Sci,
Journal Year:
2024,
Volume and Issue:
6(4), P. 83 - 83
Published: Dec. 10, 2024
This
study
presents
the
synthesis
of
metal
nanoparticles
(NPs)
with
antimicrobial
properties
from
cyanobacterial
biomass.
Silver
(AgNP),
copper
(CuNP),
and
zinc
(ZnNP)
were
prepared
exopolysaccharides
(EPSs)
obtained
isolated
strains.
The
activity
AgNPs
against
Escherichia
coli
Staphylococcus
aureus
was
evaluated,
compared
CuNPs
ZnNPs,
found
to
have
a
greater
capacity
inhibit
bacterial
growth.
main
factors
influencing
are
concentration
type
used.
Using
an
optimized
experimental
design,
specific
conditions
established
maximize
efficacy
synthesized
NPs.
characterization
included
UV–VIS,
FTIR,
EDX
techniques,
which
confirmed
formation
purity
AgNPs.
highlights
effectiveness
EPS
as
reducing
stabilizing
agent
provides
sustainable
efficient
alternative
for
producing
biomedical
applications.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 7, 2024
Abstract
The
current
research
aimed
to
study
the
green
synthesis
of
silver
oxide
nanoparticles
(AgONPs)
using
Rhynchosia
capitata
(RC)
aqueous
extract
as
a
potent
reducing
and
stabilizing
agent.
obtained
RC-AgONPs
were
characterized
UV,
FT-IR,
XRD,
DLS,
SEM,
EDX
investigate
morphology,
size,
elemental
composition.
size
was
found
be
~
21.66
nm
an
almost
uniform
distribution
executed
by
XRD
analysis.
In
vitro
studies
performed
reveal
biological
potential.
AgONPs
exhibited
efficient
DPPH
free
radical
scavenging
potential
(71.3%),
power
(63.8
±
1.77%),
total
antioxidant
capacity
(88.5
4.8%)
estimate
their
antioxidative
power.
Antibacterial
antifungal
potentials
evaluated
disc
diffusion
method
against
various
bacterial
fungal
strains,
zones
inhibition
(ZOI)
determined.
A
brine
shrimp
cytotoxicity
assay
conducted
measure
(LC
50
:
2.26
μg/mL).
addition,
biocompatibility
tests
evaluate
biocompatible
nature
red
blood
cells,
HEK,
VERO
cell
lines
(<
200
An
alpha-amylase
carried
out
with
67.6%
inhibition.
Moreover,
vitro,
anticancer
activity
Hep-2
liver
cancer
lines,
LC
value
45.94
μg/mL
achieved.
Overall,
present
has
demonstrated
that
utilization
R.
for
biosynthesis
offers
cost-effective,
eco-friendly,
forthright
alternative
traditional
approaches
nanoparticle
synthesis.
significant
bioactive
properties,
positioning
them
promising
candidates
diverse
applications
in
spheres
medicine
beyond.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(3)
Published: Jan. 1, 2025
Abstract
The
aim
of
this
study
was
to
explore
the
potential
bio‐silver
nanoparticles
(Ag‐NPs)
synthesized
from
Tetraclinis
articulata
extract,
a
Moroccan
plant,
for
treatment
inflammatory
diseases
related
oxidative
stress,
such
as
arthritis,
cardiovascular
and
metabolic
disorders.
objective
reduce
inflammation
neutralize
free
radicals
by
transferring
therapeutic
properties
secondary
metabolites
plant
nanoparticles.
synthesis
Ag‐NPs
carried
out
an
environmentally
friendly
method,
using
exclusively
extract.
results
showed
that
formation
induced
dark
brown
color
change,
accompanied
absorption
peak
at
450
nm
in
UV‐visible
spectrum,
specific
Scanning
electron
microscopy
analysis
revealed
spherical
approximately
80
nm,
X‐ray
spectroscopy
confirmed
presence
silver.
FTIR
identified
phenolic
compounds
(flavonoids,
polyphenols)
sugars,
responsible
reduction
silver
ions
stability
On
bioactive
level,
these
strong
antioxidant
anti‐inflammatory
potential,
with
activity
comparable
control,
without
cellular
toxicity,
cell
proliferation
tests.
These
open
new
perspectives
targeted
applications,
highlighting
importance
sustainable
methods.
European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
11, P. 100169 - 100169
Published: May 16, 2024
NSAIDs,
glucocorticoids,
aminosalicylates,
and
immunosuppressants
are
nowadays
the
most
commonly
used
anti-inflammatory
medicines,although
they
have
cosiderable
side
effects.
Nanoparticles
(NPs),
notably
metallic
NPs,
gained
appeal
in
development
of
safer
drugs.
