iScience,
Journal Year:
2024,
Volume and Issue:
27(6), P. 109845 - 109845
Published: April 29, 2024
The
field
of
small-diameter
vascular
grafts
remains
a
challenge
for
biomaterials
scientists.
While
decades
research
have
brought
us
much
closer
to
developing
biomimetic
materials
regenerating
tissues
and
organs,
the
physiological
challenges
involved
in
manufacturing
small
conduits
that
can
transport
blood
while
not
inducing
an
immune
response
or
promoting
clots
continue
limit
progress
this
area.
In
short
review,
we
present
some
most
recent
methods
advancements
made
by
researchers
working
grafts.
We
also
discuss
critical
aspects
scientists
should
consider
when
lab-made
Polymers,
Journal Year:
2022,
Volume and Issue:
14(9), P. 1661 - 1661
Published: April 20, 2022
Nowadays,
nanofibers
with
antimicrobial
activity
are
of
great
importance
due
to
the
widespread
antibiotic
resistance
many
pathogens.
Electrospinning
is
a
versatile
method
producing
ultrathin
fibers
desired
properties,
and
this
technique
can
be
optimized
by
controlling
parameters
such
as
solution/melt
viscosity,
feeding
rate,
electric
field.
High
viscosity
slow
rate
cause
blockage
spinneret,
while
low
high
result
in
fiber
discontinuities
or
droplet
formation.
The
field
must
properly
set
because
strength
shortens
solidification
time
fluid
streams,
unable
form
Taylor
cone.
Environmental
conditions,
temperature,
humidity
also
affect
electrospinning.
In
recent
years,
significant
advances
have
been
made
development
electrospinning
methods
engineering
electrospun
for
various
applications.
This
review
discusses
current
research
on
use
fabricate
composite
polymer
properties
incorporating
well-defined
nanoparticles
(silver,
titanium
dioxide,
zinc
copper
oxide,
etc.),
encapsulating
classical
therapeutic
agents
(antibiotics),
plant-based
bioactive
(crude
extracts,
essential
oils),
pure
compounds
(antimicrobial
peptides,
photosensitizers)
controlled
release
anti-degradation
protection.
analyzed
works
prove
that
process
an
effective
strategy
formation
biomedicine,
pharmacy,
food
industry.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1159 - 1159
Published: April 20, 2024
Natural
and
synthetic
polymers
are
a
versatile
platform
for
developing
biomaterials
in
the
biomedical
environmental
fields.
organic
compounds
that
found
nature.
The
most
common
natural
include
polysaccharides,
such
as
alginate,
hyaluronic
acid,
starch,
proteins,
e.g.,
collagen,
silk,
fibrin,
bacterial
polyesters.
have
already
been
applied
numerous
sectors,
carriers
drug
delivery,
tissue
engineering,
stem
cell
morphogenesis,
wound
healing,
regenerative
medicine,
food
packaging,
etc.
Various
polymers,
including
poly(lactic
acid),
poly(acrylic
poly(vinyl
alcohol),
polyethylene
glycol,
etc.,
biocompatible
biodegradable;
therefore,
they
studied
controlled
release
systems,
nano-carriers,
dispersion
of
biofilms,
gene
delivery
bio-ink
3D-printing,
textiles
agriculture,
heavy
metals
removal,
packaging.
In
following
review,
recent
advancements
polymer
chemistry,
which
enable
imparting
specific
functions
will
be
discussed
detail,
antiviral,
anticancer,
antimicrobial
activities.
This
work
contains
authors’
experimental
contributions
to
applications.
review
is
vast
overview
used
fields,
synthesis,
isolation
methods,
critically
assessessing
their
advantages,
limitations,
prospects.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 695 - 695
Published: Feb. 18, 2023
Modern
drug
discovery
methods
led
to
evolving
new
agents
with
significant
therapeutic
potential.
However,
their
properties,
such
as
solubility
and
administration-related
challenges,
may
hinder
benefits.
