Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2433 - 2433
Published: May 23, 2023
Depression is classified as one of the most common mental disorders. Its prevalence has recently increased, becoming a growing public health threat. This review focuses on clarifying role and importance individual nutrients in diet impact nutrient deficiencies risk depression. Deficiencies such protein, B vitamins, vitamin D, magnesium, zinc, selenium, iron, calcium, omega-3 fatty acids have significant brain nervous system function, which can affect appearance depressive symptoms. However, it important to remember that itself not only factor influencing or helping treat There are many other aspects, physical activity, sleep, stress management, social support, also play an maintaining health. The data observed available analyses based cross-sectional studies. Further studies, including prospective cohort, case-control recommended draw more reliable conclusions.
Language: Английский
Citations
46
Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1054 - 1054
Published: April 4, 2024
The microbiota-gut-brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health disease. Dysbiosis, disturbance in gut microbiome equilibrium, can significantly impact MGB axis, leading to alterations microbial composition function. Emerging evidence highlights connection between microbiota neurological psychiatric disorders, including depression. This review explores potential psychobiotics managing depressive emphasizing their role restoring balance axis. Psychobiotics exhibit positive effects on intestinal barrier, immune response, cortisol levels, hypothalamic-pituitary-adrenal (HPA) Studies suggest that probiotics may serve as an adjunct therapy for depression, especially treatment-resistant cases. discusses key findings from studies interventions, gut-brain mental health. increasing acceptance expanded concept underscores importance microorganisms well-being. As our understanding microbiome's disease grows, emerge promising agents addressing issues, providing new avenues therapeutic interventions disorders.
Language: Английский
Citations
17
Experimental Gerontology, Journal Year: 2022, Volume and Issue: 172, P. 112072 - 112072
Published: Dec. 21, 2022
Depression is one of the leading health problems, and >300 million people have a major depressive disorder this number getting increasing. complicates management existing chronic diseases complications that may arise. A person's mental state can affect their food preferences, preferences also state. In paper, depression eating behavior, diet quality, folic acid, vitamin B12, B6, D, omega-3 fatty acids, magnesium, selenium, zinc copper, prebiotics probiotics are discussed. Research on subject emphasizes quality occurrence depression. However, studies indicated dietary nutrients such as zinc, magnesium might be associated with risk
Language: Английский
Citations
60
Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: 126, P. 214 - 224
Published: Feb. 18, 2025
Language: Английский
Citations
1
Schizophrenia Research, Journal Year: 2025, Volume and Issue: 281, P. 30 - 44
Published: May 1, 2025
Language: Английский
Citations
1
Human Genomics, Journal Year: 2021, Volume and Issue: 15(1)
Published: Aug. 21, 2021
Abstract Whether microRNAs (miRNAs) from plasma exosomes might be dysregulated in patients with depression, especially treatment-resistant depression (TRD), remains unclear, based on study of which novel biomarkers and therapeutic targets could discovered. To this end, a small sample was performed by isolation TRD diagnosed Hamilton scale. In study, 4 peripheral samples healthy controls were collected for extraction exosomes. Exosomal miRNAs analyzed miRNA sequencing, followed image collection, expression difference analysis, target gene GO enrichment KEGG pathway analysis. Compared the controls, 2 showed significant differences expression, among has-miR-335-5p significantly upregulated has-miR-1292-3p downregulated. Go analysis that affect postsynaptic density axonogenesis as well signaling axon formation cell growths. The identification these their genes may provide improving diagnosis accuracy treatment effectiveness TRD.
