Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 28, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5483 - 5483
Published: May 17, 2024
Molecular chaperones are highly conserved across evolution and play a crucial role in preserving protein homeostasis. The 60 kDa heat shock (HSP60), also referred to as chaperonin (Cpn60), resides within mitochondria is involved maintaining the organelle’s proteome integrity HSP60 family, encompassing Cpn60, plays diverse roles cellular processes, including folding, cell signaling, managing high-temperature stress. In prokaryotes, well understood GroEL/GroES complex, which forms double-ring cavity aids folding. eukaryotes, implicated numerous biological functions, like facilitating folding of native proteins influencing disease development processes. Notably, research highlights its critical involvement sustaining oxidative stress mitochondrial integrity. perturbation results loss activates apoptosis. Currently, clinical investigations progress explore targeting both vivo vitro various models. These studies aim enhance our comprehension mechanisms potentially harness therapeutic target for conditions, cancer, inflammatory disorders, neurodegenerative diseases. This review delves into functions regulating proteo-homeostasis, stress, ROS, apoptosis, implications diseases cancer neurodegeneration.
Language: Английский
Citations
19
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: March 12, 2025
Abstract Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention protein misfolding and abnormal aggregation, modulation homeostasis, protection cells from damage under constantly changing environmental conditions. As understanding biological mechanisms molecular chaperones has increased, their link with occurrence progression disease suggested that these proteins are promising targets for therapeutic intervention, drawing intensive interest. Here, we review recent advances determining structures heat shock 90 (HSP90) chaperone system complexes. We also describe features shed light on complicated mechanism operates through interactions various co-chaperones cycles. In addition, how affect diseases by regulating pathogenic been thoroughly analyzed. Furthermore, focus to systematically discuss clinical drug design strategies preclinical stage. Recent studies have identified variety novel targeting systems compounds act different those traditional inhibitors. Therefore, as more developed, will significantly contribute discovery new potential drugs.
Language: Английский
Citations
1
The Microbe, Journal Year: 2024, Volume and Issue: 4, P. 100151 - 100151
Published: Aug. 24, 2024
Language: Английский
Citations
7
Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(10), P. 2957 - 2971
Published: Aug. 21, 2024
Language: Английский
Citations
5
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 965, P. 178614 - 178614
Published: Jan. 29, 2025
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 204 - 204
Published: Jan. 30, 2025
The epichaperome, a dynamic and integrated network of chaperone proteins, extends its roles beyond basic protein folding to stabilization intracellular signal transduction orchestrating multitude cellular processes critical for tumor survival. In this review, we explore the multifaceted delving into diverse locations, factors that modulate formation function, liquid–liquid phase separation, key signaling crosstalk pathways it regulates, including metabolism transduction. We further highlight techniques isolating identifying epichaperome networks, pitfalls, opportunities. Further, review profound implications cancer treatment therapy design, underscoring need strategic engineering hinges on comprehensive insight structure workings across heterogeneous cell subpopulations in milieu. By presenting holistic view epichaperome’s functions mechanisms, aim underscore potential as target novel anti-cancer strategies, revealing is not merely piece machinery but mastermind facilitates malignant phenotype.
Language: Английский
Citations
0
European Journal of Cardio-Thoracic Surgery, Journal Year: 2025, Volume and Issue: 67(2)
Published: Jan. 31, 2025
Abstract OBJECTIVES Transient heat stress (HS) application during experimental ex vivo lung perfusion (EVLP) of warm ischaemic (WI) rat lungs produces a range therapeutic benefits. Here, we explored whether different EVLP durations after HS would influence its effects. METHODS In protocol 1, WI were exposed to (41.5°C, 60–90 min EVLP), and was maintained for 3, 4.5 or 6 h (n = 5/group), followed by physiological measurements (compliance, oedema, oxygenation capacity). 2, treated with (HS groups) without (control 3 evaluation (lung tissue) shock proteins (HSP70, HSP27, HS90, GRP78), endogenous (surfactant protein-D, CC16, platelet endothelial cell adhesion molecule-1), anti-apoptotic (Bcl2, Bcl-xL) pro-apoptotic (Bcl2-associated X protein, CCAAT/enhancer binding-protein homologous protein), antioxidant enzymes (heme-oxygenase-1, nicotinamide di-phospho-nucleotide dehydrogenase quinone-1) nitrotyrosine (oxidative biomarker). RESULTS variables stable but deteriorated h. at EVLP, HS-treated differed from controls higher expression HSP70 heme-oxygenase-1, lower CC16 expression. contrast, displayed improved physiology, levels all HSPs, preserved increased surfactant CC-16 molecule-1, proteins, reduced nitrotyrosine. CONCLUSIONS The protective effects WI-damaged strictly depend on the duration post-HS recovery. An appears optimize potential HS, while maintaining in state.
