A Wonderful Journey: The Diverse Roles of Adenosine Deaminase Action on RNA 1 (ADAR1) in Central Nervous System Diseases

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 1, 2025

ABSTRACT Background Adenosine deaminase action on RNA 1 (ADAR1) can convert the adenosine in double‐stranded (dsRNA) molecules into inosine a process known as A‐to‐I editing. ADAR1 regulates gene expression output by interacting with and other proteins; plays important roles development, including growth; is linked to innate immunity, tumors, central nervous system (CNS) diseases. Results In recent years, role of tumors has been widely discussed, but its CNS diseases not reviewed. It worth noting that studies have shown great potential treatment neurodegenerative diseases, mechanisms are still unclear. Therefore, it necessary elaborate Conclusions Here, we focus effects such Aicardi–AicardiGoutières syndrome, Alzheimer's disease, Parkinson's glioblastoma, epilepsy, amyotrophic lateral sclerosis, autism. We also evaluate impact ADAR1‐based strategies these particular development new technologies microRNAs, nanotechnology, editing, stem cell therapy. hope provide directions insights for future editing technology brain science

Language: Английский

---

Transcriptome analysis reveals that the injection of mesenchymal stem cells remodels extracellular matrix and complement components of the brain through PI3K/AKT/FOXO1 signaling pathway in a neuroinflammation mouse model

Genomics, Journal Year: 2025, Volume and Issue: 117(3), P. 111033 - 111033

Published: March 22, 2025

Language: Английский

---

The study of Alzheimer's disease risk diagnosis based on natural killer cell marker genes in the multi-omics data

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

Alzheimer's disease (AD) is a common neurodegenerative disorder, currently lacking effective early diagnostic methods. However, natural killer (NK) cells may play potential role in AD pathogenesis.

Language: Английский

---

Sinapic acid alleviates glutamate-induced excitotoxicity by inhibiting neuroinflammation and endoplasmic reticulum stress pathway in C6 glioma cells

Toxicology in Vitro, Journal Year: 2024, Volume and Issue: 103, P. 105977 - 105977

Published: Nov. 28, 2024

Language: Английский

---

Neuroprotective Potential of Indole-Based Compounds: A Biochemical Study on Antioxidant Properties and Amyloid Disaggregation in Neuroblastoma Cells

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1585 - 1585

Published: Dec. 23, 2024

Based on the established neuroprotective properties of indole-based compounds and their significant potential as multi-targeted therapeutic agents, a series synthetic indole–phenolic was evaluated multifunctional neuroprotectors. Each compound demonstrated metal-chelating properties, particularly in sequestering copper ions, with quantitative analysis revealing approximately 40% chelating activity across all compounds. In cellular models, these hybrid exhibited strong antioxidant cytoprotective effects, countering reactive oxygen species (ROS) generated by Aβ(25–35) peptide its oxidative byproduct, hydrogen peroxide, showing average 25% increase cell viability reduction ROS levels to basal states. Further using thioflavin T fluorescence assays, circular dichroism, computational studies indicated that synthesized derivatives effectively promoted self-disaggregation fragment. Taken together, findings suggest unique profile actions for derivatives, combining chelating, antioxidant, anti-aggregation which position them promising development agents Alzheimer’s disease therapy. The methods used provide reliable vitro data, although further vivo validation assessment blood–brain barrier penetration are needed confirm efficacy safety.

Language: Английский

---

Live and let die: analyzing ultrastructural features in cell death

Ultrastructural Pathology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: Nov. 17, 2024

Cell death is an important process that supports morphogenesis during development and tissue homeostasis adult life by removing damaged or unwanted cells its dysregulation associated with numerous disease states. There are different pathways through which a cell can undergo death, each relying on peculiar molecular mechanisms morpho-ultrastructural features. To date, however, while genetic approaches have been successfully integrated into the field, studies rarely incorporate ultrastructural data from electron microscopy. This review article reports gallery of original transmission microscopy images to describe features undergoing types programs, including necrosis, apoptosis, autophagy, mitotic catastrophe, ferroptosis, methuosis, paraptosis. TEM has technology in biology for well over 50 years still continues offer significant advantages area research. allows detailed characterization changes within cell, such as alteration organelles subcellular structures, nuclear reorganization, loss membrane integrity enable distinction between forms based morphological criteria. Possible pitfalls also described.

Language: Английский

---

Cuproptosis: a new mechanism for anti-tumour therapy

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155790 - 155790

Published: Dec. 25, 2024

Language: Английский

---