Oxidative stress and antioxidants in health and disease

Journal of Laboratory Medicine, Journal Year: 2023, Volume and Issue: 47(1), P. 1 - 11

Published: Feb. 1, 2023

Abstract The increase in the formation of reactive oxygen and nitrogen species endogenous or exogenous origin causes oxidative stress due to pro-oxidant antioxidant imbalance that cellular damage metabolism. This can inflammation cells, apoptosis necrosis, DNA base damage, protein cross-links, lipid membrane peroxidation, mitochondrial dysfunction. Antioxidants be described as a system protects biomolecules organism against harmful effects free radicals, reduces repairs done by (ROS) target molecule, this is called defense. It known mechanisms caused ROS resulting from are positively related pathology many diseases such cancer, metabolic syndrome, atherosclerosis, malaria, Alzheimer’s disease, rheumatoid arthritis, neurodegenerative preeclampsia.

Language: Английский

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Toxicity of inorganic arsenic to animals and its treatment strategies

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2023, Volume and Issue: 271, P. 109654 - 109654

Published: May 23, 2023

Language: Английский

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Negative Impacts of Arsenic on Plants and Mitigation Strategies

Plants, Journal Year: 2023, Volume and Issue: 12(9), P. 1815 - 1815

Published: April 28, 2023

Arsenic (As) is a metalloid prevalent mainly in soil and water. The presence of As above permissible levels becomes toxic detrimental to living organisms, therefore, making it significant global concern. Humans can absorb through drinking polluted water consuming As-contaminated food material grown having problems. Since human beings are mobile they use clean uncontaminated found various channels or switch from an area area; but plants sessile obtain along with essential minerals roots that make them more susceptible arsenic poisoning consequent stress. phosphorus have many similarities terms their physical chemical characteristics, commonly compete cause physiological anomalies biological systems contribute further Initial indicators arsenic’s propensity induce toxicity decrease yield loss plant biomass. This accompanied by considerable alterations; including instant oxidative surge; followed biomolecule oxidation. These variables ultimately result cell permeability electrolyte imbalance. In addition, disturbs the nucleic acids, transcription process, enzymes engaged system’s primary metabolic pathways. To lessen absorption plants, variety mitigation strategies been proposed which include agronomic practices, breeding, genetic manipulation, computer-aided modeling, biochemical techniques, altering approaches regarding consumption pollution, these ways, increased awareness may be generated. will help ensuring good health, security, environmental sustainability. article summarises nature impact on physio-biochemical mechanisms evolved cope stress, measures employed eliminate negative effects As.

Language: Английский

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Arsenic toxicity: sources, pathophysiology and mechanism

Toxicology Research, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 8, 2023

Arsenic is a naturally occurring element that poses significant threat to human health due its widespread presence in the environment, affecting millions worldwide. Sources of arsenic exposure are diverse, stemming from mining activities, manufacturing processes, and natural geological formations. manifests both organic inorganic forms, with trivalent meta-arsenite (As3+) pentavalent arsenate (As5+) being most common forms. The state, particular, holds toxicological significance potent interactions sulfur-containing proteins.

Language: Английский

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Association between heavy metals exposure and infertility among American women aged 20–44 years: A cross-sectional analysis from 2013 to 2018 NHANES data

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 14, 2023

Background Infertility has been confirmed as a significant medical and social problem. Heavy metal exposure refers to risk factor for infertility, which is capable of damaging the reproductive system males females. However, heavy female infertility have rarely investigated. The aim this study was analyze association between infertility. Methods A cross-sectional using data from three cycles National Health Nutrition Examination Survey (NHANES, 2013–2018) performed. Female evaluated by positive responses question rhq074 in questionnaire. Cadmium (Cd), lead (Pb), mercury (Hg), arsenic (As) levels blood or urine were examined inductively coupled plasma mass spectrometry. correlation analyzed through weighted logistic regression. Results total 838 American women aged 20–44 years covered study. Among all participants, 112 (13.37%) subjected Urinary Cd urinary As significantly higher infertile than control ( P < 0.05, 0.05). showed with prevalence rose increase trend = 0.045). associated some regression (Crude, Q2: OR 3.99, 95% CI 1.82, 8.74, Q3: 2.90, 1.42, 5.92. Model 1, 3.68, 1.64, 8.27, 2.33, 1.13, 4.48. 2, 4.11, 1.63, 10.07, 2.44, 1.07, 5.53. 3, 3.77, 1.52, 9.35). Moreover, Pb (OR 2.16), 1.68, 1.11, 2.55), 1.02, 1.00, 1.03) positively correlated 35–44 years. 1.67, 1.16, 2.40, 2.49) 1.54, 2.38) BMI ≥25 Conclusions increased levels. To extent, Blood/urine related advanced age overweight/obese women. results need be further validated future prospective studies.

