Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Pharmaceutics, Journal Year: 2020, Volume and Issue: 13(1), P. 4 - 4

Published: Dec. 22, 2020

With the growth of aging population worldwide, chronic wounds represent an increasing burden to healthcare systems. Wound healing is complex and not only affected by patient's physiological conditions, but also bacterial infections inflammation, which delay wound closure re-epithelialization. In recent years, there has been a growing interest for electrospun polymeric dressings with fiber diameters in nano- micrometer range. Such display number properties, support accelerate healing. For instance, they provide physical mechanical protection, exhibit high surface area, allow gas exchange, are cytocompatible biodegradable, resemble structure native extracellular matrix, deliver antibacterial agents locally into wound. This review paper gives overview on biodegradable fibrous obtained electrospinning proteins peptides animal plant origin years. Focus placed requirements fabrication such drug delivery systems as well their properties therapeutic potential. Moreover, incorporation antimicrobial fibers or attachment onto activity discussed.

Language: Английский

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Polymeric wound dressings, an insight into polysaccharide-based electrospun membranes

Applied Materials Today, Journal Year: 2021, Volume and Issue: 24, P. 101148 - 101148

Published: Aug. 10, 2021

Language: Английский

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Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications

Polymers, Journal Year: 2021, Volume and Issue: 13(8), P. 1209 - 1209

Published: April 8, 2021

Natural polymers have been widely used for biomedical applications in recent decades. They offer the advantages of resembling extracellular matrix native tissues and retaining biochemical cues properties necessary to enhance their biocompatibility, so they usually improve cellular attachment behavior avoid immunological reactions. Moreover, a rapid degradability through natural enzymatic or chemical processes. However, present poor mechanical strength, which frequently makes manipulation processes difficult. Recent advances biofabrication, 3D printing, microfluidics, cell-electrospinning allow manufacturing complex polymer matrixes with biophysical structural similar those matrix. In addition, these techniques possibility incorporating different cell lines into fabrication process, revolutionary strategy broadly explored years produce cell-laden scaffolds that can better mimic functional tissues. this review, use electrospinning approaches has extensively investigated biofabrication naturally derived encapsulated cells intended (e.g., therapies, bone dental grafts, cardiovascular musculoskeletal tissue regeneration, wound healing).

Language: Английский

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Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

Polymers, Journal Year: 2021, Volume and Issue: 13(10), P. 1546 - 1546

Published: May 12, 2021

Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range injuries degenerative diseases skin. Nevertheless, many related studies demonstrated modest improvement organ functions due low survival rate transplanted cells at targeted injured area. Thus, incorporating into biomaterial offer niches cells, enhancing their delivery therapeutic effects. Currently, through skin approach, attempts have employed biomaterials as platform improve engraftment implanted facilitate function exogenous by mimicking microenvironment. This review aims identify limitations potentially highlight how use various can enhance efficiency regeneration post-implantation. Moreover, discusses combined effects vitro vivo settings followed identifying key factors contributing outcomes. Apart from biomaterials, role growth other cellular substitutes effective been mentioned. In conclusion, synergistic effect provided significant effectiveness outcomes mainly improvement.

Language: Английский

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Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

Journal of Functional Biomaterials, Journal Year: 2021, Volume and Issue: 12(4), P. 59 - 59

Published: Oct. 28, 2021

The rise of antibiotic resistance has become a major threat to human health and it is spreading globally. It can cause common infectious diseases be difficult treat leads higher medical costs increased mortality. Hence, multifunctional polymeric nanofibers with distinctive structures unique physiochemical properties have emerged as neo-tool target biofilm overcome deadly bacterial infections. This review emphasizes electrospun nanofibers’ design criteria that utilized enhance their therapeutic activity for antimicrobial therapy. Also, we present recent progress in designing the surface functionalization non-antibiotic agents effective antibacterial Lastly, discuss future trends remaining challenges nanofibers.

Language: Английский

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Valorization of Starch to Biobased Materials: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(11), P. 2215 - 2215

Published: May 30, 2022

Many concerns are being expressed about the biodegradability, biocompatibility, and long-term viability of polymer-based substances. This prompted quest for an alternative source material that could be utilized various purposes. Starch is widely used as a thickener, emulsifier, binder in many food non-food sectors, but research focuses on increasing its application beyond these areas. Due to low cost, renewability, abundance, starch considered "green path" raw generating porous substances such aerogels, biofoams, bioplastics, which have sparked academic interest. Existing has focused strategies developing biomaterials from organic polymers (e.g., cellulose), there been little polysaccharide counterpart (starch). review paper highlighted structure starch, context amylose amylopectin, extraction modification with their processes limitations. Moreover, this describes nanofillers, intelligent pH-sensitive films, aerogels types, precursors, including drying manufacturing. The perspectives reveal great potential starch-based food, pharmaceuticals, biomedicine, applications.

