Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

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The Beneficial Effects of Lactobacillus Strains on Gut Microbiome in Alzheimer’s Disease: A Systematic Review

Healthcare, Journal Year: 2025, Volume and Issue: 13(1), P. 74 - 74

Published: Jan. 3, 2025

Background/Objectives: Growing evidence suggests that the gut–brain axis influences brain function, particularly role of intestinal microbiota in modulating cognitive processes. Probiotics may alter function and behavior by gut microbiota, with implications for neurodegenerative diseases like Alzheimer’s disease (AD). The purpose this review is to systematically current literature exploring effects probiotic supplementation on AD mild impairment (MCI). Methods: A comprehensive search was conducted across PubMed/Medline, Embase, Scopus identify relevant randomized controlled trials (RCTs) from inception 20 August 2024. focused comparing outcomes between intervention control/placebo groups. Data searches, article selection, data extraction, risk bias assessment were performed accordance Cochrane guidelines. Systematic Review Registration: PROSPERO registration no: CRD42023446796. Results: four RCTs involving 293 Individuals (AD MCI patients) receiving mainly Lactobacillus Bifidobacterium strains showed some beneficial altered composition, positively affected metabolic biomarkers. However, variability studies limits interpretation results. limited number quality existing make it difficult draw definitive conclusions data. Additional high-quality research clearly needed. Conclusions: show promise as an adjunctive decline, but larger, long-term are needed confirm their efficacy clinical applicability AD.

Language: Английский

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Fermentation's pivotal role in shaping the future of plant-based foods: An integrative review of fermentation processes and their impact on sensory and health benefits

Applied Food Research, Journal Year: 2024, Volume and Issue: 4(2), P. 100468 - 100468

Published: Aug. 9, 2024

Given the environmental, ethical, and food security challenges posed by conventional agriculture animal husbandry, transition towards sustainable systems is essential. Plant-based foods, especially those enhanced fermentation, present a viable solution. Fermentation reduces ecological footprint, aligns with ethical standards, enhances plant-based proteins' nutritional value sensory attributes, offering credible alternative to products. This paper explores fermentation's transformative role in developing meats, dairy, protein alternatives, emphasizing its benefits, including improved gut health through probiotics prebiotics. It also addresses such as producing undesirable by-products, potential risks, increased costs associated fermentation. Detailed examinations of specific fermentation processes—alcoholic, lactic acid, acetic propionic butyric acid—and their impact on enhancing value, digestibility, flavor foods are presented. Case studies from pioneering companies demonstrate technologies' practical applications market potential. Lastly, discusses future opportunities scaling up processes incorporating advanced biotechnological techniques further enhance sustainability outcomes.

Language: Английский

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Evaluating the health risk of probiotic supplements from the perspective of antimicrobial resistance

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

ABSTRACT Antimicrobial resistance remains a public health threat. Probiotics harboring antimicrobial resistant genes (ARGs) have, in recent years, been considered potential risk. Studies conducted on probiotics from increasingly popular supplements have raised the possibility of transmitting ARGs to commensals human gut, concomitantly establishing reservoir and risking acquisition by opportunistic pathogens. Building our previous study that reported multiple antibiotic supplements, this research, we attempted detect their may account for phenotypes. responsible tetracycline, macrolide, aminoglycoside, glycopeptide were prevalent probiotics. Through laboratory adaptive evolution studies, also show streptomycin-adapted gained erythromycin, doxycycline more effectively than non-adapted ones. When co-incubated with Enterococcus faecalis , Escherichia coli or Staphylococcus aureus Caco-2 and/or HCT-116 cells, streptomycin was transferred adapted generate transconjugants at frequencies comparable higher other studies through filter mating. Consistently, conferring ( aadA ) erythromycin [ erm(B)−1 ] detected E. S. transconjugants, respectively, after co-incubation cells. both transconjugant same Our data future comparative genomics metagenomics animal models healthy, immunocompromised, antibiotic-treated cohorts will contribute comprehensive understanding probiotic consumption, application, safety. IMPORTANCE are becoming popular, promising applications food medicine, but risk transferring disease-causing bacteria has concerns. drugs. Streptomycin-adapted antibiotics Importantly, showed could be intestinal resistance, which initially absent recipient bacteria, transconjugants. build foundation humans leveraging advanced approaches clarify long-term consumption.

