Mercury Exposure and Health Effects: What Do We Really Know?

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2326 - 2326

Published: March 5, 2025

Mercury is widely used in medicine, agriculture, and industry. Meanwhile, according to the World Health Organization, it has been ranked as one of ten most hazardous substances world, with Agency for Toxic Substances Disease Registry ranking third. It no known positive functionality human body, even at low concentrations, can have harmful long-term health effects, seriously affecting healthcare system well posing a serious public threat. This review focuses on effects mercury its major sources environment. We highlight toxic role almost every possible aspect. forms, smallest doses, cause numerous disorders including nervous system, respiratory cardiovascular system. such various cancers; endothelial dysfunction; gastric vascular disorders; liver, kidney, brain damage; hormonal imbalances, miscarriages, reproductive skin lesions; vision death. The fact widespread use toxicity body prompts further in-depth research populations both moderate exposure. constant controlling monitoring problem, requiring urgent attention attentiveness from governments all countries and, long run, rapid concerted response. Thus, important analyze depth impact this highly metal prepare precisely targeted interventions among decision- policy-makers.

Language: Английский

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Toxicity and bioconcentration of bisphenol A alternatives in the freshwater pulmonate snail Planorbella pilsbryi

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

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A Proposal for Research Involving New Biomarkers of Hypertension, Lifestyle, and Environmental Exposure

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 206 - 206

Published: March 18, 2025

The constant monitoring of the population’s diet and assessment occupational exposure environmental impacts are key to determining health risks understanding factors contributing potential abnormalities in developing lifestyle diseases. Extensive long-term studies can provide data on population risks, including most common cardiovascular diseases like hypertension. This paper presents research recommendations for future researchers doctors improve diagnosis hypertension targeted, personalised treatment. proposal includes a study, diagnostic panel with new biomarkers, an men working metallurgical industry. New developments improved interventions constantly being sought, biomarkers high utility should enable early diagnosis, consequently allow appropriate and, importantly, therapy, prevent increase CVD deaths. Only effective treatment, reduce risk associated I propose that several parameters (NO, cfDNA, MPO, PCSK9, MyBPC3, microRNA, TAS, Pb, Cd) prognostic and/or predictive be included screening confirm need extensive testing middle-aged by healthcare professionals due

Language: Английский

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Potential-resolved real-time ultrasensitive sensing of bisphenol compounds based on ionic liquid coupled Zr-MOF@GO nanosensor

Microchemical Journal, Journal Year: 2024, Volume and Issue: 207, P. 111888 - 111888

Published: Oct. 11, 2024

Language: Английский

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Bisphenol a Disrupts Steroidogenesis and Induces Apoptosis in Human Granulosa Cells Cultured In Vitro

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4081 - 4081

Published: April 25, 2025

Bisphenol A (BPA) is a common synthetic chemical compound classified as an endocrine disruptor. It affects multiple physiological systems in the body, including female reproductive system, particularly granulosa cells (GCs) ovaries, where steroidogenesis occurs. This study investigated impact of various BPA concentrations (environmentally relevant 0.001 µM and 0.1 toxicological concentration 100 µM) exposure times (24 72 h) on cell viability counts vitro production estradiol progesterone human GCs collected from waste follicular fluid IVF patients. Gene expression analysis 182 genes associated with apoptosis was performed using PCR arrays, followed by protein Western blot. Our results demonstrate that after longer (72 h), higher (100 negatively cellular significantly alters steroid hormone biosynthesis vitro, leading to reduced culture medium. We found all altered different steroidogenesis- apoptosis-related GCs. At μM, decreased TRIM25, UGT2B15, CASP3, RPS6KA3 increased NR6A1 PPID genes. AR, HSD3B1, BID, IKBKG, while reducing TRIM25 CASP3 highest upregulated GPER30, downregulated FOXO1 UGT2B15 These highlight BPA’s concentration-specific effects show its potential compromise GC function, possible negative implications for fertility ovarian health, even at environmentally concentrations.

Language: Английский

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Biological and Behavioural Effects of Bisphenol A (BPA) Exposure: An In Vivo Study in Drosophila melanogaster

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(10), P. 5588 - 5588

Published: May 16, 2025

Bisphenol A (BPA) is one of the most produced compounds worldwide. It acts as an endocrine disruptor and can cause adverse effects in body, even at low-dose exposures. By interacting with estrogen receptors, it play important role pathogenesis several diseases, such infertility, hormone-dependent tumours various metabolic disorders. Exposure humans, especially early life, particular concern, since have a big impact on individual’s development growth. The objective this study was to evaluate, vivo, genotoxicity BPA its longevity, prolificacy behaviour Drosophila melanogaster. To evaluate biological behavioural effects, flies were crossed subjected different concentrations (0.5 mM, 1 2 5 mM 10 mM) instant “Carolina” medium hydrated solution for 3 days, then transferred non-treated medium, where they continued lay eggs. This procedure repeated obtain F2 generation. genotoxicity, somatic mutation recombination test (SMART) Comet assays performed. In these cases, higher chosen (1 20 50 mM). results showed that compound caused changes longevity prolificacy, also affected subsequent generations. They Drosophila’s social interaction, but exposure levels investigated here, did not significant genotoxic effects.

Language: Английский

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Establishment of a cell culture from Daphnia magna as an in vitro model for (eco)toxicology assays: Case study using Bisphenol A as a representative cytotoxic and endocrine disrupting chemical

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 278, P. 107173 - 107173

Published: Nov. 23, 2024

Language: Английский

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