“From Decomposers to Superheroes”: Unleashing the Hidden Powers of Fungi to Save Our Planet DOI Creative Commons
Dinushani A. Daranagama

˜The œjournal of desk research review and analysis., Journal Year: 2023, Volume and Issue: 1(1), P. 98 - 113

Published: Dec. 31, 2023

Fungi, often overlooked but omnipresent, hold remarkable potential to address some of the most pressing environmental challenges facing our planet. This article explores multifaceted roles fungi, transcending their conventional image as decomposers, and showcases how they emerge unsung superheroes in battle for sustainability. From mycorrhizal symbiosis enhancing plant growth bioremediation activities cleansing polluted environments, fungi play pivotal diverse ecological processes. examines promising applications sustainable agriculture, food production, waste decomposition, production biofuels, highlighting capacity revolutionise these fields. Furthermore, medicinal biotechnological contributions are also explored, revealing a rich source bioactive compounds with pharmaceutical applications. The role various fermented foods combat pests biologically underscore significance production. Fungi proves vital carbon sequestration, erosion control, soil stabilisation, contributing global efforts mitigating climate change preserving ecosystems. By delving into world fungal biodiversity, paper emphasises importance conservation maintaining ecosystem resilience preventing loss critical functions. sheds light on transformative urging paradigm shift we perceive harness organisms. As understanding biology deepens, recognising vast number undescribed unexplored species becomes increasingly important. With adaptations significance, continue captivate scientific community need sustained exploration this understudied kingdom. Recognising provides novel perspective that could inspire innovative solutions development preservation planet's health.

Language: Английский

Enhancing Safety and Quality in the Global Cheese Industry: A Review of Innovative Preservation Techniques DOI Creative Commons

Mohammed A Falih,

Ammar B. Altemimi,

Qausar Hamed ALKaisy

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40459 - e40459

Published: Nov. 19, 2024

Language: Английский

Citations

11
A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment DOI Creative Commons

Khushbu Wadhwa,

Neha Kapoor,

Hardeep Kaur

et al.

Mycobiology, Journal Year: 2024, Volume and Issue: 52(6), P. 335 - 387

Published: Nov. 1, 2024

Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to increasing applications healthcare, environmental cleanup, biotechnology-based industries. The fungi produce these metabolites (SMs) during different phases of growth, which are categorized into terpenoids, alkaloids, polyketides, non-ribosomal peptides. These SMs exhibit significant biological activity, contributes formulation novel pharmaceuticals, biopesticides, bioremediation agents. Nowadays, fungal-derived widely used food beverages, for fermentation, preservatives, protein sources, dairy In it is being as an antimicrobial, anticancer, anti-inflammatory, immunosuppressive drug. usage modern tools biotechnology can achieve increase large-scale production. present review comprehensively analyses diversity fungal along with emerging agriculture, sustainability, nutraceuticals. Here, authors reviewed recent advancements genetic engineering, metabolic pathway manipulation, synthetic biology improve production yield SMs. Advancement fermentation techniques, bioprocessing, co-cultivation approaches Investigators further highlighted importance omics technologies understanding regulation biosynthesis SMs, offers drug discovery sustainable agriculture. Finally, addressed potential manipulation biotechnological innovations exploitation commercial benefits.

Language: Английский

Citations

6
Penicillium chrysogenum: Beyond the penicillin DOI
Carlos Barreiro, Silvia M. Albillos, Carlos Garcı́a-Estrada

et al.

Advances in applied microbiology, Journal Year: 2024, Volume and Issue: unknown, P. 143 - 221

Published: Jan. 1, 2024

Language: Английский

Citations

5
Use of Penicillium roqueforti in plant-based veined-blue cheese: a source of mycotoxin hazards? DOI Creative Commons

Oriane Gauthier,

Stéphane Bernillon,

Rayan Khireddine

et al.

Food Control, Journal Year: 2025, Volume and Issue: 171, P. 111130 - 111130

Published: Jan. 1, 2025

Language: Английский

Citations

0
Identification of quantitative trait loci (QTLs) for key cheese making phenotypes in the blue-cheese mold Penicillium roqueforti DOI Creative Commons
Thibault Caron, Ewen Crequer,

Mélanie Le Piver

et al.

PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(4), P. e1011669 - e1011669

Published: April 15, 2025

Elucidating the genomic architecture of quantitative traits is essential for our understanding adaptation and breeding in domesticated organisms. Penicillium roqueforti mold used worldwide blue cheese maturation, contributing to flavors through proteolytic lipolytic activities. The two populations display very little genetic diversity, but are differentiated carry opposite mating types. We produced haploid F1 progenies from five crosses, using parents belonging non-cheese populations. Analyses high-quality genome assemblies parental strains revealed large translocations, having occurred via a circular intermediate, one with footprints Starship giant mobile elements. Offspring genotyping genotype-by-sequencing (GBS) several regions segregation distortion, possibly linked degeneration lineages. found transgressions relevant making, offspring more extreme trait values than strains. identified loci (QTLs) colony color, lipolysis, proteolysis, extrolite production, including mycotoxins, not growth rates. Some appeared rich QTLs both lipid protein metabolism, other production multiple extrolites, indicating that have pleiotropic effects. corresponded known biosynthetic gene clusters, e.g., melanin or extrolites. hybrids constitute valuable producers, new allelic combinations, allowed identifying target important paving way strain improvement. findings further contribute mechanisms underlying rapid adaptation, revealing convergent targeting major regulators.

