Effect of bisphenol A on the neurological system: a review update

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 98(1), P. 1 - 73

Published: Oct. 19, 2023

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins polycarbonate plastics, which are frequently used food storage baby bottles. However, bind mainly to estrogen receptors, interfering with various neurologic functions, its use a topic significant concern. Nonetheless, neurotoxicity has not been fully understood despite numerous investigations on disruptive effects. Therefore, this review aims highlight recent studies implications system. Our findings suggest that exposure impairs structural molecular brain changes, promoting oxidative stress, changing expression levels several crucial genes proteins, destructive effects neurotransmitters, excitotoxicity neuroinflammation, damaged blood-brain barrier function, neuronal damage, apoptosis effects, disruption intracellular Ca

Language: Английский

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Photocatalytically reactive surfaces for simultaneous water harvesting and treatment

Nature Sustainability, Journal Year: 2023, Volume and Issue: 6(12), P. 1663 - 1672

Published: Aug. 17, 2023

Abstract Atmospheric water harvesting provides decentralized and sustainable supplies of fresh in areas away from natural resources. However, an important challenge is that sources such as fog are subject to contamination airborne pollutants, especially near population centres. Here we demonstrate a rationally designed system can capture at high efficiency while simultaneously degrading organic pollutants. At the heart our design wire mesh coated with anatase titanium dioxide nanoparticles embedded polymer matrix. Once activated by sunlight, photoactive layer decomposes molecules diesel, even absence sunlight; moreover, wettability surface engineered enhance extraction. In outdoor tests, device maintain good performance well treatment >85%. The continuous production passive purification demonstrated study energy-free solution address scarcity.

Language: Английский

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The Effects of Bisphenol A on Human Male Infertility: A Review of Current Epidemiological Studies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12417 - 12417

Published: Aug. 4, 2023

Endocrine disruptor chemicals (EDCs) can have a harmful effect on the human body’s endocrine system and thus adversely affect development, reproduction, neurological, cardiovascular, immune systems metabolism in humans wildlife. According to World Health Organization, EDCs are mostly man-made found ubiquitously our daily lives, notably pesticides, metals, additives or contaminants food personal care products. Human exposure occurs through ingestion, inhalation, dermal contact. Bisphenol A (BPA) is proven EDC capable of mimicking blocking receptors altering hormone concentrations metabolism. Although consumed low doses, it stimulate cellular responses functions. In humans, BPA has been correlated with onset development several diseases. This literature review aimed verify effects male infertility using most recently published literature. Thus, this allowed us conclude that compound seems fertility, causing changes hormonal semen characteristics. However, these conclusions lack more robust reproducible scientific studies. Even so, since prevalence increasing, preventive measures must be taken ensure fertility.

Language: Английский

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The Role of the Vascular System in Degenerative Diseases: Mechanisms and Implications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2169 - 2169

Published: Feb. 11, 2024

Degenerative diseases, encompassing a wide range of conditions affecting various organ systems, pose significant challenges to global healthcare systems. This comprehensive review explores the intricate interplay between vascular system and degenerative shedding light on underlying mechanisms profound implications for disease progression management. The pivotal role in maintaining tissue homeostasis is highlighted, as it serves conduit oxygen, nutrients, immune cells vital organs tissues. Due homeostasis, its dysfunction, characterized by impaired blood flow, endothelial inflammation, emerges common denominator diseases across multiple In nervous system, we explored influence factors neurodegenerative such Alzheimer’s Parkinson’s, emphasizing critical cerebral flow regulation blood–brain barrier. Within kidney relationship health chronic scrutinized, unraveling which hypertension other contribute renal dysfunction. Throughout this review, emphasize clinical significance understanding involvement potential therapeutic interventions targeting health, highlighting emerging treatments prevention strategies. conclusion, appreciation essential advancing our pathogenesis developing innovative approaches treatment. provides foundation researchers, clinicians, policymakers seeking address pursuit improved patient outcomes enhanced public health.

