Advancements in nanoparticle-based treatment approaches for skin cancer therapy

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Jan. 12, 2023

Skin cancer has emerged as the fifth most commonly reported in world, causing a burden on global health and economy. The enormously rising environmental changes, industrialization, genetic modification have further exacerbated skin statistics. Current treatment modalities such surgery, radiotherapy, conventional chemotherapy, targeted therapy, immunotherapy are facing several issues related to cost, toxicity, bioavailability thereby leading declined anti-skin therapeutic efficacy poor patient compliance. In context of overcoming this limitation, nanotechnological advancements been witnessed so far. Among various nanomaterials, nanoparticles endowed exorbitant advantages by acting both agents drug carriers for remarkable cancer. small size large surface area volume ratio escalate tumor uptake through their leaky vasculature resulting enhanced efficacy. context, present review provides up date information about different types pathology cancer, followed current associated drawbacks. Furthermore, it meticulously discusses role numerous inorganic, polymer, lipid-based therapy with subsequent descriptions patents clinical trials.

Language: Английский

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Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities

ACS Omega, Journal Year: 2023, Volume and Issue: 8(16), P. 14290 - 14320

Published: April 10, 2023

Cancer is ranked as the second leading cause of death globally. Traditional cancer therapies including chemotherapy are flawed, with off-target and on-target toxicities on normal cells, requiring newer strategies to improve cell selective targeting. The application nanomaterial has been extensively studied explored chemical biology tools in theranostics. It shows greater applications toward stability, biocompatibility, increased permeability, resulting precise targeting, mitigating shortcomings traditional therapies. nanoplatform offers an exciting opportunity gain targeting multifunctionality. advent nanotechnology, particular development smart nanomaterials, transformed diagnosis treatment. large surface area nanoparticles enough encapsulate many molecules ability functionalize various biosubstrates such DNA, RNA, aptamers, antibodies, which helps theranostic action. Comparatively, biologically derived nanomaterials perceive advantages over produced by conventional methods terms economy, ease production, reduced toxicity. present review summarizes techniques theranostics emphasizes (such organic (NPs), inorganic NPs, carbon-based NPs). We also critically discussed challenges impeding their translation treatment diagnostic applications. This concludes that use could significantly will facilitate new dimensions for tumor detection therapy.

Language: Английский

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Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment

Cancer Letters, Journal Year: 2023, Volume and Issue: 574, P. 216397 - 216397

Published: Sept. 18, 2023

Language: Английский

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Nanoparticle drug delivery systems for synergistic delivery of tumor therapy

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 16, 2023

Nanoparticle drug delivery systems have proved anti-tumor effects; however, they are not widely used in tumor therapy due to insufficient ability target specific sites, multidrug resistance drugs, and the high toxicity of drugs. With development RNAi technology, nucleic acids been delivered sites replace or correct defective genes knock down genes. Also, synergistic therapeutic effects can be achieved for combined delivery, which is more effective overcoming cancer cells. These combination therapies achieve better than delivering chemotherapeutic drugs alone, so scope has also expanded three aspects: drug-drug, drug-gene, gene-gene. This review summarizes recent advances nanocarriers co-delivery agents, including i) characterization preparation nanocarriers, such as lipid-based polymer inorganic carriers; ii) advantages disadvantages approaches; iii) effectual cases that applied systems; iv) future perspectives design nanoparticle co-deliver agents.

Language: Английский

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Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

Cancer is a severe disease that results in death all countries of the world. A nano-based drug delivery approach best alternative, directly targeting cancer tumor cells with improved cellular uptake. Different types nanoparticle-based carriers are advanced for treatment cancer, and to increase therapeutic effectiveness safety therapy, many substances have been looked into as carriers. Lipid-based nanoparticles (LBNPs) significantly attracted interest recently. These natural biomolecules alternate other polymers frequently recycled medicine due their amphipathic properties. Lipid typically provide variety benefits, including biocompatibility biodegradability. This review covers different classes LBNPs, characterization synthesis technologies. discusses most significant advancements lipid nanoparticle technology use administration. Moreover, also emphasized applications used types.

Language: Английский

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Clinical applications and therapeutic potentials of advanced nanoparticles: a comprehensive review on completed human clinical trials

Frontiers in Nanotechnology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 21, 2024

Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the potentials cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches major scientific databases, relevant studies published up March 2024 were included, focusing trials utilizing advanced for purposes. The discusses diverse applications oncology, infectious diseases, neurology, other medical fields. Additionally, it scrutinizes safety profiles, efficacy outcomes, challenges associated with nanoparticle-based therapies. findings underscore significant progress translating nanoparticle research into practice highlight potential these innovative platforms revolutionize treatments. contributes valuable insights growing field therapeutics, fostering deeper understanding implications practice.

Language: Английский

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Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.

Language: Английский

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Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 70 - 70

Published: Jan. 7, 2025

Malignant growth is expected to surpass other significant causes of death as one the top reasons for dismalness and mortality worldwide. According a World Health Organization (WHO) study, this illness approximately between 9 10 million instances deaths annually. Chemotherapy, radiation, surgery are three main methods treating cancer. These seek completely eradicate all cancer cells while having fewest possible unintended impacts on healthy cell types. Owing lack target selectivity, majority medications have substantial side effects. On hand, nanomaterials transformed identification, diagnosis, management Nanostructures with biomimetic properties been grown late, fully intent observing sickness. nanostructures be consumed by in areas profound disease. Furthermore, because their extraordinary physicochemical properties, which incorporate nanoscale aspects, more prominent surface region, explicit geometrical features, ability embody different substances within or outside surfaces, remarkable nano-vehicles conveying restorative specialists designated regions. This review discusses recent developments nanostructured materials such graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid magnetic nano-omics diagnosis

Language: Английский

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Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(12), P. 1960 - 1976.e9

Published: Dec. 1, 2022

Language: Английский

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Lipid-engineered nanotherapeutics for cancer management

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

Cancer causes significant mortality and morbidity worldwide, but existing pharmacological treatments are greatly limited by the inherent heterogeneity of cancer as a disease, well unsatisfactory efficacy specificity therapeutic drugs. Biopharmaceutical barriers such low permeability poor water solubility, along with absence active targeting capabilities, often result in suboptimal clinical results. The difficulty successfully reaching destroying tumor cells is also compounded undesirable impacts on healthy tissue, including off-target effects high toxicity, which further impair ability to effectively manage disease optimize patient outcomes. However, last few decades, development nanotherapeutics has allowed for use rational design order maximize success. Advances fabrication nano-sized delivery systems, coupled variety surface engineering strategies promote customization, have resulted promising approaches targeted, site-specific drug fewer unwanted better efficacy. These nano systems been able overcome some challenges conventional related pharmacokinetics, biodistribution, target specificity. In particular, lipid-based nanosystems extensively explored due their biocompatibility, versatility, adaptability. Lipid-based treatment varied diverse, liposomal therapeutics, lipidic nanoemulsions, solid lipid nanoparticles, nanostructured carriers, lipid-polymer nanohybrids, supramolecular nanolipidic structures. This review aims provide an overview diverse formulations lipid-engineered current field, researchers attempt translate these from bench clinic.

Language: Английский

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