Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 6, 2025
The
Systemic
Inflammation
Response
Index
(SIRI),
a
marker
used
to
assess
systemic
inflammation,
is
associated
with
lower
patient
survival
rates
in
various
cancer
types.
Factors
contributing
the
recurrence
of
colorectal
(CRC)
have
been
examined
previously
using
preoperative
SIRI.
Herein,
we
investigated
association
between
SIRI
level
and
both
recurrence-free
(RFS)
overall
(OS)
patients
diagnosed
CRC.
We
retrospectively
analyzed
case
406
who
underwent
curative
surgery
for
Stage
I-III
CRC
at
single
institution
during
2012-
2017.
Based
on
their
levels,
categorized
into
low-SIRI
group
(≤
1700)
high-SIRI
(>
1700).
Multivariable
analyses
revealed
that
was
an
independent
risk
factor
5-year
RFS
(p
=
0.045)
OS
0.048)
patients.
A
Kaplan–Meier
analysis
demonstrated
significantly
poorer
outcomes
compared
0.0001,
p
0.017
respectively).
These
findings
suggest
prognosis
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 13, 2024
Background
It
has
been
demonstrated
that
in
diabetic
patients,
an
elevated
neutrophil-lymphocyte
ratio
(NLR)
is
independently
connected
with
higher
cardiovascular
and
all-cause
mortality.
unclear,
however,
if
the
systemic
immune-inflammatory
index
(SII)
mortality
rate
among
patients
are
related.
Investigating
linkage
between
SII
diabetes
patients’
risk
of
death
was
aim
study.
Methods
4972
diabetics
who
were
chosen
from
six
rounds
National
Health
Nutrition
Examination
Survey
(NHANES)
2005
2016
study’s
participants.
The
optimal
threshold
highest
correlation
survival
outcomes
identified
by
applying
Maximum
Selection
Ranking
Statistical
Method
(MSRSM).
To
assess
relationship
diabetics,
subgroup
analysis
Cox
regression
modeling
employed.
Furthermore,
smoothed
curve
fitting
utilized
to
determine
nonlinear
them.
Results
Over
course
a
median
follow-up
69
months
(interquartile
range
[IQR],
54-123
months),
1,172
(23.6%)
4,972
passed
away.
These
deaths
included
332
(6.7%)
840
(16.9%)
non-cardiovascular
deaths.
Individuals
categorized
into
(>983.5714)
lower
(≤983.5714)
groups
according
MSRSM.
In
multi-variable
adjusted
models,
subjects
had
significantly
increased
chance
dying
disease
(HR
2.05;
95%
confidence
interval
(CI):1.42,2.97)
all
causes
1.60;
CI:1.22,1.99).
Kplan-Meier
curves
showed
similar
results.
Subgroup
studies
based
on
age,
sex,
BMI,
drinking,
smoking,
hypertension
revealed
connection
maintained
intact.
previously
stated
variables
did
not
interact
(p
interaction
>
0.05).
smooth
Conclusion
linked
Journal of Orthopaedic Surgery and Research,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: May 28, 2024
Sarcopenia
is
associated
with
increased
morbidity
and
mortality.
The
systemic
immune-inflammation
index
(SII)
has
been
correlated
to
a
variety
of
disorders.
present
study
conducted
systematic
review
meta-analysis
investigate
the
relationship
between
SII
sarcopenia.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: June 5, 2024
There
is
limited
research
on
the
relationship
between
Systemic
Oxidative
Stress
(SOS)
status
and
inflammatory
indices.
Adding
onto
existing
literature,
this
study
aimed
to
examine
association
dietary
Balance
Score
(OBS)
lifestyle
OBS
(which
make
up
overall
OBS),
Cardiovascular
Disease
(CVD)
prevalence
at
different
Immune
Inflammation
Index
(SII)
Inflammatory
Response
(SIRI)
levels.
This
involved
9,451
subjects
selected
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2007-2018.
The
comprised
20
factors.
Statistical
methods
included
Weighted
Linear
Regression
Analysis
(WLRA),
Logistic
(LRA),
Sensitivity
(SA),
Restricted
Cubic
Spline
(RCS)
analysis.
multivariate
WLRA
revealed
that
was
significantly
negatively
correlated
with
both
SII
(β
=
-5.36,
p
<
0.001)
SIRI
-0.013,
In
SA,
removing
any
single
component
had
no
significant
effect
results
of
SIRI.
Further
subgroup
analyses
more
impactful
in
lowering
women
than
men.
Additionally,
low-age
group
high-age
group.
Moreover,
RCS
analysis
confirmed
linear
relationship.
Compared
OBS,
exerted
a
Coronary
Artery
(CAD)
(OR:
0.794,
0.002),
hypertension
0.738,
0.001),
Congestive
Heart
Failure
(CHF)
0.736,
0.005),
Myocardial
Infarction
(MI)
0.785,
stroke
0.807,
0.029)
prevalence.
Furthermore,
exhibited
interaction
CHF
(P
for
0.001).
On
other
hand,
MI
0.05).
including
were
associated
Higher
reduced
risks
CAD,
hypertension,
CHF,
MI,
stroke.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 6, 2025
The
Systemic
Inflammation
Response
Index
(SIRI),
a
marker
used
to
assess
systemic
inflammation,
is
associated
with
lower
patient
survival
rates
in
various
cancer
types.
Factors
contributing
the
recurrence
of
colorectal
(CRC)
have
been
examined
previously
using
preoperative
SIRI.
Herein,
we
investigated
association
between
SIRI
level
and
both
recurrence-free
(RFS)
overall
(OS)
patients
diagnosed
CRC.
We
retrospectively
analyzed
case
406
who
underwent
curative
surgery
for
Stage
I-III
CRC
at
single
institution
during
2012-
2017.
Based
on
their
levels,
categorized
into
low-SIRI
group
(≤
1700)
high-SIRI
(>
1700).
Multivariable
analyses
revealed
that
was
an
independent
risk
factor
5-year
RFS
(p
=
0.045)
OS
0.048)
patients.
A
Kaplan–Meier
analysis
demonstrated
significantly
poorer
outcomes
compared
0.0001,
p
0.017
respectively).
These
findings
suggest
prognosis
