Attenuating Treatment-Related Cardiotoxicity in Women Recently Diagnosed With Breast Cancer via a Tailored Therapeutic Exercise Program: Protocol of the ATOPE Trial DOI Open Access
Paula Postigo-Martín, Rafael Peñafiel-Burkhardt,

Tania Gallart‐Aragón

et al.

Physical Therapy, Journal Year: 2021, Volume and Issue: 101(3)

Published: Jan. 14, 2021

Therapeutic exercise is already used to ameliorate some of the side effects cancer treatment. Recent studies examined its preventive potential regarding treatment-related toxicity, which can increase risk functional decline and lead disease recurrence death. This trial will examine whether Tailored Exercise Recovery Strategies (ATOPE) program, performed before treatment, mitigate onset extent cardiotoxicity beyond that achieved when program followed during treatment in recently diagnosed breast patients.The intervention has a preparatory phase plus 12 18 sessions tailored, high-intensity exercise, post-exercise recovery strategies. A total 120 women with cancer, at due anticancer awaiting surgery by chemotherapy and/or radiotherapy, be randomized either group. In feasibility study, measurements related recruitment rate, satisfaction adherence them, retention participants, safety, adverse explored. main trial, efficacy these interventions examined. The major outcome cardiotoxicity, assessed echocardiographically via left ventricular ejection fraction. Other clinical, physical, anthropometric outcomes biological hormonal variables also after diagnosis, 1 year ends, 3 years ends.Given effect on patient survival, mitigation priority, physical therapists have an important role this mitigation. If ATOPE returns better cardioprotection results, it may recommendable patients follow program.The highlight need for therapist from moment prevention or cancer. It could help establish adequate therapeutic dose adapted propose correct prescription according assimilation sessions.

Language: Английский

Effectiveness of exercise-based interventions in preventing cancer therapy-related cardiac dysfunction in patients with breast cancer: A systematic review and network meta-analysis DOI
Dandan Zhang, Xingyu Xiong,

Hexiao Ding

et al.

International Journal of Nursing Studies, Journal Year: 2025, Volume and Issue: 163, P. 104997 - 104997

Published: Jan. 10, 2025

Language: Английский

Citations

3
Harms of exercise training in patients with cancer undergoing systemic treatment: a systematic review and meta-analysis of published and unpublished controlled trials DOI Creative Commons
Simon Nørskov Thomsen, Ian M. Lahart,

Laura M. Thomsen

et al.

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 59, P. 101937 - 101937

Published: April 6, 2023

Exercise is recommended for people with cancer. The aim of this study was to evaluate the harms exercise in patients cancer undergoing systemic treatment.

Language: Английский

Citations

35
Mechanisms of trastuzumab induced cardiotoxicity – is exercise a potential treatment? DOI Creative Commons
Holden Eaton, Kerstin N. Timm

Cardio-Oncology, Journal Year: 2023, Volume and Issue: 9(1)

Published: April 25, 2023

Abstract The use of the adjuvant therapeutic antibody trastuzumab in breast cancer is associated with a range cardiotoxic side effects despite successfully reducing severity outcomes patients,. most common cardiac effect, reduction left ventricular ejection fraction (LVEF), known precursor to heart failure and often requires interruption chemotherapy avoid endangering patients further. An understanding trastuzumab’s cardiac-specific interactions therefore critical devising new methods not only permanent damage, but also prolong treatment time, effectiveness, for patients. Increasingly, exercise as has been indicated across field cardio-oncology due encouraging evidence that it can protect against LVEF reductions failure. This review explores mechanisms trastuzumab-mediated cardiotoxicity, well physiological on heart, order assess suitability intervention antibody-therapy. We furthermore draw comparison existing cardioprotective doxorubicin-induced cardiotoxicity. Although preclinical seems support exercise-based approaches trastuzumab-cardiotoxicity, current clinical too limited confidently recommend treatment, largely owing issues adherence. Future studies should examine how variety duration be adjusted improve effectiveness at more personalised level.

Language: Английский

Citations

24
Exercise-based cardio-oncology rehabilitation for cardiotoxicity prevention during breast cancer chemotherapy: The ONCORE randomized controlled trial DOI Creative Commons
Estíbaliz Díaz-Balboa, Carlos Peña, Beatriz Rodríguez‐Romero

et al.

Progress in Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 85, P. 74 - 81

Published: Feb. 21, 2024

Breast cancer (BC) treatment with anthracyclines and/or anti-human epidermal growth factor receptor-2 (HER2) antibodies is associated an increased risk of cardiovascular disease complications, including therapy-related cardiac dysfunction (CTRCD). While Cardio-Oncology Rehabilitation (CORe) programs exercise have emerged to minimize these risks, its role in preventing CTRCD unclear.

Language: Английский

Citations

12
The efficacy and safety of exercise regimens to mitigate chemotherapy cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Ahmed Mazen Amin, Yehya Khlidj, Mohamed Abuelazm

et al.

