Effects of micro(nano)plastics on the reproductive system: A review DOI Creative Commons
Xuan Song,

Lixia Du,

Ling Sima

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 336, P. 139138 - 139138

Published: June 5, 2023

Microplastics (100nm-5 mm) and nanoplastics (1-100 nm) are collectively referred to as micro(nano)plastics (MNPs), which refractory degradation, easy migration, small in size, strong adsorption, can widely present human living environment. A number of studies have confirmed that MNPs be exposed the body through a variety routes, penetrate various barriers enter reproductive system, suggesting may pose potential harm health. Current most were limited phenotypic their subjects basically lower marine organisms mammals. Therefore, order provide theoretical base for further exploring effects on this paper searched relevant literature at home abroad, mainly analyzed rodent experiments, concluded main exposure routes dietary intake, air inhalation, skin contact medical plastics. After entering produce toxicity oxidative stress, inflammation, metabolic disorders, cytotoxicity other mechanisms. More work is required comprehensively identify improve detection methods evaluate effective deeply study specific mechanisms toxic effects, withing aim conducting population level next step.

Language: Английский

Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans? DOI
Rakesh Kumar, Camelia Manna, Shaveta Padha

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 298, P. 134267 - 134267

Published: March 14, 2022

Language: Английский

Citations

269
Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice DOI

Zhaolan Wei,

Yunyi Wang, Shuwei Wang

et al.

Toxicology, Journal Year: 2021, Volume and Issue: 465, P. 153059 - 153059

Published: Dec. 2, 2021

Language: Английский

Citations

192
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway DOI Creative Commons

Haibo Jin,

Minghao Yan, Chun Pan

et al.

Particle and Fibre Toxicology, Journal Year: 2022, Volume and Issue: 19(1)

Published: Feb. 17, 2022

Abstract Background Microplastics (MPs), which are smaller in size and difficult to degrade, can be easily ingested by marine life enter mammals through the food chain. Our previous study demonstrated that following acute exposure MPs, serum testosterone content reduced sperm quality declined, resulting male reproductive dysfunction mice. However, toxic effect of long-term MPs at environmental levels on system remains unclear. Results In vivo, mice were given drinking water containing 100 μg/L 1000 polystyrene (PS-MPs) with particle sizes 0.5 μm, 4 10 μm for 180 consecutive days. We observed alterations testicular morphology reductions testosterone, LH FSH contents serum. addition, viability was declined rate abnormality increased PS-MPs. The expression steroidogenic enzymes StAR downregulated testis tissues. vitro, we used primary Leydig cells explore underlying mechanism decrease induced First, discovered PS-MPs attached became internalized cells. And then found supernatant declined. Meanwhile, LHR, concentration-dependent also confirmed decreased inhibiting activation AC/cAMP/PKA pathway. Moreover, overexpression LHR alleviated reduction levels, finally Conclusions resulted histology, abnormal spermatogenesis, interference hormone secretion a level downregulation LH-mediated LHR/cAMP/PKA/StAR summary, our showed chronic toxicity reproduction under these potential risks may ring alarm bells public health. Graphical abstract

Language: Английский

Citations

165
From natural environment to animal tissues: A review of microplastics(nanoplastics) translocation and hazards studies DOI
Xusheng Dong, Xinbei Liu, Qiuling Hou

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 855, P. 158686 - 158686

Published: Sept. 10, 2022

Language: Английский

Citations

155
A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals DOI Creative Commons
Sana Ullah,

Shahid Ahmad,

Xinle Guo

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 16, 2023

Over the years, vaste expansion of plastic manufacturing has dramatically increased environmental impact microplastics [MPs] and nanoplastics [NPs], making them a threat to marine terrestrial biota because they contain endocrine disrupting chemicals [EDCs] other harmful compounds. MPs NPs have deleteriouse impacts on mammalian components such as hypothalamus, pituitary, thyroid, adrenal, testes, ovaries. absorb act transport medium for bisphenols, phthalates, polybrominated diphenyl ether, polychlorinated biphenyl organotin, perfluorinated compounds, dioxins, polycyclic aromatic hydrocarbons, organic contaminants, heavy metals, which are commonly used additives in production. As EDCs not covalently bonded plastics, can easily leach into milk, water, liquids affecting system mammals upon exposure. The toxicity induced by is size-dependent, smaller particles better absorption capacity larger surface area, releasing more EDC toxic chemicals. Various contained or carried share structural similarities with specific hormone receptors; hence interfere normal receptors, altering hormonal action glands. This review demonstrates size-dependent MPs’ bioaccumulation, distribution, translocation potential hazards gland. We reviewed that disrupt hypothalamic-pituitary axes, including hypothalamic-pituitary-thyroid/adrenal/testicular/ovarian axis leading oxidative stress, reproductive toxicity, neurotoxicity, cytotoxicity, developmental abnormalities, decreased sperm quality, immunotoxicity. direct consequences testis, ovaries documented. Still, studies need be out identify effects adrenal

Language: Английский

Citations

121
Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice DOI Creative Commons
Chiang‐Wen Lee, Lee‐Fen Hsu,

