similar manner young- (-34.97 ± 2.97% vs. -37.50 6.03% at 2.1 × 10-5 M; p < 0.05). Interestingly, concomitant THC aggravated EtOH-related impairment (-49.92 1.69%, -34.97 2.97 Concerning soleus, mainly decreased (-42.39 2.42% -17.09 7.61% M, 0.001, 12 was less weeks association than ±1.69 -27.22 8.96% respectively, In conclusion, significantly aggravates EtOH-induced muscle. Age phenotypes modulate these effects, being more prone impairments muscles.

Language: Английский

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