Because
conventional
NP
synthesis
methods
limited
by
environmentally
unfriendly
chemicals
high
energy
consumption,
alternative
green
metal
oxide
including
plant-mediated
synthesis,
has
piqued
interest
researchers
due
to
phytochemicals
that
can
reduce
precursors
stabilize
generated
NPs.
This
method
is
an
eco-friendly,
non-toxic,
cost-effective.
review
aimed
highlight
studies
concerningthe
activity
different
nanoparticles
with
properties
covering
papers
since
2017.
According
findings,
majority
NPs
tested
were
AgNPs.
Noticeably,
few
investigations
conducted
assess
stability
safety
these
Remarkably,
someNPs
exert
more
than
plant
extract
itself
standard.
Some
tests
vitro
testing.
Obviously,
there
a
lack
information
regarding
issues
determination
their
active
doses.Thus,
further
invitro
invivo
pharmacological
toxicological
studiesare
required
for
identify
medicinal
uses
avoid
unintended
adverse
consequences.It
also
urgent
test
various
dosage
forms
after
determining
optimal
dose
Journal of Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
ABSTRACT
The
purpose
of
the
present
study
was
to
develop
a
nano‐coating
for
fresh
vegetables
and
fruits
using
combination
curcumin,
sesame
oil,
stearic
acid,
dextran
(CSSDNs).
anti‐bacterial
nontoxic
nature
nanoparticles
were
tested
against
Gram‐positive
bacteria
(
Staphylococcusaureus
)
human
fibroblast
cells.
Enhanced
aqueous
solubility
curcumin
its
stability
in
bloodstream
observed
from
vitro
blood
compatibility
studies.
anti‐cancer
activity
curcumin‐loaded
SK‐BR3
cells,
demonstrating
excellent
antitumor
activity.
These
findings
indicate
that
CSSDNs
system
can
be
used
as
an
edible
coating
with
strong
antibacterial
properties
effective
means
delivering
which
has
proven
successful
treating
or
preventing
cancer.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(8), P. e0297716 - e0297716
Published: Aug. 6, 2024
Magnetic
drug
delivery
systems
using
nanoparticles
present
a
promising
opportunity
for
clinical
treatment.
This
study
explored
the
potential
anti-inflammatory
properties
of
RosA-
CrFe
2
O
4
nanoparticles.
These
were
developed
through
rosmarinic
acid
(RosA)
co-precipitation
via
photo-mediated
extraction
technique.
XRD,
FTIR,
and
TEM
techniques
employed
to
characterize
nanoparticles,
results
indicated
that
they
had
cubic
spinel
ferrite
(FCC)
structure
with
an
average
particle
size
25nm.
The
antioxidant
evaluated
by
LPS-induced
raw
264.7
macrophages
hydrogen
peroxide
scavenging
assay,
respectively.
showed
moderate
DPPH
effects
IC50
value
59.61±4.52μg/ml.
Notably,
these
effectively
suppressed
expression
pro-inflammatory
genes
(IL-1β,
TNF-α,
IL-6,
iNOS)
in
LPS-stimulated
cells.
Additionally,
activity
was
confirmed
reducing
release
secretory
cytokines
(IL-6
TNF-α)
macrophages.
investigation
highlights
Phyto-mediated
-RosA
as
agent
biomedical
applications.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 16, 2024
Abstract
The
green
synthesis
of
Iron
oxide
nanoparticles
(IONPs)
has
shown
numerous
advantages
over
conventional
physical
and
chemical
methods
as
these
non-ecofriendly
uses
toxic
chemicals
complicated
equipments.
In
present
study,
were
created
using
simple,
sustainable,
eco-friendly
chemistry
protocol.
roots
novel
medicinal
plant
Sageretia
thea
was
used
a
bio-template
for
the
preparation
IONPs.
Further,
IONPs
confirmed
different
analytical
tools
like
UV-Vis,
FT-IR,
XRD,
EDX,
SEM.
average
sizes
(NPs)
found
to
be
16.04
nm.
asynthesized
evaluated
several
biological
potentials
including
antibacterial,
antifungal
Anti-radical
(DPPH)
cytotoxicity
assays.
Antibacterial
potencies
investigated
bacterial
strains
(in
concentration
range
1000–31.25
µg/mL)
revealing
significant
antibacterial
potentials.
ABA
SAU
reported
least
susceptible
while
KPN
observed
most
strain
in
bactericidal
studies.
fungal
investigate
revealed
strong
against
pathogenic
strains.
Furthermore,
MRA,
FA
ANI
fungicidal
examination.
Significant
potential
examined
brine
shrimps
assay,
thus
cytotoxic
IC
50
S.
based
recorded
33.85
µg/mL.
