Ganoderma : bridging traditional wisdom with modern innovation in medicinal mushroom and dietary supplement industry DOI
Samantha C. Karunarathna, Kandeeparoopan Prasannath, Wenhua Lu

et al.

New Zealand Journal of Botany, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 60

Published: Oct. 23, 2024

More than fifty medicinal mushrooms exhibit diverse therapeutic properties, with Ganoderma species holding particular historical significance in human diets and traditional medicine, especially Asia, where they are esteemed for their purported contributions to vitality longevity. Extensive research involving both vitro vivo investigations has been undertaken elucidate the metabolic activities associated Ganoderma. Nonetheless, a contentious issue persists regarding classification of as either health-promoting food supplement or drug medical purposes. Various based products, including coffee, powder, tea, beverages, syrups, lotions, have commercially promoted efficacious supplements offering health benefits. The industry grown substantially over past three decades, resulting many products saturating market. Despite substantial scale industry, it grapples inherent challenges establishing robust market presence. This review provides comprehensive overview current status while recommendations fostering advanced research.

Language: Английский

Two-Dimensional Chromatographic Isolation of High Purity Erinacine A from Hericium erinaceus DOI Creative Commons
Katerina Naumoska, Andrej Gregori, Alen Albreht

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(2), P. 150 - 150

Published: Feb. 15, 2025

A simple and robust two-dimensional chromatographic fractionation protocol for the isolation of neuroprotective compound erinacine from Hericium erinaceus is proposed. This production platform yielded 19.4 mg approximately 130 g mushroom material, with a purity 97.4%. The procedure includes extraction, concentration, fractionation, purification, characterisation bioactive compound. crude H. extract was fractionated in first dimension by normal-phase flash chromatography, fraction containing further purified second semi-preparative reversed-phase chromatography. strategy utilises orthogonality two modes to effectively eliminate difficult impurities, including structural isomers analogues A. Complementary analytical approaches such as high-performance thin-layer chromatography (HPTLC) liquid ultraviolet tandem mass spectrometric detection (HPLC-UV-MS/MS) were employed unambiguously confirm isolated fractions, while HPLC charged aerosol detector (CAD) used determine its purity. Given limited commercial availability high price A, described method offers straightforward cost-effective alternative obtain this valuable research applications.

Language: Английский

Citations

1
Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products DOI Creative Commons

A. K. Singh,

Ramesh Kumar Saini,

Amit Kumar

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 741 - 741

Published: Feb. 22, 2025

Mushrooms are known to be a nutritional powerhouse, offering diverse bioactive compounds that promote and enhance health. provide distinguishable taste aroma an essential source of vitamin D2, B complex, hydroxybenzoic acids (HBAs) hydroxycinnamic (HCAs), terpenes, sterols, β-glucans. Edible mushroom varieties such as Hericium erinaceus, Ganoderma sp., Lentinula edodes recognized functional foods due their remarkable potential for disease prevention promotion overall health well-being. These have antioxidants, anti-inflammatory, cytoprotective, cholesterol-lowering, antidiabetic, antimicrobial, anticancer properties, well controlling blood pressure, being immunity booster, strengthening bone properties. In addition, they contain non-digestible oligosaccharides (NDOs) ergothioneine, substrate gut microflora. Supplementing our daily meals with those can add value food, providing benefits. Novel edible mushrooms investigated explore substances therapeutic benefit human The scientific community (mycologists) is currently studying the prospects unlocking full advantages mushrooms. This review aims knowledge culturing conditions, potential, value-added products 11 varieties.

