Dietary fibre supplementation promotes symbiotic interactions among the intestinal microbiota in preweaning calves DOI Creative Commons
Wentao Lu, Yi Xia, Y. C. Ge

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Dietary fiber plays a significant role in gastrointestinal health. In order to thoroughly comprehend the protective effect of dietary on calf intestinal health, we conducted randomized controlled trial with135 calves. We profiled gut bacterial community fecal samples from calves without diarrhea at five time points (0, 7, 14, 28, and 56 days age) using both 16s amplicon sequencing metagenomic sequencing. Our findings revealed significantly elevated abundance Bifidobacterium Prevotella intestine fed with compared control group. may mitigate damage protect health by modulating secondary bile acid metabolism flavonoid pathways. Furthermore, CAZy differential analysis reveals that feeding different fibers can induce increased CAZymes. also found changes CAZymes induced are associated distinct microbial communities. This suggests stimulates colonization species intestine, thereby increasing activity carbohydrate enzymes microbiota. lays foundation for management during transition period. Additionally, our research psyllium husk powder age harbored intergeneric symbiotic clusters their intestines consisting Clostridium, Prevotella, Bacteriodes, others. The symbiosis among these collectively maintain micro-environment study provides initial insights into pre-weaning microbiota theoretical groundwork further this area.

Language: Английский

The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health DOI Open Access

Suyeon Yoo,

Suk‐Chae Jung, Kihyuck Kwak

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4834 - 4834

Published: April 29, 2024

The human gut microbiota, an intricate ecosystem within the gastrointestinal tract, plays a pivotal role in health and disease. Prebiotics, non-digestible food ingredients that beneficially affect host by selectively stimulating growth and/or activity of beneficial microorganisms, have emerged as key modulator this complex microbial community. This review article explores evolution prebiotic concept, delineates various types prebiotics, including fructans, galactooligosaccharides, xylooligosaccharides, chitooligosaccharides, lactulose, resistant starch, polyphenols, elucidates their impact on microbiota composition. We delve into mechanisms through which prebiotics exert effects, particularly focusing producing short-chain fatty acids modulating towards health-promoting implications are extensively reviewed, conditions such obesity, inflammatory bowel disease, immune function, mental health. further discusses emerging concept synbiotics—combinations probiotics synergistically enhance health—and highlights market potential response to growing demand for functional foods. By consolidating current knowledge identifying areas future research, aims understanding prebiotics’ underscoring importance maintaining healthy microbiome overall well-being.

Language: Английский

Citations

61
The emerging role of the gut microbiota and its application in inflammatory bowel disease DOI Open Access
Wang Xiu, Jianhua Peng,

Peipei Cai

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117302 - 117302

Published: Aug. 19, 2024

Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a complex disorder with an unknown cause. However, the dysbiosis of gut microbiome has been found to play role in IBD etiology, exacerbated immune responses defective intestinal barrier integrity. The can also be potential biomarker for several diseases, IBD. Currently, conventional treatments targeting pro-inflammatory cytokines pathways IBD-associated do not yield effective results. Other therapies that directly target dysbiotic outcomes are emerging. We review health its as diagnostic, prognostic, therapeutic This explores emerging advancements microbiome-associated alterations IBD, such nanoparticle or encapsulation delivery, fecal microbiota transplantation, nutritional therapies, microbiome/probiotic engineering, phage therapy, mesenchymal stem cells (MSCs), proteins, herbal formulas.

Language: Английский

Citations

23
Diet and Microbiome-Directed Therapy 2.0 for IBD DOI
Ashwin N. Ananthakrishnan, Kevin Whelan,

Jessica R. Allegretti

et al.