Language: Английский

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Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 124, P. 108531 - 108531

Published: Jan. 2, 2024

Language: Английский

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Single and mixed effects of seven heavy metals on stroke risk: 11,803 adults from National Health and Nutrition Examination Survey (NHANES)

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 12, 2025

Background The accumulation of heavy metals in soil and plants poses risks to food safety. Human exposure has been linked stroke risk, though research on this connection is limited findings are inconsistent. Methods We estimated the associations 7 blood [cadmium (Cd), lead (Pb), mercury (Hg), manganese (Mn), copper (Cu), selenium (Se), zinc (Zn)] with risk among 11,803 U.S. adults. Logistic regression account for intricate sampling design restricted cubic spline (RCS) was used explore between single metal risk. weighted quantile sum (WQS) g-computation (qgcomp) were employed joint effects seven stroke. Potential confounders adjusted. Results After adjusting potential confounders, logistic analysis showed log-transformed Cd Zn level associated (All p < 0.05). WQS qgcomp analyses consistently demonstrated a positive correlation metals-mixed identifying Cu as key contributors outcomes, while may serve protective factor. Conclusion These indicated that effect deserves further verify.

Language: Английский

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The interplay of arsenic, silymarin, and NF-ĸB pathway in male reproductive toxicity: A review

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 252, P. 114614 - 114614

Published: Feb. 6, 2023

Arsenic toxicity is one of the most trending reasons for several malfunctions, particularly reproductive toxicity. The exact mechanism arsenic poisoning a big question mark. Exposure to reduces sperm count, impairs fertilization, and causes inflammation genotoxicity through interfering with autophagy, epigenetics, ROS generation, downregulation essential protein expression, metabolite changes, hampering signaling cascades, by alteration NF-ĸB pathway. This work tries give clear idea about different aspects resulting in male complications, often leading infertility. first part this article explains implications crosstalk pathway Silymarin bioactive compound that exerts anti-cancer anti-inflammatory properties has demonstrated hopeful outcomes cancers, including colon cancer, breast skin downregulating hyperactive next half thus sheds light on silymarin's therapeutic potential inhibiting cascade, offering protection against arsenic-induced

Language: Английский

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Natural antioxidants mitigate heavy metal induced reproductive toxicity: prospective mechanisms and biomarkers

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(31), P. 11530 - 11542

Published: Aug. 1, 2023

Heavy metals are harmful environmental pollutants that have attracted widespread attention, attributed to their health hazards humans and animals. Due the non-degradable property of heavy metals, organisms inevitably exposed such as arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg). Several studies revealed can cause reproductive damage by excessive production reactive oxygen species (ROS), which exacerbates oxidative stress, inflammation, endocrine disruption. Natural antioxidants, mainly polyphenols, carotenoids, vitamins, been shown mitigate metal-induced toxicity potentially. In this review, accumulated evidences on influences four non-essential As, Cd, Pb, Hg both males females system were established. The purpose review is explore potential mechanisms effects function point out biomarkers natural antioxidants interventions toward toxicity. Notably, increasing evidence proven regulations hypothalamic-pituitary-gonadal axis, Nrf2, MAPK, or NF-κB pathways important for amelioration metal induced antioxidants. It also provided a promising guidance prevention management

Language: Английский

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Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 5, 2024

Language: Английский

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