Strong
anti-radical
assay
performed
evaluate
ROS
scavenging
S.T@IONPs.
highest
noted
78.06%,
TRP
81.92%
TAC
84%
on
maximum
200
summary,
our
experimental
results
concluded,
that
have
antifungal,
DPPH
can
applications.
nutshell,
as-prepared
bioactivities
we
recommend,
other
vitro
vivo
further
analyze
Caused
by
pathogenic
microorganisms,
such
as
bacteria,
parasites,
fungi,
among
others,
infectious
diseases
can
spread
directly
or
from
one
individual
to
another.
According
the
World
Health
Organization,
these
are
known
cause
high
mortality
rates,
severe
burdens
of
disability
and
serious
worldwide
aftermaths.
The
inappropriate
use
antibiotics
in
humans
main
origins
development
drug-resistant
pathogens,
which
reduce
efficacy
therapies,
thus
accentuating
need
search
for
effective
antimicrobials.
Medicinal
plants
have
served
starting
material
preparation
a
number
antimicrobial
agents.
To
this
end,
present
study
highlights
green
synthesis
Cocos
nucifera-based
nanomaterials
evaluation
mechanistic
basis
their
action.
Accordingly,
nucifera
extract
was
used
different
concentrations
(5,
10
20
mM)
silver
nitrate
solution
afford
nanoparticles
(AgNPs).
These
entities
were
further
incorporated
onto
activated
carbons
(obtained
chemical
activation
using
sulphuric
acid
agent)
generate
nanocomposites.
activity
as-prepared
evaluated
broth
microdilution
method,
while,
antioxidant
assessed
through
standard
methods,
2,2-diphenyl-1-picrylhydrazyl
(DPPH),
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic
(ABTS)
assays.
Cytotoxicity
potent
on
Vero
cells
spectrophotometric
method.
As
result,
successfully
synthesized
evidenced
color
change
transparent
dark
brown.
Further
characterization
carried
out
UV-visible
spectroscopy
that
showed
an
intense
absorption
spectrum
at
433
nm.
Fourier
Transform
Infrared
Spectroscopy
(FTIR)
revealed
functional
group
moieties
involved
capping
reducing
agent
AgNPs.
incubation
with
selected
bacterial
fungal
strains
led
significant
inhibitory
effects
pathogens
minimum
ranging
7.813
250
μg/ml.
In
assays,
nanocomposites
presented
scavenging
activities
comparable
ascorbic
acid.
experiment
no
toxic
human
mammalian
(range
selectivity
indices:
&gt;4
&gt;128).
results
provide
evidence
implication
targeting
systems
mediate
free-radical
damage
inhibiting
oxidative
caused
bacteria
most
susceptible
being
Escherichia
coli
Candida
albicans,
respectively.
Micro,
Journal Year:
2024,
Volume and Issue:
4(4), P. 706 - 720
Published: Nov. 20, 2024
The
search
for
new
synthesis
methodologies
based
on
the
principles
of
green
chemistry
has
led
to
various
studies
production
silver
nanoparticles
(AgNPs)
using
extracts
from
different
parts
plants.
Based
this,
present
study
aims
carry
out
(biosynthesis),
characterization,
and
antibacterial
evaluation
reduced
stabilized
with
aqueous
Minthostachys
acris
in
a
simple,
ecological,
environmentally
safe
manner.
extraction
process
organic
components
is
performed
two
methods:
immersion
agitation
leaves
Schmidt
Lebuhn
(Muña)
at
0.1%
times
(0.5,
1,
3,
6,
10
min).
Compounds
such
as
hydroxycinnamic
acid
derivatives,
quinic,
caffeic,
rosmarinic
acids,
flavonols
Muña
extract
facilitate
formation
AgNPs;
this
compounds
act
coating
stabilizing
agent.
bioactive
natural
resources
AgNPs,
partially
or
completely
replacing
contaminating
toxic
elements
chemical
reagents.
biosynthesis
carried
room
temperature
pH
7
8.
synthesized
AgNPs
are
characterized
by
UV-visible
spectroscopy
identify
surface
plasmon
resonance
(SPR)
band,
which
shows
an
absorption
peak
around
419
nm
423
p.H
8,
respectively,
Fourier-transform
infrared
(FTIR)
possible
biomolecules
responsible
bioreduction
stabilization,
1634
cm−1.
Dynamic
light
scattering
(DLS)
hydrodynamic
size
colloidal
between
11
200
nm,
scanning
electron
microscopy
(SEM)
reveals
monodisperse
morphologies,
mostly
nanospheres,
while
Laser-Induced
Breakdown
Spectroscopy
(LIBS)
demonstrates
presence
Ag
solution.
bactericidal
activity
disk
diffusion
method
against
Escherichia
coli
(E.
coli)
Staphylococus
aureus
(S.aureus)
that
have
effective
E.
obtained
6
min
both
methods,
respectively.
significance
work
lies
use
plants
obtain
rapid,
economical
way,
potential
applications
biomedical
fields.