Cardio-Oncology, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 23, 2024

Abstract Background Cardiotoxicity is one of the most common adverse events chemotherapy. Physical exercise was shown to be cardioprotective. We aim estimate efficacy and safety in cancer patients receiving cardiotoxic Methods conducted a systematic review meta-analysis randomized controlled trials (RCTs), which were retrieved by systematically searching PubMed, Web Science, SCOPUS, Cochrane, Clinical Trials.gov, MedRxiv through July 17th, 2023. used RevMan V. 5.4 pool dichotomous data using risk ratio (RR) continuous mean difference (MD), with 95% confidence interval (CI). PROSPERO ID: CRD42023460902. Results included thirteen RCTs total 952 patients. Exercise significantly increased VO 2 peak (MD: 1.95 CI [0.59, 3.32], P = 0.005). However, there no significant effect regarding left ventricular ejection fraction, global longitudinal strain, cardiac output, stroke volume, end-diastolic end-systolic E/A ratio, resting heart rate, systolic blood pressure, diastolic pressure. Also, any (AEs) (RR: 4.44 [0.47, 41.56], 0.19), AEs leading withdrawal 2.87 [0.79, 10.43], 0.11), serious 3.00 [0.14, 65.90], 0.49), or all-cause mortality 0.25 [0.03, 2.22], 0.21). Conclusion associated between usual care echocardiographic outcomes.

Language: Английский

Citations

9
Comment on Zhang et al. (2025) ‘Effectiveness of exercise-based interventions in preventing cancer therapy-related cardiac dysfunction in patients with breast cancer: A systematic review and network meta-analysis’ DOI
Da Qian, HaiFeng Su,

Xuli Meng

et al.

International Journal of Nursing Studies, Journal Year: 2025, Volume and Issue: unknown, P. 105106 - 105106

Published: April 1, 2025

Language: Английский

Citations

1
Six-Minute Walk Distance in Breast Cancer Survivors—A Systematic Review with Meta-Analysis DOI Open Access

Jasna But-Hadžić,

Mirza Dervisevic,

Damir Karpljuk

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(5), P. 2591 - 2591

Published: March 5, 2021

The six-minute walk test (6MWT) is a widely used for the indirect measurement of cardiorespiratory fitness in various cancer populations. Although 6MWT simple test, there are no normative values breast survivors (BCS) or comparisons results with healthy counterparts. A systematic review meta-analysis was carried out, which included studies from 2007 to 2020. Ninety-one were found, 21 quantitative synthesis. Among them 9 randomized controlled trials (RCT), 8 prospective cohort and 4 cross-sectional studies. total 1084 BCS included. Our revealed that subjects (n = 878) covered significantly greater distance than during (589.9 m vs. 477.4 m, p < 0.001), meta-regression analysis showed 6MWD predicted by participants’ BMI (p but not their age 0.070). After adjustment BMI, also distances (103 m; 0.001). presented BCS. Besides, distinguish between counterparts, therefore, relevant parameter assessment monitoring medical exercise interventions

Language: Английский

Citations

37
Incorporating Exercise Training into Cardio-Oncology Care DOI Creative Commons
Rebekah L. Wilson, Cami N. Christopher, Eric H. Yang

et al.

JACC CardioOncology, Journal Year: 2023, Volume and Issue: 5(5), P. 553 - 569

Published: Oct. 1, 2023

Cancer treatment–induced cardiotoxicities are an ongoing concern throughout the cancer care continuum from treatment initiation to survivorship. Several "standard-of-care" primary, secondary, and tertiary prevention strategies available prevent development or further progression of their risk factors. Despite exercise's established benefits on cardiovascular system, it has not been widely adopted as a nonpharmacologic cardioprotective strategy within cardio-oncology care. In this state-of-the-art review, authors discuss cardiotoxicities, review existing evidence supporting role exercise in preventing managing these sequelae at-risk affected individuals living after diagnoses, propose considerations for implementing exercise-based services practice.

Language: Английский

Citations

16
Preventing broken hearts in women with breast cancer: a concise review on chemotherapy-mediated cardiotoxicity DOI Creative Commons

Hilary Bews,

Lana Mackic,

Davinder S. Jassal

et al.

Canadian Journal of Physiology and Pharmacology, Journal Year: 2024, Volume and Issue: 102(9), P. 487 - 497

Published: Sept. 1, 2024

Cancer and cardiovascular disease are the leading causes of death for Canadian women. One in eight women will receive life-changing diagnosis breast cancer (BC) their lifetime, with 1 34 dying from disease. Although doxorubicin (DOX) trastuzumab (TRZ) have significantly improved survival diagnosed human epidermal growth factor receptor 2 (HER2)-positive BC, approximately one four who this treatment at risk developing chemotherapy-induced cardiotoxicity. Cardiotoxicity is defined as a decline left ventricular ejection fraction (LVEF) >10% to an absolute value <53%. Current guidelines recommend serial monitoring LVEF patient population using non-invasive cardiac imaging modalities including transthoracic echocardiography or multi-gated acquisition scan; however, only allow detection established Recent studies demonstrated that reduction global longitudinal strain by speckle tracking can identify pre-clinical systolic dysfunction prior overall LVEF. Implementation early techniques would prompt initiation cardioprotective strategies. In addition chemotherapy-mediated cardiotoxicity, prophylactic use angiotensin-converting enzyme inhibitors, angiotensin blockers, β-blockers, statins, exercise, nutraceutical therapies been studied setting cardio-oncology.

Language: Английский

Citations

6
Effects of aerobic combined with resistance exercise on cardiorespiratory fitness and cardiometabolic health in breast cancer survivors: A Systematic Review, meta-analysis and meta-regression DOI Creative Commons

Linjie Cheng,

Wenxiang Tian,

Hua Mu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(4), P. e26318 - e26318

Published: Feb. 1, 2024

Cardiotoxicity from chemotherapy is a serious risk to the quality of survival breast cancer survivors (BCS), and aerobic combined with resistance exercise (CE) has potential combat this cardiac damage. However, there lack high-quality studies assess specific effects CE. This study aimed investigate CE on cardiopulmonary function (CRF) cardiometabolic health in BCS.

Language: Английский

Citations

4