Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(8), P. 1680 - 1680
Published: Aug. 12, 2022
Iron
oxide
nanoparticles
are
commonly
used
in
many
medical
applications
as
they
can
be
easily
modified,
have
a
high
surface-to-volume
ratio,
and
biocompatible
biodegradable.
This
study
was
performed
to
synthesize
designed
for
multimodal
HER2-positive
cancer
treatment
involving
radionuclide
therapy
magnetic
hyperthermia.
The
core
(Fe3O4)
coated
with
gold-198
layer
creating
so-called
core-shell
nanoparticles.
These
were
then
further
modified
bifunctional
PEG
linker
monoclonal
antibody
achieve
the
targeted
therapy.
Monoclonal
antibody-trastuzumab
target
specific
breast
nipple
cells.
measured
by
transmission
electron
microscopy
small
9
nm.
bioconjugation
of
trastuzumab
confirmed
two
separate
methods:
thermogravimetric
analysis
iodine-131
labeling.
Synthesized
showed
that
good
heat
mediators
an
alternating
field
exhibit
great
binding
internalization
capabilities
towards
SKOV-3
(HER2
positive)
cell
line.
Radioactive
also
regarding
spheroid
degradation
without
application
hyperthermia
greater
impact
case
latter.
Designed
radiobioconjugate
shows
promise
has
potential
vivo
studies
combined
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(11), P. 2388 - 2388
Published: Nov. 5, 2022
Cancer
immunotherapy
has
tremendous
promise,
but
it
yet
to
be
clinically
applied
in
a
wider
variety
of
tumor
situations.
Many
therapeutic
combinations
are
envisaged
improve
their
effectiveness.
In
this
way,
strategies
capable
inducing
immunogenic
cell
death
(e.g.,
doxorubicin,
radiotherapy,
hyperthermia)
and
the
reprogramming
immunosuppressive
microenvironment
(TME)
M2-to-M1-like
macrophages
repolarization
tumor-associated
(TAMs))
particularly
appealing
enhance
efficacy
approved
immunotherapies
immune
checkpoint
inhibitors,
ICIs).
Due
modular
construction
versatility,
iron
oxide-based
nanomedicines
such
as
superparamagnetic
oxide
nanoparticles
(SPIONs)
can
combine
these
different
approaches
single
agent.
SPIONs
have
already
shown
safety
biocompatibility
possess
both
drug-delivery
chemotherapy,
ICIs)
magnetic
capabilities
hyperthermia
(MHT),
resonance
imaging).
review,
we
will
discuss
multiple
applications
cancer
immunotherapy,
focusing
on
theranostic
properties
target
TAMs
generate
MHT.
The
first
section
review
briefly
describe
targets
for
NPs.
following
sections
deal
with
overall
(including
MHT).
last
is
dedicated
SPION-induced
response
through
its
effects
Discover Nano,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Oct. 10, 2023
Abstract
The
significance
of
green
synthesized
nanomaterials
with
a
uniform
shape,
reduced
sizes,
superior
mechanical
capabilities,
phase
microstructure,
magnetic
behavior,
and
performance
cannot
be
overemphasized.
Iron
oxide
nanoparticles
(IONPs)
are
found
within
the
size
range
1–100
nm
in
have
diverse
applications
fields
such
as
biomedicine,
wastewater
purification,
environmental
remediation.
Nevertheless,
understanding
their
fundamental
material
composition,
chemical
reactions,
toxicological
properties,
research
methodologies
is
constrained
extensively
elucidated
during
practical
implementation.
importance
producing
IONPs
using
advanced
nanofabrication
techniques
that
exhibit
strong
potential
for
disease
therapy,
microbial
pathogen
control,
elimination
cancer
cells
underscored
by
adoption
synthesis
approach.
These
can
serve
viable
alternatives
soil
remediation
contaminants.
Therefore,
this
paper
presents
comprehensive
analysis
conducted
on
different
types
IONP
composite-based
materials.
It
examines
methods
characterization
employed
these
studies
also
addresses
obstacles
encountered
prior
investigations
comparable
objectives.
A
engineering
strategy
was
proposed
synthesis,
characterization,
application
composites
impact.
Additionally,
influence
structure,
biocompatibility,
toxicity,
milling
time,
nanoparticle
size,
shape
discussed.
study
proposes
use
biological
physicochemical
more
alternative
mitigate
limitations
imposed
conventional
synthesis.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: Nov. 6, 2024
Cancer
remains
one
of
the
most
challenging
health
issues
globally,
demanding
innovative
therapeutic
approaches
for
effective
treatment.
Nanoparticles,
particularly
those
composed
gold,
silver,
and
iron
oxide,
have
emerged
as
promising
candidates
changing
cancer
therapy.
This
comprehensive
review
demonstrates
landscape
nanoparticle-based
oncological
interventions,
focusing
on
remarkable
advancements
potentials
oxide
nanoparticles.
Gold
nanoparticles
garnered
significant
attention
their
exceptional
biocompatibility,
tunable
surface
chemistry,
distinctive
optical
properties,
rendering
them
ideal
various
diagnostic
strategies.
Silver
nanoparticles,
renowned
antimicrobial
exhibit
potential
in
therapy
through
multiple
mechanisms,
including
apoptosis
induction,
angiogenesis
inhibition,
drug
delivery
enhancement.
With
magnetic
properties
offer
unique
diagnosis
targeted
opportunities.
critically
examines
recent
synthesis,
functionalization,
biomedical
applications
these
Moreover,
challenges
are
discussed,
toxicity
concerns,
immunogenicity,
translational
barriers,
ongoing
efforts
to
overcome
hurdles
highlighted.