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: Feb. 4, 2025
Neurodegenerative diseases (NDs) and Long COVID represent critical growing global health challenges, characterized by complex pathophysiological mechanisms including neuronal deterioration, protein misfolding, persistent neuroinflammation. The emergence of innovative therapeutic approaches, such as whole-body hyperthermia (WBH), offers promising potential to modulate underlying in NDs related conditions like COVID. WBH, particularly fever-range, enhances mitochondrial function, induces heat shock proteins (HSPs), modulates neuroinflammation—benefits that pharmacological treatments often struggle replicate. HSPs HSP70 HSP90 play pivotal roles folding, aggregation prevention, cellular protection, directly targeting pathological processes seen Alzheimer's, Parkinson's, Huntington's disease. Preliminary findings also suggest WBH's alleviate neurological symptoms COVID, where neuroinflammation serotonin dysregulation are prominent. Despite the absence robust clinical trials, implications WBH extend immune modulation restoration disrupted physiological pathways. However, dual nature hyperthermia's effects—balancing pro-inflammatory anti-inflammatory responses—emphasizes need for dose-controlled applications stringent patient monitoring minimize risks vulnerable populations. While shows interest, significant challenges remain. These include individual variability response, limited accessibility advanced technologies, standardized protocols. Future research must focus on targeted biomarker identification, personalized treatment strategies optimize efficacy integration into paradigms could mark a transformative step addressing these conditions.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 263 - 263
Published: Feb. 11, 2025
Autophagy plays a crucial role in the physiopathological mechanisms of diseases by regulating cellular functions and maintaining homeostasis, which has garnered extensive attention from researchers worldwide. The holistic regulation bidirectional effects acupuncture can modulate autophagy, promoting or restoring homeostasis body's internal environment to achieve therapeutic outcomes. This paper systematically reviews research progress on use for treating various via autophagy pathway, summarizes signal pathways related analyzes deficiencies present existing research. review results indicate that mechanism action dysfunction is reflected changes LC3, Beclin1, p53, autophagy-associated (ATG) protein expression, regulates signaling key proteins genes. regulatory effect capacity bidirectional: it inhibits abnormal activation prevent exacerbation injury reduce apoptosis, while also activating enhancing promote elimination inflammation oxidative stress. Further analysis suggests are insufficiently explored. Future should prioritize development more appropriate animal models, analyzing accuracy relevant specificity indicators, exploring synergistic among targets pathways, clarifying at stages evaluating efficacy modulating. offers valuable insights into acupuncture.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 28, 2025
The emergence of immunotherapies has revolutionized cancer treatment by leveraging the immune system to target malignancies, offering new hope where traditional therapies often fall short. Within this context, hyperthermia (HT) re-emerged as a promising adjunctive treatment, capable enhancing effectiveness radiotherapy, chemotherapy, and immunotherapy. HT influences both innate adaptive systems, activity cells such neutrophils, NK cells, dendritic while also modulating tumor microenvironment (TME) promote immunogenic cell death (ICD) reduce immunosuppressive conditions. These effects contribute transformation immunologically “cold” tumors into “hot” tumors, making them more susceptible immune-mediated destruction. Furthermore, can amplify efficacy checkpoint inhibitors (ICIs) improving infiltration, inducing damage-associated molecular pattern (DAMP) release, antigen presentation. Preclinical clinical studies support combination with ICIs, demonstrating improved outcomes in otherwise resistant tumors. However, full therapeutic potential different technologies allowing apply remains be fully understood, further research is needed optimize protocols, explore differential impacts local versus whole-body hyperthermia, identify biomarkers for patient stratification. This review underscores multifaceted role immunity its significantly enhance
Language: Английский
Citations
0