Therapeutic Potential of Artemisia campestris Essential Oil: Antioxidant, Anti‐Inflammatory, and Anticancer Insights From In Silico Analysis
Biomedical Chromatography,
Journal Year:
2025,
Volume and Issue:
39(3)
Published: Feb. 7, 2025
Artemisia
campestris
subsp.
(tuguft)
is
a
medicinal
plant
traditionally
used
in
Algerian
medicine.
This
study
investigates
the
chemical
composition
and
bioactivity
of
its
essential
oil
(ACEO).
Gas
chromatography-mass
spectrometry
(GC-MS)
analysis
identified
key
compounds,
including
linalyl
acetate
(2.92%),
geranyl
(2.45%),
eucalyptol
(1.38%).
ACEO
demonstrated
significant
antioxidant
activity,
with
IC50
values
11.09
μg/mL
(DPPH),
15.81
(FRAP),
22.70
(β-carotene).
It
also
enhanced
peroxidase
activity
by
82.67
U/g.
The
anti-inflammatory
effects
were
confirmed
an
18.87
μg/mL.
Notably,
silico
molecular
docking
revealed
that
3-cyclopentyl-N-(2-(3,4-dimethoxyphenyl)ethyl)
exhibits
strong
binding
affinity
to
phosphoinositide
3-kinase
gamma,
target
for
pancreatic
cancer
therapy,
suggesting
potential
anticancer
activity.
These
findings
underscore
therapeutic
ACEO,
highlighting
antioxidant,
anti-inflammatory,
properties.
Language: Английский
In vitro and in silico pharmacological effects of Rosmarinus officinalis leaf methanolic extracts and essential oils
Khalid Abdullah Alaboudi,
No information about this author
Ibrahim M. Aziz,
No information about this author
Abdulaziz Abdullah Almosa
No information about this author
et al.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 28, 2025
Rosmarinus
officinalis
L.
has
been
widely
used
as
a
spice
to
enhance
the
shelf-life
of
food
for
centuries.
While
existing
research
in
literature
suggests
that
primary
antibacterial
component
this
plant
is
its
essential
oil
(EO),
there
lack
comparative
studies
employing
both
vitro
and
silico
approaches
evaluate
antimicrobial,
antioxidant,
anticancer,
antidiabetic
properties
R.
leaf
EO
(ROLEO)
methanolic
extract
(ROLME).
The
present
study
investigates
bioactive
components
biological
activities
ROLEO
ROLME
using
gas
chromatography-mass
spectrometry
analysis.
Additionally,
total
phenolic
content
(TPC)
flavonoid
(TFC)
were
quantified,
their
antidiabetic,
evaluated
studies.
GC-MS
analysis
revealed
20
compounds
ROLME,
compared
73
ROLEO.
TPC
was
higher,
measuring
49.34
±
2.84
mg
GAE
per
gram
dry
weight
extract,
which
had
38.13
3.31
extract.
TFC
measured
at
24
1.47
QE/g
weight,
higher
than
19
weight.
demonstrated
superior
antioxidant
activity
low
concentrations
greater
by
suppressing
actions
α-amylase
α-glucosidase
enzymes.
Moreover,
showed
promising
anticancer
effects
lower
doses,
capabilities,
particularly
against
Gram-positive
bacteria.
Molecular
docking
have
identified
key
exhibit
significant
bioactivity.
Among
these
compounds,
1H-Cycloprop[e]azulen-4-ol,
decahydro-1,1,4,7-tetramethyl-,
[1ar-(1α,4β,4aβ,7α,7aβ,7bα)]-demonstrated
highest
α-amylase,
while
thymol
exhibited
strongest
caspase-3
E.
coli
gyrase
B.
Overall,
molecular
pharmacokinetic
inhibitory
on
caspase-3,
B,
with
favorable
drug-like
properties.
These
findings
suggest
may
serve
basis
development
innovative
synthetic
medications,
offering
valuable
insights
pharmaceutical
industry
design
novel
treatments
various
diseases.
Language: Английский
GC/MS and LC Composition Analysis of Essential Oil and Extracts From Wild Rosemary: Evaluation of Their Antioxidant, Antimicrobial, and Anti‐Inflammatory Activities
Nasma Mahboub,
No information about this author
Inasse Cherfi,
No information about this author
Salah Eddine Laouini
No information about this author
et al.
Biomedical Chromatography,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: April 10, 2025
ABSTRACT
Rosmarinus
officinalis
L.
(rosemary)
is
a
widely
used
medicinal
plant
known
for
its
antioxidant,
antimicrobial,
and
anti‐inflammatory
properties.
This
study
evaluates
the
bioactive
potential
of
essential
oil
(EO),
methanolic
(ME),
aqueous
(AE)
extracts.
GC‐MS
analysis
identified
α‐pinene
(21.37%),
bornanone
(12.73%),
eucalyptol
(8.28%)
as
major
EO
components,
while
HPLC
revealed
ME's
richness
in
salicylic
acid
(5.11
μg/mg)
rutin
(0.43
μg/mg).
Antioxidant
activity,
assessed
via
DPPH
FRAP
assays,
showed
ME
with
strongest
radical
scavenging
capacity
(IC
50
=
27.30
±
2.4%)
reducing
power
90.88
6.7%).
Antimicrobial
testing
most
effective,
particularly
against
Staphylococcus
aureus
(33
mm
inhibition
zone)
Bacillus
subtilis
(32
mm),
AE
exhibited
moderate
activity.
Pseudomonas
aeruginosa
was
resistant
to
all
Additionally,
demonstrated
notable
activity
55.88
1.02%).
