Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(1), P. 57 - 57
Published: Jan. 9, 2025
Antimicrobial
resistance
is
a
critical
global
challenge
in
the
21st
century,
validating
Sir
Alexander
Fleming's
warning
about
misuse
of
antibiotics
leading
to
resistant
microbes.
With
dwindling
arsenal
effective
antibiotics,
it
imperative
concentrate
on
alternative
antimicrobial
strategies.
Previous
studies
have
not
comprehensively
discussed
advantages
and
limitations
various
strategies,
including
bacteriophage
therapy,
probiotics,
immunotherapies,
photodynamic
essential
oils,
nanoparticles
peptides
(AMPs)
within
single
review.
This
review
addresses
that
gap
by
providing
an
overview
these
non-antibiotic
highlighting
their
pros
cons,
with
particular
emphasis
(AMPs).
We
explore
mechanism
action
AMPs
against
bacteria,
viruses,
fungi
parasites.
While
hold
significant
promise,
application
mainstream
drug
development
hindered
challenges
such
as
low
bioavailability
potential
toxicity.
However,
advancements
peptide
engineering
chemical
modifications
offer
solutions
enhance
clinical
utility.
Additionally,
this
presents
updates
strategies
aimed
at
improving
cost,
stability
selective
toxicity
through
peptidomimetics.
These
molecules
demonstrated
activity
broad
range
pathogens,
making
them
valuable
candidates
for
integration
into
surface
coatings
prevent
device-associated
infections.
Furthermore,
we
discuss
approaches
attaching
functionalising
surfaces.
Finally,
recommend
comprehensive
vivo
evaluate
efficacy
mimetics,
investigate
synergistic
combinations
other
assess
medical
devices.
Language: Английский
Antiviral activity of peptide and peptide mimic coated surfaces
Applied Surface Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 163242 - 163242
Published: April 1, 2025
Language: Английский
The application and prospects of antimicrobial peptides in antiviral therapy
Amino Acids,
Journal Year:
2024,
Volume and Issue:
56(1)
Published: Dec. 4, 2024
Antimicrobial
peptides
(AMPs)
have
broad-spectrum
antimicrobial
activity,
enabling
them
to
rapidly
detect
and
eliminate
targets.
In
addition,
many
AMPs
are
natural
peptides,
making
promising
candidates
for
therapeutic
drugs.
This
review
discusses
the
basic
properties
mechanisms
of
action
AMPs,
highlighting
their
ability
disrupt
microbial
membranes
modulate
host
immune
responses.
It
also
reviews
current
state
research
into
using
against
various
viral
infections,
focusing
on
potential
viruses
that
contribute
global
health
crisis.
Despite
developments,
therapies
based
still
face
challenges
such
as
stability,
toxicity,
production
costs.
this
text,
we
will
discuss
these
latest
technological
advances
aimed
at
overcoming
them.
The
combination
nanotechnology
bioengineering
approaches
offers
new
ways
enhance
delivery,
efficacy,
safety
AMPs.
We
emphasize
importance
further
fully
exploit
in
antiviral
therapy,
advocating
a
multifaceted
approach
includes
optimizing
clinical
use
exploring
synergies
with
existing
Language: Английский
Macromolecular interaction mechanism of the bacteriocin EntDD14 with the receptor binding domain (RBD) for the inhibition of SARS-CoV-2 and the JN.1 variant: Biomedical study based on elastic networks, stochastic Markov models, and macromolecular volumetric analysis
Biophysical Chemistry,
Journal Year:
2024,
Volume and Issue:
318, P. 107388 - 107388
Published: Dec. 29, 2024
Language: Английский