Neuropharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 110264 - 110264
Published: Dec. 1, 2024
Language: Английский
Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 217, P. 111058 - 111058
Published: Aug. 27, 2024
The establishment of positive early parent-infant relationships provide essential nourishment and social stimulation for newborns. During the stages postnatal brain development, events such as synaptogenesis, neuronal maturation glial differentiation occur in a highly coordinated manner. Maternal separation, an early-life stress introducer, can disrupt formation parent-child bonds exert long-term adverse effects throughout life. When offspring are exposed to maternal body regulates separation through multiple mechanisms, including neuroinflammatory responses, neuroendocrinology, electrical activity. In adulthood, has effects, induction neuropsychiatric disorders anxiety, depression, cognitive dysfunction. This review summarized application models mechanisms system response disorders, serving both reminder inspiration approaches improve neonatal care, "from bench bedside".
Language: Английский
Citations
7
Chemical Papers, Journal Year: 2024, Volume and Issue: 78(12), P. 7175 - 7185
Published: July 20, 2024
Language: Английский
Citations
6
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18
Published: Jan. 8, 2025
The ventrolateral preoptic nucleus (VLPO) is a crucial regulator of sleep, and its neurons are implicated in both sleep-wake regulation anesthesia-induced loss consciousness. Propofol (PRO), widely used intravenous anesthetic, modulates the activity VLPO neurons, but underlying mechanisms, particularly role dopaminergic receptors, remain unclear. This study aimed to investigate effects PRO on NA (-) determine involvement D1 D2 receptors mediating these effects. Using vitro patch-clamp techniques, we identified characterized (+) based their morphological, pharmacological, electrophysiological properties. We assessed spontaneous excitatory postsynaptic currents (sEPSCs) inhibitory (sIPSCs) presence absence receptor modulators. significantly increased firing frequency while decreasing neurons. activation was mediated through GABA_A as evidenced by sEPSCs altered sIPSCs dynamics. Dopamine (DA) attenuated PRO-induced increase suppression via not receptors. Blocking with SCH23390 reversed DA changes, antagonist sulpiride had minimal impact. Our findings demonstrate that excites sleep-promoting VLPO, primarily modulation occurring These results provide new insights into neural mechanisms general anesthesia highlight potential signaling modulating anesthetic sleep-related circuits.
Language: Английский
Citations
0
ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 16(3), P. 483 - 486
Published: Feb. 10, 2025
In this study, we provide the first evidence that sonepiprazole, a dopamine D4 receptor antagonist, acts as potent inhibitor of human carbonic anhydrases (hCAs). Sonepiprazole exhibited significant inhibitory activity across panel catalytically active hCAs, with exception hCA IV, and III. The most inhibition was observed against brain-associated isoform VII, KI 2.9 nM. Insights from X-ray crystallographic structures complexes I, II, XII revealed sulfonamide group sonepiprazole coordinates zinc ion in site, typical interaction for class inhibitors. Despite presence isoform-specific residues at rim site pocket, these variations seem not to significantly impact compound overall potency. These findings highlight dual functionality both antagonist anhydrase inhibitor.
Language: Английский
Citations
0
Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 223, P. 111283 - 111283
Published: Feb. 28, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: March 13, 2025
The mesolimbic dopamine system is crucial for drug reinforcement and reward learning, leading to addiction. We previously demonstrated that Arvcf was associated significantly with nicotine alcohol addiction through genome-wide association studies. However, the role mechanisms of in dopamine-mediated processes were largely unknown. In this study, we first showed mediates nicotine-induced behavior by using conditioned place preference (CPP) model on Arvcf-knockout (Arvcf-KO) animal model. Then, revealed mainly expressed VTA dopaminergic neurons whose expression could be upregulated treatment. Subsequently, our SnRNA-seq analysis directly involved biosynthesis neurons. Furthermore, found Arvcf-KO led a significant reduction both synthesis release nucleus accumbens (NAc) stimulation. Specifically, inhibition decreased within VTA-NAc circuit suppressed reward-related behavior, while overexpression opposite results. Taken together, these findings highlight regulating signaling its enhancement as novel mechanism reward. Catenin gene promotes theformation learning enhancing mice.
Language: Английский
Citations
0
Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111309 - 111309
Published: March 1, 2025
The ventral tegmental area (VTA), which is rich in dopaminergic neurons, may play a role influencing clinical symptoms Parkinson's Disease (PD). However, the degeneration dynamics of VTA during early and prodromal stages PD remain unclear. This study aims to explore microstructural changes among patients with idiopathic REM sleep behavior disorder (iRBD) early-stage using free water imaging (FWI) assess (FW) its correlation symptoms. Diffusion tensor data from 238 participants, including 69 healthy controls (HC), 54 iRBD patients, 115 patients. FW values were computed bi-tensor model, comparisons done between HC, iRBD, groups. Additionally, relationship substantia nigra pars compacta (SNc) was explored through baseline assessments longitudinal tracking SNc significantly increased compared group exhibiting even higher values. Initially, did not differ those HC but PD, correlating anxiety motor deficits. Longitudinal revealed increases over time. present findings desynchronized pattern SNc, no observed phase gradual time, leading pronounced PD. underscores impact on symptoms, contributing understanding pathophysiology.
Language: Английский
Citations
0
Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130704 - 130704
Published: March 1, 2025
Language: Английский
Citations
0
Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown
Published: April 28, 2025
Abstract Chronic visceral pain is a persistent and debilitating condition arising from dysfunction or sensitization of the organs their associated nervous pathways. Increasing evidence suggests that imbalances in central system function play an essential role progression pain, but exact mechanisms underlying neural circuitry molecular targets remain largely unexplored. In present study, ventral tegmental area (VTA) was shown to mediate mice. Visceral stimulation increased c-Fos expression Ca 2+ activity glutamatergic VTA neurons, optogenetic modulation neurons altered pain. particular, upregulation NMDA receptor 2A (NR2A) subunits within resulted Administration selective NR2A inhibitor decreased number pain-induced positive attenuated Pharmacology combined with chemogenetics further demonstrated regulated behaviors based on NR2A. summary, our findings plays critical These insights provide foundation for comprehension circuits involved chronic may pave way targeted therapies
Language: Английский
Citations
0