Moreover,
advances
in
biotechnology
resulted
the
development
of
a
generation
molecules
short
half-life
that
necessitates
frequent
administration.
In
this
context,
controlled
release
systems
are
required
enhance
treatment
efficacy
improve
patient
compliance.
Innovative
delivery
promising
tools
protect
proteins
peptides
against
proteolytic
degradation
where
is
achievable.
The
present
review
provides
an
overview
different
approaches
used
for
delivery.
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Jan. 30, 2023
Osteoarthritis
(OA)
is
the
most
common
type
of
degenerative
joint
disease
which
affects
7%
global
population
and
more
than
500
million
people
worldwide.
One
research
frontier
development
hydrogels
for
OA
treatment,
operate
either
as
functional
scaffolds
tissue
engineering
or
delivery
vehicles
additives.
Both
approaches
address
big
challenge:
establishing
stable
integration
such
systems
implants.
Adhesive
provide
possible
solutions
to
this
challenge.
However,
few
studies
have
described
current
advances
in
using
adhesive
hydrogel
treatment.
This
review
summarizes
commonly
used
with
their
adhesion
mechanisms
components.
Additionally,
recognizing
that
a
complex
involving
different
biological
mechanisms,
bioactive
therapeutic
strategies
are
also
presented.
By
presenting
an
interdisciplinary
way,
including
both
fields
chemistry
biology,
will
attempt
comprehensive
insight
designing
novel
bioadhesive
therapy.
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(7), P. 409 - 409
Published: July 5, 2024
The
aim
of
this
study
is
to
provide
an
overview
the
current
state-of-the-art
in
fabrication
bioceramic
scaffolds
for
bone
tissue
engineering,
with
emphasis
on
use
three-dimensional
(3D)
technologies
coupled
generative
design
principles.
field
modern
medicine
has
witnessed
remarkable
advancements
and
continuous
innovation
recent
decades,
driven
by
a
relentless
desire
improve
patient
outcomes
quality
life.
Central
progress
which
holds
immense
promise
regenerative
applications.
Scaffolds
are
integral
engineering
serve
as
3D
frameworks
that
support
cell
attachment,
proliferation,
differentiation.
A
wide
array
materials
been
explored
scaffolds,
including
bioceramics
(i.e.,
hydroxyapatite,
beta-tricalcium
phosphate,
bioglasses)
bioceramic–polymer
composites,
each
offering
unique
properties
functionalities
tailored
specific
Several
methods,
such
thermal-induced
phase
separation,
electrospinning,
freeze-drying,
gas
foaming,
particle
leaching/solvent
casting,
fused
deposition
modeling,
printing,
stereolithography
selective
laser
sintering,
will
be
introduced
thoroughly
analyzed
discussed
from
point
view
their
characteristics,
have
proven
invaluable
obtaining
scaffolds.
Moreover,
highlighting
important
role
scaffold
optimization,
review
seeks
pave
way
development
innovative
strategies
personalized
solutions
address
significant
gaps
literature,
mainly
related
complex
defects
engineering.
Journal of Tissue Viability,
Journal Year:
2025,
Volume and Issue:
34(2), P. 100858 - 100858
Published: Jan. 14, 2025
Despite
extensive
clinical
studies
and
therapeutic
interventions,
addressing
significant
skin
wounds
remains
challenging,
necessitating
novel
approaches
for
effective
regeneration
therapy.
In
the
current
review,
we
analyzed
evaluated
application,
advancements,
future
directions
of
biomaterials-based
scaffolds
tissue
construct.
addition,
investigated
role
other
biological
substitutes
in
promoting
wound
healing
regeneration.
The
review
highlights
impact
biomaterial-based
on
healing.
After
presenting
physiological
process
regeneration,
emphasizes
different
biochemical
components
Subsequently,
it
delves
into
engineering.
