Biomaterial Scaffolds for Periodontal Tissue Engineering

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 233 - 233

Published: Aug. 20, 2024

Advanced periodontitis poses a significant threat to oral health, causing extensive damage and loss of both hard soft periodontal tissues. While traditional therapies such as scaling root planing can effectively halt the disease’s progression, they often fail fully restore original architecture function tissues due limited capacity for spontaneous regeneration. To address this challenge, tissue engineering has emerged promising approach. This technology centers on utilization biomaterial scaffolds, which three-dimensional (3D) templates or frameworks, supporting guiding regeneration tissues, including ligament, cementum, alveolar bone, gingival tissue. These scaffolds mimic extracellular matrix (ECM) native aiming foster cell attachment, proliferation, differentiation, and, ultimately, formation new, functional structures. Despite inherent challenges associated with preclinical testing, intensification research coupled continuous advancement fabrication technology, leads us anticipate expansion in their application review comprehensively covers recent advancements engineered specifically regeneration, provide insights into current state field potential directions future research.

Language: Английский

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Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 24, 2024

Periodontal disease is the most common type of oral disease. bone defect clinical outcome advanced periodontal disease, which seriously affects quality life patients. Promoting tissue regeneration and repairing defects ultimate treatment goal for but means methods are very limited. Hydrogels a class highly hydrophilic polymer networks, their good biocompatibility has made them popular research material in field medicine recent years. This paper reviews current mainstream types characteristics hydrogels, summarizes relevant basic on hydrogels promoting repair The possible mechanisms action efficacy evaluation discussed depth, application prospects also discussed.

Language: Английский

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Preliminary study on the preparation of antler powder/chitosan/β-glycerophosphate sodium/polyvinyl alcohol porous hydrogel scaffolds and their osteogenic effects

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: June 26, 2024

Introduction: The production of bone-like structural scaffolds through bone tissue engineering technology is a promising method for regeneration to repair defects. Deer antler, an easily harvested and abundantly sourced initial structure, resembles the composition structure human cancellous can serve as new material allogeneic transplantation. Methods: This study involved preparation characterization antler powder/chitosan/β-glycerophosphate sodium/polyvinyl alcohol (AP/CS/β-GP/PVA) porous hydrogel verify their properties osteogenic mechanisms. microstructure, hydrophilicity, mechanical were studied using Scanning Electron Microscopy (SEM), contact angle measurement, universal testing machine. interactions between various components investigated Fourier-Transform Infrared Spectroscopy (FTIR). Biocompatibility, properties, expression osteogenesis-related proteins evaluated Cell Counting Kit-8 (CCK-8) assays, alkaline phosphatase staining, Alizarin Red live/dead cell Western blot analysis. Results: results showed that content deer powder increased, both hydrophilicity scaffold materials improved, while porosity slightly decreased with increase in content. culture experiments demonstrated higher proportion beneficial proliferation differentiation mouse pre-osteoblast (MC3T3-E1) cells, containing 10% 8% showing best effects. upregulation RUNX2, OCN, OSX, OPN protein may promote differentiation. Discussion: Therefore, AP/CS/β-GP/PVA have potential become biomaterial engineering.

Language: Английский

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Oral and maxillofacial mechanomedicine: Exploring biomechanical insights and their clinical implications

Translational dental research., Journal Year: 2025, Volume and Issue: 1(1), P. 100008 - 100008

Published: Jan. 1, 2025

Language: Английский

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Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration

International Journal of Oral Science, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 9, 2025

Abstract Regenerating periodontal bone defect surrounding tissue is crucial for orthodontic or dental implant treatment. The declined osteogenic ability of ligament stem cells (PDLSCs) induced by inflammation stimulus contributes to reduced capacity regenerate bone, which brings about a huge challenge treating periodontitis. Here, inspired the adhesive property mussels, we have created and mineralized hydrogel microspheres loaded with traditional compound cordycepin (MMS-CY). MMS-CY could adhere surface alveolar then promote migration PDLSCs thus recruit them inflammatory tissues. Furthermore, rescued impaired osteogenesis ligament-forming PDLSCs, were suppressed stimulus. Moreover, also displayed excellent inhibitory effect on osteoclastic activity. Mechanistically, inhibited premature senescence through nuclear factor erythroid 2-related (NRF2) pathway reducing DNA injury. Utilizing in vivo rat periodontitis model, was demonstrated enhance regeneration improving inhibiting Altogether, our study indicated that multi-pronged approach promising condition inflammation-induced cell maintaining homeostasis.