Language: Английский

Citations

0
Mycotoxins and secondary metabolites from fruit postharvest pathogenic Penicillium species DOI

Youming Shen,

Ning Ma, S. Liu

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144880 - 144880

Published: May 1, 2025

Language: Английский

Citations

0
PrlaeA Affects the Production of Roquefortine C, Mycophenolic Acid, and Andrastin A in Penicillium roqueforti, but It Has Little Impact on Asexual Development DOI Creative Commons

Yudethzi Marcano,

Mariana Montanares,

Carlos Gil-Durán

et al.

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(10), P. 954 - 954

Published: Sept. 22, 2023

The regulation of fungal specialized metabolism is a complex process involving various regulators. Among these regulators, LaeA, methyltransferase protein originally discovered in Aspergillus spp., plays crucial role. Although the role LaeA has been studied different fungi, its function Penicillium roqueforti remains unknown. In this study, we employed CRISPR-Cas9 technology to disrupt laeA gene P. (PrlaeA) aiming investigate impact on production metabolites roquefortine C, mycophenolic acid, and andrastin A, as well asexual development, because they are processes that occur same temporal stages within physiology fungus. Our results demonstrate substantial reduction three upon disruption PrlaeA, suggesting positive regulatory their biosynthesis. These findings were further supported by qRT-PCR analysis, which revealed significant downregulation expression genes associated with biosynthetic clusters (BGCs) responsible for producing A ΔPrlaeA strains compared wild-type roqueforti. Regarding PrlaeA led slight decrease colony growth rate, while conidiation conidial germination remained unaffected. Taken together, our suggest positively regulates analyzed BGCs corresponding roqueforti, but it little development.

Language: Английский

Citations

6
Different metabolite profiles across Penicillium roqueforti populations associated with ecological niche specialisation and domestication DOI Creative Commons
Ewen Crequer, Emmanuel Coton,

Gwennina Cueff

et al.

IMA Fungus, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 28, 2024

Fungi are known to produce many chemically diversified metabolites, yet their ecological roles not always fully understood. The blue cheese fungus Penicillium roqueforti thrives in different niches and is a wide range of including mycotoxins. Three P. populations have been domesticated for production two thrive other anthropized environments, i.e., food, lumber silage. In this study, we looked differences targeted untargeted metabolite profiles between using HPLC-HR-Q-TOF UHPLC-Q-TOF-HR-MS/MS. non-cheese produced several fatty acids terpenoids, lacking strains. Termignon population displayed intermediate populations, as previously shown traits. non-Roquefort with the strongest domestication syndrome, lowest quantities measured mycophenolic acid (MPA), andrastin A PR toxin. Its inability MPA was due deletion mpaC gene, while premature stop codon ORF 11 toxin gene cluster explained absence accumulation its intermediates, eremofortins B. Roquefort population, detected no nor or B, but found indel frameshift mutation, suggesting downregulation. hypotoxigenic trait can be hypothesized linked loss ability through degeneration and/or selection low producers. It may also fact that from environments maintained high diversity bioactivities these compounds likely important niches.

Language: Английский

Citations

2
Penicillium roqueforti Secondary Metabolites: Biosynthetic Pathways, Gene Clusters, and Bioactivities DOI Creative Commons
Banu Metin

Fermentation, Journal Year: 2023, Volume and Issue: 9(9), P. 836 - 836

Published: Sept. 13, 2023

Penicillium roqueforti is a fungal starter culture used for the production of blue-veined cheeses, such as Roquefort, Gorgonzola, Stilton, Cabrales, and Danablue. During ripening, this species grows in veins cheese, forming emblematic blue-green color establishing characteristic flavor owin to its biochemical activities. P. synthesizes diverse array secondary metabolites, including well-known compounds roquefortine C, clavine alkaloids, isofumigaclavine A B, mycophenolic acid, andrastin A, PR-toxin. This review provides an in-depth exploration roqueforti’s focusing on their biosynthetic pathways, gene clusters responsible production, bioactivities. The presence these blue cheeses also reviewed. Furthermore, silent potential producing metabolites were discussed. highlights recently identified sesterterpenoids; tetrapeptides, D-Phe-L-Val-D-Val-L-Tyr, D-Phe-L-Val-D-Val-L-Phe; cis-bis(methylthio)silvatin; 1,8-dihydroxynaphthalene (DHN)-melanin precursor, scytalone. Additionally, cluster DHN–melanin biosynthesis presented. Finally, revised C comprising three rather than four genes proposed.

Language: Английский

Citations

4
Different metabolite profiles acrossPenicillium roquefortipopulations associated with ecological niche specialisation and domestication DOI Creative Commons
Ewen Crequer, Emmanuel Coton,

Gwennina Cueff

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 13, 2024

Abstract Fungi are known to produce many chemically diversified metabolites, yet their ecological roles not always fully understood. The blue cheese making fungus Penicillium roqueforti thrives in different niches and is a wide range of including mycotoxins. Three P. populations have been domesticated for production two thrive other anthropized environments, i.e., spoiled food, lumber silage. Here, we looked differences targeted untargeted metabolite profiles between using HPLC-HR-Q-TOF UHPLC-Q-TOF-HR-MS/MS. non-cheese produced several fatty acids terpenoids, lacking strains. Termignon population displayed intermediate populations, as previously shown traits. non-Roquefort population, the with strongest domestication syndrome, lowest quantities measured mycotoxins such mycophenolic acid (MPA), andrastin A PR toxin. Its inability MPA was due deletion mpaC gene, while premature stop codon ORF 11 toxin gene cluster explained its absence accumulation eremofortin & B intermediates. In Roquefort detected no nor eremofortins or B, but found indel frameshift mutation, suggesting downregulation. Our results suggest that were selected lower from environments maintained high diversity, bioactivities these compounds being likely important niches.

Language: Английский

Citations

1