Language: Английский

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Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 197 - 197

Published: Jan. 17, 2025

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration plasma cells into endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women's health, contributing to conditions such as uterine bleeding endometriosis. Treatment typically involves antibiotic therapy; however, efficacy these treatments increasingly compromised rise antimicrobial resistance (AMR). This paper examines critical links between AMR CE, proposing strategies enhance clinical management optimize treatment outcomes.

Language: Английский

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Isolation and Immunomodulatory Activity of Cyanidin-3-O-(3,6-O-dimalonyl-β-D-glucoside) from the Black Corncob (Zea mays L.) and its Effect on Gut Microbiota in Elderly Feces under Anaerobic Conditions in vitro

Plant Foods for Human Nutrition, Journal Year: 2025, Volume and Issue: 80(1)

Published: Feb. 10, 2025

Language: Английский

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Systematic Reviews to Inform Practice, March/April 2025

Journal of Midwifery & Women s Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Probiotics and nanoparticle-mediated nutrient delivery in the management of transfusion-supported diseases

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 11, 2025

Bone marrow is vital for hematopoiesis, producing blood cells essential oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy stem cell transplants, have significantly improved patient outcomes but are often associated with severe side effects limitations, necessitating the exploration of safer, more targeted therapeutic strategies. Nanotechnology has emerged as a promising approach addressing these challenges, particularly in delivery nutraceuticals—bioactive compounds derived from food sources potential benefits. Despite their promise, nutraceuticals face clinical limitations due poor bioavailability, instability, inefficient target sites. Nanoparticles offer viable solution by enhancing stability, absorption, transport bone while minimizing systemic effects. This study explores range disorders, conventional treatment modalities, nanoparticles enhance nutraceutical-based therapies. By improving efficacy, could revolutionize disease management, providing patients effective less invasive options. These advancements represent significant step toward safer efficient approaches, ultimately prognosis overall health.

Language: Английский

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Progress in Probiotic Science: Prospects of Functional Probiotic‐Based Foods and Beverages

International Journal of Food Science, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

This comprehensive review explores the evolving role of probiotic‐based foods and beverages, highlighting their potential as functional “ future ” that could significantly enhance nutrition, health, overall well‐being. These products are gaining prominence for benefits in gut immune support, holistic wellness. However, success depends on addressing critical safety concerns navigating administrative complexities. Ensuring these do more good than harm involves rigorous evaluations probiotic strains, particularly those sourced from human gastrointestinal tract. Lactic acid bacteria (LABs) serve versatile effective starter cultures development beverages. The emphasizes LABs precision probiotics advancing products. Establishing standardized guidelines transparent practices is essential, requiring collaboration among regulatory bodies, industry stakeholders, scientific community. underscores importance innovation developing friendly ,” super fermentation, assessments. prospects beverages rely refining elements adapting to emerging advancements. Ultimately, empowering consumers with accurate information, fostering innovation, maintaining stringent standards will shape trusted beneficial components a health‐conscious society. Probiotic‐based often infused LABs, designed health.

Language: Английский

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Bridging Science and Lifestyle: A Feasibility Study for Developing a Novel Functional Food to Support Well-Being

Nutraceuticals, Journal Year: 2025, Volume and Issue: 5(2), P. 10 - 10

Published: April 15, 2025

This feasibility study investigates the relationship between functional food consumption and mental well-being, focusing on natural foods traditionally linked to health benefits. research also examines consumer preferences identify key characteristics that novel designed enhance well-being should possess. Additionally, this lays groundwork for a clinical trial exploring effects of well-being. Data were collected through an online bilingual survey (Greek/English) from 362 participants across Greece Cyprus, using adapted Functional Food Frequency Questionnaire (FFFQ) featuring 30 with documented cognitive function mood regulation. The included validated scales measuring health-related quality life (HRQoL), sleep quality, choice motives, along demographic anthropometric data. Analysis revealed significant associations outcomes, particularly in HRQoL, body mass index (BMI). Most consumed aligned Mediterranean dietary pattern, such as fruits, vegetables, nuts, herbal infusions, honey, all demonstrating positive physical health. Consumer showed strong inclination toward balance sensory appeal benefits, including milk-based plant-based beverages, protein bars, granola bars. Ingredients like St. John’s wort Greek mountain tea identified potentially beneficial consistent their established efficacy psychological A majority (66.9%) expressed interest participating trials, highlighting need further into components. provides foundation future trials examining impact formulations health, addressing growing demand products resilience

Language: Английский

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