Association between depression and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 337, P. 57 - 65

Published: May 25, 2023

Language: Английский

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Dietary Nutrient Deficiencies and Risk of Depression (Review Article 2018–2023)

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2433 - 2433

Published: May 23, 2023

Depression is classified as one of the most common mental disorders. Its prevalence has recently increased, becoming a growing public health threat. This review focuses on clarifying role and importance individual nutrients in diet impact nutrient deficiencies risk depression. Deficiencies such protein, B vitamins, vitamin D, magnesium, zinc, selenium, iron, calcium, omega-3 fatty acids have significant brain nervous system function, which can affect appearance depressive symptoms. However, it important to remember that itself not only factor influencing or helping treat There are many other aspects, physical activity, sleep, stress management, social support, also play an maintaining health. The data observed available analyses based cross-sectional studies. Further studies, including prospective cohort, case-control recommended draw more reliable conclusions.

Language: Английский

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Food as medicine, community as medicine: Mental health effects of a social care intervention

Health Services Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Objective To assess mental health related outcomes of Recipe4Health, a multisectoral social care partnership implementing produce prescriptions with or without group medical visits (GMVs). Study Setting and Design Recipe4Health was implemented at five community centers from 2020 to 2023. Primary teams referred patients food insecurity and/or nutrition‐sensitive chronic conditions (e.g., diabetes, depression) 16 weeks Food Farmacy (produce prescriptions) the option GMV participation. We used convergent mixed‐methods design including survey interview data. Data Sources Analytic Sample conducted (1) participant surveys pre‐ post‐intervention (2) semi‐structured interviews participants partner organization staff. Linear mixed effects models examined changes in outcomes. Interviews were analyzed using codebook thematic analysis. Principal Findings Program middle‐aged, primarily women, diverse racial/ethnic backgrounds (majority Latine Black). At baseline, moderate severe depression anxiety symptoms reported by 77/188 (41%) Farmacy‐only participants, 113/284 (40%) +GMV participants. Among significantly improved only among those who did not have baseline depression/anxiety (PHQ9: −1.7 [95% CI: −2.8, −0.6]; GAD7: −1.8 −2.9, −0.8]). regardless health; depression/anxiety: PHQ9: −2.4 (95% −3.6, −1.2); −0.9 −2.0, 0.1); without: −2.2 −3.2, −3.1, −1.2). Improvements needs (food insecurity, loneliness) health‐related behaviors (fruit/vegetable intake, physical activity) varied intervention arm symptom level. In interviews, staff endorsed for improving nutrition GMVs increasing support. Conclusion Social interventions providing vegetables fruit, visits, may concurrently address needs.

Language: Английский

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Risk factors and consequences of mental health problems in nurses: A scoping review of cohort studies

International Journal of Mental Health Nursing, Journal Year: 2024, Volume and Issue: 33(5), P. 1197 - 1211

Published: April 15, 2024

Abstract Mental health problems in nurses are prevalent and impairing. To date, no literature has comprehensively synthesised cohort evidence on mental among nurses. This scoping review aimed to synthesise the existing risk factors consequences of A systematic search was conducted PubMed, EMBASE, Epistemonikos database, Web Science, CINAHL, PsycINFO from inception March 2023. We identified 171 studies 16 countries, mostly (95.3%) high‐income economies. indicated that worldwide encountered significant challenges, including depression, cognitive impairment, anxiety, trauma/post‐traumatic stress disorder, burnout, sleep other negative problems. These were closely related various modifiable such as nurses' behaviours lifestyles, social support, workplace bullying violence, shift work, job demands, resources. Moreover, have effects their physical health, behaviour lifestyle, occupation organisation, intrapersonal factors. findings provided an enhanced understanding complexities nurses, shed light policy enactment alleviate impact Addressing should be a top priority.