Language: Английский

Citations

1
Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review DOI Open Access
Alex Graça Contato, Carlos Adam Conté-Júnior

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1307 - 1307

Published: April 9, 2025

Hericium erinaceus, commonly known as lion’s mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a comprehensive overview the nutritional therapeutic potential H. with particular focus on anti-inflammatory, antioxidant, antimicrobial activities. A structured literature search was performed using databases such PubMed, Scopus, Science Direct, Web Science, Google Scholar. Studies published in last two decades focusing erinaceus’ were included. The chemical erinaceus includes polysaccharides, terpenoids (hericenones erinacines), phenolic compounds, which exhibit potent antioxidant effects by scavenging reactive oxygen species (ROS) inducing endogenous enzymes. Additionally, shows promising activity against bacterial fungal pathogens, applications combating antibiotic-resistant infections. mushroom’s capacity stimulate nerve growth factor (NGF) synthesis highlighted preventing managing neurodegenerative diseases, Alzheimer’s Parkinson’s. Advances biotechnological methods, including optimized cultivation techniques novel extraction may further enhance bioavailability pharmacological erinaceus. Despite findings, clinical validation remains limited. Future research should prioritize large-scale trials, standardization elucidation pharmacokinetics facilitate integration into evidence-based medicine. functional food, nutraceutical, adjunct agent highlights need for interdisciplinary collaboration between researchers, clinicians, regulatory bodies.

Language: Английский

Citations

1
Metabolic Profiling and Substrate Utilization of Hericium erinaceus (Lion’s Mane) Mycelia Isolate Using Biolog Phenotype Microarray DOI Creative Commons

Soumaya Boudagga,

Chadlia Hamdi, Henda Mahmoudi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Hericium erinaceus, has long been recognized in traditional Chinese medicine for its extensive health benefits. H. erinaceus is notable production of various bioactive compounds. Among these, the terpenoid compounds hericenones and erinacines, derived from fruiting bodies cultured mycelia respectively, have particularly highlighted their ability to stimulate nerve growth factor (NGF) synthesis, contributing mushroom's neuroprotective properties. This study focuses on metabolic characterization mycelium using Biolog Phenotype MicroArray (PM) technology, a high-throughput method analyzing microbial phenotypes. For first time, PMs were applied elucidate comprehensive nutritional utilization profile erinaceus. The involved testing 950 different conditions, including 190 carbon sources, 380 nitrogen 94 biosynthetic pathways, 59 phosphorus 35 sulfur 96 osmotic pressures, pH conditions. results revealed that relatively restricted profile, efficiently utilizing only 23 out mainly simple sugars certain complex carbohydrates like D-Cellobiose, D-Xylose, Arbutin. also demonstrated effective Urea D-glucosamine, was capable growing all sources most with few exceptions. Additionally, exhibited under 65 56 conditions tested. detailed not enhances our understanding erinaceus' requirements capabilities but provides valuable insights into potential applications development functional foods alternative medicines.

Language: Английский

Citations

0
Hericium erinaceus ethanol extract exhibits potent DNA-protective and antioxidant action: Evidence from in vitro and Drosophila melanogaster studies DOI
Vladimir J. Cvetković, Ivan Milovanović, Sanja Matić

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 212, P. 116374 - 116374

Published: April 21, 2025

Language: Английский

Citations

0
Ganoderma : bridging traditional wisdom with modern innovation in medicinal mushroom and dietary supplement industry DOI
Samantha C. Karunarathna, Kandeeparoopan Prasannath, Wenhua Lu

et al.

New Zealand Journal of Botany, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 60

Published: Oct. 23, 2024

More than fifty medicinal mushrooms exhibit diverse therapeutic properties, with Ganoderma species holding particular historical significance in human diets and traditional medicine, especially Asia, where they are esteemed for their purported contributions to vitality longevity. Extensive research involving both vitro vivo investigations has been undertaken elucidate the metabolic activities associated Ganoderma. Nonetheless, a contentious issue persists regarding classification of as either health-promoting food supplement or drug medical purposes. Various based products, including coffee, powder, tea, beverages, syrups, lotions, have commercially promoted efficacious supplements offering health benefits. The industry grown substantially over past three decades, resulting many products saturating market. Despite substantial scale industry, it grapples inherent challenges establishing robust market presence. This review provides comprehensive overview current status while recommendations fostering advanced research.

Language: Английский

Citations

1