Recent
advancements
nanotechnology
are
also
highlighted
with
a
specific
focus
utilization
nanomaterials
enhancing
healing,
facilitating
reconstruction.
Biomaterial
have
emerged
as
potential
intervention
forming
foundation
These
scaffolds,
intricate
three-dimensional
frameworks,
serve
carriers
cells,
medications,
genes,
their
delivery
body.
integration
degradable
porous
cells
offers
promising
avenue
repair.
Biomaterials
play
crucial
engineering,
providing
temporary
mechanical
support
cellular
processes
to
augment
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Cancer
immunotherapy,
which
leverages
immune
system
components
to
treat
malignancies,
has
emerged
as
a
cornerstone
of
contemporary
therapeutic
strategies.
Yet,
critical
concerns
about
the
efficacy
and
safety
cancer
immunotherapies
remain
formidable.
Nanotechnology,
especially
polymeric
nanoparticles
(PNPs),
offers
unparalleled
flexibility
in
manipulation‐from
chemical
composition
physical
properties
precision
control
nanoassemblies.
PNPs
provide
an
optimal
platform
amplify
potency
minimize
systematic
toxicity
broad
spectrum
immunotherapeutic
modalities.
In
this
comprehensive
review,
basics
polymer
chemistry,
state‐of‐the‐art
designs
from
physicochemical
standpoint
for
encompassing
vaccines,
situ
vaccination,
adoptive
T‐cell
therapies,
tumor‐infiltrating
cell‐targeted
antibodies,
cytokine
therapies
are
delineated.
Each
immunotherapy
necessitates
distinctively
tailored
design
strategies
nanoplatforms.
The
extensive
applications
PNPs,
investigation
their
mechanisms
action
enhanced
particularly
focused
on.
profiles
clinical
research
progress
discussed.
Additionally,
forthcoming
developments
emergent
trends
nano‐immunotherapeutics
poised
transform
treatment
paradigms
into
clinics
explored.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(19), P. 10337 - 10337
Published: Sept. 25, 2021
The
success
of
modern
dental
treatment
is
strongly
dependent
on
the
materials
used
both
temporarily
and
permanently.
Among
all
materials,
polymers
are
a
very
important
class
with
wide
spectrum
applications.
This
review
aims
to
provide
state-of-the-art
overview
recent
advances
in
field
natural
maintain
or
restore
oral
health.
It
focuses
properties
most
common
proteins
polysaccharides
origin
terms
meeting
specific
biological
requirements
increasingly
demanding
dentistry.
use
naturally
derived
different
specialties
for
preventive
therapeutic
purposes
has
been
discussed.
major
fields
application
cover
caries
management
periodontal
diseases,
fabrication
membranes
scaffolds
regeneration
structures,
manufacturing
appliances
dentures
as
well
providing
systems
drug
delivery.
paper
also
includes
comparative
characteristic
synthetic
polymers.
Finally,
current
highlights
new
perspectives,
possible
future
advancements,
challenges
that
may
be
encountered
by
researchers
applications
origin.
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(12), P. 1727 - 1727
Published: Nov. 22, 2022
Chronic
diabetic
wounds
are
one
of
the
main
complications
diabetes,
manifested
by
persistent
inflammation,
decreased
epithelialization
motility,
and
impaired
wound
healing.
This
will
not
only
lead
to
repeated
hospitalization
patients,
but
also
bear
expensive
costs.
In
severe
cases,
it
can
amputation,
sepsis
or
death.
Electrospun
nanofibers
membranes
have
characteristics
high
porosity,
specific
surface
area,
easy
functionalization
structure,
so
they
be
used
as
a
safe
effective
platform
in
treatment
great
application
potential.
article
briefly
reviewed
pathogenesis
chronic
types
dressings
commonly
used,
then
development
electrospinning
technology
recent
years
advantages
electrospun
wounds.
Finally,
reports
different
nanofiber
on
summarized,
method
using
multi-drug
combination
therapy
is
emphasized,
which
provides
new
ideas
for
