Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Language: Английский

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From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4271 - 4271

Published: April 30, 2025

The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.

Language: Английский

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Impact of Physical Activity on Cellular Metabolism Across Both Neurodegenerative and General Neurological Conditions: A Narrative Review

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1940 - 1940

Published: Nov. 22, 2024

Background: Regular physical activity plays a crucial role in modulating cellular metabolism and mitigating the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Multiple Sclerosis. Objective: The objective this review is to evaluate molecular mechanisms by which exercise influences metabolism, with focus on its potential therapeutic intervention for neurological disorders. Methods: A comprehensive literature was conducted using peer-reviewed scientific articles, period between 2015 2024, analyze effects mitochondrial function, oxidative stress, metabolic health. Results: findings indicate that promotes biogenesis, enhances phosphorylation, reduces reactive oxygen species, contributing improved energy production resilience. These adaptations are associated delayed disease reduced symptoms patients conditions. Additionally, integrating nutritional strategies may further enhance outcomes addressing disturbances comprehensively. Conclusions: This concludes personalized protocols should be developed optimize benefits diseases, while future research biomarker development individualized treatment approaches. highlight importance non-pharmacological interventions managing diseases.

Language: Английский

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Multisensory Stimulation in Amyotrophic Lateral Sclerosis Disease: Case Report of an Innovative Proposal through Immersive Virtual Reality

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(20), P. 9238 - 9238

Published: Oct. 11, 2024

Physical–cognitive stimulation has emerged as a promising strategy for improving the quality of life patients with amyotrophic lateral sclerosis (ALS). This case study reports on use immersive virtual reality (IVR) tool multisensory in woman ALS (76 years old; 11 since diagnosis; stage 2). The program consisted IVR sessions (three per week 12 weeks). results showed that implementation was feasible and safe (no adverse symptoms Simulator Sickness Questionnaire), well easy to execute (>80% System Usability Scale). Additionally, participant reported improvements aspects related her mental health (44% depression 20% anxiety) life, she also maintained values functional capacity. presents novel important findings by demonstrating feasibility implementing physical–cognitive programs person ALS, allowing commercially available hardware software generation benefits their health-related health.

Language: Английский

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Multiple action specialized product: Production and effectiveness‎ ‎

Journal Of Advanced Pharmacy Education And Research, Journal Year: 2024, Volume and Issue: 14(3), P. 102 - 108

Published: Jan. 1, 2024

Language: Английский

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