Finally,
insights
into
future
directions
regulatory
considerations,
provided
aiming
accelerate
translation
technologies
from
bench
bedside.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2809 - 2809
Published: Feb. 28, 2024
This
review
focuses
on
the
latest
advancements
in
magnetic
hydroxyapatite
(mHA)
nanoparticles
and
their
potential
applications
nanomedicine
regenerative
medicine.
mHA
have
gained
significant
interest
over
last
few
years
for
great
potential,
offering
advanced
multi-therapeutic
strategies
because
of
biocompatibility,
bioactivity,
unique
physicochemical
features,
enabling
on-demand
activation
control.
The
most
relevant
synthetic
methods
to
obtain
apatite-based
materials,
either
form
iron-doped
HA
showing
intrinsic
properties
or
composite/hybrid
compounds
between
superparamagnetic
metal
oxide
nanoparticles,
are
described
as
highlighting
structure–property
correlations.
Following
this,
this
discusses
application
various
nanomaterials
bone
regeneration
nanomedicine.
Finally,
novel
perspectives
investigated
with
respect
ability
improve
nanocarriers
homogeneous
structures
promote
multifunctional
biological
applications,
such
cell
stimulation
instruction,
antimicrobial
activity,
drug
release
triggering.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(11), P. 3437 - 3437
Published: June 5, 2021
Over
the
last
decade,
an
important
challenge
in
nanomedicine
imaging
has
been
work
to
design
multifunctional
agents
that
can
be
detected
by
single
and/or
multimodal
techniques.
Among
broad
spectrum
of
nanoscale
materials
being
investigated
for
use,
iron
oxide
nanoparticles
have
gained
significant
attention
due
their
intrinsic
magnetic
properties,
low
toxicity,
large
moments,
superparamagnetic
behaviour
and
surface
area—the
latter
a
particular
advantage
its
conjunction
with
specific
moieties,
dye
molecules,
probes.
Tracers-based
are
promising
candidates,
since
they
combine
synergistic
advantages
non-invasive,
highly
sensitive,
high-resolution,
quantitative
on
different
modalities.
This
study
represents
overview
current
advancements
clinical
potential
will
hopefully
provide
effective
system
diagnosis
near
future.
Further
exploration
is
still
needed
reveal
as
candidates
from
simple
functionalization
metal
nanomaterials
up
medical
imaging.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(5), P. 645 - 645
Published: May 10, 2024
In
recent
years,
nanotechnology
has
achieved
a
remarkable
status
in
shaping
the
future
of
biological
applications,
especially
combating
fungal
diseases.
Owing
to
excellence
nanotechnology,
iron
nanoparticles
(Fe
NPs)
have
gained
enormous
attention
years.
this
review,
we
provided
comprehensive
overview
Fe
NPs
covering
key
synthesis
approaches
and
underlying
working
principles,
factors
that
influence
their
properties,
essential
characterization
techniques,
optimization
antifungal
potential.
addition,
diverse
kinds
NP
delivery
platforms
command
highly
effective
release,
with
fewer
toxic
effects
on
patients,
are
great
significance
medical
field.
The
issues
biocompatibility,
toxicity
profiles,
applications
optimized
field
biomedicine
also
been
described
because
these
most
significant
determining
inclusion
clinical
use.
Besides
this,
difficulties
regulations
exist
transition
from
laboratory
experimental
studies
(toxicity,
specific
standards,
safety
concerns)
NPs-based
agents
summarized.
Cancer Nanotechnology,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Nov. 12, 2022
Abstract
The
development
of
nanoparticle
agents
for
MRI-guided
radiotherapy
is
growing
at
an
increasing
pace,
with
clinical
trials
now
underway
and
many
pre-clinical
evaluation
studies
ongoing.
Gadolinium
iron-oxide-based
nanoparticles
remain
the
most
clinically
advanced
to
date,
although
several
promising
candidates
are
currently
under
varying
stages
development.
Goals
current
future
generation
nanoparticle-based
contrast
include
achieving
positive
signal
on
T1-weighted
MRI
scans,
local
radiation
enhancement
relevant
concentrations
and,
where
applicable,
avoidance
uptake
by
reticuloendothelial
system.
Exploiting
enhanced
permeability
retention
effect
or
use
active
targeting
ligands
surfaces
utilised
promote
tumour
uptake.
This
review
outlines
status
therapy,
including
platforms
undergoing
various
process.
Challenges
facing
possible
avenues
discussed.
Advanced Drug Delivery Reviews,
Journal Year:
2022,
Volume and Issue:
192, P. 114621 - 114621
Published: Nov. 17, 2022
The
past
decades
have
shown
significant
advancements
in
the
development
of
solid
tumor
treatment.
For
instance,
implementation
nanosystems
for
drug
delivery
has
led
to
a
reduction
side
effects
and
improved
region.
However,
clinical
translation
faced
challenges,
as
levels
are
still
considered
be
inadequate.
Interdisciplinary
research
resulted
more
advanced
systems.
These
coined
"smart"
due
ability
followed
actively
manipulated
order
better
control
over
local
release.
Therefore,
image-guided
can
powerful
strategy
improve
activity
at
target
site.
Being
able
visualize
inflow
administered
smart
nanosystem
within
gives
potential
determine
right
moment
apply
facilitator
initiate
Here
we
provide
an
overview
available
nanosystems,
imaging
moieties,
techniques.
We
discuss
preclinical
application
these
systems,
strength
delivery,
future
personalized
