Andrologia,
Journal Year:
2022,
Volume and Issue:
54(8)
Published: June 18, 2022
L-Proline
is
a
natural
anti-oxidative
and
osmoprotectant
agent,
playing
versatile
role
in
cell
metabolism
physiology.
The
present
study
aimed
to
explore
the
antioxidant
effects
of
on
human
sperm
function
during
incubation.
Thirty
healthy,
normozoospermic
men
(27–40
years)
were
enrolled.
Sperm
samples
incubated
an
unsupplemented
medium
(control
group),
or
supplemented
with
(1,
2
4
mmol/L)
evaluate
its
effect
0,
1,
24
h
assessed
terms
motility,
viability,
morphology,
chromatin
DNA
integrity.
Moreover,
levels
reactive
oxygen
species
(ROS),
malondialdehyde
(MDA),
total
capacity
(TAC)
determined
medium.
results
indicated
that
mmol/L
significantly
improved
maintenance
normal
integrity,
TAC
compared
control
group
incubation
(p
<
0.05).
However,
1
could
not
preserve
parameters,
quality,
status
different
times
>
Collectively,
inclusion
(2
maintains
parameters
quality
probably
by
modulating
oxidative
status.
International Journal of Environmental Research and Public Health,
Journal Year:
2021,
Volume and Issue:
18(5), P. 2392 - 2392
Published: March 1, 2021
Much
of
the
planet
is
swimming
in
discarded
plastic,
which
harming
animal
and
possibly
human
health.
Once
at
sea,
sunlight,
wind,
wave
action
break
down
plastic
waste
into
small
particles:
microplastics
(MPs).
Currently,
particular
attention
has
been
drawn
to
their
effects
on
aquatic
environments
but
health
risks,
especially
mammals,
are
poorly
known.
These
non-biodegradable
materials
can
act
as
a
vector
for
environmental
pollutants,
be
ingested
by
humans
food
water,
enter
accumulate
tissues
with
possible
risk
heath.
Recent
studies
revealed
deleterious
MPs
exposure
male
reproduction
sperm
quality,
making
them
potential
hazard
reproductive
success.
This
manuscript
summarizes
main
changes
quality
along
lifespan
upcoming
fertility
mammals.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(2), P. 424 - 424
Published: Jan. 10, 2022
The
use
of
polyphenols
as
adjuvants
in
lowering
risk
factors
for
various
debilitating
diseases
has
been
investigated
recent
years
due
to
their
possible
antioxidant
action.
Polyphenols
represent
a
fascinating
and
relatively
new
subject
research
nutraceuticals
nutrition,
with
interest
rapidly
expanding
since
they
can
help
maintain
health
by
controlling
metabolism,
weight,
chronic
diseases,
cell
proliferation.
Resveratrol
is
phenolic
compound
found
mostly
the
pulp,
peels,
seeds,
stems
red
grapes.
It
wide
variety
biological
actions
that
be
used
prevent
beginning
or
manage
symptoms.
influence
multiple
inflammatory
non-inflammatory
responses,
protecting
organs
tissues,
thanks
its
interaction
immune
cells
activity
on
SIRT1.
This
anti-inflammatory,
antioxidant,
anti-apoptotic,
neuroprotective,
cardioprotective,
anticancer,
antiviral
properties,
making
it
potential
adjunct
traditional
pharmaceutical
therapy
public
health.
review
aims
provide
comprehensive
analysis
resveratrol
terms
active
effects
mechanism
action
modifying
cellular
response
promote
human
psychophysical
Journal of Clinical Medicine,
Journal Year:
2020,
Volume and Issue:
9(5), P. 1400 - 1400
Published: May 9, 2020
In
up
to
50%
of
cases,
infertility
issues
stem
solely
from
the
male.
According
some
data,
quality
human
semen
has
deteriorated
by
50%-60%
over
last
40
years.
A
high-fat
diet
and
obesity,
resulting
an
unhealthy
lifestyle,
affects
structure
spermatozoa,
but
also
development
offspring
their
health
in
later
stages
life.
obese
individuals,
disorders
on
hypothalamic-pituitary-gonadal
axis
are
observed,
as
well
elevated
oestrogen
levels
with
a
simultaneous
decrease
testosterone,
luteinizing
hormone
(LH),
follicle-stimulating
(FSH)
levels.
Healthy
dietary
models
clearly
correlate
better
sperm
smaller
risk
abnormalities
parameters
such
count,
concentration
motility,
lower
DNA
fragmentation.
Apart
mineral
components
zinc
selenium,
role
omega-3
fatty
acids
antioxidant
vitamins
should
be
emphasized,
since
action
will
primarily
based
minimization
oxidative
stress
inflammation
process.
Additionally,
incorporation
carnitine
supplements
coenzyme
Q10
therapeutic
interventions
seems
promising.
Therefore,
it
is
advisable
have
varied
balanced
vegetables
fruit,
fish
seafood,
nuts,
seeds,
whole-grain
products,
poultry,
low-fat
dairy
products.
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(4), P. 507 - 507
Published: March 24, 2021
Aging
and,
particularly,
the
onset
of
age-related
diseases
are
associated
with
tissue
dysfunction
and
macromolecular
damage,
some
which
can
be
attributed
to
accumulation
oxidative
damage.