These
findings
highlight
rosemary
rich
source
compounds
strong
pharmacological
potential,
positioning
best
potent
an
effective
agent.
Language: Английский
Vapor-Phase Essential Oils as Antifungal Agents against Penicillium olsonii Causing Postharvest Cherry Tomato Rot
Foods,
Journal Year:
2024,
Volume and Issue:
13(19), P. 3202 - 3202
Published: Oct. 9, 2024
Recent
reports
of
Language: Английский
Hops Across Continents: Exploring How Terroir Transforms the Aromatic Profiles of Five Hop (Humulus lupulus) Varieties Grown in Their Countries of Origin and in Brazil
Published: Sept. 2, 2024
Humulus
lupulus,
or
hops,
is
a
vital
ingredient
in
brewing,
contributing
bitterness,
flavor,
and
aroma.
The
female
plants
produce
strobiles
rich
essential
oils
acids,
along
with
bioactive
compounds
like
polyphenols,
humulene,
myrcene,
which
offer
health
benefits.
This
study
examined
the
aromatic
profiles
of
five
hop
varieties
grown
Brazil
versus
their
countries
origin.
Fifty
grams
pelletized
hops
from
each
strain
were
collected
analyzed
using
HS-SPME/GC-MS
to
identify
volatile
compounds,
followed
by
statistical
analysis
PLS-DA
ANOVA.
identified
330
found
significant
differences
among
different
regions.
For
instance,
H.
Mittelfrüher
has
fruity
herbaceous
profile,
while
German-grown
variety
more
herbal
spicy.
Similar
variations
noted
Magnum,
Nugget,
Saaz,
Sorachi
Ace
varieties.
findings
underscore
impact
terroir
on
profiles,
Brazilian-grown
displaying
distinct
compared
counterparts
origin,
including
notes
α-acid
content.
Language: Английский
Polyphenols Investigation and Antioxidant and Anticholinesterase Activities of Rosmarinus officinalis L. Species from Southwest Romania Flora
Ludovic Everard Bejenaru,
No information about this author
Andrei Biţă,
No information about this author
George Dan Mogoșanu
No information about this author
et al.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(18), P. 4438 - 4438
Published: Sept. 18, 2024
Rosemary
is
one
of
the
most
important
medicinal
plants
for
natural
therapy
due
to
its
multiple
pharmacological
properties,
such
as
antioxidant,
anti-inflammatory,
neuroprotective,
antiproliferative,
antitumor,
hepato-
and
nephroprotective,
hypolipidemic,
hypocholesterolemic,
antihypertensive,
anti-ischemic,
hypoglycemic,
radioprotective,
antimicrobial,
antiviral,
antiallergic,
wound
healing
properties.
Our
study
reports
first
time,
over
a
12-month
period,
identification
quantification
polyphenols
investigation
antioxidant
acetylcholinesterase
(AChE)
inhibitory
activities
Rosmarinus
officinalis
L.
species
harvested
at
flowering
from
flora
southwestern
Romania
(Oltenia
Region).
Identification
polyphenolic
acids
was
made
by
ultra-high-performance
liquid
chromatography/mass
spectrometry
(UHPLC/MS).
Total
phenolic
content
determined
using
spectrophotometric
method.
In
situ
anticholinesterase
were
evaluated
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
AChE
assay,
respectively,
on
high-performance
thin-layer
chromatography
(HPTLC)
plates.
DPPH
radical
scavenging
activity
also
assessed
spectrophotometrically.
The
results
revealed
significant
correlations
between
specific
compounds
measured
biological
activities,
understanding
role
seasonal
variations
providing
insights
into
optimal
harvesting
times
benefits
rosemary.
research
brings
new
information
phytochemical
profile
R.
source
with
Language: Английский
Hops across Continents: Exploring How Terroir Transforms the Aromatic Profiles of Five Hop (Humulus lupulus) Varieties Grown in Their Countries of Origin and in Brazil
Plants,
Journal Year:
2024,
Volume and Issue:
13(19), P. 2675 - 2675
Published: Sept. 24, 2024
,
or
hops,
is
a
vital
ingredient
in
brewing,
contributing
bitterness,
flavor,
and
aroma.
The
female
plants
produce
strobiles
rich
essential
oils
acids,
along
with
bioactive
compounds
like
polyphenols,
humulene,
myrcene,
which
offer
health
benefits.
This
study
examined
the
aromatic
profiles
of
five
hop
varieties
grown
Brazil
versus
their
countries
origin.
Fifty
grams
pelletized
hops
from
each
strain
were
collected
analyzed
using
HS-SPME/GC-MS
to
identify
volatile
compounds,
followed
by
statistical
analysis
PLS-DA
ANOVA.
identified
330
found
significant
differences
among
different
regions.
For
instance,
H.
Mittelfrüher
has
fruity
herbaceous
profile,
while
German-grown
variety
more
herbal
spicy.
Similar
variations
noted
Magnum,
Nugget,
Saaz,
Sorachi
Ace
varieties.
findings
underscore
impact
terroir
on
profiles,
Brazilian-grown
displaying
distinct
compared
counterparts
origin,
including
notes
α-acid
content.
Language: Английский
Unlocking the Hidden Potential of Rosemary (Salvia rosmarinus Schleid): New Insights into Phenolics, Terpenes, and Antioxidants of Mediterranean Cultivars
Plants,
Journal Year:
2024,
Volume and Issue:
13(23), P. 3395 - 3395
Published: Dec. 3, 2024
Rosemary
(
Language: Английский