Language: Английский

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Structural insight into the mechanisms and interacting features of endocrine disruptor Bisphenol A and its analogs with human estrogen-related receptor gamma

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123549 - 123549

Published: Feb. 11, 2024

Bisphenol A (BPA) is a very important chemical from the commercial perspective. Many useful products are made it, so its production increasing day by day. It widely known that and analogs present in environment they enter our body through various routes on daily basis as we use things of this lives. BPA has already been reported to be an endocrine disruptor. Studies have shown binds strongly human estrogen-related receptor gamma (ERRγ) target it. This study seeks understand how it interacts with ERRγ. Molecular docking ERRγ was performed, estradiol taken reference. Then, physico-chemical toxicological analysis compounds performed. Subsequently, dynamic behavior ERRγ-BPA compound complexes studied molecular dynamics simulations over 500 ns, using simulated data, their binding energies were again calculated MM-PBSA method. We observed affinity much higher than estradiol, apart being toxic, can easily absorbed physicochemical properties similar those oral medicines. Therefore, facilitates understanding structure–activity relationship provides information about key amino acid residues interact compounds, which helpful design competitive inhibitors interrupt interaction In addition, will also developing new therapeutics.

Language: Английский

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Mechanistic interplay of dual environmental stressors: Bisphenol-A and cadmium-induced ovarian follicular damage and hepatocyte dysfunction in vivo

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 924, P. 171706 - 171706

Published: March 13, 2024

Language: Английский

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The relationship between perfluoroalkyl substances and hypertension: A systematic review and meta-analysis

Environmental Research, Journal Year: 2023, Volume and Issue: 232, P. 116362 - 116362

Published: June 7, 2023

Language: Английский

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Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 108, P. 104467 - 104467

Published: May 17, 2024

Language: Английский

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Bisphenol A—What Do We Know? A Global or Local Approach at the Public Health Risk Level

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6229 - 6229

Published: June 5, 2024

BPA has demonstrated enormous multisystem and multi-organ toxicity shown mainly in animal models. Meanwhile, the effects of its exposure humans still require years observation, research, answers to many questions. Even minimal short-term contributes disorders or various types dysfunction. It is released directly indirectly into environment at every stage product life cycle, demonstrating ease penetration body. The ubiquity general prevalence influenced main objective study, which was assess health derivatives based on available literature. In addition, guidelines international institutions regions world terms reduction individual products were checked. Bisphenol A most widely known chemical perhaps even studied by virtually all national organizations, but nonetheless, it controversial. general, level biomonitoring too high poses a potential threat public health. beginning be argued that future studies should focus molecular biology assessment human BPA, as well substitutes. extensive necessary continue deepen knowledge interest companies, consumers around order make rational purchases choices, not only consumer ones.

Language: Английский

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Effects of BPA substitutes on the prenatal and cardiovascular systems

Critical Reviews in Toxicology, Journal Year: 2022, Volume and Issue: 52(6), P. 469 - 498

Published: July 3, 2022

Bisphenol A (BPA) is a ubiquitous chemical compound constantly being released into the environment, making it one of most persistent endocrine-disrupting (EDC) in nature. This EDC has already been associated with developing various pathologies, such as diabetes, obesity, and cardiovascular, renal, behavioral complications, among others. Therefore, over years, BPA replaced, gradually, by its analog compounds. However, these compounds are structurally similar to BPA, so, recent questions have raised concerning their safety for human health. Numerous investigations performed determine effects substitutes may cause, particularly during pregnancy prenatal life. On other hand, studies investigating association development cardiovascular diseases (CVD) developed. In this sense, review summarizes existing literature on transgenerational transfer consequent maternal offspring health following exposure. addition, compounds’ system susceptibility develop CVD will be presented. aims highlight need investigate further benefits, or hazards, replacing analogs.

Language: Английский

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