Language: Английский

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Evaluating polymeric biomaterials to improve next generation wound dressing design

Biomaterials Research, Journal Year: 2022, Volume and Issue: 26(1)

Published: Sept. 30, 2022

Abstract Wound healing is a dynamic series of interconnected events with the ultimate goal promoting neotissue formation and restoration anatomical function. Yet, complexity wound can often result in development complex, chronic wounds, which currently results significant strain burden to our healthcare system. The advancement new effective care therapies remains critical issue, current therapeutic modalities remaining inadequate. Notably, field tissue engineering has grown significantly last several years, part, due diverse properties applications polymeric biomaterials. interdisciplinary cohesion chemical, biological, physical, material sciences pertinent advancing understanding biomaterials generating modalities. However, there still room for closing gap between clinical science realms order more effectively develop novel that aid treatment complex wounds. Thus, this review, we discuss key principles context biomaterials, provide breadth how these affect dressing design, role innovation design next generation dressings.

Language: Английский

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Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

Antibiotics, Journal Year: 2021, Volume and Issue: 10(3), P. 248 - 248

Published: March 2, 2021

In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have a recurrent solution in both cases, with some reaching already market, even though their mechanical stability remains challenge. To overcome this limitation, reinforcement of hydrogels fibers explored. The structural resemblance fiber–hydrogel composites natural tissues driving force for optimization exploration these systems biomedicine. Indeed, combination hydrogel-forming techniques fiber spinning approaches crucial development scaffolding improved strength medicinal properties. review, comprehensive overview recently developed composite strategies delivery is provided. methodologies employed hydrogel formation are also highlighted, together most compatible polymer combinations, as well incorporation creating stimuli-sensitive triggered release towards an enhanced host response.

Language: Английский

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Polyurethane‐basedcomposites with promising antibacterial properties

Journal of Applied Polymer Science, Journal Year: 2022, Volume and Issue: 139(20)

Published: Feb. 3, 2022

Abstract Polyurethane (PU) is a well‐known synthetic polymer consisting of isocyanates, polyols, and chain extenders. The incorporation fillers into the PU polymeric matrix, including inorganic nanomaterials, polymers, natural components, quaternary ammonium salts, commercial drugs, bestows end‐products with unique improved physicochemical properties. Fillers can be used to tailor molecular orientation, crystallinity, cross‐linking, functional chemical groups PU‐based composites. bactericidal ability composites highly depends on their surface composition, morphology, charge, stability. Recent advancements highlight potential in combating bacterial infections. In this review, cutting‐edge organic‐based for antibacterial applications addressed. Notably, selective examples scientific reports' key findings crucial information are discussed. Furthermore, positive impact future prospects field explored. This review comprehensively deliberates values towards practical biomedical activity. help researchers gain widespread knowledge better understanding applications.

Language: Английский

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Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering

Polymers, Journal Year: 2022, Volume and Issue: 14(11), P. 2141 - 2141

Published: May 24, 2022

Tissue engineering technology aids in the regeneration of new tissue to replace damaged or wounded tissue. Three-dimensional biodegradable and porous scaffolds are often utilized this area mimic structure function extracellular matrix. Scaffold material design significant areas biomaterial research most favorable for seeding vitro vivo cells. Polyhydroxyalkanoates (PHAs) biopolyesters (thermoplastic) that appropriate application due their biodegradability, thermo-processability, enhanced biocompatibility, mechanical properties, non-toxicity, environmental origin. Additionally, they offer enormous potential modification through biological, chemical physical alteration, including blending with various other materials. PHAs produced by bacterial fermentation under nutrient-limiting circumstances have been reported perspectives devices biological applications. The present review discusses applications conventional medical devices, especially soft (sutures, wound dressings, cardiac patches blood vessels) hard (bone cartilage scaffolds) paper also addresses a recent advance highlighting usage implantable such as heart valves, stents, nerve guidance conduits nanoparticles, drug delivery. This summarizes biodegradability conducts an overview current scientific achievements development biomedical sector. In future, may synthetic plastics choice researchers practitioners.

Language: Английский

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