Recently,
growing
interest
has
emerged
on
beneficial
effects
plant-based
diets
for
prevention
chronic
including
obesity,
diabetes,
cardiovascular
disease.
Several
studies
collectively
suggests
that
intake
polyphenols
their
major
food
sources
may
exert
improving
insulin
resistance
related
diabetes
risk
factors,
such
as
inflammation
stress.
They
most
abundant
antioxidants
in
diet,
been
a
reduced
aging
humans.
Polyphenolic
shown
effective
at
ameliorating
several
phenotypes,
stress,
inflammation,
impaired
proteostasis,
cellular
senescence,
both
vitro
vivo.
In
this
paper,
these
phytochemicals
(either
pure
forms
or
polyphenolic-food)
reviewed
summarized
according
affected
signaling
pathways.
Finally,
effectiveness
anti-aging
preventive
action
nutritional
interventions
based
rich
polyphenolic
food,
Blue
zones,
discussed.
Metabolites,
Journal Year:
2021,
Volume and Issue:
11(12), P. 840 - 840
Published: Dec. 4, 2021
In
recent
decades,
the
worldwide
prevalence
of
obesity
has
risen
dramatically
and
is
currently
estimated
to
be
around
20%.
Obesity
linked
an
increased
risk
comorbidities
premature
mortality.
Several
studies
have
shown
that
negatively
impacts
male
fertility
through
various
mechanisms.
This
review
aims
investigate
molecular
mechanisms
which
impairs
reproduction,
including
obesity-associated
hypogonadism
its
effects
on
spermatogenesis,
chronic
inflammation,
oxidative
stress.
both
conventional
biofunctional
sperm
parameters,
it
also
induces
epigenetic
changes
can
transferred
offspring.
Moreover,
obesity-related
diseases
are
a
dysregulation
adipocyte
function
micro-environmental
inflammatory
processes.
The
dysregulated
adipokines
significantly
influence
insulin
signaling,
they
may
detrimental
effect
testicular
function.
Sirtuins
play
important
role
in
metabolic
responses
obese
patients.
Understanding
involved
obesity-induced
infertility
could
increase
our
ability
identify
novel
targets
for
prevention
treatment
related
consequences.
Ecotoxicology and Environmental Safety,
Journal Year:
2021,
Volume and Issue:
215, P. 112165 - 112165
Published: March 24, 2021
Exposure
to
metals/metalloids,
including
essential
and
nonessential
elements,
has
been
associated
male
reproductive
health
in
animals.
However,
findings
from
human
studies
are
inconsistent.
To
investigate
the
impact
of
exposure
multiple
metals/metalloids
at
environmental
levels
on
conventional
semen-quality
parameters.
Men
living
rural
or
industrial
areas
were
recruited
by
personalized
letters.
No
exclusion
criteria
applied.
Each
man
provided
one
semen
sample
blood
sample.
We
analyzed
both
determine
sperm
parameters
(concentration,
progressive
motility
normal
forms)
quantify
lead
(Pb),
cadmium
(Cd),
mercury
(Hg),
arsenic
(As),
nickel
(Ni),
vanadium
(V)
selenium
(Se)
levels.
The
these
also
quantified
venous
spermatozoa
samples.
Associations
between
blood/seminal
plasma
metal/metalloid
quality
assessed
using
confounder
adjusted
logistic
regression
models.
Correlation
interactions
investigated
Spearman's
correlation.
found
a
positive
association
seminal
level
with
lower
Total
count
(OR
=
4.48,
95%CI
0.25–80);
whereas
4.51,
0.86–23)
3.45,
0.77–16)
had
motility.
Overall,
associations
remained
suggestive
after
adjustment,
though
statistically
unstable
risks.
Finally,
we
weak
beneficial
effects
Se
detrimental
ones
only
for
Cd
Pb
concentration,
total
Our
suggest
that
contributes
decline
quality,
can
have
effects.
Measurements
fluid
may
be
more
predictable
than
measurements
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1568 - 1568
Published: Jan. 29, 2022
The
role
of
environmental
factors
in
influencing
health
status
is
well
documented.
Heavy
metals,
polycyclic
aromatic
hydrocarbons
(PAHs),
polychlorinated
biphenyls,
dioxins,
pesticides,
ultrafine
particles,
produced
by
human
activities
put
a
strain
on
the
body’s
entire
defense
system.
Therefore,
together
with
public
measures,
evidence-based
individual
resilience
measures
are
necessary
to
mitigate
cancer
risk
under
stress
and
prevent
reproductive
dysfunction
non-communicable
diseases;
this
especially
relevant
for
workers
occupationally
exposed
pollutants
and/or
populations
residing
highly
polluted
areas.
Mediterranean
diet
characterized
high
intake
fruits
vegetables
rich
flavonoids,
that
can
promote
elimination
tissues
fluids
their
effects
through
different
mechanisms.
In
review,
we
collected
evidence
from
pre-clinical
clinical
studies
showing
impairment
male
fertility
gonadal
development,
as
cancers
system,
due
exposure
organic
inorganic
pollutants,
may
be
counteracted
flavonoids.
