ACS symposium series,
Journal Year:
2023,
Volume and Issue:
unknown, P. 117 - 133
Published: Nov. 28, 2023
Heavy
metals
are
increasingly
becoming
relevant
to
human
health
due
their
increasing
concentrations
in
the
environment
and
numerous
food
chains.
Excessive
exposure
heavy
metals,
including
essential
can
have
serious
consequences
on
health,
development
of
various
cancers.
Exposure
is
hard
avoid
prevalence
our
chains;
thus,
it
crucial
importance
understand
outcomes
may
as
well
contribution
disease
aetiology
pathogenesis.
In
this
chapter,
effects
a
multitude
discussed
through
concise
review
recent
studies
which
investigate
contributions
disease.
Toxics,
Journal Year:
2022,
Volume and Issue:
10(12), P. 744 - 744
Published: Nov. 30, 2022
Arsenic
(As)
is
a
poisonous
metalloid
that
toxic
to
both
humans
and
animals.
Drinking
water
contamination
has
been
linked
the
development
of
cancer
(skin,
lung,
urinary
bladder,
liver),
as
well
other
disorders
such
diabetes
cardiovascular,
gastrointestinal,
neurological,
developmental
damage.
According
epidemiological
studies,
As
contributes
male
infertility,
sexual
dysfunction,
poor
sperm
quality,
consequences
low
birth
weight,
spontaneous
abortion,
small
for
gestational
age
(SGA).
exposure
negatively
affected
reproductive
systems
by
lowering
testicular
accessory
organ
weights,
counts,
increasing
abnormalities
causing
apoptotic
cell
death
in
Leydig
Sertoli
cells,
which
resulted
decreased
testosterone
synthesis.
Furthermore,
during
toxicity,
several
molecular
signalling
pathways,
apoptosis,
inflammation,
autophagy
are
involved.
Phytonutrient
intervention
arsenic-induced
toxicity
various
species
received
lot
attention
over
years.
The
current
review
provides
an
in-depth
summary
available
literature
on
therapeutic
approaches
future
directions.
Frontiers in Veterinary Science,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 9, 2025
Fertility
rates
are
declining
in
livestock
such
as
cattle,
and
more
than
one
five
Japanese
couples
have
undergone
infertility
treatment
or
currently
infertile.
Improving
the
fertilization
of
domesticated
animals
is
imperative
for
improving
their
productivity
maintaining
valuable
lineages.
In
this
study,
effects
rutin
quercetin
on
fertility
pregnancy
were
investigated
by
incorporating
these
compounds
into
preculture
medium
vitro
(IVF)
administering
them
orally
to
mice.
The
addition
increased
IVF
rate
twofold.
Oral
administration
aged
male
nulliparous
female
mice
improved
outcomes.
These
findings
important
implications
non-invasive
infertility.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
287, P. 117258 - 117258
Published: Nov. 1, 2024
The
current
study
evaluated
the
efficacy
of
Moringa
oleifera
leaf
extract
in
mitigating
histo-biochemical
alterations
Labeo
rohita
caused
by
arsenic.
A
medical
plant
(Moringa
oleifera)
known
for
its
numerous
pharmacological
qualities,
was
added
to
three
different
diets
at
0,
2,
and
4
%
level,
prepared
mixing
M.
with
basal
diet.
96
hr
lethal
concentration
arsenic
20.25
mg
L
Journal of Toxicology and Environmental Health,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: May 6, 2025
The
aim
of
this
study
was
to
investigate
the
attenuating
effect
vitamin
C
(VC)
on
lead
(Pb)-induced
toxicity
in
male
Wistar
rats.
Twenty-four
mature
rats
were
divided
into
4
groups
consisting
6
animals
using
a
completely
randomized
design.
Rats
treated
orally
with
either
60
mg/kg
body
weight
(BW)
Pb
acetate
or
100
BW
VC
singly
combination.
Controls
group
received
water
(vehicle
control).
After
65
days
exposure,
testes
and
epididymis
measured
for
testicular
weight,
epididymal
sperm
estimations,
while
blood
liver
samples
collected
function,
hormonal
assays,
oxidative
stress
responses
including
transcript
expression
real-time
PCR.
Lead
initiated
significant
increases
activities
antioxidant
enzymes
catalase
(CAT),
superoxide
dismutase
(SOD,)
glutathione
peroxidase
(Gpx)
levels
malondialdehyde
(MDA)
nitric
oxide
(NO).
Liver
function
enzyme
alkaline
phosphatase
(ALP,)
aspartate
aminotransferase
(AST),
alanine
(ALP)
also
elevated
exposed
In
contrast,
decrease
noted
reproductive
hormones
testosterone,
luteinizing
hormone
(LH),
follicle
stimulating
(FSH),
variables
motility,
viability
counts,
as
well
weights
following
treatment.
However,
reduced
combined
exposure
group,
profile
increased
significantly
compared
alone.
Data
indicate
that
exerts
an
effect.
Our
findings
showed
potential
Pb-induced
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
274, P. 116183 - 116183
Published: March 11, 2024
Arsenic
is
an
environmentally
ubiquitous
toxic
metalloid.
Chronic
exposure
to
arsenic
may
lead
arsenicosis,
while
no
specific
therapeutic
strategies
are
available
for
the
arsenism
patients.
And
Ginkgo
biloba
extract
(GBE)
exhibited
protective
effect
in
our
previous
study.
However,
mechanisms
by
which
GBE
protects
patients
remain
poorly
understood.
A
liquid
chromatography-mass
spectrometry
(LC-MS)
based
untargeted
metabolomics
analysis
was
used
study
metabolic
response
upon
intervention.
In
total,
39
coal-burning
type
of
and
50
healthy
residents
were
enrolled
from
Guizhou
province
China.
The
intervention
group
(n
=
39)
orally
administered
with
(three
times
per
day)
continuous
90
days.
Plasma
samples
controls
(HC)
before
after
collected
analyzed
established
LC-MS
method.
Statistical
performed
MetaboAnalyst
5.0
identify
differential
metabolites.
Multivariate
revealed
a
separation
between
(BG)
(AG)
group.
It
observed
that
35
metabolites
identified
BG
AG
group,
30
them
completely
or
partially
reversed
intervention,
14
significantly
up-regulated
16
considerably
down-regulated.
These
involved
promoting
immune
anti-inflammatory
functions,
alleviating
oxidative
stress.
Taken
together,
these
findings
indicate
could
probably
exert
its
effects
reversing
disordered
modulating
functions
patients,
provide
insights
into
further
exploration
mechanistic
studies.
