The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies DOI Open Access
Daniela Călina, Ana Maria Bugă,

Mihaela Mitroi

et al.

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(8), P. 2395 - 2395

Published: July 27, 2020

Neurological disorders such as neurodegenerative diseases or traumatic brain injury are associated with cognitive, motor and behavioural changes that influence the quality of life patients. Although different therapeutic strategies have been developed tried until now to decrease neurological decline, no treatment has found cure these pathologies. In last decades, implication endocannabinoid system in function extensively studied, cannabinoids a new promising potential treatment. this study, we aimed overview recent available literature regarding vivo natural synthetic underlying mechanisms action for protecting against cognitive decline impairments. The results studies on animal models showed increase neurobehavioral function, working memory performance, deficit ameliorate through down-regulation pro-inflammatory markers, oedema formation blood–brain barrier permeability, preventing neuronal cell loss up-regulating levels adherence junction proteins. diseases, beneficial effects decreasing disability disease progression by complex mechanism targeting more signalling pathways further than classical receptors system. light results, use could be injuries multiple sclerosis treatment, especially those patients who display resistance conventional

Language: Английский

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases DOI Creative Commons
Mehdi Sharifi‐Rad, N. V. Anil Kumar, Paolo Zucca

et al.

Frontiers in Physiology, Journal Year: 2020, Volume and Issue: 11

Published: July 2, 2020

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative and cancer. Long term exposure to increased levels pro-oxidant factors can cause structural defects at a mitochondrial DNA level, well functional alteration several enzymes cellular structures leading aberrations gene expression. The modern lifestyle associated with processed food, wide range chemicals lack exercise important oxidative induction. However, use medicinal plants antioxidant properties has been exploited for their ability treat or prevent human pathologies which seems be one causes. In this review we discuss is triggers plant-derived compounds mechanisms defenses that help prevention these diseases. Finally, both beneficial detrimental effects molecules are used reduce conditions discussed.

Language: Английский

Citations

1508
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence DOI Creative Commons
Bahare Salehi, Cristina Quispe, Imane Chamkhi

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 18, 2021

Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by series preclinical and clinical studies. In this article, different scientific databases were searched retrieve studies depicting biological activities chalcones their derivatives. This review comprehensively describes on derivatives describing immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, neuroprotective agents. Besides, trials revealed use in treatment chronic venous insufficiency, skin conditions, cancer. Bioavailability indicate possible hindrance improvement relation its nutraceutical pharmaceutical applications. Multifaceted complex underlying mechanisms chalcone actions demonstrated ability modulate number cancer cell lines, inhibit pathological microorganisms parasites, control signaling molecules cascades related disease modification. Clinical general absence adverse effects besides reducing signs symptoms decent bioavailability. Further needed elucidate structure activity, toxicity concerns, cellular basis mode action, interactions other molecules.

Language: Английский

Citations

236
The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action DOI Creative Commons
Bahare Salehi, Javad Sharifi‐Rad,

Francesca Cappellini

et al.

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Aug. 26, 2020

Anthocyanins are natural phenolic pigments with biological activity. They well-known to have potent antioxidant and anti-inflammatory activity, which explains the various effects reported for these substances suggesting their antidiabetic anticancer activities, role in cardiovascular neuroprotective prevention. This review aims comprehensively analyze different studies performed on this class of compounds, bioavailability therapeutic potential. An in-depth look preclinical, vitro vivo, clinical indicates preventive anthocyanins cardioprotection, neuroprotection, anti-obesity as well antidiabetes effects.

Language: Английский

Citations

229
Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds DOI Open Access
Javad Sharifi‐Rad, Célia F. Rodrigues, Farukh Sharopov

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(7), P. 2326 - 2326

Published: March 30, 2020

Heart and blood vessels disorders comprise one of the main causes death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around world traditional way. Dietary, bioactive compounds, well healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical clinical studies reported that consumption plant-food derivatives including polyphenolic peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on This review aims summarize risk factors, pre-clinical trials related cardioprotective properties plant-food-derived compounds. Molecular mechanisms by exert their also highlighted.

Language: Английский

Citations

218
Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms DOI Creative Commons
Javad Sharifi‐Rad, Natália Martins, Pía López‐Jornet

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti‐inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase‐2 (CK2) inhibitory, antifungal, antiviral, Alzheimer’s disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on bioavailability coumarins; therefore, further investigations necessitated study different which already showed good biological activities previous studies. On evidence varied properties, present work presents an overall review derivation, availability, capacities with consideration essential mode their therapeutic actions. In conclusion, variety available, current interest thanks synthetic accessibility riches perform valuable function as agents range medical fields.

Language: Английский

Citations

179
Carbon monoxide poisoning DOI Creative Commons
Hiroshi Kinoshita, Hülya Türkan, Slavica Vučinić

et al.

Toxicology Reports, Journal Year: 2020, Volume and Issue: 7, P. 169 - 173

Published: Jan. 1, 2020

Carbon monoxide (CO) is the leading cause of poisoning deaths in many countries, including Japan. Annually, CO claims about 2000–5000 lives Japan, which over half total number deaths. This paper discusses physicochemical properties and toxicological evaluation poisoning.

Language: Английский

Citations

165
Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases DOI Open Access
Bahare Salehi, Daniela Călina, Anca Oana Docea

et al.

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(2), P. 430 - 430

Published: Feb. 5, 2020

The brain is the body's control center, so when a disease affects it, outcomes are devastating. Alzheimer's and Parkinson's disease, multiple sclerosis diseases that cause large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on health through several mechanisms such as antioxidant, amyloid β-binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, synaptogenesis promotion. therapeutic limitation curcumin its bioavailability, to address this problem, new nanoformulations being developed. present review aims summarize general bioactivity in neurological disorders, how functional molecules extracted, different types available.

Language: Английский

Citations

162
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19 DOI Open Access
Aristides Tsatsakis, Daniela Călina, Luca Falzone

et al.

Food and Chemical Toxicology, Journal Year: 2020, Volume and Issue: 146, P. 111769 - 111769

Published: Sept. 30, 2020

Language: Английский

Citations

151
COVID-19 pandemic and alcohol consumption: Impacts and interconnections DOI Creative Commons
Daniela Călina, Thomas Härtung, Ileana Mardare

et al.

Toxicology Reports, Journal Year: 2021, Volume and Issue: 8, P. 529 - 535

Published: Jan. 1, 2021

Alcohol consumption is associated with multiple diseases and might contribute to vulnerability SARS-CoV-2 infection. It can also catalyze exacerbations of mental organic illnesses predispose behaviors an increased risk infection, severity disease but independently sociopathic behavior violence. Globally, millions premature deaths from excessive alcohol occur each year. This paper discusses the effects most important consequences on health population during social isolation lockdown current COVID-19 pandemic.

Language: Английский

Citations

145
Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits DOI Creative Commons
Javad Sharifi‐Rad, Abhijit Dey, Niranjan Koirala

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: May 11, 2021

The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for long time. Different traditional healing systems have these plants herbal remedies to cure diverse ailments. aim this comprehensive updated review is summarize the biodiversity , its bioactive compounds, mechanisms that underlie pharmacological activities molecular targets toxicological safety. All data in been collected from databases recent scientific literature including Web Science, PubMed, ScienceDirect etc. results showed compounds possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer neuroprotective effects. preclinical ( vitro / vivo ) studies provided possible action. As novelty, clinical described paper support confirm importance Cinnamomum. In conclusion, obtained trials, well reduced side effects provide insights into future research new drugs based on extracts plants.

Language: Английский

Citations

134