Recent advances in nanoparticle-based photothermal therapy for breast cancer

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 349, P. 269 - 303

Published: July 9, 2022

Language: Английский

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Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine

Nanotheranostics, Journal Year: 2023, Volume and Issue: 7(4), P. 424 - 449

Published: Jan. 1, 2023

Medical imaging is an important factor for diagnosis.It can be used to diagnose patients, differentiate disease stages, and monitor treatment regimens.Although different technologies are available, MRI sensitive over other modalities as it capable of deep tissue penetration allowing image the anatomical, structural, molecular level diseased organs.Thus, screening tool staging.One components contrast agents which increase sensitivity technology.While types iron-oxide based nanoparticles (IONPS) widely these easy formulate, functionalize, biocompatible cost effective.In addition its use agents, have been drug carriers diseases ranging from cancer, cardiovascular diseases, neurological disorders, autoimmune infectious diseases.For last two decades, there has advancement in nanotheranostics, where IONPs formulated carry one system so that image-guided therapy real-life response tissue.This technology stratify patients into responders non-responders reduce adverse toxicity lead a tailored treatment.However, success nanotheranostics depends on several factor, including identification associated biomarkers targeted during formulation.While many challenges exist clinical translation still potential implemented personalized strategy.In this review article, we discussed relation their application diagnosis medicine.

Language: Английский

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Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies

Micro, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 3, 2025

Due to their biocompatibility, nontoxicity, and surface conjugation properties, nanomaterials are effective nanocarriers capable of encapsulating chemotherapeutic drugs facilitating targeted delivery across the blood–brain barrier (BBB). Although research on nanoparticles for brain cancer treatment is still in its early stages, these systems hold great potential revolutionize drug delivery. Glioblastoma multiforme (GBM) one most common lethal tumors, heterogeneous aggressive nature complicates current treatments, which primarily rely surgery. One significant obstacles poor penetration BBB. Moreover, GBM often referred as a “cold” tumor, characterized by an immunosuppressive tumor microenvironment (TME) minimal immune cell infiltration, limits effectiveness immunotherapies. Therefore, developing novel, more treatments critical improving survival rate patients. Current strategies enhancing outcomes focus controlled, agents cells BBB using nanoparticles. These therapies must be designed engage specialized transport systems, allowing efficient penetration, improved therapeutic efficacy, reduced systemic toxicity degradation. Lipid inorganic can enhance while minimizing side effects. formulations may include epitopes—small antigen fragments that bind directly free antibodies, B receptors, or T receptors—that interact with enable crossing, thereby boosting efficacy. Lipid-based (LNPs), such liposomes, niosomes, solid lipid (SLNs), nanostructured carriers (NLCs), among promising due unique including size, modification capabilities, proven biosafety. Additionally, gold nanoparticles, mesoporous silica, superparamagnetic iron oxide dendrimers offer alternatives. Inorganic (INPs) easily engineered, surfaces modified various elements biological ligands delivery, biocompatibility. Strategies engineering functionalization have been employed ensure biocompatibility reduce cytotoxicity, making safer clinical applications. The use INPs has shown promise efficacy traditional like chemotherapy, radiotherapy, gene therapy, well advancing newer strategies, immunotherapy, photothermal photodynamic therapies, magnetic hyperthermia. This article reviews latest treating GBM, focusing active passive targeting approaches.

Language: Английский

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PET‐Based Dual‐Modal Probes for In Vivo Imaging

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Molecular imaging has significantly advanced the detection and analysis of in vivo metabolic processes, while single‐modal techniques remain limited. Dual‐modal imaging, particularly positron emission tomography (PET)‐based combinations emerged as a powerful solution, offering enhanced capabilities through integration with magnetic resonance (MRI) or near‐infrared fluorescence (NIRF) imaging. This review highlights recent progress PET‐based dual‐modal focusing on development various bimodal probes derived from antibodies, nanoparticles, peptides, key applications including image‐guided surgery disease assessment. holds substantial potential for advancing research diagnostics by improving resolution providing functional insights. By combining complementary modalities, these systems deliver more comprehensive view leading to accurate diagnoses targeted treatments. Future prioritizes optimizing probe design biocompatibility safety, facilitating clinical translation, broadens beyond cancer. Through interdisciplinary collaboration, are poised play pivotal role patient outcomes, diagnosing managing complex diseases.

Language: Английский

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Emerging Application of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer

Polymers, Journal Year: 2021, Volume and Issue: 13(23), P. 4146 - 4146

Published: Nov. 27, 2021

Cancer is a disease that has resulted in millions of deaths worldwide. The current conventional therapies utilized for the treatment cancer have detrimental side effects. This led scientific researchers to explore new therapeutic avenues with an improved benefit risk profile. Researchers found nanoparticles, particles between 1 and 100 nm range, be encouraging tools area cancer. Magnetic nanoparticles are one many available at present. increasingly been receiving considerable amount attention recent years owing their unique magnetic properties, among others. can controlled by external field, signifying ability site specific. most popular approaches synthesis co-precipitation, thermal decomposition, hydrothermal, polyol synthesis. functionalization essential as it significantly increases biocompatibility. agents comprised polymers. will further explored this review. biomedical applications investigated review drug delivery, hyperthermia, diagnosis. diagnosis aspect focuses on utilization contrast resonance imaging. Clinical trials toxicology studies relating application also discussed