Language: Английский
Citations
48
Heliyon, Journal Year: 2023, Volume and Issue: 9(4), P. e14932 - e14932
Published: April 1, 2023
Major depressive disorder (MDD) is a multimodal neuropsychiatric and neurodegenerative illness characterized by anhedonia, continued melancholy, dysfunctional circadian rhythm many other behavioral infirmities. Depression also associated with somatic ailments such as cardiometabolic diseases. The existing upcoming hypotheses have succeeded in explaining the pathophysiology of depression. Only few most validated theories, hyperactivity HPA axis, activated inflammatory-immune response, monoaminergic GABAergic deficit hypotheses, been discussed this review. So, an effective safer alternative approach beyond symptomatic relief has desired. Therefore, botanical products steadily probed to strengthen modern medicinal system promising medicament. In line, Asparagus racemosus Willd. belongs Asparagaceace family well-documented adaptogen cited ancient texts namely, Ayurvedic, Greek, Chinese medicine system. whole plant possesses pleiotropic therapeutic activity, antioxidant, anti-inflammatory, immunomodulatory, neuroprotective, nootropic, antidepressant, etc., without showing any remarkable side effects. literature review suggested that A. administration at varied levels alleviates depression modulating increasing BDNF levels, neurotransmission. Alongside, spikes level antioxidant enzymes, SOD, GSH peroxidase, GSH, catalase distinct brain regions (i.e., hippocampus, prefrontal cortex, amygdala, hypothalamus) promote neurogenesis neuroplasticity. Thus, it could be new generation antidepressant provides from both illness. first describes characteristics, then discusses pathogenesis depression, gives insight into properties underlying mechanism.
Language: Английский
Citations
18
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: May 15, 2024
Treatment-resistant depression (TRD) occurs when at least two different antidepressants, taken the right dosage, for adequate period of time and with continuity, fail to give positive clinical effects. Esketamine, S-enantiomer ketamine, was recently approved TRD treatment from U.S. Food Drug Administration European Medicine Agency. Despite proved efficacy, many misconceptions by clinicians patients accompany this medication. We aimed review most common "false myths" regarding esketemine, counterarguing evidence-based facts.
Language: Английский
Citations
8
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 488 - 488
Published: May 3, 2024
Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological psychiatric health. It exerts a profound effect on immune cell activation brain function, suggesting potential roles in both neuroprotection neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation disease progression. Additionally, CXCL8 gene polymorphisms can alter production, leading differences susceptibility, progression, severity across populations. levels vary among neuropsychiatric conditions, demonstrating sensitivity psychosocial stressors severity. be detected blood circulation, cerebrospinal fluid (CSF), urine, making it promising candidate for broad-spectrum biomarker. This review highlights the need further research diverse effects of associated implications personalized medicine. A thorough understanding its complex role could lead development more effective treatment strategies conditions.
Language: Английский
Citations
7
Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(3), P. 480 - 480
Published: Jan. 18, 2022
(1) Background: Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders worldwide. Although several antidepressant drugs have been developed, up to 30% patients fail achieve remission, and acute remission rates decrease with number treatment steps required. The aim current project was estimate describe population treatment-resistant depression (TRD) in outpatient clinics Poland. (2) Methods: involved a representative sample psychiatrists working clinics, chosen through process quota random sampling. doctors completed two questionnaires on consecutive series MDD, which captured patients' demographics, comorbidities, medical histories. TRD defined as no improvement seen after minimum different drug therapies applied sufficient doses for 4 weeks each. data were weighted extrapolated outpatients (3) Results: A total 76 described 1781 MDD patients, out 396 fulfilled criteria TRD. constituted 25.2% all led Poland being estimated at 34,800. histories, histories Polish described. In our (mean age: 45.6 ± 13.1 years; female: 64%), had experienced 2.1 1.6 episodes (including one), mean duration episode 4.8 4.4 months. terms strategies, (around 70%) received monotherapy during first three therapies, while combination (ADs) more often from fourth line treatment. use additional medications augmentation reported only third patients. During steps, selective serotonin reuptake inhibitor (SSRI) norepinephrine (SNRI). (4) Conclusions: serious problem, affecting approximately nearly 35,000 Poles.
Language: Английский
Citations
25