Clinical Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 23(3), P. 406 - 418

Published: July 9, 2024

Language: Английский

Citations

12
Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation DOI Open Access
Yao Du, Xinyue Chen, Susumu Kajiwara

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2263 - 2263

Published: July 13, 2024

Circadian rhythm plays an important role in intestinal homeostasis and immune function. dysregulation was reported to induce microbiota dysbiosis, barrier disruption, trigger inflammation. However, the relationship between metabolites circadian of still unclear. Urolithin A (UA), a kind microbial metabolite, selected this study. Results showed UA influenced on expression clock genes BMAL1 PER2 epithelial cells. Furthermore, study investigated effects rhythms (BMAL1 PER2) tight junctions (OCLN, TJP1, CLND1), all which were dysregulated by In addition, pre-treatment oral administration female C57BL/6 mice improvement fecal IgA concentrations, junction (Clnd1 Clnd4), gene (Bmal1 Per2) DSS-induced colitis model induced using DSS treatment. Finally, Nrf2-SIRT1 signaling pathway confirmed be involved UA’s effect cells antagonist This also evidence that feeding impact central clock, are SCN. Therefore, highlighted potential treating diseases like IBD with sleeping disorders improving both

Language: Английский

Citations

5
Therapeutic Role of Inulin in Disease Management DOI
Anchala Guglani,

S Shukla,

Ravi Tripathi

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Future Prospects in Inulin Research DOI
Akshay Kumar Lunawat, Nikhar Vishwakarma, Sarjana Raikwar

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Toxicity and Safety Aspects of Inulin DOI
Sanjay Gupta, Astha Verma

Published: Jan. 1, 2025

Language: Английский

Citations

0
Inulin Hydrogel Loaded with Self-Assembled Nanoparticles of Curcumin and Glycyrrhizic Acid for Inflammatory Bowel Disease Treatment Via Anti-Inflammation, Antioxidation, and Microbiota Modulation DOI
Jiaxin Wu,

Leyan Wang,

Lu Han

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Molecular modeling and simulation approaches to characterize potential molecular targets for burdock inulin to instigate protection against autoimmune diseases DOI Creative Commons

Huma Farooque Hashmi,

Xuan Xu, Kaoshan Chen

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 17, 2024

Abstract In the current study, we utilized molecular modeling and simulation approaches to define putative potential targets for Burdock Inulin, including inflammatory proteins such as iNOS, COX-2, TNF-alpha, IL-6, IL-1β. Molecular docking results revealed interactions good binding affinity these targets; however, IL-1β, iNOS were identified best Inulin. simulation-based stability assessment demonstrated that inulin could primarily target may also supplementarily COX-2 IL-1β during DSS-induced colitis reduce role of mechanisms. Furthermore, residual flexibility, hydrogen bonding, structural packing reported with uniform trajectories, showing no significant perturbation throughout simulation. The protein motions within trajectories clustered using principal component analysis (PCA). IL-1β–Inulin complex, approximately 70% total motion was attributed first three eigenvectors, while remaining contributed by eigenvectors. contrast, COX2–Inulin 75% in iNOS–Inulin eigenvectors 60% motion. complex through To explore thermodynamically favorable changes upon mutation, mode carried out. Free Energy Landscape (FEL) achieved a single conformation lowest energy, exhibited two lowest-energy conformations each. displayed free energies − 27.76 kcal/mol 37.78 kcal/mol, respectively, energy at 45.89 kcal/mol. This indicates stronger pharmacological than other complexes. Thus, further experiments are needed use autoimmune diseases.

Language: Английский

Citations

2
Microbial Conversion of Inulin to Valuable Products: The Biorefinery Concept DOI Creative Commons
Lidia Tsigoriyna, S. Stefanov, Nadya Armenova

et al.

Fermentation, Journal Year: 2024, Volume and Issue: 10(12), P. 640 - 640

Published: Dec. 13, 2024

The global transition to a sustainable bioeconomy requires the engagement of renewable and cost-effective substrates obtain valuable bio-based products. Inulin-rich plant materials have promising applications in white biotechnology. This review evaluates potential converting inulin through an integrated biorefinery into high-value products by microbial fermentation. It describes methods for raw biomass pretreatment, possibilities simultaneous saccharification fermentation (SSF), use wild-type genetically modified strains. bioconversion enables efficient synthesis biofuels such as ethanol, butanol, 2,3-butanediol biochemicals lactic, citric, poly-γ-glutamic acid. By analyzing advances hydrolysis methods, engineering, bioprocess optimization approaches, this highlights broad applicability context multifunctional, substrate, which contributes development circular economy.

Language: Английский

Citations

2