An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 611 - 611

Published: April 18, 2023

Calendula officinalis Linn. (CO) is a popular medicinal plant from the kingdom’s Asteraceae family that has been used for millennia. This contains flavonoids, triterpenoids, glycosides, saponins, carotenoids, volatile oil, amino acids, steroids, sterols, and quinines. These chemical constituents confer multifaceted biological effects such as anti-inflammatory, anti-cancer, antihelminthic, antidiabetes, wound healing, hepatoprotective, antioxidant activities. Additionally, it employed in cases of certain burns gastrointestinal, gynecological, ocular, skin conditions. In this review, we have discussed recent research last five years on therapeutic applications CO emphasized its myriad capabilities traditional medicine. We also elucidated CO’s molecular mechanisms clinical studies. Overall, review intends to summarize, fill gaps existing research, provide wealth possibilities researchers working validate claims advance safe effective use treating various ailments.

Language: Английский

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Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114687 - 114687

Published: April 14, 2023

Cancer is still the leading cause of death worldwide, burdening global medical system. Rosmarinic acid (RA) among first secondary metabolites discovered and it a bioactive compound identified in plants such as Boraginaceae Nepetoideae subfamilies Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, Hyptis pectinate. This updated review to highlight chemopreventive chemotherapeutic effects RA its derivatives, thus providing valuable clues for potential development some complementary drugs treatment cancers. Relevant information about RA's derivatives were collected from electronic scientific databases, PubMed/Medline, Scopus, TRIP database, Web Science, Science Direct. The results studies showed numerous significant biological antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant antiangiogenic effects. Most on anticancer with corresponding mechanisms are experimental preclinical stage missing evidence clinical trials support research. To open new therapeutic perspectives future must elucidate molecular targets action more detail, human toxic adverse

Language: Английский

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Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 1, 2023

Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has crucial role in cytoprotective response against stress, including cancer growth progression therapy resistance. For this reason, inhibitors are new targets to be studied. Traditional plant-based remedies rich phytochemicals have been used human cancers phenolic compounds known for their chemopreventive properties. This comprehensive review offers updated the as anticancer agents due action on inhibition. In addition, naturally-occurring bioactive covered clinical applications polyphenols inhibitors.

Language: Английский

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Antioxidant Activity of Coumarins and Their Metal Complexes

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(5), P. 651 - 651

Published: April 26, 2023

Ubiquitously present in plant life, coumarins, as a class of phenolic compounds, have multiple applications-in everyday organic synthesis, medicine and many others. Coumarins are well known for their broad spectrum physiological effects. The specific structure the coumarin scaffold involves conjugated system with excellent charge electron transport properties. antioxidant activity natural coumarins has been subject intense study at least two decades. Significant research into behavior natural/semi-synthetic complexes carried out published scientific literature. authors this review noted that, during past five years, efforts seem to focused on synthesis examination synthetic derivatives aim produce potential drugs enhanced, modified or entirely novel As pathologies associated oxidative stress, coumarin-based compounds could be candidates medicinal molecules. aims inform reader some prominent results from investigations properties over years.

Language: Английский

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Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: Jan. 10, 2023

Abstract Psoralea corylifolia L. (PCL), referred to as “Bu-gu-zhi” in Chinese, has great medicinal values since ancient times. PCL is the dried ripe fruit of L., which been widely used traditional Chinese medicine (TCM) for treatment kidney-yang deficiency, enuresis and urinary frequency, chills pain waist knees, dawn diarrhea vitiligo. In this paper, a systematic botany, uses, phytochemistry, pharmacology, toxicology, quality control pharmacokinetics was presented, along with future research directions. According results, contains approximately 163 chemical components, including coumarins, flavonoids, monoterpene phenols, benzofurans, glycosides, lipids, fatty acids, volatile oils. its active ingredients have variety pharmacological activities, such anti-inflammatory, antibacterial, antiviral, antioxidant, antitumor, antiosteoporosis, cardioprotective, neuroprotective, immunomodulatory. Further study standards potential mechanisms also needed. addition, more toxicological studies will contribute progress clinical trials.

Language: Английский

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Coumarin hybrids for targeted therapies: A promising approach for potential drug candidates

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 60, P. 117 - 133

Published: Feb. 8, 2024

Language: Английский

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Recent Trends in the Synthesis and Bioactivity of Coumarin, Coumarin–Chalcone, and Coumarin–Triazole Molecular Hybrids

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1026 - 1026

Published: Feb. 27, 2024

Molecular hybridization represents a new approach in drug discovery which specific chromophores are strategically combined to create novel drugs with enhanced therapeutic effects. This innovative strategy leverages the strengths of individual address complex biological challenges, synergize beneficial properties, optimize pharmacokinetics, and overcome limitations associated single-agent therapies. Coumarins documented possess several bioactivities have therefore been targeted for combination other active moieties molecular hybrids. review summarizes recent (2013–2023) trends synthesis coumarins, as well coumarin–chalcone coumarin–triazole To cover wide aspects this area, we included differently substituted chalcones, 1,2,3– 1,2,4–triazoles considered point fusion/attachment coumarin show diversity these The reported syntheses mainly relied on well-established chemistry without need strict reaction conditions usually produced high yields. Additionally, discussed compounds, including antioxidative, antimicrobial, anticancer, antidiabetic, anti-cholinesterase activities commented their IC50 where possible. Promising bioactivity results obtained so far. It is noted that mechanistic studies infrequently found published work, was also mentioned give reader better understanding. aims provide valuable information enable further developments field.

Language: Английский

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Natural Flavonoid Apigenin, an Effective Agent Against Nervous System Cancers

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(8), P. 5572 - 5583

Published: Jan. 11, 2024

Language: Английский

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Coumarin—Synthetic Methodologies, Pharmacology, and Application as Natural Fluorophore

Topics in Current Chemistry, Journal Year: 2024, Volume and Issue: 382(2)

Published: May 9, 2024

Language: Английский

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Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis

Journal of Oncology, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 11

Published: Dec. 10, 2021

Smoking a cigarette generates over 4000 chemicals that have deleterious impact on each part of the human body. It produces three main severe effects liver organ: oncogenic, immunological, and indirect or direct toxic effects. results in production cytotoxic substances, which raises fibrosis necro-inflammation. Additionally, it also directs pro-inflammatory cytokines tumour necrosis factor alfa (TNF-α) interleukins (IL-1β, IL-6) will be responsible for chronic injury. Furthermore, gives rise to secondary polycythemia successively turnover mass red cells, might common development oxidative stress due iron overload. are having oncogenic properties risk cancer especially sufferers hepatitis C. modulates both humoral cell-mediated responses by restricting proliferation lymphocytes inducing their apoptosis ultimately decreasing surveillance cells. Moreover, has been determined heavy smoking impacts response C patients interferon (IFN) therapy through different mechanisms, can improved phlebotomy. Efforts being made nations prevalence improve premature death ill nation's individuals.

Language: Английский

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