Language: Английский

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Iron oxide nanoparticles and their pharmaceutical applications

Applied Surface Science Advances, Journal Year: 2022, Volume and Issue: 11, P. 100284 - 100284

Published: Aug. 11, 2022

The importance of different polymorphic forms iron oxide nanoparticles attracted a lot attentions in various applications due to their unique electrical, optical and magnetic properties. Moreover, the excellent biocompatibility, high surface area, spherical shape, tunable nanoscale size availability synthesis route make them desirable biological pharmaceutical applications. To this aim, review, methods were discussed, also main characterization techniques used for elucidation reviewed. exploitation nanoparticles-based systems as anticancer, antiviral, antimicrobial agents its involvement drug delivery system reviewed details. Additionally, influence reagent type conditions utilized was highlighted.

Language: Английский

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Serum Albumin for Magnetic Nanoparticles Coating

Magnetochemistry, Journal Year: 2022, Volume and Issue: 8(2), P. 13 - 13

Published: Jan. 20, 2022

Magnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide demonstrated a promising effect various biomedical applications due to their high magnetic properties, large surface area, stability, easy functionalization. However, colloidal biocompatibility, toxicity of MNPs physiological environments are crucial for vivo application. this context, many research articles focused on the possible procedures coating improve physic-chemical biological properties. This review highlights one viable fabrication strategy biocompatible using human serum albumin (HSA). HSA is mainly transport protein with functions fundamental processes. As it most abundant plasma proteins, not single drug blood passes without its strength test. It influences pharmacokinetics, biodistribution different drug-delivery systems by binding or forming corona surface. The development albumin-based carriers gaining increasing importance targeted delivery cancer therapy. Considering this, highly candidate theranostics area can provide prolonged circulation, possibly resolve drug-resistance problem.

Language: Английский

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Magnetite Nanoparticles for Biomedical Applications

Encyclopedia, Journal Year: 2022, Volume and Issue: 2(4), P. 1811 - 1828

Published: Nov. 14, 2022

Magnetic nanoparticles (MNPs) have great potential in various areas such as medicine, cancer therapy and diagnostics, biosensing, material science. In particular, magnetite (Fe3O4) are extensively used for numerous bioapplications due to their biocompatibility, high saturation magnetization, chemical stability, large surface area, easy functionalization. This paper describes magnetic nanoparticle physical biological properties, emphasizing synthesis approaches, toxicity, biomedical applications, focusing on the most recent advancements of therapy, theranostics, separation, biosensing.

Language: Английский

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Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: Sept. 2, 2022

In recent decades, research scientists, molecular biologists, and pharmacologists have placed a strong emphasis on cutting-edge nanostructured materials technologies to increase medicine delivery the central nervous system (CNS). The application of nanoscience for treatment neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), Huntington’s (HD), brain cancer, hemorrhage has potential transform care. Multiple studies indicated that nanomaterials can be used successfully treat CNS disorders in case neurodegeneration. Nanomedicine development cure degenerative inflammatory is critical. Nanoparticles may act drug transporter precisely target sick sub-regions, boosting therapy success. It important develop strategies penetrate blood–brain barrier (BBB) improve effectiveness medications. One probable tactics use different nanoscale materials. These nano-based pharmaceuticals offer low toxicity, tailored delivery, high stability, loading capacity. They also therapeutic effectiveness. A few examples many kinds forms been widely employed neurological include quantum dots, dendrimers, metallic nanoparticles, polymeric carbon nanotubes, liposomes, micelles. unique qualities, including sensitivity, selectivity, ability traverse BBB when nano-sized particles, make these nanoparticles useful imaging NDs. Multifunctional carrying pharmacological medications serve two purposes: they medication distribution while enabling cell dynamics pharmacokinetic study. However, because wide-ranging clinical implications, safety concerns persist, limiting any translation. evidence using nanotechnology create systems could pass across deliver chemicals was examined this

Language: Английский

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Recent developments and applications of smart nanoparticles in biomedicine

Nanotechnology Reviews, Journal Year: 2022, Volume and Issue: 11(1), P. 2595 - 2631

Published: Jan. 1, 2022

Abstract Over the last decades, nanotechnology applied in medicine (nanomedicine) has sparked great interest from scientific community, thanks to possibility engineer nanostructured materials, including nanoparticles (NPs), for a specific application. Their small size confers them unique properties because they are subject physical laws middle between classical and quantum physics. This review is proposed explain better how design NP clarify relationship type, size, shape of NPs medical applications. classified into inorganic (metallic NPs, dots, carbon-based nanostructures, mesoporous silica NPs) organic (liposomes micelles, dendrimers, polymer NPs). Here, we report an accurate description potential each type focusing on their multiple areas application, theranostics drug delivery, imaging, tissue engineering, antimicrobial techniques, nanovaccines. All these features make promise revolutionize new era nanomedicine.

Language: Английский

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