Language: Английский

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Enzymatically Cross-Linked Hydrogel Beads Based on a Novel Poly(aspartamide) Derivative

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 93 - 93

Published: Jan. 26, 2025

In recent years, hydrogel beads and in situ hydrogels have gained wide attention various fields such as biomedicine. this study, 3-(4-hydroxyphenyl) propionic acid (HP) was introduced into the side chain of poly(α,β-[N-(2-hydroxyethyl)-D,L-aspartamide]) (PHEA) to synthesize phenolic hydroxyl-functionalized poly(aspartamide) derivative PHEA-HP with enzyme-catalyzed cross-linking potential. First, chemical structure characterized by FT-IR, UV 1H NMR, results vitro cytotoxicity against L929 cell line hemolysis experiment showed that did not toxicity cells (viability > 90%) had good blood compatibility. Then, rheological measurement confirmed formation PHEA-HP-based a high storage modulus (G') around 104 Pa, vial-tilting method revealed gelation time aqueous solution could be tuned range 5-260 s varying concentrations hydrogen peroxide (H2O2) horseradish peroxidase (HRP). Finally, different diameters containing methylene blue (for easy observation) were prepared using coaxial needle syringe pumps, effect flow rate outer phase on also investigated. Therefore, may promising safe can used prepare for applications closely related human body.

Language: Английский

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Nanotechnology applications in oral pathology: A scoping review

Journal of Oral and Maxillofacial Pathology, Journal Year: 2025, Volume and Issue: 29(1), P. 127 - 136

Published: Jan. 1, 2025

Developments in tissue engineering, diagnosis, and therapy of oral diseases can be made possible by nanotechnology. The purpose this scoping review was to assess the state nanotechnology applications pathology at moment. A thorough search for research published between 2000 2024 done using various online data bases. Relevant studies were identified, screened, included accordance with Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines standards as per selection criterion. total 57 satisfied requirements inclusion. Significant findings show that disease, greatly enhances treatment delivery, regeneration capacity, diagnostic accuracy. Among most promising tools identified nanofibers, liposomes, quantum dots, gold nanoparticles. In field pathology, has great potential novel approaches early targeted therapy, regeneration. However, additional investigation are needed solve safety biocompatibility challenges.

Language: Английский

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Biomaterials for Guided Tissue Regeneration and Guided Bone Regeneration: A Review

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(4), P. 179 - 179

Published: April 21, 2025

This review aims to provide an overview of the types membranes, bone substitutes, and mucosal substitutes used for GTR GBR briefly explores recent innovations tissue regeneration their future perspectives. Since this is a narrative review, no systematic search, meta-analysis, or statistical analysis was conducted. Using biomaterials provides reduction in postoperative morbidity, as it contributes less invasive clinical procedures, serving alternative autogenous grafts. Moreover, randomized trials (RCTs) reviews are essential evaluation new biomaterials. These studies more robust evidence help guide practice selection safer effective biomaterials, allowing personalization treatment protocols each patient.

Language: Английский

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Hierarchical Biomaterial Scaffolds for Periodontal Tissue Engineering: Recent Progress and Current Challenges

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8562 - 8562

Published: Aug. 6, 2024

The periodontium is a complex hierarchical structure composed of alveolar bone, periodontal ligament, cementum, and gingiva. Periodontitis an inflammatory disease that damages destroys the tissues supporting tooth. Periodontal therapies aim to regenerate lost tissues, yet current treatments lack integration multiple structural/biochemical instructive cues induce coordinated regeneration, which leads limited clinical outcomes. Hierarchical biomaterial scaffolds offer opportunity recreate organization architecture with distinct compartments, providing structural biomimicry facilitates regeneration. Various have been fabricated tested preclinically, showing positive regenerative results. This review provides overview recent research on for tissue engineering (TE). First, described, covering limitations used regeneration presenting alternative therapeutic strategies, including biochemical factors. Recent regarding highlighted discussed, in particular, scaffold composition, fabrication methods, results from vitro/in vivo studies are summarized. Finally, challenges associated application TE debated future directions proposed.

Language: Английский

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CHITOSAN COLLAGEN HYDROGEL: A POTENTIAL SCAFFOLD BIOMATERIAL FOR PERIODONTAL REGENERATIVE TREATMENT

Interdental Jurnal Kedokteran Gigi (IJKG), Journal Year: 2024, Volume and Issue: 20(1), P. 124 - 132

Published: April 21, 2024

Introduction: Hydrogels are considered a promising scaffold biomaterial for regenerative periodontal treatment. The development of collagen and chitosan based hydrogels can improve the final characteristics hydrogel. Review: Collagen two main materials used to design scaffolds tissue engineering. is material that often develop because it has advantage high biocompatibility. In biomedical field, as drug delivery system. weak mechanical strength so other biomaterials needed its use. Chitosan biocompatibility slow degradation rate. So combination these strategic choice making in Conclusion: hydrogel potential

Language: Английский

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