I.-Lin Wu

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 430, P. 128431 - 128431

Published: Feb. 4, 2022

Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its potential effects on health remain unknown. The administration of polystyrene MPs (PS-MPs) to mice for eight weeks impaired learning and memory behavior. PS-MPs were detected in the brain especially hippocampus these mice. Concurrently, had decreased levels immediate-early genes, aberrantly enhanced synaptic glutamate AMPA receptors, elevated neuroinflammation, all which are critical plasticity memory. Interestingly, ablation vagus nerve, modulator gut-brain axis, improved function These results indicate that exposure alters expression neuronal activity-dependent genes proteins, increases neuroinflammation hippocampus, subsequently causing behavioral changes through nerve-dependent pathway. Our findings shed light adverse impacts hippocampal

Language: Английский

Citations

118
Microplastics: Detection in human samples, cell line studies, and health impacts DOI Creative Commons
‪Damià Barceló, Yolanda Picó, Ahmed Alfarhan

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 101, P. 104204 - 104204

Published: June 28, 2023

Microplastics (MPs) are in all environmental compartments, including atmosphere, terrestrial, and aquatic environments as well marine organisms, foods, drinking water, indoor outdoor environments. MPs can enter the human body through food chain contaminated environment. Ingestion, inhalation, dermal contact routes of their entry into body. Recent studies reporting detection within have raised concern among scientific community knowledge about exposure is still very limited impact on health not well-understood yet. In this review article, we briefly cover reports evidencing MP body, e.g., stool, placenta, lungs, liver, sputum, breast milk, blood. A concise synopsis sample preparation analysis such matrices also provided. This article presents a summary effect cell lines health.

Language: Английский

Citations

115
From properties to toxicity: Comparing microplastics to other airborne microparticles DOI Creative Commons
Simon Wieland, Aylin Balmes, Julian Bender

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 428, P. 128151 - 128151

Published: Jan. 3, 2022

Microplastic (MP) debris is considered as a potentially hazardous material. It omnipresent in our environment, and evidence that MP also abundant the atmosphere increasing. Consequently, inhalation of these particles significant exposure route to humans. Concerns about potential effects airborne on human health are rising. However, currently, there not enough studies putative toxicity adequately assess its impact health. Therefore, we examined drivers toxicity. Physicochemical properties like size, shape, ζ-potential, adsorbed molecules pathogens, MP’s bio-persistence have been proposed possible Since their role largely unknown, reviewed literature toxicologically well-studied non-plastic microparticles (asbestos, silica, soot, wood, cotton, hay). We aimed link observed toxicology abovementioned properties. By comparing this information with MP, analyzed mechanisms Thus, provide basis for mechanistic understanding This may enable assessment risks associated pollution, facilitating effective policymaking product design.

Language: Английский

Citations

89
From oceans to dinner plates: The impact of microplastics on human health DOI Creative Commons
Ebuka Chizitere Emenike, Chika J. Okorie,

Toluwalase Ojeyemi

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(10), P. e20440 - e20440

Published: Sept. 26, 2023

Microplastics, measuring less than 5 mm in diameter, are now found various environmental media, including soil, water, and air, have infiltrated the food chain, ultimately becoming a part of human diet. This study offers comprehensive examination intricate nexus between microplastics health, thereby contributing to existing knowledge on subject. Sources microplastics, microfibers from textiles, personal care products, wastewater treatment plants, among others, were assessed. The meticulously examined diverse routes microplastic exposure—ingestion, inhalation, dermal contact—offering insights into associated health risks. Notably, ingestion has been linked gastrointestinal disturbances, endocrine disruption, potential transmission pathogenic bacteria. Inhalation airborne emerges as critical concern, with possible implications for respiratory cardiovascular health. Dermal contact, although explored, raises prospect skin irritation allergic reactions. impacts COVID-19 pollution also highlighted. Throughout manuscript, need deeper mechanistic understanding interactions systems is emphasized, underscoring urgency further research public awareness.

Language: Английский

Citations

79
Maternal Exposure to Polystyrene Micro- and Nanoplastics Causes Fetal Growth Restriction in Mice DOI
Zahra Aghaei, John G. Sled, John‏ Kingdom

et al.

Environmental Science & Technology Letters, Journal Year: 2022, Volume and Issue: 9(5), P. 426 - 430

Published: April 22, 2022

Plastics are ubiquitous and, when released into the environment, break down smaller particles termed microplastics (MPs) and nanoplastics (NPs). These MPs NPs can be ingested by organisms potentially accumulate in tissues organs. Recently, were found placentas of healthy women, raising concern that exposure to plastics may have an impact on pregnancy fetal development. In this study, we investigated effect maternal placental growth using experimental mice. The dams exposed received either 5 μm or 50 nm polystyrene filtered drinking water at one three concentrations (102, 104, 106 ng/L). late gestation, MP- NP-exposed fetuses significantly restricted, with a 12% decrease weight highest concentration. This study represents crucial first step toward evaluating risks human pregnancies posed plastics.

Language: Английский

Citations

72