Language: Английский

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Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 9, 2024

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future

Language: Английский

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Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 952 - 952

Published: March 26, 2024

High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies compellingly linked HFD consumption to obesity the development of type 2 diabetes mellitus. Moreover, synergistic interplay HFD, obesity, expedites aging process prematurely fosters age-related diseases. However, underlying mechanisms driving these associations remain enigmatic. One most conspicuous hallmarks is accumulation highly inflammatory senescent cells, with mounting evidence implicating increased cellular senescence in pathogenesis Our hypothesis posits that amplifies burden across multiple organs. To scrutinize this hypothesis, we subjected mice a 6-month regimen, assessing biomarker expression liver, white adipose tissue, brain. Aging intrinsically impaired stress resilience, driven dysfunction Nrf2-mediated cytoprotective pathways safeguard cells against oxidative stress-induced senescence. ascertain whether shield induction response consumption, explored novel model aging: Nrf2-deficient (Nrf2+/−) mice, emulating phenotype. initial findings unveiled significant Nrf2 Nrf2+/− mirroring aging-related alterations. led substantial hyperglycemia, insulin sensitivity both Nrf2+/+ mice. In control primarily heightened evidenced Cdkn2a expression. elicited surge We postulate HFD-induced augmentation may be pivotal contributor accelerated organismal premature onset

Language: Английский

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Circulating B vitamins metabolites in depressive disorders - connections with the microbiota-gut-brain axis

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 472, P. 115145 - 115145

Published: July 9, 2024

Language: Английский

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Associations between the intake of single and multiple dietary vitamins and depression risk among populations with chronic kidney disease

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Background The effects of multivitamin exposure on depression among patients with chronic kidney disease (CKD) have not been thoroughly explored. This study aimed to explore the individual vitamin intakes and joint effect intake multiple vitamins (including A, B 1 , 2 6 12 C, D, E, K) risk in participants CKD. Methods A total 3,123 CKD (weighted n = 25,186,480) from National Health Nutrition Examination Survey database 2007 2014 were included. Weighted multivariate logistic regression models utilized analyze associations dietary risk. Additionally, Bayesian kernel machine (BKMR) weighted quantile sum (WQS) performed evaluate nine Results overall prevalence was approximately 11.3% participants. In fully adjusted model, high (OR: 0.54, 95% CI: 0.40–0.74), 0.67, 0.48–0.95), 0.70, 0.49–0.99), D 0.67. 0.48–0.94), K 0.61, 0.44–0.85) associated a reduced likelihood depression. BKMR WQS showed that had significant negative depression, being largest contributor two models. Lastly, reflected mixed 0.82, 0.69–0.99). Conclusion High are low Furthermore, co-exposure is crucial factor contributing this population.

Language: Английский

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Trace Elements Levels in Major Depressive Disorder—Evaluation of Potential Threats and Possible Therapeutic Approaches

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15071 - 15071

Published: Oct. 11, 2023

The multifactorial etiology of major depressive disorder (MDD) includes biological, environmental, genetic, and psychological aspects. Recently, there has been an increasing interest in metallomic studies psychiatry, aiming to evaluate the role chosen trace elements MDD as well progression symptoms. This narrative review aims summarize available literature on relationship between concentration serum patients with onset this psychiatric condition. authors reviewed PubMed, Web Science, Scopus databases searching for that had investigated so far further evaluated them paper. Ultimately, 15 were evaluated, namely, zinc, magnesium, selenium, iron, copper, aluminium, cadmium, lead, mercury, arsenic, calcium, manganese, chromium, nickel, phosphorus. association psychiatry developing dynamically recently. According results current research, metallomics might act a potential screening tool while at same time providing assessment severity Either deficiencies or excessive amounts be associated symptoms even disease among people predisposed MDD.

Language: Английский

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The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1635 - 1635

Published: May 27, 2024

The acceleration of aging is a risk factor for numerous diseases, and diet has been identified as an especially effective anti-aging method. Currently, research on the relationship between dietary nutrient intake accelerated remains limited, with existing studies focusing small number individual nutrients. Comprehensive single mixed effects nutrients not conducted. This study aimed to comprehensively explore intakes, both singly in combination, aging. Data this were extracted from 2015–2018 National Health Nutrition Examination Surveys (NHANES). was measured by phenotypic age acceleration. Linear regression (linear), restricted cubic spline (RCS) (nonlinear), weighted quantile sum (WQS) (mixed effect) models used association A total 4692 participants aged ≥ 20 included study. In fully adjusted models, intakes 16 negatively associated (protein, vitamin E, A, beta-carotene, B1, B2, B6, K, phosphorus, magnesium, iron, zinc, copper, potassium, fiber, alcohol). Intakes sugars, C, caffeine, alcohol showed significant nonlinear associations Additionally, Single well may mitigate Moderately increasing specific maintaining balance be key strategies prevent

Language: Английский

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